Grants per year
Personal profile
Research Interests
DNA and proteins are non-randomly localized within the nucleus of the cell. The Brickner lab studies how cells control the position of genes within the nucleus, and how gene positioning affects gene expression. When genes are activated or repressed, their position in the nucleus often changes. The lab has identified DNA "zip codes" in the promoters of genes that control their positioning, transcription and, through an epigenetic mechanism, chromatin structure.
Education/Academic qualification
Biochemistry, PhD, Stanford University
1992 → 1998
Biological Sciences, BA, University of California at Santa Barbara
1988 → 1992
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The molecular mechanisms and functional significance of gene positioning
National Institute of General Medical Sciences
8/1/20 → 7/31/25
Project: Research project
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DNA zip codes and the spatial organization of the yeast genome
National Institute of General Medical Sciences
9/1/17 → 7/31/21
Project: Research project
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Defining the molecular and cellular mechanism of epigenetic transcriptional memory
Brickner, J. H. & Brickner, D. G.
National Institute of General Medical Sciences
8/1/16 → 7/31/21
Project: Research project
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Subproject for Cellular and Molecular Basis of Disease Training Program
Brickner, J. H. & Carthew, R. W.
National Institute of General Medical Sciences
7/1/16 → 6/30/18
Project: Research project
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Mitotically heritable, RNA polymerase II-independent H3K4 dimethylation stimulates INO1 transcriptional memory
Sump, B., Brickner, D. G., D'urso, A., Kim, S. H. & Brickner, J. H., May 2022, In: eLife. 11, e77646.Research output: Contribution to journal › Article › peer-review
Open Access -
The Nuclear Pore Complex as a Transcription Regulator
Sumner, M. C. & Brickner, J., Jan 1 2022, In: Cold Spring Harbor Perspectives in Biology. 14, 1, a039438.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Random sub-diffusion and capture of genes by the nuclear pore reduces dynamics and coordinates inter- chromosomal movement
Sumner, M. C., Torrisi, S. B., Brickner, D. G. & Brickner, J. H., May 2021, In: eLife. 10, 66238.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
The Role of Transcription Factors and Nuclear Pore Proteins in Controlling the Spatial Organization of the Yeast Genome
Brickner, D. G., Randise-Hinchliff, C., Corbin, M. L., Liang, J. M., Kim, S., Sump, B., D'Urso, A., Kim, S. H., Satomura, A., Schmit, H., Coukos, R., Hwang, S., Watson, R. & Brickner, J. H., Jun 17 2019, In: Developmental Cell. 49, 6, p. 936-947.e4Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Nuclear pore complex in genome organization and gene expression in yeast
Randise-Hinchliff, C. & Brickner, J. H., Jan 1 2018, Nuclear Pore Complexes in Genome Organization, Function and Maintenance. Springer International Publishing, p. 87-109 23 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
2 Scopus citations