• 24951 Citations
1968 …2018

Research output per year

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Personal profile

Research Interests

Autopsy pathology, Liver and pancreatic pathology

Our current work focuses on the molecular mechanisms responsible for PPAR action. Transcription of specific genes initiated by transcription factors/nuclear receptors is a complex process and involves the participation of multiprotein complexes composed of transcription coactivators. Coactivators contain one or more highly conserved LXXLL (L, leucine; X, any amino acid) motif for direct interaction with AF-2 (activation function 2) region in nuclear receptor. Our laboratory cloned PBP, PRIP, PIMT, PRIC285 and PRIC320 using either yeast two-hybrid screening or by isolating receptor binding proteins and their identification by MALDI-TOF analysis. We are generating gene knockout mouse models to elucidate the role of these coactivators in the regulation of specific gene transcription. Our work demonstrated that the deletion of PBP, PRIP PIMT and PRIC320 genes in the mouse results in embryonic lethality, indicating that these are vital for development and they alter the function of many nuclear receptors and other transcription factors during critical developmental stages. Recent developments in the area of conditional targeted somatic mutagenesis have opened new avenues for analyzing the physiological functions of coactivator signaling in a variety of tissues and cell types during early development and in the adult.

Certifications and Licenses

Anatomic Pathology & Clinical Pathology

Training Experience

1968Residency, University of Kansas Hospital
1970Fellowship, University of Kansas Hospital

Education/Academic qualification

MD, All India Institute of Medical Sciences

… → 1965

Research interests

  • Liver Disease / Pathobiology
  • Pathology

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Research Output

Mouse cardiac Pde1C is a direct transcriptional target of pparα

Shete, V., Liu, N., Jia, Y., Viswakarma, N., Reddy, J. K. & Thimmapaya, B., Dec 2018, In : International journal of molecular sciences. 19, 12, 3704.

Research output: Contribution to journalArticle

  • 1 Scopus citations
  • 2 Scopus citations

    Mediator 1 Is Atherosclerosis Protective by Regulating Macrophage Polarization

    Bai, L., Li, Z., Li, Q., Guan, H., Zhao, S., Liu, R., Wang, R., Zhang, J., Jia, Y., Fan, J., Wang, N., Reddy, J. K., Shyy, J. Y. J. & Liu, E., Aug 1 2017, In : Arteriosclerosis, thrombosis, and vascular biology. 37, 8, p. 1470-1481 12 p.

    Research output: Contribution to journalArticle

  • 11 Scopus citations

    Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice

    Jia, Y., Chang, H. C., Schipma, M. J., Liu, J., Shete, V., Liu, N., Sato, T., Thorp, E. B., Barger, P. M., Zhu, Y. J., Viswakarma, N., Kanwar, Y. S., Ardehali, H., Thimmapaya, B. & Reddy, J. K., Aug 2016, In : PloS one. 11, 8, e0160755.

    Research output: Contribution to journalArticle

  • 9 Scopus citations

    Mediator facilitates transcriptional activation and dynamic long-range contacts at the IgH locus during class switch recombination

    Thomas-Claudepierre, A. S., Robert, I., Rocha, P. P., Raviram, R., Schiavo, E., Heyer, V., Bonneau, R., Luo, V. M., Reddy, J. K., Borggrefe, T., Skok, J. A. & Reina-San-Martin, B., Jan 1 2016, In : Journal of Experimental Medicine. 213, 3, p. 303-312 10 p.

    Research output: Contribution to journalArticle

  • 15 Scopus citations