Grants per year
Personal profile
Research Interests
Our research is focused on the role of the glucocorticoid receptor (GR) and its target genes in skin and prostate tumor development, and regulation of stem cells. We are also very much interested in translational aspects of the GR biology, and my laboratory has been involved in the development of novel selective GR activators (SEGRA) that preserve therapeutic potential of glucocorticoids but have fewer side effects. We also study the molecular mechanisms of the major side effect of topical glucocorticoids - skin atrophy using mice with knockout of identified GR target genes.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, MD, PhD, NAES Coll
… → 1976
Research interests keywords
- Chemotherapy
- Prostate Cancer
- Skin Cancer
Fingerprint
Dive into the research topics where Irina Budunova is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Core D Subproject
Budunova, I. (Co-Investigator)
National Institute of Arthritis and Musculoskeletal and Skin Diseases
8/1/24 → 6/30/29
Project: Research project
-
Potential role of skin in SARS-CoV-2 infection
Budunova, I. (PD/PI) & Perez White, B. E. (Co-Investigator)
National Institute of Allergy and Infectious Diseases
7/21/23 → 6/30/25
Project: Research project
-
Role of healthy skin molecular phenotype in the switch to specific skin diseases
Budunova, I. (PD/PI), Budunova, I. (PD/PI), Budunova, I. (PD/PI), Perez White, B. E. (Co-Investigator), Perez White, B. E. (Co-Investigator) & Perez White, B. E. (Co-Investigator)
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/23/22 → 8/31/25
Project: Research project
-
Northwestern University Skin Biology and Diseases Resource-based Center
Paller, A. (PD/PI), Paller, A. (PD/PI), Rangel, S. M. (Co-Investigator), Rangel, S. M. (Co-Investigator), Budunova, I. (Other), Budunova, I. (Other), Green, K. J. (Other), Green, K. J. (Other), Lavker, R. M. (Other), Le Poole, I. C. (Other), Le Poole, I. C. (Other), Lu, K. (Other), Lu, K. (Other), Perez White, B. E. (Other), Perez White, B. E. (Other), Yemelyanov, A. (Other), Yemelyanov, A. (Other), Yi, R. (Other) & Yi, R. (Other)
National Institute of Arthritis and Musculoskeletal and Skin Diseases
8/20/19 → 7/31/24
Project: Research project
-
REDD1 dissociates the therapeutic and adverse effects of glucocorticoids in skin
Budunova, I. (PD/PI) & Bryce, P. J. (Co-Investigator)
National Institute of Allergy and Infectious Diseases
3/22/17 → 2/29/24
Project: Research project
-
REDD1 (regulated in development and DNA damage 1) modulates the glucocorticoid receptor function in keratinocytes
Chudakova, D. A., Trubetskoy, D., Baida, G., Bhalla, P., Readhead, B. & Budunova, I., Oct 2023, In: Experimental Dermatology. 32, 10, p. 1725-1733 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Synephrine and Its Derivative Compound A: Common and Specific Biological Effects
Dodonova, S. A., Zhidkova, E. M., Kryukov, A. A., Valiev, T. T., Kirsanov, K. I., Kulikov, E. P., Budunova, I. V., Yakubovskaya, M. G. & Lesovaya, E. A., Dec 2023, In: International journal of molecular sciences. 24, 24, 17537.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Nutritional Sensor REDD1 in Cancer and Inflammation: Friend or Foe?
Zhidkova, E. M., Lylova, E. S., Grigoreva, D. D., Kirsanov, K. I., Osipova, A. V., Kulikov, E. P., Mertsalov, S. A., Belitsky, G. A., Budunova, I., Yakubovskaya, M. G. & Lesovaya, E. A., Sep 2022, In: International journal of molecular sciences. 23, 17, 9686.Research output: Contribution to journal › Review article › peer-review
Open Access8 Scopus citations -
Roles Played by Stress-Induced Pathways in Driving Ethnic Heterogeneity for Inflammatory Skin Diseases
Jamerson, T. A., Li, Q., Sreeskandarajan, S., Budunova, I. V., He, Z., Kang, J., Gudjonsson, J. E., Patrick, M. T. & Tsoi, L. C., Apr 28 2022, In: Frontiers in immunology. 13, 845655.Research output: Contribution to journal › Review article › peer-review
Open Access3 Scopus citations -
The long winding road to the safer glucocorticoid receptor (GR) targeting therapies
Lesovaya, E. A., Chudakova, D., Baida, G., Zhidkova, E. M., Kirsanov, K. I., Yakubovskaya, M. G. & Budunova, I. V., 2022, In: Oncotarget. 13, 1, p. 408-424 17 p.Research output: Contribution to journal › Review article › peer-review
Open Access16 Scopus citations