Grants per year
Personal profile
Research Interests
Isabelle De Plaen, MD, is an attending physician in the Division of Neonatology (Neonatal Intensive Care Unit) at Lurie Children’s, Associate Professor of Pediatrics at Northwestern University Feinberg School of Medicine, and a member of the Center for Intestinal and Liver Inflammation Research at Stanley Manne Children’s Research Institute.
Dr. De Plaen’s research focuses on understanding mucosal microcirculatory and inflammatory mechanisms contributing to necrotizing enterocolitis (NEC), a devastating disease of the premature infant, causing sudden bowel inflammation and necrosis.
Certifications and Licenses
| Pediatrics | |
| Neonatal-Perinatal Medicine |
Training Experience
| 1994 | Residency, California Pacific Medical Center |
| 1998 | Fellowship, Northwestern University, McGaw Medical Center (Children’s Memorial Hospital) |
Education/Academic qualification
Medicine, MD, Université catholique de Louvain
… → 1989
Research interests
- Cytokines
- Digestive System (including gallbladder and liver)
- Immunology
- Pediatrics
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Role of the intestinal microvasculature in necrotizing enterocolitis
National Institute of Diabetes and Digestive and Kidney Diseases
3/1/19 → 2/28/24
Project: Research project
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Role of the intestinal microvasculature in necrotizing enterocolitis
National Institute of Diabetes and Digestive and Kidney Diseases
3/1/19 → 2/28/24
Project: Research project
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Role of IGF-1 in a mouse model of Necrotizing Enterocolitis
Shire Human Genetic Therapies, Inc.
5/1/18 → 5/1/23
Project: Research project
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Role of Inter-alpha inhibitor protein in a mouse model of Necrotizing Enterocolitis
ProMetic BioTherapeutics, Inc.
9/20/16 → 8/31/18
Project: Research project
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Macrophage-derived IGF-1 protects the neonatal intestine against necrotizing enterocolitis by promoting microvascular development
Yan, X., Managlia, E., Zhao, Y. Y., Tan, X. D. & De Plaen, I. G., Dec 2022, In: Communications Biology. 5, 1, 320.Research output: Contribution to journal › Article › peer-review
Open Access -
Human milk growth factors and their role in nec prevention: A narrative review
York, D. J., Smazal, A. L., Robinson, D. T. & De Plaen, I. G., Nov 2021, In: Nutrients. 13, 11, 3751.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
MFG-E8 plays an important role in attenuating cerulein-induced acute pancreatitis in mice
Bu, H. F., Subramanian, S., Geng, H., Wang, X., Liu, F., Chou, P. M., Du, C., De Plaen, I. G. & Tan, X. D., Apr 2021, In: Cells. 10, 4, 728.Research output: Contribution to journal › Article › peer-review
Open Access -
SARS-CoV-2 ORF8 Forms Intracellular Aggregates and Inhibits IFNγ-Induced Antiviral Gene Expression in Human Lung Epithelial Cells
Geng, H., Subramanian, S., Wu, L., Bu, H. F., Wang, X., Du, C., De Plaen, I. G. & Tan, X. D., 2021, In: Frontiers in immunology. 12, p. 679482 1 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Interferon-γ inhibits sirtuin 6 gene expression in intestinal epithelial cells through a microRNA-92b-dependent mechanism
Liu, F., Wang, X., Geng, H., Bu, H. F., Wang, P., de Plaen, I. G., Yang, H., Qian, J. & Tan, X. D., Apr 2020, In: American Journal of Physiology - Cell Physiology. 318, 4, p. C732-C739Research output: Contribution to journal › Article › peer-review
Open Access