Grants per year
Personal profile
Research Interests
I have been an active clinical investigator vested in the immune-based therapy of melanoma. This has led to my role in the clinical development of initially Interleukin-2 and more recently anti-CTLA-4 and anti-PD1/PDL-1. While checkpoint therapy has been a great breakthrough in cancer treatment, additional immune-based strategies are still critically needed. Efforts to identify mechanisms of resistance to checkpoint inhibitors and approaches to overcome de novo and acquired resistance are one of my major interest. In addition I have ongoing efforts in the personalized therapy of melanoma with well-defined targets (BRAF v600, NRAS mutations, CKIT mutations). I co-lead the Northwestern Cancer Center Translational Research in Solid Tumors (TRIST) program which is critical to the success of the Cancer Center. In this role, I am working to bring translational studies including immunotherapy based trials to all solid tumors. The development of translational studies that will provide a better understanding to sensitivity and resistance to both immune checkpoint therapy and targeted therapy is my highest priority. As Co-Leader of TRIST program, I am determined to bring creative immune based trials to cancers .
Training Experience
1982 | Internship, University of Chicago Hospitals |
1985 | Residency, University of Chicago Hospitals |
1986 | Residency, University of Wisconsin Hospital & Clinics |
1989 | Fellowship, University of Wisconsin Hospital & Clinics |
Education/Academic qualification
MD, Albert Einstein College
… → 1981
Research interests
- Genomic Medicine/Personalized Medicine
- Immunology
- Kidney Cancer / Urinary Tract Cancer
- Skin Cancer
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Network
Grants
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Prot #PACT-0101: A Phase 1a/1b, Open Label First-in-Human Study of The Safety, Tolerability and Feasibility of Gene Edited Autologous NeoTCR T Cells (NeoTCR-P1) Administered as a Single Agent or in Combination with Anti-PD-1 to Patients with Locally Advan
ICON Clinical Research, LLC, PACT Pharma, Inc.
1/28/21 → 1/28/24
Project: Research project
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Prot #NIT-106 (ION-02): A Phase 1b/2a, Open Label Study to Evaluate Anti-Tumor Efficacy and Safety of rhIL-7-hyFc (NT-I7) in Combination with Anti-PD-L1 (Atezolizumab) in Patients with Anti-PD-1/PD-L1 Naïve or Relapsed/Refractory High-Risk Skin Cancers
Fred Hutchinson Cancer Research Center, NeoImmuneTech, Inc.
10/14/20 → 10/14/23
Project: Research project
Research Output
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A multicenter characterization of hepatitis associated with immune checkpoint inhibitors
Patrinely, J. R., McGuigan, B., Chandra, S., Fenton, S. E., Chowdhary, A., Kennedy, L. B., Mooradian, M. J., Palmeri, M., Portal, D., Horst, S. N., Scoville, E. A., Long, G. V., Shi, C., Mehnert, J. M., Sullivan, R. J., Salama, A. K., Sosman, J. A., Menzies, A. M. & Johnson, D. B., 2021, In: OncoImmunology. 10, 1, 1875639.Research output: Contribution to journal › Article › peer-review
Open Access -
Antibody targeting tumor-derived soluble NKG2D ligand sMIC reprograms NK cell homeostatic survival and function and enhances melanoma response to PDL1 blockade therapy
Basher, F., Dhar, P., Wang, X., Wainwright, D. A., Zhang, B., Sosman, J., Ji, Z. & Wu, J. D., Jun 9 2020, In: Journal of Hematology and Oncology. 13, 1, 74.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Dermatomyositis in a patient undergoing nivolumab therapy for metastatic melanoma: A case report and review of the literature
Kosche, C., Stout, M., Sosman, J., Lukas, R. V. & Choi, J. N., 2020, (Accepted/In press) In: Melanoma Research. p. 313-316 4 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Health care utilization and steroid-refractory toxicities from immune checkpoint inhibitors
Wang, L. X., Quach, H. T., Moodabigil, N. V., Davis, E. J., Sosman, J. A., Dusetzina, S. B. & Johnson, D. B., Jan 15 2020, In: Cancer. 126, 2, p. 322-328 7 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Hyperacute Onset of Immune Checkpoint Inhibitor–Related Acute Interstitial Nephritis
Tawhari, I., Fenton, S. E., Sosman, J. A., Sustento-Reodica, N., Kanwar, Y. S. & Aggarwal, V., Nov 2020, In: Kidney International Reports. 5, 11, p. 2084-2088 5 p.Research output: Contribution to journal › Article › peer-review
Open Access