Grants per year
Personal profile
Research Interests
My research focus is on the development of novel targeted approaches for the treatment of malignant brain tumors. In particular, I am interested in developing and utilizing antibodies and genetically engineered variants against tumor-specific antigens in order to enhance and deliver therapeutics specifically to brain and other tumors. Another area of my interest is in the development of stem cells as therapeutic carriers. It includes investigation of various routes of delivery, mechanism of migration of stem cells and non-invasive tracking of therapeutic stem cell to solid brain tumors and metastatic lesions.
Training Experience
| 1997 | Postdoctoral Fellowship, University of Pennsylvania |
| 2000 | Postdoctoral Fellowship, University of Illinois, Chicago |
Education/Academic qualification
PhD, National Cardiology Research Center, Moscow, Russia
… → 1994
Research interests
- Biologic Therapies
- Brain Cancer / Nervous System Cancer
- Molecular Imaging
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Grants
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IL13Rα2-directed SEA/E-120 for therapeutic T cells targeting to Glioblastoma
12/1/20 → 11/30/21
Project: Research project
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Bi-specific natural killer cell engager (BiKE): a novel therapy for glioblastoma
American Academy of Neurology Institute
7/14/20 → 7/13/21
Project: Research project
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Neural Stem Cell Carriers for Glioblastoma Immunotherapy
Balyasnikova, I. V., Horbinski, C. M. & James, C. D.
National Institute of Neurological Disorders and Stroke
6/1/19 → 5/31/21
Project: Research project
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Genetic Approaches to Optimize CAR T cells for Glioblastoma Therapy
Balyasnikova, I. V., Horbinski, C. M. & Lesniak, M. S.
National Institute of Neurological Disorders and Stroke
9/30/18 → 8/31/23
Project: Research project
Research Output
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Activation of 4-1BBL+ B cells with CD40 agonism and IFNγ elicits potent immunity against glioblastoma
Lee-Chang, C., Miska, J., Hou, D., Rashidi, A., Zhang, P., Burga, R. A., Jusúe, I. T., Xiao, T., Arrieta, V. A., Zhang, D. Y., Lopez-Rosas, A., Han, Y., Sonabend, A. M., Horbinski, C. M., Stupp, R., Balyasnikova, I. V. & Lesniak, M. S., Jan 4 2021, In: Journal of Experimental Medicine. 218, 1Research output: Contribution to journal › Article › peer-review
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BET inhibition increases βIII-tubulin expression and sensitizes metastatic breast cancer in the brain to vinorelbine
Kanojia, D., Panek, W. K., Cordero, A., Fares, J., Xiao, A., Savchuk, S., Kumar, K., Xiao, T., Pituch, K. C., Miska, J., Zhang, P., Kam, K. L., Horbinski, C., Balyasnikova, I. V., Ahmed, A. U. & Lesniak, M. S., Aug 2020, In: Science translational medicine. 12, 558, eaax2879.Research output: Contribution to journal › Article › peer-review
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Heterogeneity and vascular permeability of breast cancer brain metastases
Babak, M. V., Zalutsky, M. R. & Balyasnikova, I. V., Oct 1 2020, In: Cancer Letters. 489, p. 174-181 8 p.Research output: Contribution to journal › Review article › peer-review
2 Scopus citations -
Protein tyrosine phosphatase-1B inhibition disrupts IL13Rα2-promoted invasion and metastasis in cancer cells
Bartolomé, R. A., Martín-Regalado, Á., Jaén, M., Zannikou, M., Zhang, P., de los Ríos, V., Balyasnikova, I. V. & Casal, J. I., Feb 2020, In: Cancers. 12, 2, 500.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Ribosomal protein S11 influences glioma response to TOP2 poisons
Awah, C. U., Chen, L., Bansal, M., Mahajan, A., Winter, J., Lad, M., Warnke, L., Gonzalez-Buendia, E., Park, C., Zhang, D., Feldstein, E., Yu, D., Zannikou, M., Balyasnikova, I. V., Martuscello, R., Konerman, S., Győrffy, B., Burdett, K. B., Scholtens, D. M., Stupp, R. & 3 others, , Jul 2 2020, In: Oncogene. 39, 27, p. 5068-5081 14 p.Research output: Contribution to journal › Article › peer-review