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Research Output

  • 2763 Citations
  • 53 Article
  • 4 Review article
  • 1 Comment/debate
2018

Inframe deletion of human ESPN is associated with deafness, vestibulopathy and vision impairment

Ahmed, Z. M., Jaworek, T. J., Sarangdhar, G. N., Zheng, L., Gul, K., Khan, S. N., Friedman, T. B., Sisk, R. A., Bartles, J. R., Riazuddin, S. & Riazuddin, S., Jul 1 2018, In : Journal of medical genetics. 55, 7, p. 479-488 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Fascin- and α-Actinin-Bundled Networks Contain Intrinsic Structural Features that Drive Protein Sorting

Winkelman, J. D., Suarez, C., Hocky, G. M., Harker, A. J., Morganthaler, A. N., Christensen, J. R., Voth, G. A., Bartles, J. R. & Kovar, D. R., Oct 24 2016, In : Current Biology. 26, 20, p. 2697-2706 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
2014

Characterization and regulation of an additional actin-filamentbinding site in large isoforms of the stereocilia actin-bundling protein espin

Zheng, L., Beeler, D. M. & Bartles, J. R., Mar 1 2014, In : Journal of cell science. 127, 6, p. 1306-1317 12 p.

Research output: Contribution to journalArticle

15 Scopus citations
2011
55 Scopus citations
2010

Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing

Kitajiri, S. I., Sakamoto, T., Belyantseva, I. A., Goodyear, R. J., Stepanyan, R., Fujiwara, I., Bird, J. E., Riazuddin, S., Riazuddin, S., Ahmed, Z. M., Hinshaw, J. E., Sellers, J., Bartles, J. R., Hammer, J. A., Richardson, G. P., Griffith, A. J., Frolenkov, G. I. & Friedman, T. B., May 1 2010, In : Cell. 141, 5, p. 786-798 13 p.

Research output: Contribution to journalArticle

109 Scopus citations

Mutations in Grxcr1 Are The Basis for Inner Ear Dysfunction in the Pirouette Mouse

Odeh, H., Hunker, K. L., Belyantseva, I. A., Azaiez, H., Avenarius, M. R., Zheng, L., Peters, L. M., Gagnon, L. H., Hagiwara, N., Skynner, M. J., Brilliant, M. H., Allen, N. D., Riazuddin, S., Johnson, K. R., Raphael, Y., Najmabadi, H., Friedman, T. B., Bartles, J. R., Smith, R. J. H. & Kohrman, D. C., Feb 12 2010, In : American journal of human genetics. 86, 2, p. 148-160 13 p.

Research output: Contribution to journalArticle

29 Scopus citations
25 Scopus citations
2009

Cooperativity and Frustration in Protein-Mediated Parallel Actin Bundles

Shin, H., Drew, K. R. P., Bartles, J. R., Wong, G. C. L. & Grason, G. M., Nov 30 2009, In : Physical review letters. 103, 23, 238102.

Research output: Contribution to journalArticle

36 Scopus citations

Structural and Viscoelastic Properties of Actin Networks Formed by Espin or Pathologically Relevant Espin Mutants

Lieleg, O., Schmoller, K. M., Purdy Drew, K. R., Claessens, M. M. A. E., Semmrich, C., Zheng, L., Bartles, J. R. & Bausch, A. R., Nov 9 2009, In : ChemPhysChem. 10, 16, p. 2813-2817 5 p.

Research output: Contribution to journalArticle

6 Scopus citations
2008
13 Scopus citations
88 Scopus citations
2007

Microvillar size and espin expression in principal cells of the adult rat epididymis are regulated by androgens

Primiani, N., Gregory, M., Dufresne, J., Smith, C. E., Ye, L. L., Bartles, J. R., Cyr, D. G. & Hermo, L., Sep 1 2007, In : Journal of andrology. 28, 5, p. 659-669 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Postsynaptic enrichment of Eps8 at dendritic shaft synapses of unipolar brush cells in rat cerebellum

Sekerkova, G., Diño, M. R., Ilijic, E., Russo, M., Zheng, L., Bartles, J. R. & Mugnaini, E., Mar 2 2007, In : Neuroscience. 145, 1, p. 116-129 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Structural polymorphism of the actin-espin system: A prototypical system of filaments and linkers in stereocilia

Purdy, K. R., Bartles, J. R. & Wong, G. C. L., Jan 2 2007, In : Physical review letters. 98, 5, 058105.

Research output: Contribution to journalArticle

31 Scopus citations
2006
32 Scopus citations

Espin gene (ESPN) mutations associated with autosomal dominant hearing loss cause defects in microvillar elongation or organisation

Donaudy, F., Zheng, L., Ficarella, R., Ballana, E., Carella, M., Melchionda, S., Estivill, X., Bartles, J. R. & Gasparini, P., Feb 1 2006, In : Journal of medical genetics. 43, 2, p. 157-161 5 p.

