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Personal profile

Research Interests

The focus of professor Szleifer’s group research is in the molecular modeling of biointerphases. Their work is aimed at the fundamental understanding of the properties of complex molecular systems that encompass problems at the interface between medicine, biology, chemistry, physics and materials science. The group concentrates on the development and application of theoretical approaches that enable the study of the systems of interest at the molecular level. The results of these studies are then used in the design of optimal materials that interact with biological environments. Most of their projects are carried out in close collaboration with experimental collaborators. Their theoretical work has the dual purpose of: 1) the fundamental understanding of what are the molecular factors that determine the properties and behavior of the interactions between biological environments and synthetic systems, and 2) the ability to predict in a quantitative way experimental systems in order to use the theoretical approaches as a device tool for the engineer of new materials, such as biocompatible materials and drug carriers.

Specific systems of interest include: protein adsorption and biocompatible materials, lipid layers and model cell membranes, drug delivery systems, ligand-receptor binding and smart (reponsive) materials.

Education/Academic qualification

PhD, Hebrew University of Jerusalem

… → 1989

Chemistry, BSc, Hebrew University of Jerusalem

… → 1984

Research interests

  • Biocompatible materials
  • Complex fluids
  • Drug delivery systems
  • Ligand-receptor binding
  • Lipid layers
  • Model cell membranes
  • Phase behavior of polymers
  • Polymer dynamics
  • Protein adsorption
  • Responsive materials

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  • Research Output

    Disordered chromatin packing regulates phenotypic plasticity

    Virk, R. K. A., Wu, W., Almassalha, L. M., Bauer, G. M., Li, Y., VanDerway, D., Frederick, J., Zhang, D., Eshein, A., Roy, H. K., Szleifer, I. & Backman, V., Jan 8 2020, In : Science Advances. 6, 2, eaax6232.

    Research output: Contribution to journalArticle

    Open Access
  • Dynamic Crowding Regulates Transcription

    Shim, A. R., Nap, R. J., Huang, K., Almassalha, L. M., Matusda, H., Backman, V. & Szleifer, I., May 5 2020, In : Biophysical Journal. 118, 9, p. 2117-2129 13 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Physical and data structure of 3D genome

    Huang, K., Li, Y., Shim, A. R., Virk, R. K. A., Agrawal, V., Eshein, A., Nap, R. J., Almassalha, L. M., Backman, V. & Szleifer, I., Jan 10 2020, In : Science Advances. 6, 2, eaay4055.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Transport in nanopores and nanochannels: some fundamental challenges and nature-inspired solutions

    Perez Sirkin, Y. A., Tagliazucchi, M. & Szleifer, I., Mar 2020, In : Materials Today Advances. 5, 100047.

    Research output: Contribution to journalReview article

    Open Access
  • Voltage-Triggered Structural Switching of Polyelectrolyte-Modified Nanochannels

    Perez Sirkin, Y. A., Szleifer, I. & Tagliazucchi, M., Jan 1 2020, (Accepted/In press) In : Macromolecules.

    Research output: Contribution to journalArticle