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Personal profile

Research Interests

I have a long-term interest in understanding the role of the pronounced collagen-rich stromal reaction that is present in human pancreatic tumors. We have shown that the cancer cells upregulate the key collagenase MT1-MMP to invade and grow in 3D collagen. Recently, we developed a novel method to track cell invasion in 3D collagen using MT1-MMP-expressing cancer cells and found that Ga13 and DDR1-Par3 signaling differentially mediate invasion in the collagen-rich microenvironment. Besides studying the mechanisms by which collagen microenvironment regulates invasion, we are also interested in understanding the role of the collagen microenvironment in treatment resistance, and have shown that epigenetic changes induced by the collagen microenvironment contribute to resistance to chemotherapy. We have found that collagen microenvironment induces histone acetylation and that targeting “readers” of histone acetylation marks using BET inhibitors can limit growth of pancreatic cancer cells. We are currently evaluating BET inhibitors in mouse models of pancreatic cancer with the goal of eventually translating these inhibitors to studies in pancreatic cancer patients. Our ongoing work suggests that BET inhibitors, a number of which are currently being evaluated in clinical trials, will have to be combined with other therapies for maximal clinical efficacy. Finally, we have begun studies evaluating how the collagen microenvironment regulates mRNA translation to mediate pancreatic cancer progression. We have found that pharmacologic and genetic targeting of MNKs, which regulate mRNA translation, can block pancreatic cancer development and progression. We are working to translate these results with BET and MNK inhibitors into clinical trials for patients with pancreatic cancer.

Certifications and Licenses

Hematology
Medical Oncology
Internal Medicine

Training Experience

1999Residency, University of Washington Medical Center
2000Fellowship, University of Michigan Health System
2002Fellowship, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital)

Education/Academic qualification

MD, Harvard University

… → 1996

Research interests

  • Cancer Biology
  • Cell Biology
  • Extracellular Matrix
  • Hematology
  • Oncology
  • Pancreatic Cancer

Fingerprint Dive into the research topics where Hidayatullah G Munshi is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 8 Similar Profiles
Pancreatic Neoplasms Medicine & Life Sciences
Matrix Metalloproteinase 14 Medicine & Life Sciences
Collagen Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Adenocarcinoma Medicine & Life Sciences
Epithelial-Mesenchymal Transition Medicine & Life Sciences
Cells Chemical Compounds
gemcitabine Medicine & Life Sciences

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Grants 2003 2023

Pancreatic Neoplasms
Neoplasms
Pancreatitis
Drinking
Fibrosis
Pancreatic Neoplasms
Adenocarcinoma
Organoids
Collagen
Transgenic Mice
Adenocarcinoma
Collagen
varespladib methyl
Fibrosis
Small Interfering RNA

Research Output 1992 2019

1 Citation (Scopus)

Induction of MNK kinase–dependent eIF4E phosphorylation by inhibitors targeting BET proteins limits efficacy of BET inhibitors

Pham, T. N. D., Kumar, K., DeCant, B. T., Shang, M., Munshi, S. Z., Matsangou, M., Ebine, K. & Munshi, H. G., Feb 1 2019, In : Molecular cancer therapeutics. 18, 2, p. 235-244 10 p.

Research output: Contribution to journalArticle

Protein Transport
Phosphorylation
Neoplasms
p38 Mitogen-Activated Protein Kinases
Proteolysis

P110γ deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity

Torres, C., Mancinelli, G., Cordoba-Chacon, J., Viswakarma, N., Castellanos, K., Grimaldo, S., Kumar, S., Principe, D., Dorman, M. J., McKinney, R., Hirsch, E., Dawson, D., Munshi, H. G., Rana, A. & Grippo, P. J., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 29, p. 14724-14733 10 p.

Research output: Contribution to journalArticle

Carcinogenesis
Phosphatidylinositol 3-Kinases
Diet
gemcitabine
Neoplasms

Potent antineoplastic effects of combined PI3Kα-MNK inhibition in medulloblastoma

Eckerdt, F. D., Bell, J. B., Beauchamp, E. M., Clymer, J., Blyth, G. T., Kosciuczuk, E. M., Ma, Q., Chen, D. Z., Horbinski, C. M., Goldman, S., Munshi, H. G., Hashizume, R. & Platanias, L. C., Jun 1 2019, In : Molecular Cancer Research. 17, 6, p. 1305-1315 11 p.

Research output: Contribution to journalArticle

Medulloblastoma
Mitogen-Activated Protein Kinase Kinases
Phosphatidylinositol 3-Kinases
Antineoplastic Agents
Neoplastic Stem Cells

Quantitative method to track proteolytic invasion in 3D collagen

Ebine, K., Chow, C. R. & Munshi, H. G., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc, p. 161-169 9 p. (Methods in Molecular Biology; vol. 1882).

Research output: Chapter in Book/Report/Conference proceedingChapter

Collagen
Neoplasms
Gels
1 Citation (Scopus)

TGFb blockade augments PD-1 inhibition to promote T-cell–mediated regression of pancreatic cancer

Principe, D. R., Park, A., Dorman, M. J., Kumar, S., Viswakarma, N., Rubin, J., Torres, C., McKinney, R., Munshi, H. G., Grippo, P. J. & Rana, A., Mar 1 2019, In : Molecular cancer therapeutics. 18, 3, p. 613-620 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Neoplasms
Adoptive Transfer
Genetic Models