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Personal profile

Research Interests

Dr. Dong’s laboratory has focused on a continuous and integrated program of investigating genetic alterations and environmental effects on neurodevelopment and aging, and their relevance to the pathogenesis of neurodegenerative and neuropsychiatric disorders, particularly Alzheimer’s disease. Ongoing NIH funded projects to discover novel molecular genetics and epigenetic mechanisms underlying neuropsychological disorders, using human antemortem clinical assessments and postmortem tissues, as well as animal models. The findings from the translational work will help in the development of new therapeutic strategies to slow disease onset and prevent progression.

Education/Academic qualification

PhD, West China University

… → 1992

MD, Zhunyi Medical College

… → 1983

Research interests

  • Aging
  • Alzheimer's Disease
  • Cognitive Neuroscience
  • Dementia
  • Neurobiology
  • Neurogenetics
  • Neuroscience
  • Psychiatry

Fingerprint Dive into the research topics where Hongxin Dong is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Alzheimer Disease Medicine & Life Sciences
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Brain Medicine & Life Sciences
Amyloid Plaques Medicine & Life Sciences

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Grants 2006 2023

Behavioral Symptoms
Dementia
Alzheimer Disease
Psychology
Apathy
Liver
Genes
Qi
Obesity
Endoplasmic Reticulum-Associated Degradation
Sex Characteristics
Alzheimer Disease
Corticotropin-Releasing Hormone
Transgenic Mice
Phosphorylation
Sex Characteristics
Alzheimer Disease
Corticotropin-Releasing Hormone
Transgenic Mice
Phosphorylation
Histone Code
Antipsychotic Agents
Histone Deacetylase Inhibitors
Drug-Related Side Effects and Adverse Reactions
Epigenomics

Research Output 1998 2019

  • 2252 Citations
  • 47 Article
  • 8 Review article
  • 2 Comment/debate
  • 1 Editorial

Editorial: Stress and its impact on Alzheimer's Disease

Dong, H. & Csernansky, J. G., Feb 1 2019, In : Neurobiology of Stress. 10, 100167.

Research output: Contribution to journalEditorial

Open Access
Alzheimer Disease
2 Citations (Scopus)

Serotonergic system, cognition, and BPSD in Alzheimer's disease

Chakraborty, S., Lennon, J. C., Malkaram, S. A., Zeng, Y., Fisher, D. W. & Dong, H., Jun 21 2019, In : Neuroscience Letters. 704, p. 36-44 9 p.

Research output: Contribution to journalReview article

Behavioral Symptoms
Cognition
Dementia
Alzheimer Disease
Psychology
8 Citations (Scopus)

Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice

Ou-Yang, M. H., Kurz, J., Nomura, T., Popovic, J., Rajapaksha, T. W., Dong, H., Contractor, A., Chetkovich, D. M., Tourtellotte, W. G. & Vassar, R. J., Sep 19 2018, In : Science translational medicine. 10, 459, eaao5620.

Research output: Contribution to journalArticle

Knockout Mice
Hippocampus
Phenotype
Alzheimer Disease
Brain
4 Citations (Scopus)

Corticotrophin releasing factor receptor 1 antagonists prevent chronic stress-induced behavioral changes and synapse loss in aged rats

Dong, H., Keegan, J. M., Hong, E., Gallardo, C., Montalvo-Ortiz, J., Wang, B., Rice, K. C. & Csernansky, J. G., Apr 1 2018, In : Psychoneuroendocrinology. 90, p. 92-101 10 p.

Research output: Contribution to journalArticle

R 121919
Memory Disorders
Synapses
Anxiety
Dendritic Spines

Differential neurotoxicity related to tetracycline transactivator and TDP-43 expression in conditional TDP-43 mouse model of frontotemporal lobar degeneration

Kukreja, L., Shahidehpour, R., Kim, G., Keegan, J., Sadleir, K. R., Russell, T., Csernansky, J. G., Mesulam, M-M., Vassar, R. J., Wang, L., Dong, H. & Geula, C., Jul 4 2018, In : Journal of Neuroscience. 38, 27, p. 6045-6062 18 p.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Trans-Activators
DNA-Binding Proteins
Tetracycline
Atrophy