Grants per year
Personal profile
Research Interests
My research interests are centered on elucidating the pathogenic mechanisms which drive synaptopathies and proteinopathies in the mammalian nervous system. As a first step, we use reductionist biochemical approaches with discovery-based proteomic analysis to generate unbiased hypothesizes. Next, we test and characterize candidate proteins and pathways for potential functional relevance with molecular approaches. Ultimately, the goal of my research is to identify keystone proteins and proteomes as potential therapeutic targets to hopefully ameliorate neurodevelopmental and degenerative diseases.
Training Experience
2015 | Postdoctoral Fellowship, Scripps Research Institute |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, New York University, School of Medicine
… → 2009
Research interests keywords
- Alzheimer's Disease
- Autism Spectrum Disorders
- Biochemistry: Proteins
- Neuroscience
- Proteomics
- Schizophrenia
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Collaborations and top research areas from the last five years
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THE ROLE OF EXTREMELY LONG-LIVED PROTEINS IN ACQUIRED HEARING LOSS
Savas, J. N. (PD/PI)
American Hearing Research Foundation
1/1/25 → 12/31/25
Project: Research project
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CNS Demyelination: Initiation, Protection, and Correction
Popko, B. (PD/PI), Elbaz-Eilon, B. (Co-Investigator), Kiskinis, E. (Co-Investigator), Savas, J. N. (Co-Investigator) & Wong, Y. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
5/15/24 → 4/30/32
Project: Research project
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Stable Isotope-based dating of the amyloid fibril proteome
Savas, J. N. (PD/PI)
7/1/23 → 6/30/25
Project: Research project
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Mechanisms of Angiotensin I Converting Enzyme in Alzheimer's disease
Vassar, R. J. (PD/PI), Cuddy, L. K. (Co-Investigator), Gate, D. (Co-Investigator) & Savas, J. N. (Co-Investigator)
12/15/22 → 11/30/25
Project: Research project
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A deafness-blindness syndrome results from ATF6-based disruption of the unfolded protein response
Joshi, Y. & Savas, J. N., Feb 3 2025, In: Journal of Clinical Investigation. 135, 3, e188708.Research output: Contribution to journal › Review article › peer-review
Open Access -
A novel, rapidly progressive ataxia due to a spontaneous Myo5a mutation in mice impairs transport proteins and alters mitochondria
Telenson, A. M., Hsieh, R. R., Cowen, G. J., Sode, E. P., Kwon, J. M., Vo, A. H., Hadhazy, M., Page, P. G., Rao, N. R., Pesce, L., Demonbreun, A. R., Puckelwartz, M. J., Savas, J. N. & McNally, E. M., Mar 15 2025, In: FASEB Journal. 39, 5, e70423.Research output: Contribution to journal › Article › peer-review
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Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum
Koutarapu, S., Ge, J., Dulewicz, M., Srikrishna, M., Szadziewska, A., Wood, J., Blennow, K., Zetterberg, H., Michno, W., Ryan, N. S., Lashley, T., Savas, J. N., Schöll, M. & Hanrieder, J., Dec 2025, In: Nature communications. 16, 1, 3889.Research output: Contribution to journal › Article › peer-review
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DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning
Mohar, B., Michel, G., Wang, Y. Z., Hernandez, V., Grimm, J. B., Park, J. Y., Patel, R., Clarke, M., Brown, T. A., Bergmann, C., Gebis, K. K., Wilen, A. P., Liu, B., Johnson, R., Graves, A., Tchumatchenko, T., Savas, J. N., Fornasiero, E. F., Huganir, R. L. & Tillberg, P. W. & 3 others, , May 2025, In: Nature neuroscience. 28, 5, p. 1089-1098 10 p., e34202.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Keratinocyte-derived extracellular vesicles in painful diabetic neuropathy
Coy-Dibley, J., Jayaraj, N. D., Ren, D., Pacifico, P., Belmadani, A., Wang, Y. Z., Gebis, K. K., Savas, J. N., Paller, A. S., Miller, R. J. & Menichella, D. M., Jan 1 2025, In: Neurobiology of Pain. 17, 100176.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Data from: Long-lived metabolic enzymes in the crystalline lens identified by pulse-labeling of mice and mass spectrometry
Liu, P. (Creator), Ali, L. (Creator), Thomson, B. R. (Creator), Savas, J. N. (Creator) & Jin, J. (Creator), Dryad, Dec 6 2019
DOI: 10.5061/dryad.r6h8dr2, https://datadryad.org/dataset/doi:10.5061/dryad.r6h8dr2
Dataset
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Crystal structure of the human neuroligin 1 cholinesterase domain containing spliced sequence B (SSB) (NL1(-A+B))
Elegheert, J. (Contributor), Cvetkovska, V. (Contributor), Clayton, A. J. (Contributor), Heroven, C. (Contributor), Vennekens, K. M. (Contributor), Smukowski, S. N. (Contributor), Regan, M. C. (Contributor), Jia, W. (Contributor), Smith, A. C. (Contributor), Furukawa, H. (Contributor), Savas, J. N. (Contributor), de Wit, J. (Contributor), Begbie, J. (Contributor), Craig, A. M. (Contributor) & Aricescu, A. R. (Contributor), Protein Data Bank (PDB), Aug 23 2017
DOI: 10.2210/pdb5OJK/pdb, https://www.wwpdb.org/pdb?id=pdb_00005ojk
Dataset
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Crystal structure of the chicken MDGA1 ectodomain in complex with the human neuroligin 1 (NL1(-A-B)) cholinesterase domain.
Elegheert, J. (Contributor), Cvetkovska, V. (Contributor), Clayton, A. J. (Contributor), Heroven, C. (Contributor), Vennekens, K. M. (Contributor), Smukowski, S. N. (Contributor), Regan, M. C. (Contributor), Jia, W. (Contributor), Smith, A. C. (Contributor), Furukawa, H. (Contributor), Savas, J. N. (Contributor), de Wit, J. (Contributor), Begbie, J. (Contributor), Craig, A. M. (Contributor) & Aricescu, A. R. (Contributor), Protein Data Bank (PDB), Aug 23 2017
DOI: 10.2210/pdb5OJ6/pdb, https://www.wwpdb.org/pdb?id=pdb_00005oj6
Dataset
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Solution structure of the Sushi 1 domain of GABAbR1a
Rice, H. C. (Contributor), De Malmazet, D. (Contributor), Schreurs, A. (Contributor), Frere, S. (Contributor), Van Molle, I. (Contributor), Volkov, A. N. (Contributor), Creemers, E. (Contributor), Vertkin, I. (Contributor), Nys, J. (Contributor), Ranaivoson, F. M. (Contributor), Comoletti, D. (Contributor), Savas, J. N. (Contributor), Remaut, H. (Contributor), Balschun, D. (Contributor), Wierda, K. D. (Contributor), Slutsky, I. (Contributor), Farrow, K. (Contributor), De Strooper, B. (Contributor) & De Wit, J. (Contributor), Protein Data Bank (PDB), Jan 23 2019
DOI: 10.2210/pdb6HKC/pdb, https://www.wwpdb.org/pdb?id=pdb_00006hkc
Dataset