Jaehyuk Choi

  • 986 Citations
20032022
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Personal profile

Research Interests

We utilize cutting-edge genomics approaches with three goals: 1) computational clinical oncology. We utilize computational approaches to identify driver gene mutations in cancer and determine the impact of mutations on disease course and responses to therapy. 2) mechanistic dissection of skin cancer. We study incurable skin cancers with a primary focus on cutaneous T cell lymphoma. We are using human and animal models with two goals. We seek to determine 1) the molecular basis of the aberrant immunophenotype with the goal of developing novel immunotherapies and 2) the epigenetic basis of disease with the goal of developing novel epigenetic therapies. 3) technology development. In the course of our studies, we are encountering the need for tools that are not publically available. We are therefore developing tools that we need. For the most part, these tools are designed to garner high-dimensinoal data from increasingly low numbers of cells.

Training Experience

2010Residency, Yale University
2012Postdoctoral Fellowship, Yale University

Education/Academic qualification

PhD, Yale University

… → 2006

MD, Yale University School of Medicine

… → 2006

Research interests

  • Cutaneous T-Cell Lymphoma
  • Dermatology
  • Genetics
  • Immunogenetics
  • Immunology
  • Melanoma
  • Skin Cancer

Fingerprint Dive into the research topics where Jaehyuk Choi is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
Cutaneous T-Cell Lymphoma Medicine & Life Sciences
Mutation Medicine & Life Sciences
Skin Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
T-cells Chemical Compounds
Neoplasms Medicine & Life Sciences
Melanoma Medicine & Life Sciences
Merkel Cell Carcinoma Medicine & Life Sciences

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Grants 2015 2022

Merkel Cell Carcinoma
Immunotherapy
Genome
Cutaneous T-Cell Lymphoma
NF-kappa B
Costimulatory and Inhibitory T-Cell Receptors
T-Lymphocytes
Cell Lineage

Research Output 2003 2019

  • 986 Citations
  • 30 Article
  • 8 Review article
  • 3 Comment/debate
  • 1 Letter
3 Citations (Scopus)

Celastrol-loaded PEG-: B -PPS nanocarriers as an anti-inflammatory treatment for atherosclerosis

Allen, S. D., Liu, Y. G., Kim, T., Bobbala, S., Yi, S., Zhang, X., Choi, J. & Scott, E. A., Feb 1 2019, In : Biomaterials Science. 7, 2, p. 657-668 12 p.

Research output: Contribution to journalArticle

Micelles
Polyethylene glycols
Anti-Inflammatory Agents
Polypropylenes
Polydispersity
3 Citations (Scopus)

The coincidence between increasing age, immunosuppression, and the incidence of patients with glioblastoma

Ladomersky, E., Scholtens, D. M., Kocherginsky, M., Hibler, E. A., Bartom, E. T., Otto-Meyer, S., Zhai, L., Lauing, K. L., Choi, J., Sosman, J. A., Wu, J. D., Zhang, B., Lukas, R. V. & Wainwright, D. A., Jan 1 2019, In : Frontiers in Pharmacology. 10, MAR, 200.

Research output: Contribution to journalArticle

Open Access
Glioblastoma
Immunosuppression
Immunotherapy
Central Nervous System
Incidence
15 Citations (Scopus)

A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers

Gettinger, S. N., Choi, J., Mani, N., Sanmamed, M. F., Datar, I., Sowell, R., Du, V. Y., Kaftan, E., Goldberg, S., Dong, W., Zelterman, D., Politi, K., Kavathas, P., Kaech, S., Yu, X., Zhao, H., Schlessinger, J., Lifton, R., Rimm, D. L., Chen, L. & 2 others, Herbst, R. S. & Schalper, K. A., Dec 1 2018, In : Nature communications. 9, 1, 3196.

Research output: Contribution to journalArticle

Open Access
Tumor-Infiltrating Lymphocytes
phenotype
Lymphocytes
lymphocytes
Non-Small Cell Lung Carcinoma
1 Citation (Scopus)

Are MicroRNAs Key to Developing Biomarkers for Cutaneous T-Cell Lymphoma?

Martinez-Escala, M. E. & Choi, J., Sep 1 2018, In : Journal of Investigative Dermatology. 138, 9, p. 1906-1908 3 p.

Research output: Contribution to journalComment/debate

Cutaneous T-Cell Lymphoma
T-cells
Biomarkers
MicroRNAs
Hematologic Neoplasms
14 Citations (Scopus)

Are there multiple cells of origin of Merkel cell carcinoma?

Sunshine, J. C., Jahchan, N. S., Sage, J. & Choi, J., Mar 1 2018, In : Oncogene. 37, 11, p. 1409-1416 8 p.

Research output: Contribution to journalReview article

Merkel cell polyomavirus
Merkel Cell Carcinoma
Keratinocytes
Neoplasms
Fibroblasts