Grants per year
Personal profile
Research Interests
The focus of professor Szleifer’s group research is in the molecular modeling of biointerphases. Their work is aimed at the fundamental understanding of the properties of complex molecular systems that encompass problems at the interface between medicine, biology, chemistry, physics and materials science. The group concentrates on the development and application of theoretical approaches that enable the study of the systems of interest at the molecular level. The results of these studies are then used in the design of optimal materials that interact with biological environments. Most of their projects are carried out in close collaboration with experimental collaborators. Their theoretical work has the dual purpose of: 1) the fundamental understanding of what are the molecular factors that determine the properties and behavior of the interactions between biological environments and synthetic systems, and 2) the ability to predict in a quantitative way experimental systems in order to use the theoretical approaches as a device tool for the engineer of new materials, such as biocompatible materials and drug carriers.
Specific systems of interest include: protein adsorption and biocompatible materials, lipid layers and model cell membranes, drug delivery systems, ligand-receptor binding and smart (reponsive) materials.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Hebrew University of Jerusalem
… → 1989
Chemistry, BSc, Hebrew University of Jerusalem
… → 1984
Research interests keywords
- Biocompatible materials
- Complex fluids
- Drug delivery systems
- Ligand-receptor binding
- Lipid layers
- Model cell membranes
- Phase behavior of polymers
- Polymer dynamics
- Protein adsorption
- Responsive materials
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Collaborations and top research areas from the last five years
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Optical hyperspectral nanoscale chromatin analysis for colon cancer risk-stratification
Backman, V. (PD/PI), Szleifer, I. G. (Co-PD/PI) & Kocherginsky, M. (Co-Investigator)
5/1/25 → 4/30/30
Project: Research project
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Translating buccal nanocytology for lung cancer screening into clinical practice
Backman, V. (PD/PI), Bharat, A. (Co-PD/PI), Kocherginsky, M. (Co-Investigator) & Szleifer, I. G. (Co-Investigator)
8/13/24 → 7/31/29
Project: Research project
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Northwestern University Center for Chromatin NanoImaging in Cancer (NU-CCNIC)
Backman, V. (PD/PI), Backman, V. (PD/PI), Adli, M. (Co-Investigator), Adli, M. (Co-Investigator), Dravid, V. P. (Co-Investigator), Dravid, V. P. (Co-Investigator), Katsaggelos, A. K. (Co-Investigator), Katsaggelos, A. K. (Co-Investigator), Szleifer, I. G. (Co-Investigator), Szleifer, I. G. (Co-Investigator), Matei, D. E. (Other), Matei, D. E. (Other), Zhang, H. F. (Other) & Zhang, H. F. (Other)
12/10/21 → 11/30/26
Project: Research project
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Development of Affinity Rod Scaffolds for Cryo-EM Sample Preparation
Szleifer, I. G. (PD/PI)
Purdue University, National Institute of General Medical Sciences
9/18/18 → 8/31/21
Project: Research project
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From the Nuclear Pore Complex to Smart Artificial Nanochannels
Szleifer, I. G. (PD/PI)
9/1/18 → 8/31/22
Project: Research project
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Chromatin conformation, gene transcription, and nucleosome remodeling as an emergent system
Almassalha, L. M., Carignano, M., Pujadas Liwag, E., Li, W. S., Gong, R., Acosta, N., Dunton, C. L., Gonzalez, P. C., Carter, L. M., Kakkaramadam, R., Kröger, M., MacQuarrie, K. L., Frederick, J., Ye, I. C., Su, P., Kuo, T., Medina, K. I., Pritchard, J. A., Skol, A. & Nap, R. & 4 others, , Jan 10 2025, In: Science Advances. 11, 2, eadq6652.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Mature chromatin packing domains persist after RAD21 depletion in 3D
Li, W. S., Carter, L. M., Almassalha, L. M., Gong, R., Pujadas-Liwag, E. M., Kuo, T., MacQuarrie, K. L., Carignano, M., Dunton, C., Dravid, V., Kanemaki, M. T., Szleifer, I. & Backman, V., Jan 24 2025, In: Science Advances. 11, 4, eadp0855.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Formamide denaturation of double-stranded DNA for fluorescence in situ hybridization (FISH) distorts nanoscale chromatin structure
Shim, A. R., Frederick, J., Pujadas, E. M., Kuo, T., Ye, I. C., Pritchard, J. A., Dunton, C. L., Gonzalez, P. C., Acosta, N., Jain, S., Anthony, N. M., Almassalha, L. M., Szleifer, I. & Backman, V., May 2024, In: PloS one. 19, 5 May, e0301000.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Local volume concentration, packing domains, and scaling properties of chromatin
Carignano, M. A., Kroeger, M., Almassalha, L. M., Agrawal, V., Li, W. S., Pujadas-Liwag, E. M., Nap, R. J., Backman, V. & Szleifer, I., Aug 27 2024, In: eLife. 13Research output: Contribution to journal › Article › peer-review
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Orientational Pathways during Protein Translocation through Polymer-Modified Nanopores
Gonzalez Solveyra, E., Perez Sirkin, Y. A., Tagliazucchi, M. & Szleifer, I., Apr 16 2024, In: ACS nano. 18, 15, p. 10427-10438 12 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations