• 25045 Citations
1968 …2018

Research output per year

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Research Output

2018

Mouse cardiac Pde1C is a direct transcriptional target of pparα

Shete, V., Liu, N., Jia, Y., Viswakarma, N., Reddy, J. K. & Thimmapaya, B., Dec 2018, In : International journal of molecular sciences. 19, 12, 3704.

Research output: Contribution to journalArticle

2 Scopus citations
2 Scopus citations
2017

Mediator 1 Is Atherosclerosis Protective by Regulating Macrophage Polarization

Bai, L., Li, Z., Li, Q., Guan, H., Zhao, S., Liu, R., Wang, R., Zhang, J., Jia, Y., Fan, J., Wang, N., Reddy, J. K., Shyy, J. Y. J. & Liu, E., Aug 1 2017, In : Arteriosclerosis, thrombosis, and vascular biology. 37, 8, p. 1470-1481 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
2016

Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice

Jia, Y., Chang, H. C., Schipma, M. J., Liu, J., Shete, V., Liu, N., Sato, T., Thorp, E. B., Barger, P. M., Zhu, Y. J., Viswakarma, N., Kanwar, Y. S., Ardehali, H., Thimmapaya, B. & Reddy, J. K., Aug 2016, In : PloS one. 11, 8, e0160755.

Research output: Contribution to journalArticle

10 Scopus citations

Mediator facilitates transcriptional activation and dynamic long-range contacts at the IgH locus during class switch recombination

Thomas-Claudepierre, A. S., Robert, I., Rocha, P. P., Raviram, R., Schiavo, E., Heyer, V., Bonneau, R., Luo, V. M., Reddy, J. K., Borggrefe, T., Skok, J. A. & Reina-San-Martin, B., Jan 1 2016, In : Journal of Experimental Medicine. 213, 3, p. 303-312 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Transcriptional and translational modulation of myo-inositol oxygenase (Miox) by fatty acids: Implications in renal tubular injury induced in obesity and diabetes

Tominaga, T., Dutta, R. K., Joladarashi, D., Doi, T., Reddy, J. K. & Kanwar, Y. S., Jan 15 2016, In : Journal of Biological Chemistry. 291, 3, p. 1348-1367 20 p.

Research output: Contribution to journalArticle

15 Scopus citations
2015

Co-activator binding protein PIMT mediates TNF-α induced insulin resistance in skeletal muscle via the transcriptional down-regulation of MEF2A and GLUT4

Kain, V., Kapadia, B., Viswakarma, N., Seshadri, S., Prajapati, B., Jena, P. K., Teja Meda, C. L., Subramanian, M., Kaimal Suraj, S., Kumar, S. T., Prakash Babu, P., Thimmapaya, B., Reddy, J. K., Parsa, K. V. L. & Misra, P., Oct 15 2015, In : Scientific reports. 5, 15197.

Research output: Contribution to journalArticle

12 Scopus citations

Med1 regulates meiotic progression during spermatogenesis in mice

Huszar, J. M., Jia, Y., Reddy, J. K. & Payne, C. J., Jun 1 2015, In : Reproduction. 149, 6, p. 597-604 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

PPARα-deficient ob/ob obese mice become more obese and manifest severe hepatic steatosis due to decreased fatty acid oxidation

Gao, Q., Jia, Y., Yang, G., Zhang, X., Boddu, P. C., Petersen, B., Narsingam, S., Zhu, Y. J., Thimmapaya, B., Kanwar, Y. S. & Reddy, J. K., May 1 2015, In : American Journal of Pathology. 185, 5, p. 1396-1408 13 p., 1984.

Research output: Contribution to journalArticle

24 Scopus citations

Preparation of recombinant adenoviruses of PPARγ and its transcriptional coactivator MED1 and their biological function analysis

Bai, L., Li, Q. W., Zhao, S. H., Jia, Y. Z., Reddy, J. K. & Liu, E. Q., May 1 2015, In : Journal of Xi'an Jiaotong University (Medical Sciences). 36, 3, p. 294-298 5 p.

