Grants per year
Personal profile
Research Interests
Isabelle De Plaen, MD, is an attending physician in the Division of Neonatology (Neonatal Intensive Care Unit) at Lurie Children’s, Associate Professor of Pediatrics at Northwestern University Feinberg School of Medicine, and a member of the Center for Intestinal and Liver Inflammation Research at Stanley Manne Children’s Research Institute.
Dr. De Plaen’s research focuses on understanding mucosal microcirculatory and inflammatory mechanisms contributing to necrotizing enterocolitis (NEC), a devastating disease of the premature infant, causing sudden bowel inflammation and necrosis.
Certifications and Licenses
| Pediatrics | |
| Neonatal-Perinatal Medicine |
Training Experience
| 1994 | Residency, California Pacific Medical Center |
| 1998 | Fellowship, Northwestern University, McGaw Medical Center (Children’s Memorial Hospital) |
Education/Academic qualification
MD, Universite Catholique de Louvain
… → 1989
Research interests
- Cytokines
- Digestive System (including gallbladder and liver)
- Immunology
- Pediatrics
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Grants
Role of the intestinal microvasculature in necrotizing enterocolitis
National Institute of Diabetes & Digestive & Kidney
3/1/19 → 2/28/24
Project: Research project
Role of IGF-1 in a mouse model of Necrotizing Enterocolitis
Shire Human Genetic Therapies, Inc.
5/1/18 → 5/1/23
Project: Research project
Surgical studies of gut epithelial apoptosis-initiated critical illness
National Institute of General Medical Sciences
9/1/16 → 8/31/20
Project: Research project
Surgical studies of gut epithelial apoptosis-initiated critical illness
De Plaen, I., De Plaen, I., Wang, X. & Wang, X.
National Institute of General Medical Sciences
9/1/16 → 8/31/20
Project: Research project
Surgical studies of gut epithelial apoptosis-initiated critical illness
Bu, H., De Plaen, I., Tan, X. & Wang, X.
National Institute of General Medical Sciences
9/1/16 → 8/31/20
Project: Research project
Research Output
Interferon-γ inhibits sirtuin 6 gene expression in intestinal epithelial cells through a microRNA-92b-dependent mechanism
Liu, F., Wang, X., Geng, H., Bu, H. F., Wang, P., de Plaen, I. G., Yang, H., Qian, J. & Tan, X. D., Apr 2020, In : American Journal of Physiology - Cell Physiology. 318, 4, p. C732-C739Research output: Contribution to journal › Article
Open Access
Recent Advances in Necrotizing Enterocolitis Research: Strategies for Implementation in Clinical Practice
Pammi, M., De Plaen, I. G. & Maheshwari, A., Jan 1 2020, (Accepted/In press) In : Clinics in Perinatology.Research output: Contribution to journal › Review article
Blocking NF-κB Activation in Ly6c + Monocytes Attenuates Necrotizing Enterocolitis
Managlia, E., Liu, S. X. L., Yan, X., Tan, X. D., Chou, P. M., Barrett, T. A. & De Plaen, I. G., Mar 2019, In : American Journal of Pathology. 189, 3, p. 604-618 15 p.Research output: Contribution to journal › Article
8
Scopus
citations
Prenatal inflammation impairs intestinal microvascular development through a TNF-dependent mechanism and predisposes newborn mice to necrotizing enterocolitis
Yan, X., Managlia, E., Tan, X. D. & De Plaen, I. G., Jul 2019, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 317, 1, p. G57-G66Research output: Contribution to journal › Article
1
Scopus
citations
Dimethyloxalylglycine preserves the intestinal microvasculature and protects against intestinal injury in a neonatal mouse NEC model: Role of VEGF signaling
Bowker, R. M., Yan, X., Managlia, E., Liu, S. X. L., Marek, C., Tan, X. & De Plaen, I., Feb 1 2018, In : Pediatric research. 83, 2, p. 545-553 9 p.Research output: Contribution to journal › Article
10
Scopus
citations