• 8972 Citations
1983 …2024
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Personal profile

Research Interests

Asthma, Chronic obstructive pulmonary disease (COPD), Interstitial lung disease

Certifications and Licenses

Internal Medicine
Pulmonary Disease

Training Experience

1980Internship, Rambam Medical Center, Israel
1982Residency, Rambam Medical Center, Israel
1986Fellowship, University of Chicago Hospitals

Education/Academic qualification

MD, Israel Institute of Technology

… → 1978

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Grants 1992 2024

training program
Chronic Obstructive Pulmonary Disease
Lung Diseases
Smooth Muscle
Acute Lung Injury
Lung Injury
Influenza A virus
Human Influenza
Human Influenza
Influenza A virus
Alveolar Macrophages
Lung Injury

Research Output 1983 2019

Erratum: Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis (Cell Metabolism (2019) 29(2) (335–347.e5), (S1550413118305862) (10.1016/j.cmet.2018.09.019))

Soberanes, S., Misharin, A., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C. I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 othersJain, M., Perlman, H. R., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N., Mutlu, G. M. & Budinger, GR. S., Feb 5 2019, In : Cell Metabolism. 29, 2, 1 p.

Research output: Contribution to journalComment/debate

Air Pollution
Electron Transport

Influenza A virus infection induces muscle wasting via IL-6 regulation of the E3 ubiquitin ligase atrogin-1

Radigan, K. A., Nicholson, T. T., Welch, L. C., Chi, M., Amarelle, L., Angulo, M., Shigemura, M., Shigemura, A., Runyan, C. E., Morales-Nebreda, L., Perlman, H. R., Ceco, E., Lecuona, E., Dada, L., Misharin, A., Mutlu, G. M., Sznajder, J. I. & Budinger, GR. S., Jan 15 2019, In : Journal of Immunology. 202, 2, p. 484-493 10 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Influenza A virus
Virus Diseases
Human Influenza
7 Citations (Scopus)

Future research directions in pneumonia

Dela Cruz, C. S., Wunderink, R. G., Christiani, D. C., Cormier, S. A., Crothers, K., Doerschuk, C. M., Evans, S. E., Goldstein, D. R., Khatri, P., Kobzik, L., Kolls, J. K., Levy, B. D., Metersky, M. L., Niederman, M. S., Nusrat, R., Orihuela, C. J., Peyrani, P., Prince, A. S., Ramírez, J. A., Ridge, K. M. & 9 othersSethi, S., Suratt, B. T., Sznajder, J. I., Tsalik, E. L., Walkey, A. J., Yende, S., Aggarwal, N. R., Caler, E. V. & Mizgerd, J. P., Jul 15 2018, In : American journal of respiratory and critical care medicine. 198, 2, p. 256-263 8 p.

Research output: Contribution to journalArticle

Direction compound
National Heart, Lung, and Blood Institute (U.S.)
Adult Respiratory Distress Syndrome
1 Citation (Scopus)
Lipid Metabolism
Epithelial Cells
Carbon Monoxide
1 Citation (Scopus)

Hypercapnia increases airway smooth muscle contractility via caspase-7-mediated miR-133a-RhoA signaling

Shigemura, M., Lecuona, E., Angulo, M., Homma, T., Rodríguez, D. A., Gonzalez-Gonzalez, F. J., Welch, L. C., Amarelle, L., Kim, S., Kaminski, N., Budinger, GR. S., Solway, J. & Sznajder, J. I., Sep 5 2018, In : Science Translational Medicine. 10, 457, aat1662.

Research output: Contribution to journalArticle

Caspase 7
Smooth Muscle
Chronic Obstructive Pulmonary Disease