Research output: Contribution to journalArticle

2014

Alteration of skin wound healing in keratinocyte-specific mediator complex subunit 1 null mice

Noguchi, F., Nakajima, T., Inui, S., Reddy, J. K. & Itami, S., Aug 14 2014, In : PLoS One. 9, 8, e102271.

Research output: Contribution to journalArticle

10 Scopus citations

Hepatic oxidative stress activates the Gadd45b gene by way of degradation of the transcriptional repressor STAT3

Kim, J. H., Qu, A., Reddy, J. K., Gao, B. & Gonzalez, F. J., Feb 1 2014, In : Hepatology. 59, 2, p. 695-704 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Introduction: Gene expression

Jacob, S. T. & Reddy, J. K., Apr 2014, In : Gene expression. 16, 2, 1 p.

Research output: Contribution to journalEditorial

Introduction. Special issue of Gene Expression.

Jacob, S. T. & Reddy, J. K., Jan 1 2014, In : Gene Expression. 16, 2, 1 p.

Research output: Contribution to journalEditorial

Med1 subunit of the mediator complex in nuclear receptor-regulated energy metabolism, liver regeneration, and hepatocarcinogenesis

Jia, Y., Viswakarma, N. & Reddy, J. K., Apr 2014, In : Gene expression. 16, 2, p. 63-75 13 p.

Research output: Contribution to journalReview article

14 Scopus citations

Mistargeting of peroxisomal EHHADH and inherited renal Fanconi's syndrome

Klootwijk, E. D., Reichold, M., Helip-Wooley, A., Tolaymat, A., Broeker, C., Robinette, S. L., Reinders, J., Peindl, D., Renner, K., Eberhart, K., Assmann, N., Oefner, P. J., Dettmer, K., Sterner, C., Schroeder, J., Zorger, N., Witzgall, R., Reinhold, S. W., Stanescu, H. C., Bockenhauer, D. & 19 others, Jaureguiberry, G., Courtneidge, H., Hall, A. M., Wijeyesekera, A. D., Holmes, E., Nicholson, J. K., O'Brien, K., Bernardini, I., Krasnewich, D. M., Arcos-Burgos, M., Izumi, Y., Nonoguchi, H., Jia, Y., Reddy, J. K., Ilyas, M., Unwin, R. J., Gahl, W. A., Warth, R. & Kleta, R., Jan 1 2014, In : New England Journal of Medicine. 370, 2, p. 129-138 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Peroxisome proliferator-activated receptor-α activation and excess energy burning in hepatocarcinogenesis

Misra, P. & Reddy, J. K., Jan 1 2014, In : Biochimie. 98, 1, p. 63-74 12 p.

Research output: Contribution to journalShort survey

29 Scopus citations

Role of AMACR (α-methylacyl-CoA racemase) and MFE-1 (peroxisomal multifunctional enzyme-1) in bile acid synthesis in mice

Autio, K. J., Schmitz, W., Nair, R. R., Selkäl̈a, E. M., Sormunen, R. T., Miinalainen, I. J., Crick, P. J., Wang, Y., Griffiths, W. J., Reddy, J. K., Baes, M. & Hiltunen, J. K., Jul 1 2014, In : Biochemical Journal. 461, 1, p. 125-135 11 p.

Research output: Contribution to journalArticle

10 Scopus citations
2013

ERK2-mediated phosphorylation of transcriptional coactivator binding protein PIMT/NCoA6IP at Ser298 augments hepatic gluconeogenesis

Kapadia, B., Viswakarma, N., Parsa, K. V. L., Kain, V., Behera, S., Suraj, S. K., Prakash Babu, P., Kar, A., Panda, S., Zhu, Y. J., Jia, Y., Thimmapaya, B., Reddy, J. K. & Misra, P., Dec 17 2013, In : PloS one. 8, 12, e83787.

