• 2765 Citations
20072023
If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Research Interests

My research interests are centered on elucidating the pathogenic mechanisms which drive synaptopathies and proteinopathies in the mammalian nervous system. As a first step, we use reductionist biochemical approaches with discovery-based proteomic analysis to generate unbiased hypothesizes. Next, we test and characterize candidate proteins and pathways for potential functional relevance with molecular approaches. Ultimately, the goal of my research is to identify keystone proteins and proteomes as potential therapeutic targets to hopefully ameliorate neurodevelopmental and degenerative diseases.

Training Experience

2015Postdoctoral Fellowship, Scripps Research Institute

Education/Academic qualification

PhD, New York University, School of Medicine

… → 2009

Keywords

  • Alzheimer's Disease
  • Autism Spectrum Disorders
  • Biochemistry: Proteins
  • Neuroscience
  • Proteomics
  • Schizophrenia

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 3 Similar Profiles
Synapses Medicine & Life Sciences
Proteins Medicine & Life Sciences
Proteomics Medicine & Life Sciences
Neurons Medicine & Life Sciences
Proteome Medicine & Life Sciences
Brain Chemical Compounds
AMPA Receptors Medicine & Life Sciences
Huntington Disease Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2011 2023

Cytomegalovirus Infections
Cytomegalovirus
Viruses
Microtubule-Organizing Center
Cell Movement
Synapses
Genes
Alzheimer Disease
Dendritic Spines
Glutamate Receptors
Exosomes
Alzheimer Disease
Pathology
Synapses
Amyloid beta-Protein Precursor
Amyotrophic Lateral Sclerosis
Motor Neurons
Proteins
Mutation
Proteolysis

Research Output 2007 2018

  • 2765 Citations
  • 45 Article
  • 3 Comment/debate
  • 3 Review article
  • 1 Short survey
1 Citations

An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses

Condomitti, G., Wierda, K. D., Schroeder, A., Rubio, S. E., Vennekens, K. M., Orlandi, C., Martemyanov, K. A., Gounko, N. V., Savas, J. N. & de Wit, J., Oct 10 2018, In : Neuron. 100, 1, p. 201-215.e9

Research output: Contribution to journalArticle

Hippocampal Mossy Fibers
Heparan Sulfate Proteoglycans
Glypicans
Dendrites
Synapses

Critical period inhibition of NKCC1 rectifies synapse plasticity in the somatosensory cortex and restores adult tactile response maps in fragile X mice

He, Q., Arroyo, E. D., Smukowski, S. N., Xu, J., Piochon, C., Savas, J. N., Portera-Cailliau, C. & Contractor, A., Apr 27 2018, (Accepted/In press) In : Molecular Psychiatry. p. 1-16 16 p.

Research output: Contribution to journalArticle

Fragile X Syndrome
Somatosensory Cortex
Touch
Synapses
Chlorides
5 Citations

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy

Wang, L., Zhao, Z., Ozark, P. A., Fantini, D., Marshall, S. A., Rendleman, E. J., Cozzolino, K. A., Louis, N., He, X., Morgan, M. A., Takahashi, Y., Collings, C. K., Smith, E., Ntziachristos, P., Savas, J. N., Zou, L., Hashizume, R., Meeks, J. J. & Shilatifard, A., Jun 1 2018, In : Nature Medicine. 24, 6, p. 758-769 12 p.

Research output: Contribution to journalArticle

Epigenomics
Tumors
Methyltransferases
Histones
Mutation

Selective permeability of mouse blood-aqueous barrier as determined by15N-heavy isotope tracing and mass spectrometry

Liu, P., Thomson, B. R., Khalatyan, N., Feng, L., Liu, X., Savas, J. N., Quaggin, S. E. & Jin, J., Sep 4 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 36, p. 9032-9037 6 p.

Research output: Contribution to journalArticle

Blood-Aqueous Barrier
Isotopes
Permeability
Mass Spectrometry
Blood Proteins

Uncovering discrete synaptic proteomes to understand neurological disorders

Wang, Y. Z. & Savas, J. N., Sep 1 2018, In : Proteomes. 6, 3, 30.

Research output: Contribution to journalReview article

Proteome
Nervous System Diseases
Synapses
Neurons
Proteins