Grants per year
Personal profile
Research Interests
Professor Radhakrishnan lab studies the molecular mechanisms of transcription regulation, specifically, how DNA-bound transcription factors recruit coactivators, nucleating protein-protein interaction networks that extend to the transcription machinery, and how chromatin-modifying complexes read, interpret, and modify the histone code. These questions are asked in the context of (i) cAMP signaling mediated by CREB and its coactivators and (ii) a cohort of related, yet functionally distinct, histone deacetylase-associated chromatin-modifying complexes.
Education/Academic qualification
Biochemistry and Molecular Biophysics, PhD, Columbia University
… → 1994
Chemistry, BS, University of Delhi
… → 1989
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Molecular Biophysics Training Program at Northwestern University
Pinkett, H. W. (PD/PI), Pinkett, H. W. (PD/PI) & Radhakrishnan, I. (PD/PI)
National Institute of General Medical Sciences
7/1/21 → 6/30/26
Project: Research project
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Biochemical and Structural Studies of the Sin3L/HDAC Complex
Radhakrishnan, I. (PD/PI)
7/1/17 → 12/31/20
Project: Research project
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Molecular Biophysics Training Program at Northwestern University
Radhakrishnan, I. (PD/PI)
National Institute of General Medical Sciences
7/1/16 → 5/31/22
Project: Research project
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Structural Studies of Histone Deacetylase Recruitment to the Sin3L/Rpd3L Corepressor Complex
Radhakrishnan, I. (PD/PI)
American Heart Association Midwest Affiliate
1/1/16 → 12/31/17
Project: Research project
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Regulation of Nuclear Receptor Function during Drosophila Development
Radhakrishnan, I. (PD/PI)
University of Maryland, College Park, National Science Foundation
8/15/15 → 6/30/18
Project: Research project
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Histone acetylation and deacetylation – Mechanistic insights from structural biology
Patel, A. B., He, Y. & Radhakrishnan, I., Jan 10 2024, In: Gene. 890, 147798.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Per-ARNT-Sim (PAS) Domains in Basic Helix-Loop-Helix (bHLH)-PAS Transcription Factors and Coactivators: Structures and Mechanisms
Daffern, N. & Radhakrishnan, I., Feb 1 2024, In: Journal of Molecular Biology. 436, 3, 168370.Research output: Contribution to journal › Review article › peer-review
2 Scopus citations -
Cryo-EM structure of the Saccharomyces cerevisiae Rpd3L histone deacetylase complex
Patel, A. B., Qing, J., Tam, K. H., Zaman, S., Luiso, M., Radhakrishnan, I. & He, Y., Dec 2023, In: Nature communications. 14, 1, 3061.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
A capped Tudor domain within a core subunit of the Sin3L/Rpd3L histone deacetylase complex binds to nucleic acid G-quadruplexes
Marcum, R. D., Hsieh, J., Giljen, M., Justice, E., Daffern, N., Zhang, Y. & Radhakrishnan, I., Feb 1 2022, In: Journal of Biological Chemistry. 298, 2, 101558.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
A Novel Mechanism of Coactivator Recruitment by the Nurr1 Nuclear Receptor
Daffern, N. & Radhakrishnan, I., Aug 30 2022, In: Journal of Molecular Biology. 434, 16, 167718.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations
Datasets
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2LD7 : Solution structure of the mSin3A PAH3-SAP30 SID complex
Xie, T. (Contributor), He, Y. (Contributor), Korkeamaki, H. (Contributor), Zhang, Y. (Contributor), Imhoff, R. (Contributor), Lohi, O. (Contributor) & Radhakrishnan, I. (Contributor), RCSB-PDB, 2011
DOI: 10.2210/pdb2ld7/pdb, https://www.rcsb.org/structure/2LD7
Dataset
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Crystal Structure of the Sds3 Dimerization Domain
Clark, M. D. (Contributor), Marcum, R. (Contributor), Graveline, R. (Contributor), Chan, C. W. (Contributor), Xie, T. (Contributor), Chen, Z. (Contributor), Ding, Y. (Contributor), Zhang, Y. (Contributor), Mondragón, A. (Contributor), David, G. (Contributor) & Radhakrishnan, I. (Contributor), Protein Data Bank (PDB), Jul 15 2015
DOI: 10.2210/pdb4ZQA/pdb, https://www.wwpdb.org/pdb?id=pdb_00004zqa
Dataset
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1KDX : KIX DOMAIN OF MOUSE CBP (CREB BINDING PROTEIN) IN COMPLEX WITH PHOSPHORYLATED KINASE INDUCIBLE DOMAIN (PKID) OF RAT CREB (CYCLIC AMP RESPONSE ELEMENT BINDING PROTEIN), NMR 17 STRUCTURES
Dyson, H. J. (Contributor), Wright, P. E. (Contributor), Radhakrishnan, I. (Contributor) & Pérez-Alvarado, G. C. (Contributor), RCSB-PDB, 1998
DOI: 10.2210/pdb1kdx/pdb, https://www.rcsb.org/structure/1KDX
Dataset
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Solution Structure of Tandem UIMs of Vps27
Swanson, K. A. (Contributor), Kang, R. S. (Contributor), Stamenova, S. D. (Contributor), Hicke, L. (Contributor) & Radhakrishnan, I. (Contributor), Protein Data Bank (PDB), Dec 23 2003
DOI: 10.2210/pdb1Q0V/pdb, https://www.wwpdb.org/pdb?id=pdb_00001q0v
Dataset
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1S5Q : Solution Structure of Mad1 SID-mSin3A PAH2 Complex
Cowley, S. M. (Contributor), Huang, K. (Contributor), Eisenman, R. N. (Contributor), Radhakrishnan, I. (Contributor), Swanson, K. A. (Contributor), Knoepfler, P. S. (Contributor), Kang, R. S. (Contributor) & Laherty, C. D. (Contributor), RCSB-PDB, 2004
DOI: 10.2210/pdb1s5q/pdb, https://www.rcsb.org/structure/1S5Q
Dataset