James Mathew

  • 1496 Citations
1987 …2020

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2019

Mechanistic analyses in kidney transplant recipients prospectively randomized to two steroid free regimen-Low dose Tacrolimus with Everolimus versus standard dose Tacrolimus with Mycophenolate Mofetil

Traitanon, O., Mathew, J. M., Shetty, A., Bontha, S. V., Maluf, D. G., El Kassis, Y., Park, S. H., Han, J., Ansari, M. J., Leventhal, J. R., Mas, V. & Gallon, L., May 2019, In : PloS one. 14, 5, e0216300.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Varying levels of X chromosome coalescence in female somatic cells alters the balance of X-linked dosage compensation and is implicated in female-dominant systemic lupus erythematosus

Laskowski, A. I., Neems, D. S., Laster, K., Strojny-Okyere, C., Rice, E. L., Konieczna, I. M., Voss, J. H., Mathew, J. M., Leventhal, J. R., Ramsey-Goldman, R., Smith, E. D. & Kosak, S. T., Dec 1 2019, In : Scientific reports. 9, 1, 8011.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

A Phase i Clinical Trial with Ex Vivo Expanded Recipient Regulatory T cells in Living Donor Kidney Transplants

Mathew, J. M., H-Voss, J., LeFever, A., Konieczna, I., Stratton, C., He, J., Huang, X., Gallon, L., Skaro, A. I., Ansari, M. J. & Leventhal, J. R., Dec 1 2018, In : Scientific reports. 8, 1, 7428.

Research output: Contribution to journalArticle

36 Scopus citations

Generation and Characterization of Alloantigen-Specific Regulatory T Cells for Clinical Transplant Tolerance

Mathew, J. M., Voss, J. H., McEwen, S. T., Konieczna, I., Chakraborty, A., Huang, X., He, J., Gallon, L., Kornbluth, R. S. & Leventhal, J. R., Dec 1 2018, In : Scientific reports. 8, 1, 1136.

Research output: Contribution to journalArticle

10 Scopus citations

Intragraft Molecular Pathways Associated with Tolerance Induction in Renal Transplantation

Gallon, L., Mathew, J. M., Bontha, S. V., Dumur, C. I., Dalal, P., Nadimpalli, L., Maluf, D. G., Shetty, A. A., Ildstad, S. T., Leventhal, J. R. & Mas, V. R., Feb 2018, In : Journal of the American Society of Nephrology. 29, 2, p. 423-433 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Immunoregulatory effects of everolimus on in vitro alloimmune responses

Levitsky, J., Miller, J., Huang, X., Gallon, L., Leventhal, J. R. & Mathew, J. M., Jun 1 2016, In : PloS one. 11, 6, e0156535.

Research output: Contribution to journalArticle

10 Scopus citations

Low incidence of acute rejection in hepatitis B virus positive liver transplant recipients and the impact of hepatitis B immunoglobulin

Veerappan, A., VanWagner, L. B., Mathew, J. M., Huang, X., Miller, J., Lapin, B. & Levitsky, J., Apr 1 2016, In : Human Immunology. 77, 4, p. 367-374 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Nonchimeric HLA-identical renal transplant tolerance: Regulatory immunophenotypic/genomic biomarkers

Leventhal, J. R., Mathew, J. M., Salomon, D. R., Kurian, S. M., Friedewald, J. J., Gallon, L., Konieczna, I., Tambur, A. R., Charette, J., Levitsky, J., Jie, C., Kanwar, Y. S., Abecassis, M. M. & Miller, J., Jan 1 2016, In : American Journal of Transplantation. 16, 1, p. 221-234 14 p.

Research output: Contribution to journalArticle

31 Scopus citations
2015

Cellular and molecular immune profiles in renal transplant recipients after conversion from tacrolimus to sirolimus

Gallon, L., Traitanon, O., Sustento-Reodica, N., Leventhal, J., Ansari, M. J., Gehrau, R. C., Ariyamuthu, V., De Serres, S. A., Alvarado, A., Chhabra, D., Mathew, J. M., Najafian, N. & Mas, V., Apr 8 2015, In : Kidney international. 87, 4, p. 828-838 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Differential Effects of Calcineurin and Mammalian Target of Rapamycin Inhibitors on Alloreactive Th1, Th17, and Regulatory T Cells

Gallon, L., Traitanon, O., Yu, Y., Shi, B., Leventhal, J. R., Miller, J., Mas, V., L, X. & Mathew, J. M., Sep 1 2015, In : Transplantation. 99, 9, p. 1774-1784 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Differential effects of tacrolimus versus sirolimus on the proliferation, activation and differentiation of human B cells

Traitanon, O., Mathew, J. M., Monica, G. L., Xu, L., Mas, V. & Gallon, L., Jun 18 2015, In : PloS one. 10, 6, e0129658.