Research output: Contribution to journalArticle

10 Scopus citations

Peroxisome proliferator-activated receptor-α signaling in hepatocarcinogenesis.

Misra, P., Viswakarma, N. & Reddy, J. K., Jan 1 2013, In : Sub-Cellular Biochemistry. 69, p. 77-99 23 p.

Research output: Contribution to journalReview article

17 Scopus citations

Roles of MED1 in quiescence of hair follicle stem cells and maintenance of normal hair cycling

Nakajima, T., Inui, S., Fushimi, T., Noguchi, F., Kitagawa, Y., Reddy, J. K. & Itami, S., Feb 2013, In : Journal of Investigative Dermatology. 133, 2, p. 354-360 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

The Med1 subunit of the mediator complex induces liver cell proliferation and is phosphorylated by AMP kinase

Viswakarma, N., Jia, Y., Bai, L., Gao, Q., Lin, B., Zhang, X., Misra, P., Rana, A., Jain, S., Gonzalez, F. J., Zhu, Y. J., Thimmapaya, B. & Reddy, J. K., Sep 27 2013, In : Journal of Biological Chemistry. 288, 39, p. 27898-27911 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

The Peroxisomal Enzyme L-PBE Is Required to Prevent the Dietary Toxicity of Medium-Chain Fatty Acids

Ding, J., Loizides-Mangold, U., Rando, G., Zoete, V., Michielin, O., Reddy, J. K., Wahli, W., Riezman, H. & Thorens, B., Oct 17 2013, In : Cell reports. 5, 1, p. 248-258 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
2012

Coactivator MED1 ablation in keratinocytes results in hair-cycling defects and epidermal alterations

Oda, Y., Hu, L., Bul, V., Elalieh, H., Reddy, J. K. & Bikle, D. D., Apr 2012, In : Journal of Investigative Dermatology. 132, 4, p. 1075-1083 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene

Jia, Y., Viswakarma, N., Crawford, S. E., Sarkar, J., Sambasiva Rao, M., Karpus, W. J., Kanwar, Y. S., Zhu, Y. J. & Reddy, J. K., Sep 1 2012, In : Mechanisms of Development. 129, 9-12, p. 193-207 15 p.

Research output: Contribution to journalArticle

12 Scopus citations

Nuclear receptors and transcription factors in the development of fatty liver disease

Vluggens, A. & Reddy, J. K., Dec 1 2012, In : Current Drug Metabolism. 13, 10, p. 1422-1435 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

Peroxisomal L-bifunctional enzyme (Ehhadh) is essential for the production of medium-chain dicarboxylic acids

Houten, S. M., Denis, S., Argmann, C. A., Jia, Y., Ferdinandusse, S., Reddy, J. K. & Wanders, R. J. A., Jul 1 2012, In : Journal of lipid research. 53, 7, p. 1296-1303 8 p.

Research output: Contribution to journalArticle

60 Scopus citations

Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network

Shalom-Barak, T., Zhang, X., Chu, T., Timothy Schaiff, W., Reddy, J. K., Xu, J., Sadovsky, Y. & Barak, Y., Dec 1 2012, In : Developmental Biology. 372, 1, p. 143-155 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Sustained activation of PPARα by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob mice

Huang, J., Jia, Y., Fu, T., Viswakarma, N., Bai, L., Rao, M. S., Zhu, Y., Borensztajn, J. & Reddy, J. K., Feb 1 2012, In : FASEB Journal. 26, 2, p. 628-638 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

The inflammatory response in Acyl-CoA oxidase 1 deficiency (pseudoneonatal adrenoleukodystrophy)

El Hajj, H. I., Vluggens, A., Andreoletti, P., Ragot, K., Mandard, S., Kersten, S., Waterham, H. R., Lizard, G., Wanders, R. J. A., Reddy, J. K. & Cherkaoui-Malki, M., Jun 1 2012, In : Endocrinology. 153, 6, p. 2568-2575 8 p.

