Grants per year
Personal profile
Research Interests
DNA and proteins are non-randomly localized within the nucleus of the cell. The Brickner lab studies how cells control the position of genes within the nucleus, and how gene positioning affects gene expression. When genes are activated or repressed, their position in the nucleus often changes. The lab has identified DNA "zip codes" in the promoters of genes that control their positioning, transcription and, through an epigenetic mechanism, chromatin structure.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biochemistry, PhD, Stanford University
1992 → 1998
Biological Sciences, BA, University of California at Santa Barbara
1988 → 1992
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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The molecular mechanisms and functional significance of gene positioning
Brickner, J. H. (PD/PI) & Brickner, J. H. (PD/PI)
National Institute of General Medical Sciences
8/1/20 → 7/31/25
Project: Research project
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DNA zip codes and the spatial organization of the yeast genome
Brickner, J. H. (PD/PI)
National Institute of General Medical Sciences
9/1/17 → 7/31/21
Project: Research project
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Defining the molecular and cellular mechanism of epigenetic transcriptional memory
Brickner, J. H. (PD/PI) & Brickner, D. G. (Other)
National Institute of General Medical Sciences
8/1/16 → 7/31/21
Project: Research project
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Equipment supplement for Defining the molecular and cellular mechanism of epigenetic transcriptional memory
Brickner, J. H. (PD/PI)
National Institute of General Medical Sciences
8/1/16 → 7/31/21
Project: Research project
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Subproject for Cellular and Molecular Basis of Disease Training Program
Brickner, J. H. (PD/PI) & Carthew, R. W. (PD/PI)
National Institute of General Medical Sciences
7/1/16 → 6/30/18
Project: Research project
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Exportin-1 functions as an adaptor for transcription factor-mediated docking of chromatin at the nuclear pore complex
Ge, T., Brickner, D. G., Zehr, K., VanBelzen, D. J., Zhang, W., Caffalette, C., Moeller, G. C., Ungerleider, S., Marcou, N., Jacob, A., Nguyen, V. Q., Chait, B., Rout, M. P. & Brickner, J. H., Mar 20 2025, In: Molecular cell. 85, 6, p. 1101-1116.e8Research output: Contribution to journal › Article › peer-review
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ChEC-seq2: an improved chromatin endogenous cleavage sequencing method and bioinformatic analysis pipeline for mapping in vivo protein-DNA interactions
Vanbelzen, J., Duan, C., Brickner, D. G. & Brickner, J. H., Mar 1 2024, In: NAR Genomics and Bioinformatics. 6, 1, lqae012.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Chromatin endogenous cleavage provides a global view of yeast RNA polymerase II transcription kinetics
VanBelzen, J., Sakelaris, B., Brickner, D. G., Marcou, N., Riecke, H., Mangan, N. M. & Brickner, J. H., Oct 28 2024, In: eLife. 13Research output: Contribution to journal › Article › peer-review
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Inheritance of epigenetic transcriptional memory
Ge, T. & Brickner, J. H., Apr 2024, In: Current Opinion in Genetics and Development. 85, 102174.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
Nuclear Pore Complex-Regulated Transcription and Memory
Liu, W. & Brickner, J. H., Jan 1 2024, Epigenetics in Biological Communication. Springer Nature, p. 255-275 21 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
Datasets
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Data from: Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory
D’Urso, A. (Contributor), Takahashi, Y.-H. (Contributor), Xiong, B. (Contributor), Marone, J. (Contributor), Coukos, R. (Contributor), Randise-Hinchliff, C. (Contributor), Wang, J.-P. (Contributor), Shilatifard, A. (Contributor) & Brickner, J. H. (Contributor), ZENODO, Jul 7 2016
DOI: 10.5061/dryad.93fv2, https://zenodo.org/records/5089972
Dataset
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Data from: Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory
D’Urso, A. (Contributor), Takahashi, Y.-H. (Creator), Xiong, B. (Creator), Marone, J. (Creator), Coukos, R. (Creator), Randise-Hinchliff, C. (Creator), Wang, J.-P. (Creator), Shilatifard, A. (Creator) & Brickner, J. H. (Creator), Dryad, Jul 7 2016
DOI: 10.5061/dryad.93fv2, https://datadryad.org/dataset/doi:10.5061/dryad.93fv2
Dataset