• 2399 Citations

Research output per year

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Personal profile

Research Interests

The Liu lab studies the molecular mechanisms underlying cancer stem cells (CSCs) and metastasis through four ongoing interactive basic and translational research projects: (1) to understand CSCs in metastasis using cutting-edge single cell sequencing and CRISPR/Cas9 gene editing technologies; (2) to image CSC behavior and interactions with immune cells during metastasis using bioluminescence imaging and intravital imaging systems; (3) to target CSCs with novel therapeutics delivered by exosomes and nanoparticles; (4) to develop circulating tumor cells (CTCs) and circulating exosome-based biomarkers for cancer diagnosis, treatment monitoring, and prognosis.

Education/Academic qualification

PhD, The University of Chicago

… → 2006

MD, Fourth Military Medical University

… → 1995

Research interests

  • Breast Cancer
  • Cancer Biology
  • Cell Adhesion Mechanisms
  • Cell Imaging
  • Circulation
  • Immune Regulation
  • MicroRNA
  • Nanotechnology

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  • Research Output

    Extracellular Domains i and II of cell-surface glycoprotein CD44 mediate its trans-homophilic dimerization and tumor cluster aggregation

    Kawaguchi, M., Dashzeveg, N., Cao, Y., Jia, Y., Liu, X., Shen, Y. & Liu, H., Feb 28 2020, In : Journal of Biological Chemistry. 295, 9, p. 2640-2649 10 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    ITGA2 promotes expression of ACLY and CCND1 in enhancing breast cancer stemness and metastasis

    Adorno-Cruz, V., Hoffmann, A. D., Liu, X., Dashzeveg, N. K., Taftaf, R., Wray, B., Keri, R. A. & Liu, H., Jan 1 2020, (Accepted/In press) In : Genes and Diseases.

    Research output: Contribution to journalArticle

    Open Access
  • The Clinical Impact of Cancer Stem Cells

    Lathia, J., Liu, H. & Matei, D., Feb 1 2020, In : Oncologist. 25, 2, p. 123-131 9 p.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Homophilic CD44 interactions mediate tumor cell aggregation and polyclonal metastasis in patient-derived breast cancer models

    Liu, X., Taftaf, R., Kawaguchi, M., Chang, Y. F., Chen, W., Entenberg, D., Zhang, Y., Gerratana, L., Huang, S., Patel, D. B., Tsui, E., Adorno-Cruz, V., Chirieleison, S. M., Cao, Y., Harney, A. S., Patel, S., Patsialou, A., Shen, Y., Avril, S., Gilmore, H. L. & 5 others, Lathia, J. D., Abbott, D. W., Cristofanilli, M., Condeelis, J. S. & Liu, H., Jan 2019, In : Cancer discovery. 9, 1, p. 96-113 18 p.

    Research output: Contribution to journalArticle

  • 35 Scopus citations

    Regulation and functions of integrin α2 in cell adhesion and disease

    Adorno-Cruz, V. & Liu, H., Mar 2019, In : Genes and Diseases. 6, 1, p. 16-24 9 p.

    Research output: Contribution to journalReview article

  • 10 Scopus citations