Grants per year
Personal profile
Research Interests
Isabelle De Plaen, MD, is an attending physician in the Division of Neonatology (Neonatal Intensive Care Unit) at Lurie Children’s, Associate Professor of Pediatrics at Northwestern University Feinberg School of Medicine, and a member of the Center for Intestinal and Liver Inflammation Research at Stanley Manne Children’s Research Institute.
Dr. De Plaen’s research focuses on understanding mucosal microcirculatory and inflammatory mechanisms contributing to necrotizing enterocolitis (NEC), a devastating disease of the premature infant, causing sudden bowel inflammation and necrosis.
Certifications and Licenses
| Pediatrics | |
| Neonatal-Perinatal Medicine |
Training Experience
| 1994 | Residency, California Pacific Medical Center |
| 1998 | Fellowship, Northwestern University, McGaw Medical Center (Children’s Memorial Hospital) |
Education/Academic qualification
Medicine, MD, Université catholique de Louvain
… → 1989
Research interests keywords
- Cytokines
- Digestive System (including gallbladder and liver)
- Immunology
- Pediatrics
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Collaborations and top research areas from the last five years
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Grants
- 14 Finished
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Role of the intestinal microvasculature in necrotizing enterocolitis
De Plaen, I. (PD/PI)
National Institute of Diabetes and Digestive and Kidney Diseases
3/1/19 → 2/28/24
Project: Research project
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Role of the intestinal microvasculature in necrotizing enterocolitis
De Plaen, I. (PD/PI)
National Institute of Diabetes and Digestive and Kidney Diseases
3/1/19 → 2/28/24
Project: Research project
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Role of IGF-1 in a mouse model of Necrotizing Enterocolitis
De Plaen, I. (PD/PI)
Shire Human Genetic Therapies, Inc.
5/1/18 → 5/1/23
Project: Research project
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Are exogenous sterols protective in NEC?
De Plaen, I. (PD/PI)
10/1/16 → 6/1/17
Project: Research project
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Role of Inter-alpha inhibitor protein in a mouse model of Necrotizing Enterocolitis
De Plaen, I. (PD/PI)
ProMetic BioTherapeutics, Inc.
9/20/16 → 8/31/18
Project: Research project
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Recombinant IGF-1/BP3 protects against intestinal injury in a neonatal mouse NEC model
Yan, X., Managlia, E., Carey, G., Barton, N., Tan, X. D. & De Plaen, I. G., Jun 2024, In: Pediatric research. 95, 7, p. 1803-1811 9 p.Research output: Contribution to journal › Article › peer-review
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Scattered Crypt Intestinal Epithelial Cell Apoptosis Induces Necrotizing Enterocolitis Via Intricate Mechanisms
Subramanian, S., Bu, H. F., Chou, P. M., Wang, X., Geng, H., Akhtar, S., Du, C., Tan, S. C., Ideozu, J. E., Tulluri, A., Sun, Y., Ding, W. X., De Plaen, I. G. & Tan, X. D., Jan 2024, In: CMGH. 18, 3, 101364.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Endothelial FOXC1 and FOXC2 promote intestinal regeneration after ischemia–reperfusion injury
Tan, C., Norden, P. R., Yu, W., Liu, T., Ujiie, N., Lee, S. K., Yan, X., Dyakiv, Y., Aoto, K., Ortega, S., De Plaen, I. G., Sampath, V. & Kume, T., Jul 5 2023, In: EMBO Reports. 24, 7, e56030.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Nailfold Capillaroscopy: A Promising, Noninvasive Approach to Predict Retinopathy of Prematurity
York, D., Falciglia, G. H., Managlia, E., Yan, X., Yoon, H., Hamvas, A., Kirchenbuechler, D., Arvanitis, C. & De Plaen, I. G., Aug 2023, In: journal of pediatrics. 259, 113478.Research output: Contribution to journal › Article › peer-review
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Feeding mode influences dynamic gut microbiota signatures and affects susceptibility to anti-CD3 mAb-induced intestinal injury in neonatal mice
Subramanian, S., Geng, H., Du, C., Chou, P. M., Bu, H., Wang, X., Swaminathan, S., Tan, S. C., Ridlon, J. M., De Plaen, I. G. & Tan, X., Sep 2022, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 323, 3, p. G205-G218Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations
Datasets
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Supplementary Material for: Intestinal Vascular Endothelial Growth Factor Is Decreased in Necrotizing Enterocolitis
Sabnis, A. (Creator), Carrasco, R. (Creator), Liu, S. X. L. (Contributor), Yan, X. (Creator), Managlia, E. (Creator), Chou, P. M. (Creator), Tan, X.-D. (Creator) & De Plaen, I. G. (Creator), Karger Publishers, 2015
DOI: 10.6084/m9.figshare.5127217.v1, https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Intestinal_Vascular_Endothelial_Growth_Factor_Is_Decreased_in_Necrotizing_Enterocolitis/5127217/1
Dataset
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Sirtuin-6 Preserves R-spondin-1 Expression and increases Resistance of intestinal Epithelium to injury in Mice
Liu, F. (Creator), Bu, H.-F. (Creator), Geng, H. (Creator), De Plaen, I. G. (Creator), Gao, C. (Creator), Wang, P. (Creator), Wang, X. (Creator), Kurowski, J. A. (Creator), Yang, H. (Creator), Qian, J. (Creator) & Tan, X.-D. (Creator), figshare, 2017
DOI: 10.6084/m9.figshare.c.4260446, https://springernature.figshare.com/collections/Sirtuin-6_Preserves_R-spondin-1_Expression_and_increases_Resistance_of_intestinal_Epithelium_to_injury_in_Mice/4260446
Dataset