Grants per year
Personal profile
Research Interests
My research interests are centered on elucidating the pathogenic mechanisms which drive synaptopathies and proteinopathies in the mammalian nervous system. As a first step, we use reductionist biochemical approaches with discovery-based proteomic analysis to generate unbiased hypothesizes. Next, we test and characterize candidate proteins and pathways for potential functional relevance with molecular approaches. Ultimately, the goal of my research is to identify keystone proteins and proteomes as potential therapeutic targets to hopefully ameliorate neurodevelopmental and degenerative diseases.
Training Experience
2015 | Postdoctoral Fellowship, Scripps Research Institute |
Education/Academic qualification
PhD, New York University, School of Medicine
… → 2009
Research interests keywords
- Alzheimer's Disease
- Autism Spectrum Disorders
- Biochemistry: Proteins
- Neuroscience
- Proteomics
- Schizophrenia
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Collaborations and top research areas from the last five years
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Improving Aged Neuromuscular Health and Function
Rehabilitation Institute of Chicago, National Institute on Aging
7/1/23 → 3/31/24
Project: Research project
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Orbitrap Eclipse Mass Spectrometer for Northwestern University Neuroproteomic Collaboration Hub
Savas, J. N., Caraveo Piso, G., Contractor, A., Disterhoft, J. F., Duncan, F. E., Foltz, D. R., Goel, R., Kafader, J. O., Kalb, R. G., Kelleher, N. L., Kiskinis, E., Krainc, D., Mendillo, M. L., Menichella, D. M., Penzes, P., Smith, G. A., Surmeier Jr, D. J., Vassar, R. J., Walsh, D. & Zelano, C.
Office of the Director, National Institutes of Health
3/1/23 → 2/29/24
Project: Research project
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A new biomarker for frontotemporal lobar degeneration with TDP-43 proteinopathy and Alzheimer's Disease
University of Utah, National Institute on Aging
1/1/23 → 12/31/24
Project: Research project
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Mitochondrial Fidelity in Mammalian Neurons
Savas, J. N., Savas, J. N. & Savas, J. N.
National Institute of Neurological Disorders and Stroke
1/1/23 → 12/31/25
Project: Research project
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Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity
Upadhyay, A., Chhangani, D., Rao, N. R., Kofler, J., Vassar, R. J., Rincon-Limas, D. E. & Savas, J. N., Dec 2023, In: Molecular neurodegeneration. 18, 1, 61.Research output: Contribution to journal › Article › peer-review
Open Access -
Determining and interpreting protein lifetimes in mammalian tissues
Fornasiero, E. F. & Savas, J. N., Feb 2023, In: Trends in Biochemical Sciences. 48, 2, p. 106-118 13 p.Research output: Contribution to journal › Review article › peer-review
Open Access7 Scopus citations -
Early developmental deletion of forebrain Ank2 causes seizure-related phenotypes by reshaping the synaptic proteome
Yoon, S., Santos, M. D., Forrest, M. P., Pratt, C. P., Khalatyan, N., Mohler, P. J., Savas, J. N. & Penzes, P., Jul 25 2023, In: Cell reports. 42, 7, 112784.Research output: Contribution to journal › Article › peer-review
Open Access -
Parkinson's disease-linked parkin mutation disrupts recycling of synaptic vesicles in human dopaminergic neurons
Song, P., Peng, W., Sauve, V., Fakih, R., Xie, Z., Ysselstein, D., Krainc, T., Wong, C. H. Y., Mencacci, N. E., Savas, J. N., Surmeier, D. J., Gehring, K. & Krainc, D., 2023, (Accepted/In press) In: Neuron.Research output: Contribution to journal › Article › peer-review
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Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub
Forrest, M. P., Dos Santos, M., Piguel, N. H., Wang, Y. Z., Hawkins, N. A., Bagchi, V. A., Dionisio, L. E., Yoon, S., Simkin, D., Martin-de-Saavedra, M. D., Gao, R., Horan, K. E., George, A. L., LeDoux, M. S., Kearney, J. A., Savas, J. N. & Penzes, P., Dec 2023, In: Nature communications. 14, 1, 825.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations
Datasets
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Data from: Long-lived metabolic enzymes in the crystalline lens identified by pulse-labeling of mice and mass spectrometry
Liu, P. (Creator), Ali, L. (Creator), Thomson, B. R. (Creator), Savas, J. N. (Creator) & Jin, J. (Creator), Dryad, Dec 6 2019
DOI: 10.5061/dryad.r6h8dr2, https://datadryad.org/stash/dataset/doi:10.5061/dryad.r6h8dr2
Dataset
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Data from: Long-lived metabolic enzymes in the crystalline lens identified by pulse-labeling of mice and mass spectrometry
Liu, P. (Contributor), Ali, L. (Contributor), Thomson, B. R. (Contributor), Savas, J. N. (Contributor) & Jin, J. (Contributor), ZENODO, Dec 6 2019
DOI: 10.5061/dryad.r6h8dr2, https://zenodo.org/record/5017248
Dataset