Grants per year
Personal profile
Research Interests
My research focus is on the development of novel targeted approaches for the treatment of malignant brain tumors. In particular, I am interested in developing and utilizing antibodies and genetically engineered variants against tumor-specific antigens in order to enhance and deliver therapeutics specifically to brain and other tumors. Another area of my interest is in the development of stem cells as therapeutic carriers. It includes investigation of various routes of delivery, mechanism of migration of stem cells and non-invasive tracking of therapeutic stem cell to solid brain tumors and metastatic lesions.
Training Experience
| 1997 | Postdoctoral Fellowship, University of Pennsylvania |
| 2000 | Postdoctoral Fellowship, University of Illinois, Chicago |
Education/Academic qualification
PhD, National Cardiology Research Center, Moscow, Russia
… → 1994
Research interests
- Biologic Therapies
- Brain Cancer / Nervous System Cancer
- Molecular Imaging
Fingerprint Dive into the research topics where Irina V Balyasnikova is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Peptidyl-Dipeptidase A
Medicine & Life Sciences
Glioma
Medicine & Life Sciences
Monoclonal Antibodies
Medicine & Life Sciences
Brain Neoplasms
Medicine & Life Sciences
Glioblastoma
Medicine & Life Sciences
Neural Stem Cells
Medicine & Life Sciences
Epitopes
Medicine & Life Sciences
Epitope Mapping
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2015 2023
Neural Stem Cell Carriers for Glioblastoma Immunotherapy
Balyasnikova, I. V., Horbinski, C. M., James, C. D. & Lesniak, M. S.
National Institute of Neurological Disorders and Stroke
6/1/19 → 5/31/20
Project: Research project
Genetic Approaches to Optimize CAR T cells for Glioblastoma Therapy
Balyasnikova, I. V., Horbinski, C. M. & Lesniak, M. S.
National Institute of Neurological Disorders and Stroke
9/30/18 → 8/31/23
Project: Research project
Antigen Receptors
Glioblastoma
Cell- and Tissue-Based Therapy
T-Cell Antigen Receptor
Glioma
Non-invasive immunoPET imaging for the detection of HER2+ status in preclinical model of brain metastases of breast cancer.
Northwestern Memorial Hospital
9/1/18 → 8/31/19
Project: Research project
Breast Neoplasms
Neoplasm Metastasis
Brain
SPORE for Translational Approaches to Brain Cancer
Ahmed, A. U., Balyasnikova, I. V., Bartom, E. T., Brat, D. J., Chandler, J. P., Cheng, S., Horbinski, C. M., Hu, B., James, C. D., Kumthekar, P. U., Leikin, R. G., Lesniak, M. S., Liu, B. P., Lukas, R. V., Mirkin, C. A., Platanias, L. C., Sachdev, S., Scholtens, D. M., Stegh, A. H., Stupp, R. & Wainwright, D. A.
8/17/18 → 7/31/23
Project: Research project
Brain Neoplasms
Glioblastoma
Therapeutics
Neoplasms
Survival
Combination of IL13Rα2 CAR T cell therapy with PD-1 immune checkpoint blockade for treatment of glioblastoma
Balyasnikova, I. V. & Lesniak, M. S.
U.S. Army Medical Research and Materiel Command
9/1/17 → 8/31/19
Project: Research project
Glioblastoma
Cell- and Tissue-Based Therapy
T-Lymphocytes
Therapeutics
varespladib methyl
Research Output 1994 2019
Pharmacologic modulation of nasal epithelium augments neural stem cell targeting of glioblastoma
Spencer, D., Yu, D., Morshed, R. A., Li, G., Pituch, K. C., Gao, D. X., Bertolino, N., Procissi, D., Lesniak, M. S. & Balyasnikova, I. V., Jan 1 2019, In : Theranostics. 9, 7, p. 2071-2083 13 p.Research output: Contribution to journal › Article
Open Access
Neural Stem Cells
Nasal Mucosa
Glioblastoma
Methimazole
Oncolytic Virotherapy
1
Citation
(Scopus)
Race influences survival in glioblastoma patients with KPS ≥ 80 and associates with genetic markers of retinoic acid metabolism
Wu, M., Miska, J. M., Xiao, T., Zhang, P., Kane, J. R., Balyasnikova, I. V., Chandler, J. P., Horbinski, C. M. & Lesniak, M. S., Apr 15 2019, In : Journal of Neuro-Oncology. 142, 2, p. 375-384 10 p.Research output: Contribution to journal › Article
Glioblastoma
Tretinoin
Genetic Markers
African Americans
Glioma
3
Citations
(Scopus)
A Dendritic Cell-Targeted Adenoviral Vector Facilitates Adaptive Immune Response Against Human Glioma Antigen (CMV-IE) and Prolongs Survival in a Human Glioma Tumor Model
Kim, J. W., Kane, J. R., Panek, W. K., Young, J. S., Rashidi, A., Yu, D., Kanojia, D., Hasan, T., Miska, J. M., Gómez-Lim, M. A., Ulasov, I., Balyasnikova, I. V., Ahmed, A. U., Wainwright, D. A. & Lesniak, M. S., Oct 14 2018, In : Neurotherapeutics. 15, 4, p. 1127-1138 12 p.Research output: Contribution to journal › Article
Adaptive Immunity
Glioma
Dendritic Cells
Antigens
Survival
7
Citations
(Scopus)
Adoptive Transfer of IL13Rα2-Specific Chimeric Antigen Receptor T Cells Creates a Pro-inflammatory Environment in Glioblastoma
Pituch, K. C., Miska, J. M., Krenciute, G., Panek, W. K., Li, G., Rodriguez-Cruz, T., Wu, M., Han, Y., Lesniak, M. S., Gottschalk, S. & Balyasnikova, I. V., Apr 4 2018, In : Molecular Therapy. 26, 4, p. 986-995 10 p.Research output: Contribution to journal › Article
Adoptive Transfer
Glioblastoma
T-Cell Antigen Receptor
Glioma
Antigen Receptors
4
Citations
(Scopus)
Intranasal delivery of stem cell-based therapies for the treatment of brain malignancies
Li, G., Bonamici, N., Dey, M., Lesniak, M. S. & Balyasnikova, I. V., Feb 1 2018, In : Expert Opinion on Drug Delivery. 15, 2, p. 163-172 10 p.Research output: Contribution to journal › Review article
Cell- and Tissue-Based Therapy
Stem Cells
Brain
Neoplasms
Brain Neoplasms