Grants per year
Personal profile
Research Interests
My research interests are centered on elucidating the pathogenic mechanisms which drive synaptopathies and proteinopathies in the mammalian nervous system. As a first step, we use reductionist biochemical approaches with discovery-based proteomic analysis to generate unbiased hypothesizes. Next, we test and characterize candidate proteins and pathways for potential functional relevance with molecular approaches. Ultimately, the goal of my research is to identify keystone proteins and proteomes as potential therapeutic targets to hopefully ameliorate neurodevelopmental and degenerative diseases.
Training Experience
| 2015 | Postdoctoral Fellowship, Scripps Research Institute |
Education/Academic qualification
PhD, New York University, School of Medicine
… → 2009
Keywords
- Alzheimer's Disease
- Autism Spectrum Disorders
- Biochemistry: Proteins
- Neuroscience
- Proteomics
- Schizophrenia
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- 3 Similar Profiles
Synapses
Medicine & Life Sciences
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Proteomics
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Chemical Compounds
AMPA Receptors
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Huntington Disease
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2011 2023
Nuclear rotation and cellular reorganization during Cytomegalovirus infection
National Institute of Allergy and Infectious Diseases
11/1/18 → 10/31/23
Project: Research project
Cytomegalovirus Infections
Cytomegalovirus
Viruses
Microtubule-Organizing Center
Cell Movement
Structural characterization of Aβ strain variation in AD mouse models
Sadleir, K. R., Savas, J. N. & Vassar, R. J.
University of Southern California, National Institute of Aging
9/30/18 → 5/31/23
Project: Research project
Pathology
Brain
Nitrogen
Amyloid beta-Peptides
Amyloid
LOAD risk genes in postsynaptic endosomal trafficking
Penzes, P., Savas, J. N. & Vassar, R. J.
9/30/18 → 8/31/19
Project: Research project
Synapses
Genes
Alzheimer Disease
Dendritic Spines
Glutamate Receptors
The role of activity induced exosome signaling in synaptic pathology of Alzheimer's Disease
9/30/18 → 4/30/23
Project: Research project
Exosomes
Alzheimer Disease
Pathology
Synapses
Amyloid beta-Protein Precursor
Subproject for Institution # SP0048976
National Institute of Neurological Disorders and Stroke
9/1/18 → 8/31/20
Project: Research project
Amyotrophic Lateral Sclerosis
Motor Neurons
Proteins
Mutation
Proteolysis
Research Output 2007 2018
An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses
Condomitti, G., Wierda, K. D., Schroeder, A., Rubio, S. E., Vennekens, K. M., Orlandi, C., Martemyanov, K. A., Gounko, N. V., Savas, J. N. & de Wit, J., Oct 10 2018, In : Neuron. 100, 1, p. 201-215.e9Research output: Contribution to journal › Article
Hippocampal Mossy Fibers
Heparan Sulfate Proteoglycans
Glypicans
Dendrites
Synapses
Critical period inhibition of NKCC1 rectifies synapse plasticity in the somatosensory cortex and restores adult tactile response maps in fragile X mice
He, Q., Arroyo, E. D., Smukowski, S. N., Xu, J., Piochon, C., Savas, J. N., Portera-Cailliau, C. & Contractor, A., Apr 27 2018, (Accepted/In press) In : Molecular Psychiatry. p. 1-16 16 p.Research output: Contribution to journal › Article
Fragile X Syndrome
Somatosensory Cortex
Touch
Synapses
Chlorides
Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy
Wang, L., Zhao, Z., Ozark, P. A., Fantini, D., Marshall, S. A., Rendleman, E. J., Cozzolino, K. A., Louis, N., He, X., Morgan, M. A., Takahashi, Y., Collings, C. K., Smith, E., Ntziachristos, P., Savas, J. N., Zou, L., Hashizume, R., Meeks, J. J. & Shilatifard, A., Jun 1 2018, In : Nature Medicine. 24, 6, p. 758-769 12 p.Research output: Contribution to journal › Article
Epigenomics
Tumors
Methyltransferases
Histones
Mutation
Selective permeability of mouse blood-aqueous barrier as determined by15N-heavy isotope tracing and mass spectrometry
Liu, P., Thomson, B. R., Khalatyan, N., Feng, L., Liu, X., Savas, J. N., Quaggin, S. E. & Jin, J., Sep 4 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 36, p. 9032-9037 6 p.Research output: Contribution to journal › Article
Blood-Aqueous Barrier
Isotopes
Permeability
Mass Spectrometry
Blood Proteins
Uncovering discrete synaptic proteomes to understand neurological disorders
Wang, Y. Z. & Savas, J. N., Sep 1 2018, In : Proteomes. 6, 3, 30.Research output: Contribution to journal › Review article
Proteome
Nervous System Diseases
Synapses
Neurons
Proteins