Herbert Y Meltzer

  • 68661 Citations
1961 …2022
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Research Output 1961 2019

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Review article
1976
9 Citations (Scopus)

Biochemical studies in schizophrenia

Meltzer, H. Y., Jan 1 1976, In : Schizophrenia bulletin. 2, 1, p. 10-18 9 p.

Research output: Contribution to journalReview article

Schizophrenia
Monoamine Oxidase
Acute-Phase Reaction
Hemolysin Proteins
Disease Susceptibility
53 Citations (Scopus)

Neuromuscular dysfunction in schizophrenia

Meltzer, H. Y., Jan 1 1976, In : Schizophrenia bulletin. 2, 1, p. 106-135 30 p.

Research output: Contribution to journalReview article

Psychotic Disorders
Schizophrenia
Psychiatry
Spinal Cord
Psychotic Affective Disorders
597 Citations (Scopus)

The dopamine hypothesis of schizophrenia: a review

Meltzer, H. Y. & Stahl, S. M., Jan 1 1976, In : Schizophrenia bulletin. 2, 1, p. 19-76 58 p.

Research output: Contribution to journalReview article

Dopamine
Schizophrenia
Dopamine Agents
Dopaminergic Neurons
Pharmacology
1980
71 Citations (Scopus)

Relevance of dopamine autoreceptors for psychiatry: Preclinical and clinical studies

Meltzer, H. Y., Jan 1 1980, In : Schizophrenia bulletin. 6, 3, p. 456-475 20 p.

Research output: Contribution to journalReview article

Autoreceptors
Psychiatry
Dopamine
Dopaminergic Neurons
Dopamine Agonists
1982
4 Citations (Scopus)

Effect of benzamide drugs on prolactin secretion: relation to the dopamine receptor.

Meltzer, H. Y., So, R. & Fang, V. S., Dec 1 1982, In : Advances in biochemical psychopharmacology. 35, p. 61-82 22 p.

Research output: Contribution to journalReview article

Benzamides
Sulpiride
Dopamine Receptors
Pituitary Gland
Prolactin
65 Citations (Scopus)

Effect of serotonin precursors and serotonin agonists on plasma hormone levels.

Meltzer, H. Y., Wiita, B., Tricou, B. J., Simonovic, M., Fang, V. & Manov, G., Jan 1 1982, In : Advances in biochemical psychopharmacology. 34, p. 117-139 23 p.

Research output: Contribution to journalReview article

5-Hydroxytryptophan
Serotonin Receptor Agonists
Pituitary Gland
Prolactin
Growth Hormone
1983
30 Citations (Scopus)

The nosology of schizoaffective psychosis.

Brockington, I. F. & Meltzer, H. Y., Dec 1 1983, In : Psychiatric Developments. 1, 4, p. 317-338 22 p.

Research output: Contribution to journalReview article

Psychotic Disorders
Schizophrenia
Psychotic Affective Disorders
Inheritance Patterns
Mood Disorders
1984
9 Citations (Scopus)

Dopaminergic and serotonergic control of neuroendocrine function.

Gudelsky, G. A., Simonovic, M. & Meltzer, H. Y., Jan 1 1984, In : Monographs in neural sciences. 10, p. 85-102 18 p.

Research output: Contribution to journalReview article

Methyltyrosines
Tetrahydronaphthalenes
Piperidines
Benzamides
Hypothalamo-Hypophyseal System
1985
35 Citations (Scopus)

Long-term effects of neuroleptic drugs on the neuroendocrine system.

Meltzer, H. Y., Jan 1 1985, In : Advances in biochemical psychopharmacology. 40, p. 59-68 10 p.

Research output: Contribution to journalReview article

Physiological Sexual Dysfunctions
Pituitary Diseases
Galactorrhea
Drug Tolerance
Gynecomastia
1987
67 Citations (Scopus)

Dexamethasone bioavailability: Implications for DST research

Lowy, M. T. & Meltzer, H. Y., Jan 1 1987, In : Biological psychiatry. 22, 3, p. 373-385 13 p.

Research output: Contribution to journalReview article

Dexamethasone
Biological Availability
Research
Serum
Psychiatry
1988
28 Citations (Scopus)

Platelet MAO activity in hallucinating and paranoid schizophrenics: A review and meta-analysis

Zureick, J. L. & Meltzer, H. Y., Jan 1 1988, In : Biological psychiatry. 24, 1, p. 63-78 16 p.