Research output: Contribution to journalArticle

24 Scopus citations

Immune reconstitution/immunocompetence in recipients of kidney plus hematopoietic stem/facilitating cell transplants

Leventhal, J. R., Elliott, M. J., Yolcu, E. S., Bozulic, L. D., Tollerud, D. J., Mathew, J. M., Konieczna, I., Ison, M. G., Galvin, J., Mehta, J., Badder, M. D., Abecassis, M. M. I., Miller, J., Gallon, L. & Ildstad, S. T., Feb 13 2015, In : Transplantation. 99, 2, p. 288-298 11 p.

Research output: Contribution to journalArticle

73 Scopus citations

Role of innate and acquired immune mechanisms in clinical intestinal transplant rejection

Mathew, J. M., Tryphonopoulos, P., Defaria, W., Ruiz, P., Miller, J., Barrett, T. A., Tzakis, A. G. & Kato, T., Jun 6 2015, In : Transplantation. 99, 6, p. 1273-1281 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Defining the alloreactive T cell repertoire using high-throughput sequencing of mixed lymphocyte reaction culture

Emerson, R. O., Mathew, J. M., Konieczna, I. M., Robins, H. S. & Leventhal, J. R., Nov 3 2014, In : PloS one. 9, 11, e111943.

Research output: Contribution to journalArticle

22 Scopus citations
2013

Genomic biomarkers correlate with HLA-identical renal transplant tolerance

Leventhal, J. R., Mathew, J. M., Salomon, D. R., Kurian, S. M., Suthanthiran, M., Tambur, A., Friedewald, J., Gallon, L., Charette, J., Levitsky, J., Kanwar, Y., Abecassis, M. & Miller, J., Sep 1 2013, In : Journal of the American Society of Nephrology. 24, 9, p. 1376-1385 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

HLA identical non-chimeric and HLA disparate chimeric renal transplant tolerance.

Leventhal, J. R., Mathew, J. M., Ildstad, S., Salomon, D. R., Kurian, S. M., Suthanthiran, M., Tambur, A., Friedewald, J., Gallon, L., Charette, J., Levitsky, J., Kanwar, Y., Abecassis, M. & Miller, J., Jan 1 2013, In : Clinical transplants. p. 145-156 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Inhibitory effects of belatacept on allospecific regulatory T-cell generation in humans

Levitsky, J., Miller, J., Huang, X., Chandrasekaran, D., Chen, L. & Mathew, J. M., Oct 27 2013, In : Transplantation. 96, 8, p. 689-696 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Systemic immunoregulatory and proteogenomic effects of tacrolimus to sirolimus conversion in liver transplant recipients

Levitsky, J., Mathew, J. M., Abecassis, M., Tambur, A., Leventhal, J., Chandrasekaran, D., Herrera, N., Al-Saden, P., Gallon, L., Abdul-Nabi, A., Yang, G. Y., Kurian, S. M., Salomon, D. R. & Miller, J., Jan 1 2013, In : Hepatology. 57, 1, p. 239-248 10 p.

Research output: Contribution to journalArticle

29 Scopus citations
2012

Favorable effects of alemtuzumab on allospecific regulatory T-cell generation

Levitsky, J., Leventhal, J. R., Miller, J., Huang, X., Chen, L., Chandrasekaran, D., Tambur, A. R. & Mathew, J. M., Feb 1 2012, In : Human Immunology. 73, 2, p. 141-149 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
9 Scopus citations
2011

Allospecific regulatory effects of sirolimus and tacrolimus in the human mixed lymphocyte reaction

Levitsky, J., Gallon, L., Miller, J., Tambur, A. R., Leventhal, J., Flaa, C., Huang, X., Sarraj, B., Wang, E. & Mathew, J. M., Jan 27 2011, In : Transplantation. 91, 2, p. 199-206 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8 + suppressor T cells

Yu, Y., Zitzner, J. R., Houlihan, J., Herrera, N., Xu, L., Miller, J., Mathew, J. M., Tambur, A. R. & Luo, X., Dec 14 2011, In : PloS one. 6, 12, e28948.

Research output: Contribution to journalArticle

11 Scopus citations
3 Scopus citations
2010

Immune "tolerance profiles" in donor bone marrow infused kidney transplant patients using multiple ex vivo functional assays

Mathew, J. M., Ciancio, G., Burke, G. W., Garcia-Morales, R. O., Rosen, A., Wang, E., Gomez, C. I., Blomberg, B. B., Fuller, L., Esquenazi, V., Ricordi, C. & Miller, J., Jun 1 2010, In : Human Immunology. 71, 6, p. 566-576 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Interleukin-10 delivery via mesenchymal stem cells: A novel gene therapy approach to prevent lung ischemia-reperfusion injury

Manning, E., Pham, S., Li, S., Vazquez-Padron, R. I., Mathew, J., Ruiz, P. & Salgar, S. K., Jun 1 2010, In : Human Gene Therapy. 21, 6, p. 713-727 15 p.

Research output: Contribution to journalArticle

59 Scopus citations
2009

Immunoregulatory profiles in liver transplant recipients on different immunosuppressive agents

Levitsky, J., Miller, J., Wang, E., Rosen, A., Flaa, C., Abecassis, M., Mathew, J. & Tambur, A., Mar 1 2009, In : Human Immunology. 70, 3, p. 146-150 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

The human "treg MLR": Immune monitoring for FOXP3+ T regulatory cell generation

Levitsky, J., Miller, J., Leventhal, J., Huang, X., Flaa, C., Wang, E., Tambur, A., Burt, R. K., Gallon, L. & Mathew, J. M., Dec 1 2009, In : Transplantation. 88, 11, p. 1303-1311 9 p.

Research output: Contribution to journalArticle

33 Scopus citations
2008

Evaluation of the tolerogenic effects of donor bone marrow cells using a severe combined immunodeficient mouse-human islet transplant model

Mathew, J. M., Blomberg, B., Ricordi, C., Esquenazi, V. & Miller, J., Oct 1 2008, In : Human Immunology. 69, 10, p. 605-613 9 p.

Research output: Contribution to journalArticle

2 Scopus citations
2007

FoxP3 mRNA transcripts and regulatory cells in renal transplant recipients 10 years after donor marrow infusion

Cirocco, R. E., Carreño, M. R., Mathew, J. M., Garcia-Morales, R. O., Fuller, L., Esquenazi, V., Ciancio, G., Burke, G. W., Gaynor, J. J., Blomberg, B. B., Rosen, A., Kleiner, G., Ricordi, C. & Miller, J., Jun 1 2007, In : Transplantation. 83, 12, p. 1611-1619 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Inhibition of NF-κB during human dendritic cell differentiation generates anergy and regulatory T-cell activity for one but not two human leukocyte antigen DR mismatches

Hernandez, A., Burger, M., Blomberg, B. B., Ross, W. A., Gaynor, J. J., Lindner, I., Cirocco, R., Mathew, J. M., Carreno, M., Jin, Y., Lee, K. P., Esquenazi, V. & Miller, J., Sep 1 2007, In : Human Immunology. 68, 9, p. 715-729 15 p.

Research output: Contribution to journalArticle

22 Scopus citations

Killer cell immunoglobulin-like receptor polymorphisms in HLA-identical kidney transplant recipients: Lack of 2DL2 and 2DS2 may be associated with poor graft function

Cirocco, R. E., Mathew, J. M., Burke, G. W., Esquenazi, V. & Miller, J., Apr 1 2007, In : Tissue Antigens. 69, SUPPL. 1, p. 123-124 2 p.

Research output: Contribution to journalArticle

6 Scopus citations

Transplantation of the spleen: Effect of splenic allograft in human multivisceral transplantation

Kato, T., Tzakis, A. G., Selvaggi, G., Gaynor, J. J., Takahashi, H., Mathew, J., Garcia-Morales, R., Hernandez, E., David, A., Nishida, S., Levi, D., Moon, J., Island, E., Kleiner, G. & Ruiz, P., Sep 1 2007, In : Annals of surgery. 246, 3, p. 436-444 9 p.

