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Personal profile

Research Interests

My primary research interests are in molecular mechanisms of gene regulation, particularly those involved in neural development and neural degeneration. My lab is focusing on two areas, RNA regulation and mechanisms underlying cell migration with particular interest in molecular/cellular mechanisms underlying neurodevelopmental disorders, cancer invasion/metastasis and neurodegenerative diseases.

Education/Academic qualification

PhD, Stanford University

… → 1991

MD, Shanghai Second Medical University

… → 1986

Research interests

  • Aging
  • Alzheimer's Disease
  • Amyloidosis
  • Lung Cancer / Chest Cancer
  • Neuro-Oncology
  • Neurogenetics
  • Neurology
  • Pancreatic Cancer

Fingerprint Dive into the research topics where Jane Wu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
RNA Precursors Medicine & Life Sciences
Alternative Splicing Medicine & Life Sciences
Genes Medicine & Life Sciences
Neurons Medicine & Life Sciences
Axons Medicine & Life Sciences
Cell Movement Medicine & Life Sciences
Proteins Medicine & Life Sciences
Mutation Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2004 2023

Dementia
RNA-Binding Protein FUS
Alzheimer Disease
Frontotemporal Lobar Degeneration
Molecular Biology
RNA-Binding Proteins
Alzheimer Disease
Tauopathies
Gene Regulatory Networks
Neurons
TDP-43 Proteinopathies
Mitochondria
Frontotemporal Dementia
Neurodegenerative Diseases
Frontotemporal Lobar Degeneration
Tauopathies
Alzheimer Disease
Progressive Supranuclear Palsy
Parkinson Disease
Phenotype

Pilot 1 Year 01

Wu, J.

National Cancer Institute

8/18/157/31/20

Project: Research project

Prostatic Neoplasms
Neoplasms
Castration
Research Personnel
EphB4 Receptor

Research Output 1989 2019

1 Citation (Scopus)

A crucial role for Arf6 in the response of commissural axons to Slit

Kinoshita-Kawada, M., Hasegawa, H., Hongu, T., Yanagi, S., Kanaho, Y., Masai, I., Mishima, T., Chen, X., Tsuboi, Y., Rao, Y., Yuasa-Kawada, J. & Wu, J., Feb 1 2019, In : Development (Cambridge). 146, 3, dev172106.

Research output: Contribution to journalArticle

Axons
Endocytosis
Recycling
Vertebrates
Guanosine

Reduced USP33 expression in gastric cancer decreases inhibitory effects of Slit2-Robo1 signalling on cell migration and EMT

Xia, Y., Wang, L., Xu, Z., Kong, R., Wang, F., Yin, K., Xu, J., Li, B., He, Z., Wang, L., Xu, H., Zhang, D., Yang, L., Wu, J. & Xu, Z., May 1 2019, In : Cell Proliferation. 52, 3, e12606.

Research output: Contribution to journalArticle

Open Access
Ubiquitin-Specific Proteases
Epithelial-Mesenchymal Transition
Stomach Neoplasms
Cell Movement
Neoplasms
1 Citation (Scopus)

TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response

Wang, P., Deng, J., Dong, J., Liu, J., Bigio, E. H., Mesulam, M-M., Wang, T., Sun, L., Wang, L., Lee, A. Y. L., McGee, W. A., Chen, X., Fushimi, K., Zhu, L. & Wu, J., May 1 2019, In : PLoS genetics. 15, 5, e1007947.

Research output: Contribution to journalArticle

Open Access
TDP-43 Proteinopathies
unfolded protein response
Unfolded Protein Response
Mitochondrial Proteins
animal models
5 Citations (Scopus)

FUS interacts with ATP synthase beta subunit and induces mitochondrial unfolded protein response in cellular and animal models

Deng, J., Wang, P., Chen, X., Cheng, H., Liu, J., Fushimi, K., Zhu, L. & Wu, J., Oct 9 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 41, p. E9678-E9686

Research output: Contribution to journalArticle

Unfolded Protein Response
Mitochondrial Proteins
Sarcoma
Animal Models
Adenosine Triphosphate
1 Citation (Scopus)

Measure and model a 3-D space-variant PSF for fluorescence microscopy image deblurring

Chen, Y., Chen, M., Zhu, L., Wu, J., Du, S. & Li, Y., May 28 2018, In : Optics Express. 26, 11, p. 14375-14391 17 p.

Research output: Contribution to journalArticle

microscopy
fluorescence
point spread functions
signal to noise ratios
decomposition