Grants per year
Personal profile
Research Interests
Dr. Dong’s laboratory has focused on a continuous and integrated program of investigating genetic alterations and environmental effects on neurodevelopment and aging, and their relevance to the pathogenesis of neurodegenerative and neuropsychiatric disorders, particularly Alzheimer’s disease. Ongoing NIH funded projects to discover novel molecular genetics and epigenetic mechanisms underlying neuropsychological disorders, using human antemortem clinical assessments and postmortem tissues, as well as animal models. The findings from the translational work will help in the development of new therapeutic strategies to slow disease onset and prevent progression.
Education/Academic qualification
PhD, Neurobiology, West China University
… → 1992
MD, Medicine, Zhunyi Medical College
… → 1983
Research interests keywords
- Aging
- Alzheimer's Disease
- Cognitive Neuroscience
- Dementia
- Neurobiology
- Neurogenetics
- Neuroscience
- Psychiatry
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Alzheimer’s disease and a prospective hearing-related serum biomarker
Zheng, J. (PD/PI) & Dong, H. (Co-Investigator)
National Alzheimer's Association
8/1/23 → 7/31/26
Project: Research project
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Estrogen, Astrocyte Reactivity, and Sex Differences in Alzheimer's Disease
Bulun, S. E. (PD/PI), Dong, H. (PD/PI), Zhao, H. (PD/PI) & Mesulam, M.-M. (Co-Investigator)
4/1/23 → 3/31/26
Project: Research project
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Epigenetic Regulation in Aging and Alzheimer's Disease
Dong, H. (PD/PI), Dong, H. (PD/PI), Carvill, G. L. (Co-Investigator), Carvill, G. L. (Co-Investigator), Csernansky, J. G. (Co-Investigator), Csernansky, J. G. (Co-Investigator), Geula, C. (Co-Investigator) & Geula, C. (Co-Investigator)
12/15/22 → 11/30/27
Project: Research project
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Predoctoral and Postdoctoral Training Program in Aging and Dementia
Vassar, R. J. (PD/PI), Vassar, R. J. (PD/PI), Weintraub, S. (PD/PI), Weintraub, S. (PD/PI), Allada, R. (Other), Allada, R. (Other), Bevan, M. D. (Other), Bevan, M. D. (Other), Caraveo Piso, G. (Other), Caraveo Piso, G. (Other), Carvill, G. L. (Other), Carvill, G. L. (Other), Chan, S. (Other), Chan, S. (Other), Contractor, A. (Other), Contractor, A. (Other), Disterhoft, J. F. (Other), Disterhoft, J. F. (Other), Dombeck, D. A. (Other), Dombeck, D. A. (Other), Dong, H. (Other), Dong, H. (Other), Ferreira, A. B. (Other), Ferreira, A. B. (Other), Flanagan, M. E. (Other), Flanagan, M. E. (Other), Gefen, T. D. (Other), Gefen, T. D. (Other), Geula, C. (Other), Geula, C. (Other), Gratton, C. (Other), Gratton, C. (Other), He, C. (Other), He, C. (Other), Kahnt, T. (Other), Kahnt, T. (Other), Kalb, R. G. (Other), Kalb, R. G. (Other), Kennedy, A. (Other), Kennedy, A. (Other), Kessler, J. (Other), Kessler, J. (Other), Kiskinis, E. (Other), Kiskinis, E. (Other), Klein, W. L. (Other), Klein, W. L. (Other), Kozorovitskiy, Y. (Other), Kozorovitskiy, Y. (Other), Krainc, D. (Other), Krainc, D. (Other), Li, L. (Other), Li, L. (Other), Mazzulli, J. (Other), Mazzulli, J. (Other), Mesulam, M.-M. (Other), Mesulam, M.-M. (Other), Miller, R. J. (Other), Miller, R. J. (Other), Morimoto, R. I. (Other), Morimoto, R. I. (Other), Opal, P. (Other), Opal, P. (Other), Ozdinler, H. (Other), Ozdinler, H. (Other), Paller, K. (Other), Paller, K. (Other), Parisiadou, L. (Other), Parisiadou, L. (Other), Penzes, P. (Other), Penzes, P. (Other), Pinto, L. (Other), Pinto, L. (Other), Prakriya, M. (Other), Prakriya, M. (Other), Reber, P. J. (Other), Reber, P. J. (Other), Roberts, A. L. (Other), Roberts, A. L. (Other), Rogalski, E. (Other), Rogalski, E. (Other), Savas, J. N. (Other), Savas, J. N. (Other), Surmeier Jr, D. J. (Other), Surmeier Jr, D. J. (Other), Swanson, G. T. (Other), Swanson, G. T. (Other), Voss, J. L. (Other), Voss, J. L. (Other), Zee, P. C. (Other), Zee, P. C. (Other), Zelano, C. (Other) & Zelano, C. (Other)
