Grants per year
Personal profile
Research Interests
The focus of professor Szleifer’s group research is in the molecular modeling of biointerphases. Their work is aimed at the fundamental understanding of the properties of complex molecular systems that encompass problems at the interface between medicine, biology, chemistry, physics and materials science. The group concentrates on the development and application of theoretical approaches that enable the study of the systems of interest at the molecular level. The results of these studies are then used in the design of optimal materials that interact with biological environments. Most of their projects are carried out in close collaboration with experimental collaborators. Their theoretical work has the dual purpose of: 1) the fundamental understanding of what are the molecular factors that determine the properties and behavior of the interactions between biological environments and synthetic systems, and 2) the ability to predict in a quantitative way experimental systems in order to use the theoretical approaches as a device tool for the engineer of new materials, such as biocompatible materials and drug carriers.
Specific systems of interest include: protein adsorption and biocompatible materials, lipid layers and model cell membranes, drug delivery systems, ligand-receptor binding and smart (reponsive) materials.
Education/Academic qualification
PhD, Hebrew University of Jerusalem
… → 1989
Chemistry, BSc, Hebrew University of Jerusalem
… → 1984
Research interests
- Biocompatible materials
- Complex fluids
- Drug delivery systems
- Ligand-receptor binding
- Lipid layers
- Model cell membranes
- Phase behavior of polymers
- Polymer dynamics
- Protein adsorption
- Responsive materials
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Grants
Development of Affinity Rod Scaffolds for Cryo-EM Sample Preparation
Purdue University, National Institute of General Medical Sciences
9/18/18 → 8/31/20
Project: Research project
From the Nuclear Pore Complex to Smart Artificial Nanochannels
9/1/18 → 8/31/21
Project: Research project
EFRI CEE: Macrogenomic engineering via modulation of chromatin nanoenvironment
Backman, V., Kennedy, M. & Szleifer, I. G.
8/15/18 → 7/31/22
Project: Research project
Reducing Cancer Transcriptional Heterogeneity through Regulation of Chromatin Structure
4/9/18 → 3/31/23
Project: Research project
Quantitative analyses of tumor cell extravasation
Massachusetts Institute of Technology, National Cancer Institute
9/22/15 → 8/31/20
Project: Research project
Research Output
Disordered chromatin packing regulates phenotypic plasticity
Virk, R. K. A., Wu, W., Almassalha, L. M., Bauer, G. M., Li, Y., VanDerway, D., Frederick, J., Zhang, D., Eshein, A., Roy, H. K., Szleifer, I. & Backman, V., Jan 8 2020, In : Science Advances. 6, 2, eaax6232.Research output: Contribution to journal › Article
Open Access
Dynamic Crowding Regulates Transcription
Shim, A. R., Nap, R. J., Huang, K., Almassalha, L. M., Matusda, H., Backman, V. & Szleifer, I., May 5 2020, In : Biophysical Journal. 118, 9, p. 2117-2129 13 p.Research output: Contribution to journal › Article
1
Scopus
citations
Physical and data structure of 3D genome
Huang, K., Li, Y., Shim, A. R., Virk, R. K. A., Agrawal, V., Eshein, A., Nap, R. J., Almassalha, L. M., Backman, V. & Szleifer, I., Jan 10 2020, In : Science Advances. 6, 2, eaay4055.Research output: Contribution to journal › Article
Open Access
1
Scopus
citations
Transport in nanopores and nanochannels: some fundamental challenges and nature-inspired solutions
Perez Sirkin, Y. A., Tagliazucchi, M. & Szleifer, I., Mar 2020, In : Materials Today Advances. 5, 100047.Research output: Contribution to journal › Review article
Open Access
Voltage-Triggered Structural Switching of Polyelectrolyte-Modified Nanochannels
Perez Sirkin, Y. A., Szleifer, I. & Tagliazucchi, M., Jan 1 2020, (Accepted/In press) In : Macromolecules.Research output: Contribution to journal › Article