Research output: Contribution to journalArticle

44 Scopus citations
2005

Abrogation of the alloreactive responses of cadaveric donor intestinal lymphocytes by intraoperative campath-1H exposure

Mathew, J. M., DeFaria, W., Kato, T., Blomberg, B., Carreno, M., Santiago, S., Weppler, D., Esquenazi, V., Miller, J. & Tzakis, A. G., Mar 2005, In : Transplantation proceedings. 37, 2, p. 1375-1378 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

A randomized trial of three renal transplant induction antibodies: Early comparison of tacrolimus, mycophenolate mofetil, and steroid dosing, and newer immune-monitoring

Ciancio, G., Burke, G. W., Gaynor, J. J., Carreno, M. R., Cirocco, R. E., Mathew, J. M., Mattiazzi, A., Cordovilla, T., Roth, D., Kupin, W., Rosen, A., Esquenazi, V., Tzakis, A. G. & Miller, J., Aug 27 2005, In : Transplantation. 80, 4, p. 457-465 9 p.

Research output: Contribution to journalArticle

177 Scopus citations
2003

A novel micro-cell-mediated lympholytic assay for the evaluation of regulatory cells in human alloreactive CTL responses

Mathew, J. M., Blomberg, B., Fuller, L., Burke, G. W., Ciancio, G., Kenyon, N., Ricordi, C., Tzakis, A. G., Esquenazi, V. & Miller, J., Jan 15 2003, In : Journal of Immunological Methods. 272, 1-2, p. 67-80 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Human donor bone marrow cells induce in vitro "suppressor T cells" that functionally suppress autologous B cells

Carreno, M. R., Fuller, L., Mathew, J. M., Ciancio, G., Burke, G. W., Esquenazi, V., Ricordi, C., Tzakis, A. G. & Miller, J., Jan 1 2003, In : Human Immunology. 64, 1, p. 21-30 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Immune responses and their regulation by donor bone marrow cells in clinical organ transplantation

Mathew, J. M., Garcia-Morales, R. O., Carreno, M., Jin, Y., Fuller, L., Blomberg, B., Cirocco, R., Burke, G. W., Ciancio, G., Ricordi, C., Esquenazi, V., Tzakis, A. G. & Miller, J., Jan 1 2003, In : Transplant Immunology. 11, 3-4, p. 307-321 15 p.

Research output: Contribution to journalArticle

37 Scopus citations
2002

Effect of living-related donor bone marrow infusion on chimerism and in vitro immunoregulatory activity in kidney transplant recipients

Ciancio, G., Burke, G. W., Garcia-Morales, R., Suzart, K., Rosen, A., Ricordi, C., Kenyon, N. S., Mathew, J. M., Tzakis, A. G., Esquenazi, V. & Miller, J., Aug 27 2002, In : Transplantation. 74, 4, p. 488-496 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Regulation of alloimmune responses (GvH reactions) in vitro by autologous donor bone marrow cell preparations used in clinical organ transplantation

Mathew, J. M., Carreno, M., Fuller, L., Burke, G. W., Ciancio, G., Ricordi, C., Tzakis, A. G., Esquenazi, V. & Miller, J., Sep 27 2002, In : Transplantation. 74, 6, p. 846-855 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
2001

Cells of donor phenotype present in renal transplant recipients infused with donor marrow: Potent regulators of antidonor immune responses of the recipient

Mathew, J. M., Garcia-Morales, R., Fuller, L., Rosen, A., Burke, G. W., Ciancio, G., Carreno, M., Ricordi, C., Tzakis, A. G., Esquenazi, V. & Miller, J., Apr 5 2001, In : Transplantation proceedings. 33, 1-2, p. 127-128 2 p.

Research output: Contribution to journalArticle

2 Scopus citations

Donor bone marrow cells used for the induction of allograft acceptance in clinical transplantation as regulators of autologous immune responses

Mathew, J. M., Fuller, L., Carreno, M., Burke, G. W., Ciancio, G., Ricordi, C., Tzakis, A. G., Esquenazi, V. & Miller, J., Apr 5 2001, In : Transplantation proceedings. 33, 1-2, p. 108-109 2 p.

