Jaehyuk Choi

  • 863 Citations
20032022
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Personal profile

Research Interests

We utilize cutting-edge genomics approaches with three goals: 1) computational clinical oncology. We utilize computational approaches to identify driver gene mutations in cancer and determine the impact of mutations on disease course and responses to therapy. 2) mechanistic dissection of skin cancer. We study incurable skin cancers with a primary focus on cutaneous T cell lymphoma. We are using human and animal models with two goals. We seek to determine 1) the molecular basis of the aberrant immunophenotype with the goal of developing novel immunotherapies and 2) the epigenetic basis of disease with the goal of developing novel epigenetic therapies. 3) technology development. In the course of our studies, we are encountering the need for tools that are not publically available. We are therefore developing tools that we need. For the most part, these tools are designed to garner high-dimensinoal data from increasingly low numbers of cells.

Training Experience

2010Residency, Yale University
2012Postdoctoral Fellowship, Yale University

Education/Academic qualification

PhD, Yale University

… → 2006

MD, Yale University School of Medicine

… → 2006

Keywords

  • Cutaneous T-Cell Lymphoma
  • Dermatology
  • Genetics
  • Immunogenetics
  • Immunology
  • Melanoma
  • Skin Cancer

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  • 3 Similar Profiles
Cutaneous T-Cell Lymphoma Medicine & Life Sciences
Mutation Medicine & Life Sciences
Skin Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Melanoma Medicine & Life Sciences
Merkel Cell Carcinoma Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
T-Cell Antigen Receptor Medicine & Life Sciences

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Grants 2015 2022

Cutaneous T-Cell Lymphoma
NF-kappa B
Costimulatory and Inhibitory T-Cell Receptors
T-Lymphocytes
Cell Lineage
Cutaneous T-Cell Lymphoma
Mutation
T-Cell Antigen Receptor
Mortality
Cutaneous T-Cell Lymphoma
T-Cell Antigen Receptor
Mutation
Immunosuppressive Agents

Research Output 2003 2019

  • 863 Citations
  • 28 Article
  • 8 Review article
  • 3 Comment/debate
  • 1 Letter
1 Citation (Scopus)

Celastrol-loaded PEG-: B -PPS nanocarriers as an anti-inflammatory treatment for atherosclerosis

Allen, S. D., Liu, Y. G., Kim, T., Bobbala, S., Yi, S., Zhang, X., Choi, J. & Scott, E. A., Feb 1 2019, In : Biomaterials Science. 7, 2, p. 657-668 12 p.

Research output: Contribution to journalArticle

Micelles
Polyethylene glycols
Anti-Inflammatory Agents
Polypropylenes
Polydispersity

Are MicroRNAs Key to Developing Biomarkers for Cutaneous T-Cell Lymphoma?

Martinez-Escala, M. E. & Choi, J., Sep 1 2018, In : Journal of Investigative Dermatology. 138, 9, p. 1906-1908 3 p.

Research output: Contribution to journalComment/debate

Cutaneous T-Cell Lymphoma
T-cells
Biomarkers
MicroRNAs
Hematologic Neoplasms
10 Citations (Scopus)

Are there multiple cells of origin of Merkel cell carcinoma?

Sunshine, J. C., Jahchan, N. S., Sage, J. & Choi, J., Mar 1 2018, In : Oncogene. 37, 11, p. 1409-1416 8 p.

Research output: Contribution to journalReview article

Merkel cell polyomavirus
Merkel Cell Carcinoma
Keratinocytes
Neoplasms
Fibroblasts
21 Citations (Scopus)
Non-Small Cell Lung Carcinoma
Immunotherapy
Melanoma
Clinical Trials
CTLA-4 Antigen
7 Citations (Scopus)

Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure

Haugh, A. M., Zhang, B., Quan, V. L., Garfield, E. M., Bubley, J. A., Kudalkar, E., Verzi, A. E., Walton, K., VandenBoom, T., Merkel, E. A., Lee, C. Y., Tan, T., Isales, M. C., Kong, B. Y., Wenzel, A. T., Bunick, C. G., Choi, J., Sosman, J. A. & Gerami, P., Feb 1 2018, In : Journal of Investigative Dermatology. 138, 2, p. 384-393 10 p.

Research output: Contribution to journalArticle

Cyclin D1
Solar System
Aberrations
Sun
Melanoma