Grants per year
Personal profile
Research Interests
The focus of professor Szleifer’s group research is in the molecular modeling of biointerphases. Their work is aimed at the fundamental understanding of the properties of complex molecular systems that encompass problems at the interface between medicine, biology, chemistry, physics and materials science. The group concentrates on the development and application of theoretical approaches that enable the study of the systems of interest at the molecular level. The results of these studies are then used in the design of optimal materials that interact with biological environments. Most of their projects are carried out in close collaboration with experimental collaborators. Their theoretical work has the dual purpose of: 1) the fundamental understanding of what are the molecular factors that determine the properties and behavior of the interactions between biological environments and synthetic systems, and 2) the ability to predict in a quantitative way experimental systems in order to use the theoretical approaches as a device tool for the engineer of new materials, such as biocompatible materials and drug carriers.
Specific systems of interest include: protein adsorption and biocompatible materials, lipid layers and model cell membranes, drug delivery systems, ligand-receptor binding and smart (reponsive) materials.
Education/Academic qualification
PhD, Hebrew University of Jerusalem
… → 1989
Chemistry, BSc, Hebrew University of Jerusalem
… → 1984
Research interests keywords
- Biocompatible materials
- Complex fluids
- Drug delivery systems
- Ligand-receptor binding
- Lipid layers
- Model cell membranes
- Phase behavior of polymers
- Polymer dynamics
- Protein adsorption
- Responsive materials
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Collaborations and top research areas from the last five years
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Northwestern University Center for Chromatin NanoImaging in Cancer (NU-CCNIC)
Backman, V., Backman, V., Adli, M., Adli, M., Dravid, V. P., Dravid, V. P., Katsaggelos, A. K., Katsaggelos, A. K., Szleifer, I. G., Szleifer, I. G., Matei, D. E., Matei, D. E., Zhang, H. F. & Zhang, H. F.
12/10/21 → 11/30/26
Project: Research project
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EFRI CEE: Macrogenomic engineering via modulation of chromatin nanoenvironment
Backman, V., Kennedy, M. & Szleifer, I. G.
8/15/18 → 7/31/24
Project: Research project
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Reducing Cancer Transcriptional Heterogeneity through Regulation of Chromatin Structure
4/9/18 → 3/31/24
Project: Research project
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Development of Affinity Rod Scaffolds for Cryo-EM Sample Preparation
Purdue University, National Institute of General Medical Sciences
9/18/18 → 8/31/21
Project: Research project
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From the Nuclear Pore Complex to Smart Artificial Nanochannels
9/1/18 → 8/31/22
Project: Research project
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Acid-Base Equilibrium and Dielectric Environment Regulate Charge in Supramolecular Nanofibers
Nap, R. J., Qiao, B., Palmer, L. C., Stupp, S. I., Olvera de la Cruz, M. & Szleifer, I., Mar 16 2022, In: Frontiers in Chemistry. 10, 852164.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Analysis of three-dimensional chromatin packing domains by chromatin scanning transmission electron microscopy (ChromSTEM)
Li, Y., Agrawal, V., Virk, R. K. A., Roth, E., Li, W. S., Eshein, A., Frederick, J., Huang, K., Almassalha, L., Bleher, R., Carignano, M. A., Szleifer, I., Dravid, V. P. & Backman, V., Dec 2022, In: Scientific reports. 12, 1, 12198.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Author Correction: Analysis of three-dimensional chromatin packing domains by chromatin scanning transmission electron microscopy (ChromSTEM) (Scientific Reports, (2022), 12, 1, (12198), 10.1038/s41598-022-16028-2)
Li, Y., Agrawal, V., Virk, R. K. A., Roth, E., Li, W. S., Eshein, A., Frederick, J., Huang, K., Almassalha, L., Bleher, R., Carignano, M. A., Szleifer, I., Dravid, V. P. & Backman, V., Dec 2022, In: Scientific reports. 12, 1, 12720.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Chromatin as self-returning walks: From population to single cell and back
Shim, A. R., Huang, K., Backman, V. & Szleifer, I., Mar 9 2022, In: Biophysical Reports. 2, 1, 100042.Research output: Contribution to journal › Short survey › peer-review
Open Access -
Influence of Membrane Permittivity on Charge Regulation of Weak Polyelectrolytes End-Tethered in Nanopores
Qin, S., Nap, R. J., Huang, K. & Szleifer, I., Sep 27 2022, In: Macromolecules. 55, 18, p. 8384-8398 15 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations