If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Research Interests

My primary research interests are in molecular mechanisms of gene regulation, particularly those involved in neural development and neural degeneration. My lab is focusing on two areas, RNA regulation and mechanisms underlying cell migration with particular interest in molecular/cellular mechanisms underlying neurodevelopmental disorders, cancer invasion/metastasis and neurodegenerative diseases.

Education/Academic qualification

PhD, Stanford University

… → 1991

MD, Shanghai Second Medical University

… → 1986

Keywords

  • Aging
  • Alzheimer's Disease
  • Amyloidosis
  • Lung Cancer / Chest Cancer
  • Neuro-Oncology
  • Neurogenetics
  • Neurology
  • Pancreatic Cancer

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 3 Similar Profiles
RNA Precursors Medicine & Life Sciences
Alternative Splicing Medicine & Life Sciences
Genes Medicine & Life Sciences
Neurons Medicine & Life Sciences
Axons Medicine & Life Sciences
Proteins Medicine & Life Sciences
Mutation Medicine & Life Sciences
Cell Movement Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2004 2023

TDP-43 Proteinopathies
Mitochondria
Frontotemporal Dementia
Neurodegenerative Diseases
Frontotemporal Lobar Degeneration

Pilot 1 Year 01

Wu, J.

National Cancer Institute

8/18/157/31/20

Project: Research project

Prostatic Neoplasms
Neoplasms
Castration
Research Personnel
EphB4 Receptor
Lung Neoplasms
Neoplasms
Animal Models
Deubiquitinating Enzymes
High-Throughput Nucleotide Sequencing
Imaging techniques
Microscopic examination
Microscopes
Medicine
Robotic arms
Tauopathies
Alzheimer Disease
Progressive Supranuclear Palsy
Parkinson Disease
Phenotype

Research Output 1989 2019

A crucial role for Arf6 in the response of commissural axons to Slit

Kinoshita-Kawada, M., Hasegawa, H., Hongu, T., Yanagi, S., Kanaho, Y., Masai, I., Mishima, T., Chen, X., Tsuboi, Y., Rao, Y., Yuasa-Kawada, J. & Wu, J., Feb 1 2019, In : Development (Cambridge). 146, 3, dev172106.

Research output: Contribution to journalArticle

Axons
Endocytosis
Recycling
Vertebrates
Guanosine

FUS interacts with ATP synthase beta subunit and induces mitochondrial unfolded protein response in cellular and animal models

Deng, J., Wang, P., Chen, X., Cheng, H., Liu, J., Fushimi, K., Zhu, L. & Wu, J., Oct 9 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 41, p. E9678-E9686

Research output: Contribution to journalArticle

Unfolded Protein Response
Mitochondrial Proteins
Sarcoma
Animal Models
Adenosine Triphosphate

Measure and model a 3-D space-variant PSF for fluorescence microscopy image deblurring

Chen, Y., Chen, M., Zhu, L., Wu, J., Du, S. & Li, Y., May 28 2018, In : Optics Express. 26, 11, p. 14375-14391 17 p.

Research output: Contribution to journalArticle

microscopy
fluorescence
point spread functions
signal to noise ratios
decomposition
2 Citations (Scopus)

TDP-43 regulates cancer-associated microRNAs

Chen, X., Fan, Z., McGee, W., Chen, M., Kong, R., Wen, P., Xiao, T., Chen, X., Liu, J., Zhu, L., Chen, R. & Wu, J., Oct 1 2018, In : Protein and Cell. 9, 10, p. 848-866 19 p.

Research output: Contribution to journalArticle

DNA-Binding Proteins
MicroRNAs
Neoplasms
Genes
Lung Neoplasms
4 Citations (Scopus)

Traumatic injury induces stress granule formation and enhances motor dysfunctions in ALS/FTD models

Anderson, E. N., Gochenaur, L., Singh, A., Grant, R., Patel, K., Watkins, S., Wu, J. & Pandey, U. B., Apr 15 2018, In : Human molecular genetics. 27, 8, p. 1366-1381 16 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Wounds and Injuries
Diptera
Ubiquitinated Proteins
Traumatic Brain Injury