• 2170 Citations
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Personal profile

Research Interests

The Liu lab studies the molecular mechanisms underlying cancer stem cells (CSCs) and metastasis through four ongoing interactive basic and translational research projects: (1) to understand CSCs in metastasis using cutting-edge single cell sequencing and CRISPR/Cas9 gene editing technologies; (2) to image CSC behavior and interactions with immune cells during metastasis using bioluminescence imaging and intravital imaging systems; (3) to target CSCs with novel therapeutics delivered by exosomes and nanoparticles; (4) to develop circulating tumor cells (CTCs) and circulating exosome-based biomarkers for cancer diagnosis, treatment monitoring, and prognosis.

Education/Academic qualification

PhD, University of Chicago

… → 2006

MD, Fourth Military Medical University, China

… → 1995

Research interests

  • Breast Cancer
  • Cancer Biology
  • Cell Adhesion Mechanisms
  • Cell Imaging
  • Circulation
  • Immune Regulation
  • MicroRNA
  • Nanotechnology

Fingerprint Dive into the research topics where Huiping Liu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 11 Similar Profiles
Neoplastic Stem Cells Medicine & Life Sciences
Breast Neoplasms Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Neoplasm Metastasis Medicine & Life Sciences
MicroRNAs Medicine & Life Sciences
Exosomes Medicine & Life Sciences
Stem cells Chemical Compounds
Cells Chemical Compounds

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Grants 2017 2024

Neoplasm Metastasis
Endothelial Cells
Circulating Neoplastic Cells
Breast Neoplasms
Neoplasm Metastasis
Neoplastic Stem Cells
Cluster Analysis
Circulating Neoplastic Cells
Neoplasm Metastasis
Neoplastic Stem Cells
Contrast Media
Prostatic Neoplasms
Differential Diagnosis
Breast Neoplasms
Breast Neoplasms
Neoplasm Metastasis
Neoplastic Stem Cells

Research Output 2001 2019

10 Citations (Scopus)

Homophilic CD44 interactions mediate tumor cell aggregation and polyclonal metastasis in patient-derived breast cancer models

Liu, X., Taftaf, R., Kawaguchi, M., Chang, Y. F., Chen, W., Entenberg, D., Zhang, Y., Gerratana, L., Huang, S., Patel, D. B., Tsui, E., Adorno-Cruz, V., Chirieleison, S. M., Cao, Y., Harney, A. S., Patel, S., Patsialou, A., Shen, Y., Avril, S., Gilmore, H. L. & 5 others, Lathia, J. D., Abbott, D. W., Cristofanilli, M., Condeelis, J. S. & Liu, H., Jan 1 2019, In : Cancer discovery. 9, 1, p. 96-113 18 p.

Research output: Contribution to journalArticle

Cell Aggregation
Breast Neoplasms
Neoplasm Metastasis
Circulating Neoplastic Cells

Regulation and functions of integrin α2 in cell adhesion and disease

Adorno-Cruz, V. & Liu, H., Mar 1 2019, In : Genes and Diseases. 6, 1, p. 16-24 9 p.

Research output: Contribution to journalReview article

Cell adhesion
Cell Adhesion
Integrin alpha2beta1
14 Citations (Scopus)

Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop

Li, K., Rodosthenous, R. S., Kashanchi, F., Gingeras, T., Gould, S. J., Kuo, L. S., Kurre, P., Lee, H., Leonard, J. N., Liu, H., Lombo, T. B., Momma, S., Nolan, J. P., Ochocinska, M. J., Pegtel, D. M., Sadovsky, Y., Sánchez-Madrid, F., Valdes, K. M., Vickers, K. C., Weaver, A. M. & 5 others, Witwer, K. W., Zeng, Y., Das, S., Raffai, R. L. & Howcroft, T. K., Apr 5 2018, In : JCI insight. 3, 7

Research output: Contribution to journalReview article

Open Access
RNA Transport
15 Citations (Scopus)

Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase

Thiagarajan, P. S., Sinyuk, M., Turaga, S. M., Mulkearns-Hubert, E. E., Hale, J. S., Rao, V., Demelash, A., Saygin, C., China, A., Alban, T. J., Hitomi, M., Torre-Healy, L. A., Alvarado, A. G., Jarrar, A., Wiechert, A., Adorno-Cruz, V., Fox, P. L., Calhoun, B. C., Guan, J. L., Liu, H. & 2 others, Reizes, O. & Lathia, J. D., Dec 1 2018, In : Nature communications. 9, 1, 578.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Focal Adhesion Protein-Tyrosine Kinases
Neoplastic Stem Cells
10 Citations (Scopus)

Exosomes as a Drug Delivery System in Cancer Therapy: Potential and Challenges

Kibria, G., Ramos, E. K., Wan, Y., Gius, D. R. & Liu, H., Sep 4 2018, In : Molecular Pharmaceutics. 15, 9, p. 3625-3633 9 p.

Research output: Contribution to journalReview article

Drug Delivery Systems
Pharmaceutical Preparations