Research output: Contribution to journalArticle

42 Scopus citations

Espins and the actin cytoskeleton of hair cell stereocilia and sensory cell microvilli

Sekerkova, G., Zheng, L., Loomis, P. A., Mugnaini, E. & Bartles, J. R., Oct 1 2006, In : Cellular and Molecular Life Sciences. 63, 19-20, p. 2329-2341 13 p.

Research output: Contribution to journalReview article

48 Scopus citations

FSH regulates the formation of adherens junctions and ectoplasmic specialisations between rat Sertoli cells in vitro and in vivo

Sluka, P., O'Donnell, L., Bartles, J. R. & Stanton, P. G., May 1 2006, In : Journal of Endocrinology. 189, 2, p. 381-395 15 p.

Research output: Contribution to journalArticle

39 Scopus citations

Targeted wild-type and jerker espins reveal a novel, WH2-domain-dependent way to make actin bundles in cells

Loomis, P. A., Kelly, A. E., Zheng, L., Changyaleket, B., Sekerková, G., Mugnaini, E., Ferreira, A., Mullins, R. D. & Bartles, J. R., Apr 15 2006, In : Journal of cell science. 119, 8, p. 1655-1665 11 p.

Research output: Contribution to journalArticle

25 Scopus citations
2005

Balanced levels of espin are critical for stereociliary growth and length maintenance

Rzadzinska, A., Schneider, M., Noben-Trauth, K., Bartles, J. R. & Kachar, B., Nov 1 2005, In : Cell motility and the cytoskeleton. 62, 3, p. 157-165 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Espin cytoskeletal proteins in the sensory cells of rodent taste buds

Sekerková, G., Freeman, D., Mugnaini, E. & Bartles, J. R., Sep 1 2005, In : Journal of Neurocytology. 34, 3-5, p. 171-182 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
2004

Espins are multifunctional actin cytoskeletal regulatory proteins in the microvilli of chemosensory and mechanosensory cells

Sekerková, G., Zheng, L., Loomis, P. A., Changyaleket, B., Whitlon, D. S., Mugnaini, E. & Bartles, J. R., Jun 9 2004, In : Journal of Neuroscience. 24, 23, p. 5445-5456 12 p.

Research output: Contribution to journalArticle

61 Scopus citations
2003

Espin cross-links cause the elongation of microvillus-type parallel actin bundles in vivo

Loomis, P. A., Zheng, L., Sekerková, G., Changyaleket, B., Mugnaini, E. & Bartles, J. R., Dec 8 2003, In : Journal of Cell Biology. 163, 5, p. 1045-1055 11 p.

Research output: Contribution to journalArticle

128 Scopus citations

Novel espin actin-bundling proteins are localized to Purkinje cell dendritic spines and bind the Src homology 3 adapter protein insulin receptor substrate p53

Sekerkova, G., Loomis, P. A., Changyaleket, B., Zheng, L., Eytan, R., Chen, B., Mugnaini, E. & Bartles, J. R., Feb 15 2003, In : Journal of Neuroscience. 23, 4, p. 1310-1319 10 p.

Research output: Contribution to journalArticle

41 Scopus citations
2000

Parallel actin bundles and their multiple actin-bundling proteins

Bartles, J. R., Feb 1 2000, In : Current Opinion in Cell Biology. 12, 1, p. 72-78 7 p.

Research output: Contribution to journalReview article

180 Scopus citations

Sertoli cell ectoplasmic specializations in the seminiferous epithelium of the testosterone-suppressed adult rat

O'Donnell, L., Stanton, P. G., Bartles, J. R. & Robertson, D. M., Jan 1 2000, In : Biology of reproduction. 63, 1, p. 99-108 10 p.

Research output: Contribution to journalArticle

75 Scopus citations

The deaf jerker mouse has a mutation in the gene encoding the espin actin-bundling proteins of hair cell stereocilia and lacks espins

Zheng, L., Sekerkova, G., Vranich, K., Tilney, L. G., Mugnaini, E. & Bartles, J. R., Aug 4 2000, In : Cell. 102, 3, p. 377-385 9 p.

Research output: Contribution to journalArticle

206 Scopus citations
1999
65 Scopus citations
1998

Small espin: A third actin-bundling protein and potential forked protein ortholog in brush border microvilli

Bartles, J. R., Zheng, L., Li, A., Wierda, A. & Chen, B., Oct 5 1998, In : Journal of Cell Biology. 143, 1, p. 107-119 13 p.

Research output: Contribution to journalArticle

93 Scopus citations
1996
103 Scopus citations
1995
25 Scopus citations

Distribution of the integral plasma membrane glycoprotein CE9 (MRC OX-47) among rat tissues and its induction by diverse stimuli of metabolic activation

Nehme, C. L., Fayos, B. E. & Bartles, J. R., Jan 1 1995, In : Biochemical Journal. 310, 2, p. 693-698 6 p.

Research output: Contribution to journalArticle

49 Scopus citations

The spermatid plasma membrane comes of age

Bartles, J. R., Oct 1995, In : Trends in Cell Biology. 5, 10, p. 400-404 5 p.