5/1/22 → 4/30/27
Project: Research project
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Concordance of TDP-43 Inclusions with Cortical Atrophy and Clinical Phenotype
Geula, C. (PD/PI), Geula, C. (PD/PI), Geula, C. (PD/PI), Bigio, E. H. (Co-Investigator), Bigio, E. H. (Co-Investigator), Bigio, E. H. (Co-Investigator), Dong, H. (Co-Investigator), Dong, H. (Co-Investigator), Dong, H. (Co-Investigator), Mesulam, M.-M. (Co-Investigator), Mesulam, M.-M. (Co-Investigator), Mesulam, M.-M. (Co-Investigator), Vassar, R. J. (Co-Investigator), Vassar, R. J. (Co-Investigator), Vassar, R. J. (Co-Investigator), Zhang, H. (Other), Zhang, H. (Other) & Zhang, H. (Other)
National Institute of Neurological Disorders and Stroke
4/1/20 → 3/31/26
Project: Research project
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Class 1 histone deacetylases differentially modulate memory and synaptic genes in a spatial and temporal manner in aged and APP/PS1 mice
McClarty, B. M., Rodriguez, G. & Dong, H., Aug 15 2024, In: Brain research. 1837, 148951.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Distinguishing features of depression in dementia from primary psychiatric disease
Fisher, D. W., Dunn, J. T. & Dong, H., Dec 2024, In: Discover Mental Health. 4, 1, 3.Research output: Contribution to journal › Review article › peer-review
Open Access4 Scopus citations -
Parabrachial nucleus Vglut2 expressing neurons projection to the extended amygdala involved in the regulation of wakefulness during sevoflurane anesthesia in mice
Yan, Y., Jiao, Y., Liang, E., Lei, X., Zhang, N., Xu, S., Zhang, L., Wang, J., Luo, T., Yuan, J., Yuan, C., Yang, H., Dong, H., Yu, T. & Yu, W., Aug 2024, In: CNS Neuroscience and Therapeutics. 30, 8, e70001.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Unique transcriptional signatures correlate with behavioral and psychological symptom domains in Alzheimer’s disease
Fisher, D. W., Dunn, J. T., Keszycki, R., Rodriguez, G., Bennett, D. A., Wilson, R. S. & Dong, H., Dec 2024, In: Translational psychiatry. 14, 1, 178.Research output: Contribution to journal › Article › peer-review
Open Access -
Characterization of apathy-like behaviors in the 5xFAD mouse model of Alzheimer's disease
Keszycki, R., Rodriguez, G., Dunn, J. T., Locci, A., Orellana, H., Haupfear, I., Dominguez, S., Fisher, D. W. & Dong, H., Jun 2023, In: Neurobiology of Aging. 126, p. 113-122 10 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations
Datasets
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Brain aromatase and the regulation of sexual activity in male mice
Brooks, D. C. (Creator), Coon, J. S. V. (Contributor), Ercan, C. M. (Creator), Xu, X. (Creator), Dong, H. (Creator), Levine, J. E. (Creator), Bulun, S. E. (Creator) & Zhao, H. (Creator), Dryad, Sep 18 2020
DOI: 10.5061/dryad.5mkkwh72t, https://datadryad.org/stash/dataset/doi:10.5061/dryad.5mkkwh72t
Dataset
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Brain aromatase and the regulation of sexual activity in male mice
Brooks, D. C. (Contributor), Coon, J. S. V. (Contributor), Ercan, C. M. (Contributor), Xu, X. (Contributor), Dong, H. (Contributor), Levine, J. E. (Contributor), Bulun, S. E. (Contributor) & Zhao, H. (Contributor), ZENODO, Sep 18 2020
DOI: 10.5061/dryad.5mkkwh72t, https://zenodo.org/records/4069415
Dataset