• 1819 Citations
1977 …2022
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Personal profile

Research Interests

Our research is focused on the role of the glucocorticoid receptor (GR) and its target genes in skin and prostate tumor development, and regulation of stem cells. We are also very much interested in translational aspects of the GR biology, and my laboratory has been involved in the development of novel selective GR activators (SEGRA) that preserve therapeutic potential of glucocorticoids but have fewer side effects. We also study the molecular mechanisms of the major side effect of topical glucocorticoids - skin atrophy using mice with knockout of identified GR target genes.

Education/Academic qualification

MD, PhD, NAES Coll

… → 1976

Research interests

  • Chemotherapy
  • Prostate Cancer
  • Skin Cancer

Fingerprint Dive into the research topics where Irina Budunova is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Glucocorticoid Receptors Medicine & Life Sciences
Skin Medicine & Life Sciences
Glucocorticoids Medicine & Life Sciences
Carcinogens Medicine & Life Sciences
Carcinogenesis Medicine & Life Sciences
Keratinocytes Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Cell Culture Techniques Medicine & Life Sciences

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Grants 2001 2022

Therapeutic Uses
Glucocorticoids
Atrophy
Anti-Inflammatory Agents
Skin
Informatics
Glucocorticoids
Glucocorticoid Receptors
Skin
Atrophy
Glucocorticoid Receptors
Hematologic Neoplasms
Glucocorticoids
Quality of Life
Therapeutics
Informatics
Glucocorticoids
Glucocorticoid Receptors
Skin
Atrophy
Skin
Tissue Engineering
Research
Skin Diseases
Tissue Banks

Research Output 1977 2019

  • 1819 Citations
  • 65 Article
  • 2 Review article
  • 1 Comment/debate
1 Citation (Scopus)

PI3K inhibitors protect against glucocorticoid-induced skin atrophy

Agarwal, S., Mirzoeva, S., Readhead, B., Dudley, J. T. & Budunova, I., Mar 1 2019, In : EBioMedicine. 41, p. 526-537 12 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Glucocorticoids
DNA Damage
Atrophy

Transcriptomic Network Interactions in Human Skin Treated with Topical Glucocorticoid Clobetasol Propionate

Lili, L. N., Klopot, A., Readhead, B., Baida, G., Dudley, J. T. & Budunova, I., Nov 1 2019, In : Journal of Investigative Dermatology. 139, 11, p. 2281-2291 11 p.

Research output: Contribution to journalArticle

Clobetasol
Glucocorticoids
Skin
Glucocorticoid Receptors
Kruppel-Like Transcription Factors
5 Citations (Scopus)

Deletion of the glucocorticoid receptor chaperone FKBP51 prevents glucocorticoid-induced skin atrophy

Baida, G., Bhalla, P., Yemelyanov, A., Stechschulte, L. A., Shou, W., Readhead, B., Dudley, J. T., Sánchez, E. R. & Budunova, I., Oct 1 2018, In : Oncotarget. 9, 78, p. 34772-34783 12 p.

Research output: Contribution to journalArticle

Tacrolimus Binding Proteins
Glucocorticoid Receptors
Glucocorticoids
Atrophy
Skin
5 Citations (Scopus)

Rapamycin Modulates Glucocorticoid Receptor Function, Blocks Atrophogene REDD1, and Protects Skin from Steroid Atrophy

Lesovaya, E., Agarwal, S., Readhead, B., Vinokour, E., Baida, G., Bhalla, P., Kirsanov, K., Yakubovskaya, M., Platanias, L. C., Dudley, J. T. & Budunova, I., Sep 1 2018, In : Journal of Investigative Dermatology. 138, 9, p. 1935-1944 10 p.

Research output: Contribution to journalArticle

Glucocorticoid Receptors
Sirolimus
Glucocorticoids
Atrophy
Skin
12 Citations (Scopus)

Endogenous Glucocorticoid Deficiency in Psoriasis Promotes Inflammation and Abnormal Differentiation

Sarkar, M. K., Kaplan, N., Tsoi, L. C., Xing, X., Liang, Y., Swindell, W. R., Hoover, P., Aravind, M., Baida, G., Clark, M., Voorhees, J. J., Nair, R. P., Elder, J. T., Budunova, I., Getsios, S. & Gudjonsson, J. E., Jul 1 2017, In : Journal of Investigative Dermatology. 137, 7, p. 1474-1483 10 p.

Research output: Contribution to journalArticle

Psoriasis
Glucocorticoids
Inflammation
Biosynthesis
Epidermis