Research output: Contribution to journalArticle

2 Scopus citations

Donor bone marrow infusions are tolerogenic in human renal transplantation

Ciancio, G., Garcia-Morales, R., Mathew, J., Carreno, M., Burke, G. W., Ricordi, C., Kenyon, N., Esquenazi, V., Cirocco, R., Tzakis, A. & Miller, J., Jan 1 2001, In : Transplantation proceedings. 33, 1-2, p. 1295-1296 2 p.

Research output: Contribution to journalArticle

6 Scopus citations

Induction therapy with daclizumab as part of the immunosuppressive regimen in human small bowel and multiorgan transplants

Carreño, M. R., Kato, T., Weppler, D., Mathew, J. M., Fuller, L., Gomez, C., Salman, F., Garcia-Morales, R., Ciancio, G., Burke, G. W., Esquenazi, V., Miller, J. & Tzakis, A. G., Apr 5 2001, In : Transplantation proceedings. 33, 1-2, p. 1015-1017 3 p.

Research output: Contribution to journalArticle

19 Scopus citations

Perioperative donor bone marrow infusion in cadaver kidney transplant recipients

Garcia-Morales, R. O., Ciancio, G., Mathew, J., Jin, Y., Rosen, A., Ricordi, C., Burke, G. W., Blomberg, B., Fuller, L., Tzakis, A. G., Esquenazi, V. & Miller, J., Jan 1 2001, In : Transplantation proceedings. 33, 7-8, p. 3840-3843 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
2000

Donor bone marrow-derived chimeric cells present in renal transplant recipients infused with donor marrow. I. Potent regulators of recipient antidonor immune responses

Mathew, J. M., Garcia-Morales, R., Fuller, L., Rosen, A., Ciancio, G., Burke, G. W., Carreno, M., Temple, D., Tzakis, A. G., Ricordi, C., Miller, J. & Esquenazi, V., Dec 27 2000, In : Transplantation. 70, 12, p. 1675-1682 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Involvement of multiple subpopulations of human bone marrow cells in the regulation of allogeneic cellular immune responses

Mathew, J. M., Fuller, L., Carreno, M., Garcia-Morales, R., Burke, G. W., Ricordi, C., Esquenazi, V., Tzakis, A. G. & Miller, J., Dec 27 2000, In : Transplantation. 70, 12, p. 1752-1760 9 p.

Research output: Contribution to journalArticle

25 Scopus citations
1999

Analysis of post-transplant immune status in recipients of liver/bone marrow allografts

Chatzipetrou, M. A., Mathew, J. M., Kenyon, N. S., Esquenazi, V., Miller, J., Ricordi, C. & Tzakis, A. G., Dec 1 1999, In : Human Immunology. 60, 12, p. 1281-1288 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

In vitro immunogenicity of cadaver donor bone marrow cells used for the induction of allograft acceptance in clinical transplantation

Mathew, J. M., Carreno, M., Fuller, L., Ricordi, C., Kenyon, N., Tzakis, A. G., Miller, J. & Esquenazi, V., Oct 27 1999, In : Transplantation. 68, 8, p. 1172-1180 9 p.

Research output: Contribution to journalArticle

14 Scopus citations
1998

Cellular immune responses of human cadaver donor bone marrow cells and their susceptibility to commonly used immunosuppressive drugs in transplantation

Mathew, J. M., Carreno, M., Zucker, K., Fuller, L., Kenyon, N., Esquenazi, V., Ricordi, C., Tzakis, A. G. & Miller, J., Apr 15 1998, In : Transplantation. 65, 7, p. 947-955 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Continuing observations on the regulatory effects of donor-specific bone marrow cell infusions and chimerism in kidney transplant recipients

Garcia-Morales, R., Carreno, M., Mathew, J., Cirocco, R., Zucker, K., Ciancio, G., Burke, G., Roth, D., Temple, D., Fuller, L., Esquenazi, V., Eskind, L., Kenyon, N. S., Ricordi, C., Tzakis, A. & Miller, J., Apr 15 1998, In : Transplantation. 65, 7, p. 956-965 10 p.

Research output: Contribution to journalArticle

55 Scopus citations