Grants per year
Personal profile
Research Interests
The focus of professor Szleifer’s group research is in the molecular modeling of biointerphases. Their work is aimed at the fundamental understanding of the properties of complex molecular systems that encompass problems at the interface between medicine, biology, chemistry, physics and materials science. The group concentrates on the development and application of theoretical approaches that enable the study of the systems of interest at the molecular level. The results of these studies are then used in the design of optimal materials that interact with biological environments. Most of their projects are carried out in close collaboration with experimental collaborators. Their theoretical work has the dual purpose of: 1) the fundamental understanding of what are the molecular factors that determine the properties and behavior of the interactions between biological environments and synthetic systems, and 2) the ability to predict in a quantitative way experimental systems in order to use the theoretical approaches as a device tool for the engineer of new materials, such as biocompatible materials and drug carriers.
Specific systems of interest include: protein adsorption and biocompatible materials, lipid layers and model cell membranes, drug delivery systems, ligand-receptor binding and smart (reponsive) materials.
Education/Academic qualification
PhD, Hebrew University of Jerusalem
… → 1989
Chemistry, BSc, Hebrew University of Jerusalem
… → 1984
Research interests
- Biocompatible materials
- Complex fluids
- Drug delivery systems
- Ligand-receptor binding
- Lipid layers
- Model cell membranes
- Phase behavior of polymers
- Polymer dynamics
- Protein adsorption
- Responsive materials
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Grants
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Development of Affinity Rod Scaffolds for Cryo-EM Sample Preparation
Purdue University, National Institute of General Medical Sciences
9/18/18 → 8/31/21
Project: Research project
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From the Nuclear Pore Complex to Smart Artificial Nanochannels
9/1/18 → 8/31/21
Project: Research project
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EFRI CEE: Macrogenomic engineering via modulation of chromatin nanoenvironment
Kennedy, M., Backman, V. & Szleifer, I. G.
8/15/18 → 7/31/22
Project: Research project
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Reducing Cancer Transcriptional Heterogeneity through Regulation of Chromatin Structure
4/9/18 → 3/31/23
Project: Research project
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Project 3
Goldman, R., Backman, V., Motter, A. E., Marko, J. F. & Szleifer, I. G.
5/19/15 → 4/30/21
Project: Research project
Research Output
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Nanopore gatesviareversible crosslinking of polymer brushes: a theoretical study
Perez Sirkin, Y. A., Tagliazucchi, M. & Szleifer, I., Mar 14 2021, In: Soft Matter. 17, 10, p. 2791-2802 12 p.Research output: Contribution to journal › Article › peer-review
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Nanoscale chromatin imaging and analysis platform bridges 4D chromatin organization with molecular function
Li, Y., Eshein, A., Virk, R. K. A., Eid, A., Wu, W., Frederick, J., VanDerway, D., Gladstein, S., Huang, K., Shim, A. R., Anthony, N. M., Bauer, G. M., Zhou, X., Agrawal, V., Pujadas, E. M., Jain, S., Esteve, G., Chandler, J. E., Nguyen, T. Q., Bleher, R. & 5 others, , Jan 1 2021, In: Science Advances. 7, 1, eabe4310.Research output: Contribution to journal › Article › peer-review
Open Access -
Charge regulation mechanism in end-tethered weak polyampholytes
Prusty, D., Nap, R. J., Szleifer, I. & Olvera De La Cruz, M., Oct 14 2020, In: Soft Matter. 16, 38, p. 8832-8847 16 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Disordered chromatin packing regulates phenotypic plasticity
Virk, R. K. A., Wu, W., Almassalha, L. M., Bauer, G. M., Li, Y., VanDerway, D., Frederick, J., Zhang, D., Eshein, A., Roy, H. K., Szleifer, I. & Backman, V., Jan 8 2020, In: Science Advances. 6, 2, eaax6232.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Dynamic Crowding Regulates Transcription
Shim, A. R., Nap, R. J., Huang, K., Almassalha, L. M., Matusda, H., Backman, V. & Szleifer, I., May 5 2020, In: Biophysical Journal. 118, 9, p. 2117-2129 13 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations