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Personal profile

Research Interests

DNA and proteins are non-randomly localized within the nucleus of the cell.  The Brickner lab studies how cells control the position of genes within the nucleus, and how gene positioning affects gene expression.  When genes are activated or repressed, their position in the nucleus often changes.  The lab has identified DNA "zip codes" in the promoters of genes that control their positioning, transcription and, through an epigenetic mechanism, chromatin structure.

Education/Academic qualification

Biochemistry, PhD, Stanford University

19921998

Biological Sciences, BA, University of California at Santa Barbara

19881992

Fingerprint Dive into the research topics where Jason H Brickner is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 35 Similar Profiles
Nuclear Pore Medicine & Life Sciences
Genes Medicine & Life Sciences
Yeasts Medicine & Life Sciences
Epigenomics Medicine & Life Sciences
Yeast Chemical Compounds
Genome Medicine & Life Sciences
DNA Medicine & Life Sciences
Chromatin Medicine & Life Sciences

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Grants 2006 2021

Research Output 1994 2019

The Role of Transcription Factors and Nuclear Pore Proteins in Controlling the Spatial Organization of the Yeast Genome

Brickner, D. G., Randise-Hinchliff, C., Corbin, M. L., Liang, J. M., Kim, S., Sump, B., D'Urso, A., Kim, S. H., Satomura, A., Schmit, H., Coukos, R., Hwang, S., Watson, R. & Brickner, J. H., Jun 17 2019, In : Developmental Cell. 49, 6, p. 936-947.e4

Research output: Contribution to journalArticle

Nuclear Pore
Porins
Nuclear Proteins
Yeast
Transcription Factors

Nuclear pore complex in genome organization and gene expression in yeast

Randise-Hinchliff, C. & Brickner, J. H., Jan 1 2018, Nuclear Pore Complexes in Genome Organization, Function and Maintenance. Springer International Publishing, p. 87-109 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nuclear Pore
Gene expression
Yeast
Genes
Yeasts
34 Citations (Scopus)

Epigenetic transcriptional memory

D’Urso, A. & Brickner, J. H., Jun 1 2017, In : Current Genetics. 63, 3, p. 435-439 5 p.

Research output: Contribution to journalReview article

Epigenomics
Viverridae
Chromatin
Gene Expression
RNA Polymerase II
4 Citations (Scopus)

Epigenetic transcriptional memory of GAL genes depends on growth in glucose and the tup1 transcription factor in saccharomyces cerevisiae

Sood, V., Cajigas-Rodriguez, I., D’Urso, A., Light, W. H. & Brickner, J. H., Jan 1 2017, In : Genetics. 206, 4, p. 1895-1907 13 p.

Research output: Contribution to journalArticle

Epigenomics
Saccharomyces cerevisiae
Transcription Factors
Glucose
Growth
6 Citations (Scopus)

Genetic and epigenetic control of the spatial organization of the genome

Brickner, J., Feb 1 2017, In : Molecular biology of the cell. 28, 3, p. 364-369 6 p.

Research output: Contribution to journalReview article

Epigenomics
Genome
DNA-Binding Proteins
Chromatin
Chromosomes