• 2310 Citations
20012024

Research output per year

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Personal profile

Research Interests

The Liu lab studies the molecular mechanisms underlying cancer stem cells (CSCs) and metastasis through four ongoing interactive basic and translational research projects: (1) to understand CSCs in metastasis using cutting-edge single cell sequencing and CRISPR/Cas9 gene editing technologies; (2) to image CSC behavior and interactions with immune cells during metastasis using bioluminescence imaging and intravital imaging systems; (3) to target CSCs with novel therapeutics delivered by exosomes and nanoparticles; (4) to develop circulating tumor cells (CTCs) and circulating exosome-based biomarkers for cancer diagnosis, treatment monitoring, and prognosis.

Education/Academic qualification

PhD, The University of Chicago

… → 2006

MD, Fourth Military Medical University

… → 1995

Research interests

  • Breast Cancer
  • Cancer Biology
  • Cell Adhesion Mechanisms
  • Cell Imaging
  • Circulation
  • Immune Regulation
  • MicroRNA
  • Nanotechnology

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Grants

  • Research Output

    The Clinical Impact of Cancer Stem Cells

    Lathia, J., Liu, H. & Matei, D., Feb 1 2020, In : Oncologist. 25, 2, p. 123-131 9 p.

    Research output: Contribution to journalArticle

    Open Access
  • Homophilic CD44 interactions mediate tumor cell aggregation and polyclonal metastasis in patient-derived breast cancer models

    Liu, X., Taftaf, R., Kawaguchi, M., Chang, Y. F., Chen, W., Entenberg, D., Zhang, Y., Gerratana, L., Huang, S., Patel, D. B., Tsui, E., Adorno-Cruz, V., Chirieleison, S. M., Cao, Y., Harney, A. S., Patel, S., Patsialou, A., Shen, Y., Avril, S., Gilmore, H. L. & 5 others, Lathia, J. D., Abbott, D. W., Cristofanilli, M., Condeelis, J. S. & Liu, H., Jan 2019, In : Cancer discovery. 9, 1, p. 96-113 18 p.

    Research output: Contribution to journalArticle

  • 27 Scopus citations

    Regulation and functions of integrin α2 in cell adhesion and disease

    Adorno-Cruz, V. & Liu, H., Mar 2019, In : Genes and Diseases. 6, 1, p. 16-24 9 p.

    Research output: Contribution to journalReview article

  • 5 Scopus citations

    Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop

    Li, K., Rodosthenous, R. S., Kashanchi, F., Gingeras, T., Gould, S. J., Kuo, L. S., Kurre, P., Lee, H., Leonard, J. N., Liu, H., Lombo, T. B., Momma, S., Nolan, J. P., Ochocinska, M. J., Pegtel, D. M., Sadovsky, Y., Sánchez-Madrid, F., Valdes, K. M., Vickers, K. C., Weaver, A. M. & 5 others, Witwer, K. W., Zeng, Y., Das, S., Raffai, R. L. & Howcroft, T. K., Apr 5 2018, In : JCI Insight. 3, 7

    Research output: Contribution to journalReview article

    Open Access
  • 18 Scopus citations

    Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase

    Thiagarajan, P. S., Sinyuk, M., Turaga, S. M., Mulkearns-Hubert, E. E., Hale, J. S., Rao, V., Demelash, A., Saygin, C., China, A., Alban, T. J., Hitomi, M., Torre-Healy, L. A., Alvarado, A. G., Jarrar, A., Wiechert, A., Adorno-Cruz, V., Fox, P. L., Calhoun, B. C., Guan, J. L., Liu, H. & 2 others, Reizes, O. & Lathia, J. D., Dec 1 2018, In : Nature communications. 9, 1, 578.

    Research output: Contribution to journalArticle

  • 17 Scopus citations