Jaehyuk Choi

  • 1201 Citations
20032023

Research output per year

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Personal profile

Research Interests

We utilize cutting-edge genomics approaches with three goals: 1) computational clinical oncology. We utilize computational approaches to identify driver gene mutations in cancer and determine the impact of mutations on disease course and responses to therapy. 2) mechanistic dissection of skin cancer. We study incurable skin cancers with a primary focus on cutaneous T cell lymphoma. We are using human and animal models with two goals. We seek to determine 1) the molecular basis of the aberrant immunophenotype with the goal of developing novel immunotherapies and 2) the epigenetic basis of disease with the goal of developing novel epigenetic therapies. 3) technology development. In the course of our studies, we are encountering the need for tools that are not publically available. We are therefore developing tools that we need. For the most part, these tools are designed to garner high-dimensinoal data from increasingly low numbers of cells.

Training Experience

2010Residency, Yale University
2012Postdoctoral Fellowship, Yale University

Education/Academic qualification

PhD, Yale University

… → 2006

MD, Yale University School of Medicine

… → 2006

Research interests

  • Cutaneous T-Cell Lymphoma
  • Dermatology
  • Genetics
  • Immunogenetics
  • Immunology
  • Melanoma
  • Skin Cancer

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Grants

Research Output

  • 1201 Citations
  • 33 Article
  • 8 Review article
  • 3 Comment/debate
  • 1 Letter

Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas

Daniels, J., Doukas, P. G., Escala, M. E. M., Ringbloom, K. G., Shih, D. J. H., Yang, J., Tegtmeyer, K., Park, J., Thomas, J. J., Selli, M. E., Altunbulakli, C., Gowthaman, R., Mo, S. H., Jothishankar, B., Pease, D. R., Pro, B., Abdulla, F. R., Shea, C., Sahni, N., Gru, A. A. & 4 others, Pierce, B. G., Louissaint, A., Guitart, J. & Choi, J., Dec 1 2020, In : Nature communications. 11, 1, 1806.

Research output: Contribution to journalArticle

Open Access
  • Progression of cutaneous T-cell lymphoma after dupilumab: Case review of 7 patients

    Espinosa, M. L., Nguyen, M. T., Aguirre, A. S., Martinez-Escala, M. E., Kim, J., Walker, C. J., Pontes, D. S., Silverberg, J. I., Choi, J., Pro, B., Pincus, L. B., Guitart, J. & Zhou, X. A., Jan 1 2020, (Accepted/In press) In : Journal of the American Academy of Dermatology.

    Research output: Contribution to journalArticle

    2 Scopus citations

    Celastrol-loaded PEG-: B -PPS nanocarriers as an anti-inflammatory treatment for atherosclerosis

    Allen, S. D., Liu, Y. G., Kim, T., Bobbala, S., Yi, S., Zhang, X., Choi, J. & Scott, E. A., Feb 2019, In : Biomaterials Science. 7, 2, p. 657-668 12 p.

    Research output: Contribution to journalArticle

  • 12 Scopus citations

    Drug-induced hypersensitivity syndrome with myocardial involvement treated with tofacitinib

    Damsky, W. E., Vesely, M. D., Lee, A. I., Choi, J., Meyer, A. C., Chen, M., Ahmad, T. & King, B., Dec 2019, In : JAAD Case Reports. 5, 12, p. 1018-1026 9 p.

    Research output: Contribution to journalArticle

    Open Access
    1 Scopus citations
    Open Access
  • 9 Scopus citations