• Source: Scopus
1987 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research Interests

We are interested in the basic mechanisms of cell cycle control, cellular senescence/immortalization and malignant transformation, with a focus on protein regulation by ubiquitination. We previously demonstrated that cell cycle regulators such as p27Kip1, CDK4 and CDC25A play highly tissue-specific roles in development and oncogenesis. Ubiquitination, the covalent modification of substrate proteins with the small 76-residue protein ubiquitin, exerts diverse regulation of the fate of substrates, including the cell cycle regulators, e.g, promoting proteolysis, altering subcellular localization and modulating enzymatic activities. Our current research is aimed at revealing novel functions of ubiquitination enzymes and their substrates in development and cancer, which is expected to identify new therapeutic targets against human diseases. The laboratory uses a combination of protein engineering, proteomics, bioinformatics, cell biological techniques such as time-lapse microscopy and 3-D culture, and genetically engineered mouse models. Keywords: cell cycle, ubiquitin, ubiquitination, cancer initiation, cancer progression, knockout mice, transgenic mice, breast cancer, cyclin, diabetes, pituitary, development.

Training Experience

1994Postdoctoral Fellowship, Memorial Sloan-Kettering Cancer Center
1995Postdoctoral Fellowship, Memorial Sloan-Kettering Cancer Center

Education/Academic qualification

PhD, Osaka University

… → 1990

MD, Osaka University

… → 1986

Research interests

  • Biochemistry: Proteins
  • Bioinformatics
  • Breast Cancer
  • Cancer Biology
  • Endocrinology
  • Molecular Biology
  • Proteomics
  • Transgenics

Fingerprint

Dive into the research topics where Hiroaki Kiyokawa is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles

Network

Recent external collaboration on country level. Dive into details by clicking on the dots.
If you made any changes in Pure these will be visible here soon.