Research output: Contribution to journalArticle

16 Scopus citations
2011

Deletion of a malaria invasion gene reduces death and anemia, in model hosts

Gómez, N. D., Safeukui, I., Adelani, A. A., Tewari, R., Reddy, J. K., Rao, S., Holder, A., Buffet, P., Mohandas, N. & Haldar, K., Sep 28 2011, In : PloS one. 6, 9, e25477.

Research output: Contribution to journalArticle

12 Scopus citations

Hyperlipidemia in hepatic MED1 deficient mice in response to fasting

Bai, L., Fu, T., Jia, Y., Borensztajn, J., Reddy, J. K. & Yang, G., Oct 1 2011, In : Shengwu Gongcheng Xuebao/Chinese Journal of Biotechnology. 27, 10, p. 1490-1498 9 p.

Research output: Contribution to journalArticle

Progressive endoplasmic reticulum stress contributes to hepatocarcinogenesis in fatty acyl-CoA oxidase 1-deficient mice

Huang, J., Viswakarma, N., Yu, S., Jia, Y., Bai, L., Vluggens, A., Cherkaoui-Malki, M., Khan, M., Singh, I., Yang, G., Rao, M. S., Borensztajn, J. & Reddy, J. K., Aug 1 2011, In : American Journal of Pathology. 179, 2, p. 703-713 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Transcription coactivator mediator subunit MED1 Is required for the development of fatty liver in the mouse

Bai, L., Jia, Y., Viswakarma, N., Huang, J., Vluggens, A., Wolins, N. E., Jafari, N., Musunuri, S. R., Borensztajn, J., Yang, G. & Reddy, J. K., Apr 1 2011, In : Hepatology. 53, 4, p. 1164-1174 11 p.

Research output: Contribution to journalArticle

40 Scopus citations
2010

Coactivators in PPAR-regulated gene expression

Reddy, J. K., Viswakarma, N., Jia, Y., Bai, L., Vluggens, A., Borensztajn, J. & Xu, J., Sep 24 2010, In : PPAR Research. 250126.

Research output: Contribution to journalReview article

108 Scopus citations

Dynamic and differential regulation of proteins that coat lipid droplets in fatty liver dystrophic mice

Hall, A. M., Brunt, E. M., Chen, Z., Viswakarma, N., Reddy, J. K., Wolins, N. E. & Finck, B. N., Mar 1 2010, In : Journal of lipid research. 51, 3, p. 554-563 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Erratum: Functional significance of the two ACOX1 isoforms and their crosstalks with PPARα and RXRα (Laboratory Investigation (2010) 90 (696-708) DOI: 10.1038/labinvest.2010.46)

Vluggens, A., Andreoletti, P., Viswakarma, N., Jia, Y., Matsumoto, K., Kulik, W., Khan, M., Huang, J., Guo, D., Yu, S., Sarkar, J., Singh, I., Rao, M. S., Wanders, R. J., Reddy, J. K. & Cherkaoui-Malki, M., May 1 2010, In : Laboratory Investigation. 90, 5, 1 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Functional significance of the two ACOX1 isoforms and their crosstalks with PPARα and RXRα

Vluggens, A., Andreoletti, P., Viswakarma, N., Jia, Y., Matsumoto, K., Kulik, W., Khan, M., Huang, J., Guo, D., Yu, S., Sarkar, J., Singh, I., Rao, M. S., Wanders, R. J., Reddy, J. K. & Cherkaoui-Malki, M., May 2010, In : Laboratory Investigation. 90, 5, p. 696-708 13 p.

Research output: Contribution to journalArticle

40 Scopus citations

PPARalpha: energy combustion, hypolipidemia, inflammation and cancer.

