Isabelle De Plaen

  • 1171 Citations

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research Interests

Isabelle De Plaen, MD, is an attending physician in the Division of Neonatology (Neonatal Intensive Care Unit) at Lurie Children’s, Associate Professor of Pediatrics at Northwestern University Feinberg School of Medicine, and a member of the Center for Intestinal and Liver Inflammation Research at Stanley Manne Children’s Research Institute.

Dr. De Plaen’s research focuses on understanding mucosal microcirculatory and inflammatory mechanisms contributing to necrotizing enterocolitis (NEC), a devastating disease of the premature infant, causing sudden bowel inflammation and necrosis.

Certifications and Licenses

Neonatal-Perinatal Medicine

Training Experience

1994Residency, California Pacific Medical Center
1998Fellowship, Northwestern University, McGaw Medical Center (Children’s Memorial Hospital)

Education/Academic qualification

MD, Université catholique de Louvain

… → 1989

Research interests

  • Cytokines
  • Digestive System (including gallbladder and liver)
  • Immunology
  • Pediatrics

Fingerprint Dive into the research topics where Isabelle De Plaen is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 4 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.


Research Output

  • 1171 Citations
  • 31 Article
  • 4 Review article
  • 2 Chapter

Interferon-γ inhibits sirtuin 6 gene expression in intestinal epithelial cells through a microRNA-92b-dependent mechanism

Liu, F., Wang, X., Geng, H., Bu, H. F., Wang, P., de Plaen, I. G., Yang, H., Qian, J. & Tan, X. D., Apr 2020, In : American Journal of Physiology - Cell Physiology. 318, 4, p. C732-C739

Research output: Contribution to journalArticle

Open Access
  • Recent Advances in Necrotizing Enterocolitis Research: Strategies for Implementation in Clinical Practice

    Pammi, M., De Plaen, I. G. & Maheshwari, A., Jun 2020, In : Clinics in Perinatology. 47, 2, p. 383-397 15 p.

    Research output: Contribution to journalReview article

  • Blocking NF-κB Activation in Ly6c + Monocytes Attenuates Necrotizing Enterocolitis

    Managlia, E., Liu, S. X. L., Yan, X., Tan, X. D., Chou, P. M., Barrett, T. A. & De Plaen, I. G., Mar 2019, In : American Journal of Pathology. 189, 3, p. 604-618 15 p.

    Research output: Contribution to journalArticle

  • 10 Scopus citations
  • 1 Scopus citations

    Dimethyloxalylglycine preserves the intestinal microvasculature and protects against intestinal injury in a neonatal mouse NEC model: Role of VEGF signaling

    Bowker, R. M., Yan, X., Managlia, E., Liu, S. X. L., Marek, C., Tan, X. & De Plaen, I., Feb 1 2018, In : Pediatric research. 83, 2, p. 545-553 9 p.

    Research output: Contribution to journalArticle

  • 10 Scopus citations