Research output: Contribution to journalReview article

Monoamine Oxidase
Meta-Analysis
Blood Platelets
Antipsychotic Agents
Reference Values
1989
20 Citations (Scopus)

Negative symptoms in schizophrenia: a target for new drug development.

Meltzer, H. Y. & Zureick, J., Dec 1 1989, In : Psychopharmacology series. 7, p. 68-77 10 p.

Research output: Contribution to journalReview article

Schizophrenic Psychology
Antipsychotic Agents
Schizophrenia
Pharmaceutical Preparations

Serotonergic dysfunction in depression.

Meltzer, H., Dec 1 1989, In : The British journal of psychiatry. Supplement. 8, p. 25-31 7 p.

Research output: Contribution to journalReview article

Serotonin
Depression
Hydroxyindoleacetic Acid
Blood Platelets
Tryptophan Hydroxylase
1991
6 Citations (Scopus)

The neurobiology of schizophrenia

Meltzer, H. Y., Jan 1 1991, In : Current Opinion in Psychiatry. 4, 1, p. 90-95 6 p.

Research output: Contribution to journalReview article

Neurobiology
Schizophrenia
1992
224 Citations (Scopus)

Dimensions of outcome with clozapine

Meltzer, H. Y., Jan 1 1992, In : British Journal of Psychiatry. 160, MAY. SUPPL. 17, p. 46-53 8 p.

Research output: Contribution to journalReview article

Clozapine
Patient Readmission
Cost Savings
Semantics
Health Care Costs

Dimensions of outcome with clozapine.

Meltzer, H. Y., May 1 1992, In : The British journal of psychiatry. Supplement. 17, p. 46-53 8 p.

Research output: Contribution to journalReview article

Clozapine
Patient Readmission
Cost Savings
Semantics
Health Care Costs
132 Citations (Scopus)

The importance of serotonin-dopamine interactions in the action of clozapine

Meltzer, H. Y., Jan 1 1992, In : British Journal of Psychiatry. 160, MAY. SUPPL. 17, p. 22-29 8 p.

Research output: Contribution to journalReview article

Clozapine
Antipsychotic Agents
Dopamine
Serotonin
Serotonin 5-HT2 Receptors

The importance of serotonin-dopamine interactions in the action of clozapine.

Meltzer, H. Y., May 1 1992, In : The British journal of psychiatry. Supplement. 17, p. 22-29 8 p.

Research output: Contribution to journalReview article

Clozapine
Antipsychotic Agents
Dopamine
Serotonin
Serotonin 5-HT2 Receptors
1993
74 Citations (Scopus)

New drugs for the treatment of schizophrenia

Meltzer, H. Y., Jan 1 1993, In : Psychiatric Clinics of North America. 16, 2, p. 365-385 21 p.

Research output: Contribution to journalReview article

Antipsychotic Agents
Schizophrenia
Clozapine
Pharmaceutical Preparations
Remoxipride
10 Citations (Scopus)

Serotonin receptors and antipsychotic drug action.

Meltzer, H. Y., Jan 1 1993, In : Psychopharmacology series. 10, p. 70-81 12 p.

Research output: Contribution to journalReview article

Serotonin Agents
Clozapine
Serotonin Receptors
Antipsychotic Agents
1995
389 Citations (Scopus)

Neuroleptic withdrawal in schizophrenic patients: A review of the literature

Gilbert, P. L., Harris, M. J., McAdams, L. A., Jeste, D. V., Baldessarini, R. J., Viguera, A. C., Carpenter, W. T., Tamminga, C. A., Greden, J. F., Tandon, R., Meltzer, H. Y., Nuechterlein, K. H., Gitlin, M. J., Subotnik, K. L. & Wyatt, R. J., Jan 1 1995, In : Archives of general psychiatry. 52, 3, p. 173-212 40 p.

Research output: Contribution to journalReview article

Antipsychotic Agents
Recurrence
Schizophrenia
Maintenance
Relapse
163 Citations (Scopus)

Role of serotonin in the action of atypical antipsychotic drugs.

Meltzer, H. Y., Jan 1 1995, In : Clinical neuroscience (New York, N.Y.). 3, 2, p. 64-75 12 p.

Research output: Contribution to journalReview article

Clozapine
Antipsychotic Agents
Serotonin
Aptitude
olanzapine
1996

Pre-clinical pharmacology of atypical antipsychotic drugs: a selective review.