Pyper, S. R., Viswakarma, N., Yu, S. & Reddy, J. K., Jan 1 2010, In : Nuclear receptor signaling. 8

Research output: Contribution to journalReview article

247 Scopus citations

PRIC295, a nuclear receptor coactivator, identified from PPARα -interacting cofactor complex

Reddy, J. K., Pyper, S. R., Viswakarma, N., Jia, Y., Zhu, Y. J. & Fondell, J. D., Oct 21 2010, In : PPAR Research. 173907.

Research output: Contribution to journalArticle

7 Scopus citations

Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1

Stumpf, M., Yue, X., Schmitz, S., Luche, H., Reddy, J. K. & Borggrefe, T., Dec 14 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 50, p. 21541-21546 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Transcription coactivator PBP/MED1-deficient hepatocytes are not susceptible to diethylnitrosamine-induced hepatocarcinogenesis in the mouse

Matsumoto, K., Huang, J., Viswakarma, N., Bai, L., Jia, Y., Zhu, Y. T., Yang, G., Borensztajn, J., Sambasiva Rao, M., Zhu, Y. J. & Reddy, J. K., Feb 1 2010, In : Carcinogenesis. 31, 2, p. 318-325 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
2009
37 Scopus citations
2008

Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4α

Surapureddi, S., Rana, R., Reddy, J. K. & Goldstein, J. A., Sep 1 2008, In : Molecular Pharmacology. 74, 3, p. 913-923 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor α

Chung, C., Doll, J. A., Stellmach, V. M., Gonzales, J., Surapureddi, S., Cornwell, M., Reddy, J. K. & Crawford, S. E., Dec 1 2008, Hormonal Carcinogenesis V. p. 591-597 7 p. (Advances in Experimental Medicine and Biology; vol. 617).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

21 Scopus citations

The Med1 subunit of transcriptional mediator plays a central role in regulating CCAAT/enhancer-binding protein-β-driven transcription in response to interferon-γ

Li, H., Gade, P., Nallar, S. C., Raha, A., Roy, S. K., Karra, S., Reddy, J. K., Reddy, S. P. & Kalvakolanu, D. V., May 9 2008, In : Journal of Biological Chemistry. 283, 19, p. 13077-13086 10 p.

Research output: Contribution to journalArticle

32 Scopus citations
2007

Biochemical characterization of two functional human liver acyl-CoA oxidase isoforms 1a and 1b encoded by a single gene

Oaxaca-Castillo, D., Andreoletti, P., Vluggens, A., Yu, S., van Veldhoven, P. P., Reddy, J. K. & Cherkaoui-Malki, M., Aug 24 2007, In : Biochemical and Biophysical Research Communications. 360, 2, p. 314-319 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Critical role for transcription coactivator Peroxisome Proliferator- activated Receptor (PPAR)-binding protein/TRAP220 in liver regeneration and PPARα ligand-induced liver tumor development

Matsumoto, K., Yu, S., Jia, Y., Ahmed, M. R., Viswakarma, N., Sarkar, J., Kashireddy, P. V., Rao, M. S., Karpus, W., Gonzalez, F. J. & Reddy, J. K., Jun 8 2007, In : Journal of Biological Chemistry. 282, 23, p. 17053-17060 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor α synthetic ligands in mouse liver

Guo, D., Sarkar, J., Suino-Powell, K., Xu, Y., Matsumoto, K., Jia, Y., Yu, S., Khare, S., Haldar, K., Musunuri, S. R., Foreman, J. E., Monga, S. P. S., Peters, J. M., Xu, H. E. & Reddy, J. K., Dec 14 2007, In : Journal of Biological Chemistry. 282, 50, p. 36766-36776 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Redundant enhancement of mouse constitutive androstane receptor transactivation by p160 coactivator family members

Xia, J., Liao, L., Sarkar, J., Matsumoto, K., Reddy, J. K., Xu, J. & Kemper, B., Dec 1 2007, In : Archives of biochemistry and biophysics. 468, 1, p. 49-57 9 p.

Research output: Contribution to journalArticle

10 Scopus citations