Research output: Contribution to journalReview article

17 Scopus citations
1994
47 Scopus citations

Regulation of hepatocytic glycoprotein sialylation and sialyltransferases by peroxisome proliferators

Fayos, B. E. & Bartles, J. R., Jan 21 1994, In : Journal of Biological Chemistry. 269, 3, p. 2151-2157 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
1993

Breaching the diffusion barrier that compartmentalizes the transmembrane glycoprotein CE9 to the posterior-tail plasma membrane domain of the rat spermatozoon

Nehme, C. L., Cesario, M. M., Myles, D. G., Koppel, D. E. & Bartles, J. R., Feb 9 1993, In : Journal of Cell Biology. 120, 3, p. 687-694 8 p.

Research output: Contribution to journalArticle

71 Scopus citations
1991

Decreases in the relative concentrations of specific hepatocyte plasma membrane proteins during liver regeneration: Down-regulation or dilution?

Bartles, J. R., Zhang, L. Q., Verheyen, E. M., Hospodar, K. S., Nehme, C. L. & Fayos, B. E., Feb 1991, In : Developmental Biology. 143, 2, p. 258-270 13 p.

Research output: Contribution to journalArticle

28 Scopus citations
57 Scopus citations

Expression and compartmentalization of integral plasma membrane proteins by hepatocytes and their progenitors in the rat pancreas

Bartles, J. R., Musunuri, S. R., Zhang, L., Fayos, B. E., Nehme, C. L. & Reddy, J. K., Feb 15 1991, In : Journal of cell science. 98, 1, p. 45-54 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
1990

Biogenesis of the Rat Hepatocyte Plasma Membrane

Bartles, J. R. & Hubbard, A. L., Jan 1 1990, In : Methods in enzymology. 191, C, p. 825-841 17 p.

Research output: Contribution to journalArticle

21 Scopus citations

Peroxisome Proliferator-induced Alterations in the Expression and Modification of Rat Hepatocyte Plasma Membrane Proteins

Bartles, J. R., Khuon, S., Lin, X., Zhang, L., Isoye, S. T., Nehme, C. L., Fayos, B. E., Reddy, J. K. & Musunuri, S. R., Feb 1 1990, In : Cancer Research. 50, 3, p. 669-676 8 p.

Research output: Contribution to journalArticle

25 Scopus citations
1989

Biogenesis of endogenous plasma membrane proteins in epithelial cells

Hubbard, A. L., Stieger, B. & Bartles, J. R., Jan 1 1989, In : Annual Review of Physiology. 51, p. 755-770 16 p.

Research output: Contribution to journalReview article

56 Scopus citations
1988

Immuno-isolation of hepatocyte membrane compartments using S. aureus cells.

Hubbard, A. L., Dunn, W. A., Mueller, S. C. & Bartles, J. R., 1988, In : Progress in clinical and biological research. 270, p. 115-127 13 p.

Research output: Contribution to journalArticle

Plasma membrane protein sorting in epithelial cells: Do secretory pathways hold the key?

Bartles, J. R. & Hubbard, A. L., May 1988, In : Trends in Biochemical Sciences. 13, 5, p. 181-184 4 p.

Research output: Contribution to journalArticle

79 Scopus citations
1987

Biogenesis of the rat hepatocyte plasma membrane in vivo: Comparison of the pathways taken by apical and basolateral proteins using subcellular fractionation

Bartles, J. R., Feracci, H. M., Stieger, B. & Hubbard, A. L., Jan 1 1987, In : Journal of Cell Biology. 105, 3, p. 1241-1251 11 p.

Research output: Contribution to journalArticle

250 Scopus citations
1986

Preservation of hepatocyte plasma membrane domains during cell division in situ in regenerating rat liver

Bartles, J. R. & Hubbard, A. L., Nov 1986, In : Developmental Biology. 118, 1, p. 286-295 10 p.

Research output: Contribution to journalArticle

30 Scopus citations
1985

Biochemical characterization of domain-specific glycoproteins of the rat hepatocyte plasma membrane

Bartles, J. R., Braiterman, L. T. & Hubbard, A. L., Dec 1 1985, In : Journal of Biological Chemistry. 260, 23, p. 12792-12802 11 p.

Research output: Contribution to journalArticle

78 Scopus citations

Endogenous and exogenous domain markers of the rat hepatocyte plasma membrane

Bartles, J. R., Braiterman, L. T. & Hubbard, A. L., Apr 1 1985, In : Journal of Cell Biology. 100, 4, p. 1126-1138 13 p.

Research output: Contribution to journalArticle

53 Scopus citations

Identification of rat hepatocyte plasma membrane proteins using monoclonal antibodies

Hubbard, A. L., Bartles, J. R. & Braiterman, L. T., Apr 1 1985, In : Journal of Cell Biology. 100, 4, p. 1115-1125 11 p.

Research output: Contribution to journalArticle

98 Scopus citations