Meltzer, H. Y., May 1 1996, In : The British journal of psychiatry. Supplement. 29, p. 23-31 9 p.

Research output: Contribution to journalReview article

Preclinical Drug Evaluations
Clinical Pharmacology
Serotonin Receptors
Synaptic Transmission
Antipsychotic Agents
68 Citations (Scopus)

Pre-clinical pharmacology of atypical antipsychotic drugs: A selective review

Meltzer, H. Y., Jan 1 1996, In : British Journal of Psychiatry. 168, MAY SUPPL. 29, p. 23-31 9 p.

Research output: Contribution to journalReview article

Clinical Pharmacology
Antipsychotic Agents
1997
687 Citations (Scopus)

Practice guideline for the treatment of patients with schizophrenia

Herz, M. I., Liberman, R. P., McGlashan, T. H., Lieberman, J. A., Wyatt, R. J., Marder, S. R., Wang, P., Allgulander, C., Baldessarini, R. J., Balon, R., Bellack, A. S., Berlin, J., Blackington, C. H., Buckley, P., Carlson, D. G., Cott, J., Cournos, F., Desai, P., Dickstein, L., Fenton, W. S. & 78 others, Fisher, W. A., Flaherty, L. T., Freedman, R., Galanter, M., Galton, E., Ganguli, R., Garrettson, L. K., Goldfinger, S., Goldman, L. S., Goldstein, M. Z., Gordy, T. R., Gray, S. H., Green, M. R., Greenberg, W. M., Gunderson, J. G., Hall, L. L., Haller, E., Hanin, E., Hawkins, L., Hester, T. W., Horn, T., Hsiao, J. K., Juthani, N. V., Kane, J. M., Kayser, A., Kibel, H. D., Kimmich, R. A., Koegler, R. R., Krajeski, J., Kuehnel, T., Lamberti, J. S., Lehman, A., Leunello, J., Martin, R. L., McCarley, R., McGee, M., Meltzer, H. Y., Mesulam, M., Metzner, J. L., Mosher, L. R., Motto, J. A., Mueser, K. T., Munoz, R. A., Nasrallah, H. A., Newcomer, J. W., Opler, L. A., Peterson, G. N., Rapaport, M., Riba, M., Rickert, V. I., Rifkin, A., Rivenbark, J. S., Robertson, S., Ruiz, P., Ryan, W. G., Sanderson, M. O., Schiffer, R. B., Schyve, P. M., Sebring, R. H., Shen, W. W., Shore, D., Simpson, G. M., Soufi, H. E., Stein, L. I., Stotland, N., Strauss, J., Sundberg, D., Svendsen, D., Tohen, M., Tsuang, M., Wagnitz, J. G., Weiner, R., Weitzel, W. D., Wilkerson, L. J., Wingerson, D., Zarate, J., Zito, J. & Zonana, H. V., Jan 1 1997, In : American Journal of Psychiatry. 154, 4 SUPPL., p. 1-63 63 p.

Research output: Contribution to journalReview article

250 Citations (Scopus)

Treatment-resistant schizophrenia - The role of clozapine

Meltzer, H. Y., Jan 1 1997, In : Current Medical Research and Opinion. 14, 1, p. 1-20 20 p.

Research output: Contribution to journalReview article

Clozapine
Schizophrenia
Antipsychotic Agents
Therapeutics
Suicide
1998
102 Citations (Scopus)

Adverse effects of the atypical antipsychotics

Meltzer, H. Y., Oct 5 1998, In : Journal of Clinical Psychiatry. 59, SUPPL. 12, p. 17-22 6 p.

Research output: Contribution to journalReview article

Antipsychotic Agents
Clozapine
Cholinergic Antagonists
Weight Gain
Orthostatic Hypotension
40 Citations (Scopus)

Assessing the effects of atypical antipsychotics on negative symptoms

Meltzer, H. Y., Oct 5 1998, In : Journal of Clinical Psychiatry. 59, SUPPL. 12, p. 28-34 7 p.

Research output: Contribution to journalReview article

Antipsychotic Agents
Schizophrenia
Depression
36 Citations (Scopus)

Assessment of EPS and tardive dyskinesia in clinical trials

Meltzer, H. Y., Oct 5 1998, In : Journal of Clinical Psychiatry. 59, SUPPL. 12, p. 23-27 5 p.

