Huiping Liu

  • 2005 Citations
20012024
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Personal profile

Research Interests

The Liu lab studies the molecular mechanisms underlying cancer stem cells (CSCs) and metastasis through four ongoing interactive basic and translational research projects: (1) to understand CSCs in metastasis using cutting-edge single cell sequencing and CRISPR/Cas9 gene editing technologies; (2) to image CSC behavior and interactions with immune cells during metastasis using bioluminescence imaging and intravital imaging systems; (3) to target CSCs with novel therapeutics delivered by exosomes and nanoparticles; (4) to develop circulating tumor cells (CTCs) and circulating exosome-based biomarkers for cancer diagnosis, treatment monitoring, and prognosis.

Education/Academic qualification

PhD, University of Chicago

… → 2006

MD, Fourth Military Medical University, China

… → 1995

Keywords

  • Breast Cancer
  • Cancer Biology
  • Cell Adhesion Mechanisms
  • Cell Imaging
  • Circulation
  • Immune Regulation
  • MicroRNA
  • Nanotechnology

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Grants 2017 2024

Melanoma
Recycling
Leukocytes
Neoplasm Metastasis
Endothelial Cells
Exosomes
Neoplastic Stem Cells
Breast Neoplasms
Neoplasm Metastasis
Neoplasms
Circulating Neoplastic Cells
Breast Neoplasms
Neoplasm Metastasis
Neoplastic Stem Cells
Cluster Analysis
Circulating Neoplastic Cells
Heterografts
Neoplasm Metastasis
Therapeutics
Neoplastic Stem Cells
MicroRNAs
Breast Neoplasms
Neoplasm Metastasis
Interleukin-11
Neoplastic Stem Cells

Research Output 2001 2019

4 Citations (Scopus)

Homophilic CD44 interactions mediate tumor cell aggregation and polyclonal metastasis in patient-derived breast cancer models

Liu, X., Taftaf, R., Kawaguchi, M., Chang, Y. F., Chen, W., Entenberg, D., Zhang, Y., Gerratana, L., Huang, S., Patel, D. B., Tsui, E., Adorno-Cruz, V., Chirieleison, S. M., Cao, Y., Harney, A. S., Patel, S., Patsialou, A., Shen, Y., Avril, S., Gilmore, H. L. & 5 othersLathia, J. D., Abbott, D. W., Cristofanilli, M., Condeelis, J. S. & Liu, H., Jan 1 2019, In : Cancer Discovery. 9, 1, p. 96-113 18 p.

Research output: Contribution to journalArticle

Cell Aggregation
Breast Neoplasms
Neoplasm Metastasis
Circulating Neoplastic Cells
Neoplasms

Regulation and functions of integrin α2 in cell adhesion and disease

Adorno-Cruz, V. & Liu, H., Mar 1 2019, In : Genes and Diseases. 6, 1, p. 16-24 9 p.

Research output: Contribution to journalReview article

Cell adhesion
Cell Adhesion
Integrins
Integrin alpha2beta1
Cells
10 Citations (Scopus)

Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase

Thiagarajan, P. S., Sinyuk, M., Turaga, S. M., Mulkearns-Hubert, E. E., Hale, J. S., Rao, V., Demelash, A., Saygin, C., China, A., Alban, T. J., Hitomi, M., Torre-Healy, L. A., Alvarado, A. G., Jarrar, A., Wiechert, A., Adorno-Cruz, V., Fox, P. L., Calhoun, B. C., Guan, J. L., Liu, H. & 2 othersReizes, O. & Lathia, J. D., Dec 1 2018, In : Nature communications. 9, 1, 578.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Focal Adhesion Protein-Tyrosine Kinases
Connexins
Neoplastic Stem Cells
breast
6 Citations (Scopus)

Exosomes as a Drug Delivery System in Cancer Therapy: Potential and Challenges

Kibria, G., Ramos, E. K., Wan, Y., Gius, D. R. & Liu, H., Sep 4 2018, In : Molecular Pharmaceutics. 15, 9, p. 3625-3633 9 p.

Research output: Contribution to journalReview article

Exosomes
Drug Delivery Systems
Neoplasms
Therapeutics
Pharmaceutical Preparations

Organotropism: new insights into molecular mechanisms of breast cancer metastasis

Chen, W., Hoffmann, A. D., Liu, H. & Liu, X., 2018, In : JCO Precision Oncology. 2, 1, 4.

Research output: Contribution to journalReview article

Breast Neoplasms
Neoplasm Metastasis
Neoplasms
Exosomes
Circulating Neoplastic Cells