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Personal profile

Research Interests

DNA and proteins are non-randomly localized within the nucleus of the cell.  The Brickner lab studies how cells control the position of genes within the nucleus, and how gene positioning affects gene expression.  When genes are activated or repressed, their position in the nucleus often changes.  The lab has identified DNA "zip codes" in the promoters of genes that control their positioning, transcription and, through an epigenetic mechanism, chromatin structure.

Education/Academic qualification

Biochemistry, PhD, Stanford University

19921998

Biological Sciences, BA, University of California at Santa Barbara

19881992

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Grants

Research Output

The Role of Transcription Factors and Nuclear Pore Proteins in Controlling the Spatial Organization of the Yeast Genome

Brickner, D. G., Randise-Hinchliff, C., Corbin, M. L., Liang, J. M., Kim, S., Sump, B., D'Urso, A., Kim, S. H., Satomura, A., Schmit, H., Coukos, R., Hwang, S., Watson, R. & Brickner, J. H., Jun 17 2019, In : Developmental Cell. 49, 6, p. 936-947.e4

Research output: Contribution to journalArticle

  • 5 Scopus citations

    Nuclear pore complex in genome organization and gene expression in yeast

    Randise-Hinchliff, C. & Brickner, J. H., Jan 1 2018, Nuclear Pore Complexes in Genome Organization, Function and Maintenance. Springer International Publishing, p. 87-109 23 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • 1 Scopus citations

    Epigenetic transcriptional memory

    D’Urso, A. & Brickner, J. H., Jun 1 2017, In : Current Genetics. 63, 3, p. 435-439 5 p.

    Research output: Contribution to journalReview article

  • 44 Scopus citations

    Epigenetic transcriptional memory of GAL genes depends on growth in glucose and the tup1 transcription factor in saccharomyces cerevisiae

    Sood, V., Cajigas, I., D’Urso, A., Light, W. H. & Brickner, J. H., Jan 1 2017, In : Genetics. 206, 4, p. 1895-1907 13 p.

    Research output: Contribution to journalArticle

  • 8 Scopus citations

    Genetic and epigenetic control of the spatial organization of the genome

    Brickner, J., Feb 1 2017, In : Molecular biology of the cell. 28, 3, p. 364-369 6 p.

    Research output: Contribution to journalReview article

  • 6 Scopus citations