Research output: Contribution to journalReview article

Symptom Assessment
Antipsychotic Agents
Clinical Trials
Psychomotor Agitation
Dystonia
50 Citations (Scopus)

Atypical antipsychotics for treatment of depression in schizophrenia and affective disorders

Meltzer, H. Y., Oct 5 1998, In : Journal of Clinical Psychiatry. 59, SUPPL. 12, p. 41-45 5 p.

Research output: Contribution to journalReview article

Mood Disorders
Antipsychotic Agents
Schizophrenia
Depression
Suicide
20 Citations (Scopus)

Clinical development of atypical antipsychotics: Research design and evaluation

Meltzer, H. Y., Oct 5 1998, In : Journal of Clinical Psychiatry. 59, SUPPL. 12, p. 10-16 7 p.

Research output: Contribution to journalReview article

Antipsychotic Agents
Research Design
Clinical Trials
Investigational New Drug Application
Product Labeling
33 Citations (Scopus)

Evaluating the effects of antipsychotics on cognition in schizophrenia

Meltzer, H. Y., Oct 5 1998, In : Journal of Clinical Psychiatry. 59, SUPPL. 12, p. 35-40 6 p.

Research output: Contribution to journalReview article

Cognition
Antipsychotic Agents
Schizophrenia
Aptitude
Risperidone
37 Citations (Scopus)

Measuring outcome in schizophrenia: Differences among the atypical antipsychotics

Meltzer, H. Y., Oct 5 1998, In : Journal of Clinical Psychiatry. 59, SUPPL. 12, p. 3-9 7 p.

Research output: Contribution to journalReview article

Antipsychotic Agents
Schizophrenia
olanzapine
Pharmaceutical Economics
Risperidone
109 Citations (Scopus)

Suicide in schizophrenia: Risk factors and clozapine treatment

Meltzer, H. Y., Jan 1 1998, In : Journal of Clinical Psychiatry. 59, SUPPL. 3, p. 15-20 6 p.

Research output: Contribution to journalReview article

Clozapine
Suicide
Schizophrenia
Antipsychotic Agents
Therapeutics
28 Citations (Scopus)

Treatment of special populations with the atypical antipsychotics

Meltzer, H. Y., Oct 5 1998, In : Journal of Clinical Psychiatry. 59, SUPPL. 12, p. 46-52 7 p.

Research output: Contribution to journalReview article

Antipsychotic Agents
Population
olanzapine
Therapeutics
Risperidone
1999

Pharmacoeconomic factors related to the treatment of schizophrenia

Meltzer, H., Awad, A. G., Manning W.G., J., Shon, S. P., Diamond, R., Mahmoud, R. & Weisburd, D. E., Mar 10 1999, In : Journal of Clinical Psychiatry. 60, SUPPL. 3, p. 59-60 2 p.

Research output: Contribution to journalReview article

77 Citations (Scopus)

Suicide and schizophrenia: Clozapine and the InterSePT study

Meltzer, H. Y., Jun 30 1999, In : Journal of Clinical Psychiatry. 60, SUPPL. 12, p. 47-50 4 p.

Research output: Contribution to journalReview article

Clozapine
Suicide
Schizophrenia
Antipsychotic Agents
olanzapine
885 Citations (Scopus)

The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia

Meltzer, H. Y. & McGurk, S. R., Jan 1 1999, In : Schizophrenia bulletin. 25, 2, p. 233-255 23 p.

Research output: Contribution to journalReview article

olanzapine
Risperidone
Clozapine
Cognition
Schizophrenia
20 Citations (Scopus)

Variability in response to clozapine: Potential role of cytochrome P450 1A2 and the dopamine D4 receptor gene

Ozdemir, V., Masellis, M., Basile, V. S., Kalow, W., Meltzer, H. Y., Lieberman, J. A. & Kennedy, J. L., Jun 30 1999, In : CNS spectrums. 4, 6, p. 30-56 27 p.

Research output: Contribution to journalReview article

Dopamine D4 Receptors
Cytochrome P-450 CYP1A2
Clozapine
Antipsychotic Agents
Genes
2000
69 Citations (Scopus)

Adverse events related to olanzapine

Conley, R. R. & Meltzer, H. Y., May 22 2000, In : Journal of Clinical Psychiatry. 61, SUPPL. 8, p. 26-30 5 p.

Research output: Contribution to journalReview article

olanzapine
Antipsychotic Agents
Schizophrenia
Psychomotor Agitation
Serotonin Antagonists
78 Citations (Scopus)

Pharmacogenetics of antipsychotic treatment: Lessons learned from clozapine

Masellis, M., Basile, V. S., Özdemir, V., Meltzer, H. Y., Macciardi, F. M. & Kennedy, J. L., Feb 1 2000, In : Biological psychiatry. 47, 3, p. 252-266 15 p.

