Grants per year
Personal profile
Research Interests
DNA and proteins are non-randomly localized within the nucleus of the cell. The Brickner lab studies how cells control the position of genes within the nucleus, and how gene positioning affects gene expression. When genes are activated or repressed, their position in the nucleus often changes. The lab has identified DNA "zip codes" in the promoters of genes that control their positioning, transcription and, through an epigenetic mechanism, chromatin structure.
Education/Academic qualification
Biochemistry, PhD, Stanford University
1992 → 1998
Biological Sciences, BA, University of California at Santa Barbara
1988 → 1992
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Dive into the research topics where Jason H Brickner is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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The molecular mechanisms and functional significance of gene positioning
Brickner, J. H. (PD/PI) & Brickner, J. H. (PD/PI)
National Institute of General Medical Sciences
8/1/20 → 7/31/25
Project: Research project
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DNA zip codes and the spatial organization of the yeast genome
Brickner, J. H. (PD/PI)
National Institute of General Medical Sciences
9/1/17 → 7/31/21
Project: Research project
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Defining the molecular and cellular mechanism of epigenetic transcriptional memory
Brickner, J. H. (PD/PI) & Brickner, D. G. (Other)
National Institute of General Medical Sciences
8/1/16 → 7/31/21
Project: Research project
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Equipment supplement for Defining the molecular and cellular mechanism of epigenetic transcriptional memory
Brickner, J. H. (PD/PI)
National Institute of General Medical Sciences
8/1/16 → 7/31/21
Project: Research project
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Cellular and Molecular Basis of Disease Training Program
Brickner, J. H. (PD/PI), Carthew, R. W. (PD/PI), Holmgren, R. A. (PD/PI) & Smith, G. A. (Co-Investigator)
National Institute of General Medical Sciences
7/1/16 → 6/30/18
Project: Research project
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ChEC-seq2: an improved chromatin endogenous cleavage sequencing method and bioinformatic analysis pipeline for mapping in vivo protein-DNA interactions
Vanbelzen, J., Duan, C., Brickner, D. G. & Brickner, J. H., Mar 1 2024, In: NAR Genomics and Bioinformatics. 6, 1, lqae012.Research output: Contribution to journal › Article › peer-review
Open Access -
Inheritance of epigenetic transcriptional memory
Ge, T. & Brickner, J. H., Apr 2024, In: Current Opinion in Genetics and Development. 85, 102174.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
Inheritance of epigenetic transcriptional memory through read-write replication of a histone modification
Brickner, J. H., Aug 1 2023, In: Annals of the New York Academy of Sciences. 1526, 1, p. 50-58 9 p.Research output: Contribution to journal › Review article › peer-review
Open Access5 Scopus citations -
The nuclear pore complex as a platform for epigenetic regulation
Brickner, J. H., Sep 4 2023, In: Journal of Cell Biology. 222, 9, e202307078.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Establishment and inheritance of epigenetic transcriptional memory
Sump, B. & Brickner, J., Sep 2 2022, In: Frontiers in Molecular Biosciences. 9, 977653.Research output: Contribution to journal › Review article › peer-review
Open Access4 Scopus citations
Datasets
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Data from: Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory
D’Urso, A. (Contributor), Takahashi, Y.-H. (Creator), Xiong, B. (Creator), Marone, J. (Creator), Coukos, R. (Creator), Randise-Hinchliff, C. (Creator), Wang, J.-P. (Creator), Shilatifard, A. (Creator) & Brickner, J. H. (Creator), Dryad, Jul 7 2016
DOI: 10.5061/dryad.93fv2, https://datadryad.org/stash/dataset/doi:10.5061/dryad.93fv2
Dataset
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Data from: Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory
D’Urso, A. (Contributor), Takahashi, Y.-H. (Contributor), Xiong, B. (Contributor), Marone, J. (Contributor), Coukos, R. (Contributor), Randise-Hinchliff, C. (Contributor), Wang, J.-P. (Contributor), Shilatifard, A. (Contributor) & Brickner, J. H. (Contributor), ZENODO, Jul 7 2016
DOI: 10.5061/dryad.93fv2, https://zenodo.org/records/5089972
Dataset