Personal profile

Research Interests

Our research is focused on the role of the glucocorticoid receptor (GR) and its target genes in skin and prostate tumor development, and regulation of stem cells. We are also very much interested in translational aspects of the GR biology, and my laboratory has been involved in the development of novel selective GR activators (SEGRA) that preserve therapeutic potential of glucocorticoids but have fewer side effects. We also study the molecular mechanisms of the major side effect of topical glucocorticoids - skin atrophy using mice with knockout of identified GR target genes.

Keywords

  • Chemotherapy
  • Cancer: Prostate
  • Cancer: Skin
  • Skin Cancer
  • Prostate Cancer

Fingerprint Fingerprint is based on mining the text of the persons scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 6 Similar Profiles
Skin Medicine & Life Sciences
Glucocorticoid Receptors Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Carcinogenesis Medicine & Life Sciences
Glucocorticoids Medicine & Life Sciences
Carcinogens Medicine & Life Sciences
Keratinocytes Medicine & Life Sciences
Liver Medicine & Life Sciences

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Research Output 1977 2017

  • 1609 Citations
  • 61 Article
  • 2 Review article
  • 1 Comment/debate

Endogenous Glucocorticoid Deficiency in Psoriasis Promotes Inflammation and Abnormal Differentiation

Sarkar, M. K., Kaplan, N., Tsoi, L. C., Xing, X., Liang, Y., Swindell, W. R., Hoover, P., Aravind, M., Baida, G., Clark, M., Voorhees, J. J., Nair, R. P., Elder, J. T., Budunova, I., Getsios, S. & Gudjonsson, J. E. Jul 1 2017 In : Journal of Investigative Dermatology. 137, 7, p. 1474-1483 10 p.

Research output: Contribution to journalArticle

Psoriasis
Glucocorticoids
Inflammation
Epidermis
Skin

Important role of kallikrein 6 for the development of keratinocyte proliferative resistance to topical glucocorticoids

Kishibe, M., Baida, G., Bhalla, P., Lavker, R. M., Schlosser, B., Iinuma, S., Yoshida, S., Dudley, J. T. & Budunova, I. 2016 In : Oncotarget. 7, 43, p. 69479-69488 10 p.

Research output: Contribution to journalArticle

Kallikreins
Keratinocytes
Glucocorticoids
Skin
Fluocinolone Acetonide
2 Citations

N-bromotaurine surrogates for loss of antiproliferative response and enhances cisplatin efficacy in cancer cells with impaired glucocorticoid receptor

Logotheti, S., Khoury, N., Vlahopoulos, S. A., Skourti, E., Papaevangeliou, D., Liloglou, T., Gorgoulis, V., Budunova, I., Kyriakopoulos, A. M. & Zoumpourlis, V. Jul 1 2016 In : Translational Research. 173, p. 58-73.e2

Research output: Contribution to journalArticle

Glucocorticoid Receptors
Cisplatin
Glucocorticoids
Neoplasms
Castration
3 Citations

Asymmetric expression of connexins between luminal epithelial- and myoepithelial- cells is essential for contractile function of the mammary gland

Mroue, R., Inman, J., Mott, J., Budunova, I. & Bissell, M. J. Mar 1 2015 In : Developmental Biology. 399, 1, p. 15-26 12 p.

Research output: Contribution to journalArticle

Connexins
Epithelial Cells
Connexin 43
Gap Junctions
Transgenic Mice
4 Citations

Discovery of Compound A - A selective activator of the glucocorticoid receptor with anti-inflammatory and anti-cancer activity

Lesovaya, E., Yemelyanov, A., Swart, A. C., Swart, P., Haegeman, G. & Budunova, I. 2015 In : Oncotarget. 6, 31, p. 30730-30744 15 p.

Research output: Contribution to journalArticle

Glucocorticoid Receptors
Anti-Inflammatory Agents
Neoplasms
Glucocorticoids
Transcriptional Activation