Grants per year
Personal profile
Research Interests
My research focus is on the development of novel targeted approaches for the treatment of malignant brain tumors. In particular, I am interested in developing and utilizing antibodies and genetically engineered variants against tumor-specific antigens in order to enhance and deliver therapeutics specifically to brain and other tumors. Another area of my interest is in the development of stem cells as therapeutic carriers. It includes investigation of various routes of delivery, mechanism of migration of stem cells and non-invasive tracking of therapeutic stem cell to solid brain tumors and metastatic lesions.
Training Experience
| 1997 | Postdoctoral Fellowship, University of Pennsylvania |
| 2000 | Postdoctoral Fellowship, University of Illinois, Chicago |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Cardiology, National Cardiology Research Center, Moscow, Russia
… → 1994
Research interests keywords
- Biologic Therapies
- Brain Cancer / Nervous System Cancer
- Molecular Imaging
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Bi-specific T cell Engager for Treatment of Pediatric High-Grade Gliomas
Balyasnikova, I. V. (PD/PI)
1/1/25 → 12/31/25
Project: Research project
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Targeting SEC61 complex to overcome resistance to immunotherapy in GBM
Balyasnikova, I. V. (PD/PI), Dmello, C. C. (Co-Investigator), Horbinski, C. M. (Co-Investigator), Sonabend Worthalter, A. M. (Co-Investigator), Zhang, P. (Co-Investigator), Zhang, H. (Co-Investigator) & Zhao, M. (Co-Investigator)
1/1/25 → 12/31/29
Project: Research project
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Spatial and Temporal Tracking of Neural Stem Cells Migration to Brain Metastases of Breast Cancer using High Resolution Imaging
Balyasnikova, I. V. (PD/PI), Procissi, D. (Co-Investigator) & Zhang, H. (Co-Investigator)
12/1/24 → 11/30/28
Project: Research project
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Enhancing Bispecific Antibody Therapy with Nanoparticle-Based Photothermal Therapy
Lin, A. Y. (PD/PI), Lin, A. Y. (PD/PI), Balyasnikova, I. V. (Co-Investigator), Balyasnikova, I. V. (Co-Investigator), Gordon, L. I. (Co-Investigator), Gordon, L. I. (Co-Investigator), Miller, S. D. (Co-Investigator) & Miller, S. D. (Co-Investigator)
U.S. Army Medical Research and Materiel Command
8/15/24 → 8/14/26
Project: Research project
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Novel Imaging approach for noninvasive and longitudinal monitoring of GBM responses to Immunotherapy
Balyasnikova, I. V. (PD/PI), Procissi, D. (Co-Investigator) & Zhao, M. (Co-Investigator)
2/26/24 → 2/25/26
Project: Research project
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IL13RA2-integrated genetically engineered mouse model allows for CAR T cells targeting pediatric high-grade gliomas
Seblani, M., Zannikou, M., Duffy, J. T., Joshi, T., Levine, R. N., Thakur, A., Puigdelloses-Vallcorba, M., Horbinski, C. M., Miska, J., Hambardzumyan, D., Becher, O. J. & Balyasnikova, I. V., Dec 2025, In: Acta Neuropathologica Communications. 13, 1, 69.Research output: Contribution to journal › Article › peer-review
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Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions
Anchordoquy, T., Artzi, N., Balyasnikova, I. V., Barenholz, Y., La-Beck, N. M., Brenner, J. S., Chan, W. C. W., Decuzzi, P., Exner, A. A., Gabizon, A., Godin, B., Lai, S. K., Lammers, T., Mitchell, M. J., Moghimi, S. M., Muzykantov, V. R., Peer, D., Nguyen, J., Popovtzer, R. & Ricco, M. & 8 others, , Jun 4 2024, In: ACS nano. 18, 22, p. 13983-13999 17 p.Research output: Contribution to journal › Review article › peer-review
23 Scopus citations -
STING agonist 8803 reprograms the immune microenvironment and increases survival in preclinical models of glioblastoma
Najem, H., Lea, S. T., Tripathi, S., Hurley, L., Chen, C. H., William, I., Sooreshjani, M., Bowie, M., Hartley, G., Dussold, C., Pacheco, S., Dmello, C., Lee-Chang, C., McCortney, K., Steffens, A., Walshon, J., Ott, M., Wei, J., Marisetty, A. & Balyasnikova, I. & 11 others, , Jun 17 2024, In: Journal of Clinical Investigation. 134, 12, e175033.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
A Case Study of Chimeric Antigen Receptor T Cell Function: Donor Therapeutic Differences in Activity and Modulation with Verteporfin
Liang, J., Fang, D., Gumin, J., Najem, H., Sooreshjani, M., Song, R., Sabbagh, A., Kong, L. Y., Duffy, J., Balyasnikova, I. V., Pollack, S. M., Puduvalli, V. K. & Heimberger, A. B., Feb 2023, In: Cancers. 15, 4, 1085.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Bi-Specific Killer Cell Engager Enhances NK Cell Activity against Interleukin-13 Receptor Alpha-2 Positive Gliomas
Pawlowski, K. D., Duffy, J. T., Tiwari, A., Zannikou, M. & Balyasnikova, I. V., Jul 2023, In: Cells. 12, 13, 1716.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations
Datasets
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CCDC 1939307: Experimental Crystal Structure Determination
Babak, M. V. (Contributor), Chong, K. R. (Contributor), Rapta, P. (Contributor), Zannikou, M. (Contributor), Tang, H. M. (Contributor), Reichert, L. (Contributor), Chang, M. R. (Contributor), Kushnarev, V. (Contributor), Heffeter, P. (Contributor), Meier-Menches, S. M. (Contributor), Lim, Z. C. (Contributor), Yap, J. Y. (Contributor), Casini, A. (Contributor), Balyasnikova, I. V. (Contributor) & Ang, W. H. (Contributor), Cambridge Crystallographic Data Centre, 2022
DOI: 10.5517/ccdc.csd.cc23309k, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc23309k&sid=DataCite
Dataset
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CCDC 1939306: Experimental Crystal Structure Determination
Babak, M. V. (Contributor), Chong, K. R. (Contributor), Rapta, P. (Contributor), Zannikou, M. (Contributor), Tang, H. M. (Contributor), Reichert, L. (Contributor), Chang, M. R. (Contributor), Kushnarev, V. (Contributor), Heffeter, P. (Contributor), Meier-Menches, S. M. (Contributor), Lim, Z. C. (Contributor), Yap, J. Y. (Contributor), Casini, A. (Contributor), Balyasnikova, I. V. (Contributor) & Ang, W. H. (Contributor), Cambridge Crystallographic Data Centre, 2022
DOI: 10.5517/ccdc.csd.cc23308j, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc23308j&sid=DataCite
Dataset