Research output: Contribution to journalReview article

Clozapine
Pharmacogenetics
Antipsychotic Agents
Therapeutics
Schizophrenia
36 Citations (Scopus)

Psychological and behavioural effects of interferons

Bonaccorso, S., Meltzer, H. & Maes, M., Nov 25 2000, In : Current opinion in psychiatry. 13, 6, p. 673-677 5 p.

Research output: Contribution to journalReview article

Interferons
Immunotherapy
Psychology
Depression
Tryptophan
25 Citations (Scopus)

Reducing suicide risk in schizophrenia: Focus on the role of clozapine

Meltzer, H. Y., Anand, R. & Alphs, L., Jan 1 2000, In : CNS Drugs. 14, 5, p. 355-365 11 p.

Research output: Contribution to journalReview article

Clozapine
Suicide
Schizophrenia
olanzapine
Cohort Effect
2001
201 Citations (Scopus)

Genetic dissection of atypical antipsychotic-induced weight gain: Novel preliminary data on the pharmacogenetic puzzle

Basile, V. S., Masellis, M., McIntyre, R. S., Meltzer, H. Y., Lieberman, J. A. & Kennedy, J. L., Oct 22 2001, In : Journal of Clinical Psychiatry. 62, SUPPL. 23, p. 45-66 22 p.

Research output: Contribution to journalReview article

Pharmacogenetics
Clozapine
Antipsychotic Agents
Weight Gain
Dissection
43 Citations (Scopus)

Putting metabolic side effects into perspective: Risks versus benefits of atypical antipsychotics

Meltzer, H. Y., Dec 1 2001, In : Journal of Clinical Psychiatry. 62, SUPPL. 27, p. 35-39 5 p.

Research output: Contribution to journalReview article

Antipsychotic Agents
Hyperglycemia
Psychotic Disorders
Cognition
Caregivers
2002
45 Citations (Scopus)

Assessing cardiovascular risks versus clinical benefits of atypical antipsychotic drug treatment.

Meltzer, H. Y., Davidson, M., Glassman, A. H. & Vieweg, W. V. R., Jan 1 2002, In : The Journal of clinical psychiatry. 63 Suppl 9, p. 25-29 5 p.

Research output: Contribution to journalReview article

Antipsychotic Agents
Torsades de Pointes
Therapeutics
Sudden Death
Hypoglycemia
88 Citations (Scopus)

Suicidality in schizophrenia: a review of the evidence for risk factors and treatment options.

Meltzer, H. Y., Jan 1 2002, In : Current Psychiatry Reports. 4, 4, p. 279-283 5 p.

Research output: Contribution to journalReview article

Suicide
Schizophrenia
Clozapine
olanzapine
Therapeutics
2003
31 Citations (Scopus)

Antipsychotic drugs in bipolar disorder

Ertugrul, A. & Meltzer, H. Y., Sep 1 2003, In : International Journal of Neuropsychopharmacology. 6, 3, p. 277-284 8 p.

Research output: Contribution to journalReview article

Bipolar Disorder
Antipsychotic Agents
olanzapine
Risperidone
Clozapine
90 Citations (Scopus)

Neurocognitive assessment in the clinical antipsychotic trials of intervention effectiveness (CATIE) project schizophrenia trial: Development, methodology, and rationale

Keefe, R. S. E., Mohs, R. C., Bilder, R. M., Harvey, P. D., Green, M. F., Meltzer, H. Y., Gold, J. M. & Sano, M., Jan 1 2003, In : Schizophrenia bulletin. 29, 1, p. 45-55 11 p.

Research output: Contribution to journalReview article

Antipsychotic Agents
Schizophrenia
Clinical Trials
Pharmaceutical Preparations
17 Citations (Scopus)

Psychosis of Parkinson's disease: Serotonin 2A receptor inverse agonists as potential therapeutics

Weiner, D. M., Vanover, K. E., Brann, M. R., Meltzer, H. Y. & Davis, R. E., Jul 1 2003, In : Current Opinion in Investigational Drugs. 4, 7, p. 815-819 5 p.

Research output: Contribution to journalReview article

Receptor, Serotonin, 5-HT2A
Psychotic Disorders
Parkinson Disease
Therapeutics
Movement Disorders