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Personal profile

Research Interests

My primary research interests are in molecular mechanisms of gene regulation, particularly those involved in neural development and neural degeneration. My lab is focusing on two areas, RNA regulation and mechanisms underlying cell migration with particular interest in molecular/cellular mechanisms underlying neurodevelopmental disorders, cancer invasion/metastasis and neurodegenerative diseases.

Education/Academic qualification

PhD, Stanford University

… → 1991

MD, Shanghai Second Medical University

… → 1986


  • Aging
  • Alzheimer's Disease
  • Amyloidosis
  • Lung Cancer / Chest Cancer
  • Neuro-Oncology
  • Neurogenetics
  • Neurology
  • Pancreatic Cancer

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Cell Movement Medicine & Life Sciences

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Grants 2004 2023

TDP-43 Proteinopathies
Frontotemporal Dementia
Neurodegenerative Diseases
Frontotemporal Lobar Degeneration

Pilot 1 Year 01

Wu, J.

National Cancer Institute


Project: Research project

Prostatic Neoplasms
Research Personnel
EphB4 Receptor
Lung Neoplasms
Animal Models
Deubiquitinating Enzymes
High-Throughput Nucleotide Sequencing
Imaging techniques
Microscopic examination
Robotic arms
Alzheimer Disease
Progressive Supranuclear Palsy
Parkinson Disease

Research Output 1989 2019

A crucial role for Arf6 in the response of commissural axons to Slit

Kinoshita-Kawada, M., Hasegawa, H., Hongu, T., Yanagi, S., Kanaho, Y., Masai, I., Mishima, T., Chen, X., Tsuboi, Y., Rao, Y., Yuasa-Kawada, J. & Wu, J., Feb 1 2019, In : Development (Cambridge). 146, 3, dev172106.

Research output: Contribution to journalArticle


FUS interacts with ATP synthase beta subunit and induces mitochondrial unfolded protein response in cellular and animal models

Deng, J., Wang, P., Chen, X., Cheng, H., Liu, J., Fushimi, K., Zhu, L. & Wu, J., Oct 9 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 41, p. E9678-E9686

Research output: Contribution to journalArticle

Unfolded Protein Response
Mitochondrial Proteins
Animal Models
Adenosine Triphosphate

Measure and model a 3-D space-variant PSF for fluorescence microscopy image deblurring

Chen, Y., Chen, M., Zhu, L., Wu, J., Du, S. & Li, Y., May 28 2018, In : Optics Express. 26, 11, p. 14375-14391 17 p.

Research output: Contribution to journalArticle

point spread functions
signal to noise ratios
2 Citations (Scopus)

TDP-43 regulates cancer-associated microRNAs

Chen, X., Fan, Z., McGee, W., Chen, M., Kong, R., Wen, P., Xiao, T., Chen, X., Liu, J., Zhu, L., Chen, R. & Wu, J., Oct 1 2018, In : Protein and Cell. 9, 10, p. 848-866 19 p.

Research output: Contribution to journalArticle

DNA-Binding Proteins
Lung Neoplasms
4 Citations (Scopus)

Traumatic injury induces stress granule formation and enhances motor dysfunctions in ALS/FTD models

Anderson, E. N., Gochenaur, L., Singh, A., Grant, R., Patel, K., Watkins, S., Wu, J. & Pandey, U. B., Apr 15 2018, In : Human molecular genetics. 27, 8, p. 1366-1381 16 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Wounds and Injuries
Ubiquitinated Proteins
Traumatic Brain Injury