• 3460 Citations
1991 …2019

Research output per year

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Personal profile

Research Interests

Professor Radhakrishnan lab studies the molecular mechanisms of transcription regulation, specifically, how DNA-bound transcription factors recruit coactivators, nucleating protein-protein interaction networks that extend to the transcription machinery, and how chromatin-modifying complexes read, interpret, and modify the histone code. These questions are asked in the context of (i) cAMP signaling mediated by CREB and its coactivators and (ii) a cohort of related, yet functionally distinct, histone deacetylase-associated chromatin-modifying complexes.

Education/Academic qualification

Biochemistry and Molecular Biophysics, PhD, Columbia University

… → 1994

Chemistry, BS, University of Delhi

… → 1989

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Grants

  • Research Output

    • 3460 Citations
    • 55 Article
    • 3 Review article
    • 1 Comment/debate
    • 1 Letter

    Inositol phosphates and core subunits of the Sin3L/Rpd3L histone deacetylase (HDAC) complex up-regulate deacetylase activity

    Marcum, R. D. & Radhakrishnan, I., Sep 20 2019, In : Journal of Biological Chemistry. 294, 38, p. 13928-13938 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Solution Nuclear Magnetic Resonance Studies of the Ligand-Binding Domain of an Orphan Nuclear Receptor Reveal a Dynamic Helix in the Ligand-Binding Pocket

    Daffern, N., Chen, Z., Zhang, Y., Pick, L. & Radhakrishnan, I., Apr 3 2018, In : Biochemistry. 57, 13, p. 1977-1986 10 p.

    Research output: Contribution to journalArticle

  • Molecular Basis for the Mechanism of Constitutive CBP/p300 Coactivator Recruitment by CRTC1-MAML2 and Its Implications in cAMP Signaling

    Clark, M. D., Kumar, G. S., Marcum, R., Luo, Q., Zhang, Y. & Radhakrishnan, I., Sep 8 2015, In : Biochemistry. 54, 35, p. 5439-5446 8 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations
  • 2 Scopus citations