Hiroaki Kiyokawa

Professor, Pharmacology
Professor, Pathology
Driskill Graduate Training Program in Life Sciences

Phone312/503-0699
Emailkiyokawa@northwestern.edu

7106 Citations

Research output per year

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Personal profile

Research Interests

We are interested in the basic mechanisms of cell cycle control, cellular senescence/immortalization and malignant transformation, with a focus on protein regulation by ubiquitination. We previously demonstrated that cell cycle regulators such as p27Kip1, CDK4 and CDC25A play highly tissue-specific roles in development and oncogenesis. Ubiquitination, the covalent modification of substrate proteins with the small 76-residue protein ubiquitin, exerts diverse regulation of the fate of substrates, including the cell cycle regulators, e.g, promoting proteolysis, altering subcellular localization and modulating enzymatic activities. Our current research is aimed at revealing novel functions of ubiquitination enzymes and their substrates in development and cancer, which is expected to identify new therapeutic targets against human diseases. The laboratory uses a combination of protein engineering, proteomics, bioinformatics, cell biological techniques such as time-lapse microscopy and 3-D culture, and genetically engineered mouse models. Keywords: cell cycle, ubiquitin, ubiquitination, cancer initiation, cancer progression, knockout mice, transgenic mice, breast cancer, cyclin, diabetes, pituitary, development.

Training Experience

1994	Postdoctoral Fellowship, Memorial Sloan-Kettering Cancer Center
1995	Postdoctoral Fellowship, Memorial Sloan-Kettering Cancer Center

Education/Academic qualification

PhD, Osaka University

… → 1990

MD, Osaka University

… → 1986

Research interests

Biochemistry: Proteins
Bioinformatics
Breast Cancer
Cancer Biology
Endocrinology
Molecular Biology
Proteomics
Transgenics

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Grants

2 Active
17 Finished

Orthogonal Ubiquitin Transfer to Profile E3 Substrate Specificity

Carvill, G. L. & Kiyokawa, H.

Georgia State University, National Institute of General Medical Sciences

7/1/19 → 6/30/20

Project: Research project

Orthogonal Ubiquitin Transfer to Profile E3 Substrate Specificity

Kiyokawa, H.

Georgia State University, National Institute of General Medical Sciences

9/1/18 → 6/30/22

Project: Research project

RHLCCC: Program Leaders

Backman, V., Benson III, A. B., Carthew, R. W., Chakravarti, D., Cheng, C., Eklund, E. A., Gius, D. R., Gordon, L. I., Green, K. J., Horvath, C. M., Hou, L., Khan, S. A., Kiyokawa, H., LaBonne, C., Penedo, F. J., Platanias, L. C., Simon, M. A., Spring, B. & Woloschak, G. E.

National Cancer Institute

8/1/16 → 7/31/18

Project: Research project

Training Program in Oncogenesis and Developmental Biology

Eklund, E. A., Kiyokawa, H., LaBonne, C. & Leikin, R. G.

National Cancer Institute

9/24/14 → 10/31/19

Project: Research project

Targeting a Novel Signaling Network Against Lung Metastasis of Breast Cancer

Kiyokawa, H.

Northwestern Memorial Hospital

9/1/14 → 8/31/16

Project: Research project

Research Output

7106 Citations
100 Article
6 Review article
1 Chapter
1 Conference contribution

Identifying the substrate proteins of U-box E3s E4B and CHIP by orthogonal ubiquitin transfer

Bhuripanyo, K., Wang, Y., Liu, X., Zhou, L., Liu, R., Duong, D., Zhao, B., Bi, Y., Zhou, H., Chen, G., Seyfried, N. T., Chazin, W. J., Kiyokawa, H. & Yin, J., Jan 1 2018, In : Science Advances. 4, 1, e1701393.