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Jeffrey Alan Sosman

  • 68593 Citations
1976 …2020

Research output per year

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Personal profile

Research Interests

I have been an active clinical investigator vested in the immune-based therapy of melanoma. This has led to my role in the clinical development of initially Interleukin-2 and more recently anti-CTLA-4 and anti-PD1/PDL-1. While checkpoint therapy has been a great breakthrough in cancer treatment, additional immune-based strategies are still critically needed. Efforts to identify mechanisms of resistance to checkpoint inhibitors and approaches to overcome de novo and acquired resistance are one of my major interest. In addition I have ongoing efforts in the personalized therapy of melanoma with well-defined targets (BRAF v600, NRAS mutations, CKIT mutations). I co-lead the Northwestern Cancer Center Translational Research in Solid Tumors (TRIST) program which is critical to the success of the Cancer Center. In this role, I am working to bring translational studies including immunotherapy based trials to all solid tumors. The development of translational studies that will provide a better understanding to sensitivity and resistance to both immune checkpoint therapy and targeted therapy is my highest priority. As Co-Leader of TRIST program, I am determined to bring creative immune based trials to cancers .

Training Experience

1982Internship, University of Chicago Hospitals
1985Residency, University of Chicago Hospitals
1986Residency, University of Wisconsin Hospital & Clinics
1989Fellowship, University of Wisconsin Hospital & Clinics

Education/Academic qualification

MD, Albert Einstein College

… → 1981

Research interests

  • Genomic Medicine/Personalized Medicine
  • Immunology
  • Kidney Cancer / Urinary Tract Cancer
  • Skin Cancer

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Grants

Prot #AMV564-301: A Phase 1 Dose Escalation With Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMV564 Alone and in Combination with Pembrolizumab in Subjects with Advanced Solid Tumors

Sosman, J. A.

Amphivena Therapeutics, Inc.

7/15/20 → 7/15/23

Project: Research project

Prot #PACT-0001: A Prospective Observational Cohort Study of Changes in the Neoepitope Specific T Cell Repertoire in Patients with Cancer

Sosman, J. A.

PACT Pharma, Inc.

6/1/20 → 6/1/23

Project: Research project

The distinct role of cysteinyl leukotriene receptor for myeloid-derived suppressive cells

Chae, Y. K., Fang, D., Sosman, J. A., Zhang, B. & Zou, L.

National Cancer Institute

5/15/20 → 4/30/25

Project: Research project

    • Prot #CA013-004: A Phase 1/2a Study of BMS-986179 Administered Alone and in Combination with Nivolumab (BMS-936558) in Subjects with Advanced Solid Tumors

    Sosman, J. A.

    Bristol-Myers Squibb Company

    3/10/20 → 3/10/23

    Project: Research project

    Prot #CA209-8Y8: A Phase 3b, Randomized, Double-blind Study of Nivolumab Combined with Ipilimumab versus Nivolumab Monotherapy for Patients with Previously Untreated Advanced Renal Cell Carcinoma and Intermediate- or Poor-Risk Factors

    Sosman, J. A.

    Bristol-Myers Squibb Company

    2/5/20 → 2/5/23

    Project: Research project

    Research Output

    Antibody targeting tumor-derived soluble NKG2D ligand sMIC reprograms NK cell homeostatic survival and function and enhances melanoma response to PDL1 blockade therapy

    Basher, F., Dhar, P., Wang, X., Wainwright, D. A., Zhang, B., Sosman, J., Ji, Z. & Wu, J. D., Jun 9 2020, In : Journal of hematology & oncology. 13, 1, 1 p.

    Research output: Contribution to journal › Article

    Open Access

    • Dermatomyositis in a patient undergoing nivolumab therapy for metastatic melanoma: A case report and review of the literature

    Kosche, C., Stout, M., Sosman, J., Lukas, R. V. & Choi, J. N., 2020, (Accepted/In press) In : Melanoma Research. p. 313-316 4 p.

    Research output: Contribution to journal › Article

    • 2 Scopus citations

    Health care utilization and steroid-refractory toxicities from immune checkpoint inhibitors

    Wang, L. X., Quach, H. T., Moodabigil, N. V., Davis, E. J., Sosman, J. A., Dusetzina, S. B. & Johnson, D. B., Jan 15 2020, In : Cancer. 126, 2, p. 322-328 7 p.

    Research output: Contribution to journal › Article

    • 1 Scopus citations

    Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies

    Zhai, L., Bell, A., Ladomersky, E., Lauing, K. L., Bollu, L., Sosman, J. A., Zhang, B., Wu, J. D., Miller, S. D., Meeks, J. J., Lukas, R. V., Wyatt, E. J., Doglio, L., Schiltz, G. E., McCusker, R. H. & Wainwright, D. A., Jun 16 2020, In : Frontiers in immunology. 11, 1185.

    Research output: Contribution to journal › Review article

    Open Access

    • Management of immunotherapy-related toxicities, version 1.2020 featured updates to the NCCN guidelines

    Thompson, J. A., Schneider, B. J., Brahmer, J., Andrews, S., Armand, P., Bhatia, S., Budde, L. E., Costa, L., Davies, M., Dunnington, D., Ernstoff, M. S., Frigault, M., Kaffenberger, B. H., Lunning, M., McGettigan, S., McPherson, J., Mohindra, N. A., Naidoo, J., Olszanski, A. J., Oluwole, O. & 12 others, Patel, S. P., Pennell, N., Reddy, S., Ryder, M., Santomasso, B., Shofer, S., Sosman, J. A., Wang, Y., Weight, R. M., Johnson-Chilla, A., Zuccarino-Catania, G. & Engh, A., 2020, In : JNCCN Journal of the National Comprehensive Cancer Network. 18, 3, p. 231-241 11 p.

    Research output: Contribution to journal › Article

    Open Access
    • 3 Scopus citations