Grants per year
Personal profile
Research Interests
My research interests are centered on elucidating the pathogenic mechanisms which drive synaptopathies and proteinopathies in the mammalian nervous system. As a first step, we use reductionist biochemical approaches with discovery-based proteomic analysis to generate unbiased hypothesizes. Next, we test and characterize candidate proteins and pathways for potential functional relevance with molecular approaches. Ultimately, the goal of my research is to identify keystone proteins and proteomes as potential therapeutic targets to hopefully ameliorate neurodevelopmental and degenerative diseases.
Training Experience
| 2015 | Postdoctoral Fellowship, Scripps Research Institute |
Education/Academic qualification
PhD, New York University, School of Medicine
… → 2009
Research interests
- Alzheimer's Disease
- Autism Spectrum Disorders
- Biochemistry: Proteins
- Neuroscience
- Proteomics
- Schizophrenia
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- 4 Similar Profiles
Proteins
Medicine & Life Sciences
Synapses
Medicine & Life Sciences
Proteomics
Medicine & Life Sciences
Neurons
Medicine & Life Sciences
Proteome
Medicine & Life Sciences
Brain
Chemical Compounds
AMPA Receptors
Medicine & Life Sciences
Huntington Disease
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2011 2023
Modulating the Cochlear Proteostasis Network to Prevent Hidden Hearing Loss
Cheatham, M. A., Kim, K. A. & Savas, J. N.
U.S. Army Medical Research and Materiel Command
9/1/19 → 8/31/22
Project: Research project
Noise-Induced Hearing Loss
Cochlea
Hearing Loss
Hearing Tests
Occupational Diseases
Understanding pathophysiological mechanisms underlying neurodegeneration
Goldman, R., Opal, P. & Savas, J. N.
National Institute of Neurological Disorders and Stroke
7/1/19 → 6/30/20
Project: Research project
Giant Axonal Neuropathy
Intermediate Filaments
Pathology
Proteins
Ubiquitin-Protein Ligases
Subproject for Institution # SP0048250
National Institute of Child Health and Human Development
5/15/19 → 4/30/21
Project: Research project
Proteins
Oocytes
Ovary
Germ Cells
Meiotic Prophase I
Extremely Long Lived Proteins and Female Reproductive Aging
Duncan, F. E., Savas, J. N. & Savas, J. N.
National Institute of Child Health and Human Development
5/15/19 → 4/30/21
Project: Research project
Proteins
Oocytes
Ovary
Germ Cells
Meiotic Prophase I
Postdoc Fellowship for Yi-Zhi Wang in support of: Explore ASD-related synaptic deficits in Drd1-positve MSN
Brain & Behavior Research Foundation
1/15/19 → 1/14/21
Project: Research project
Nucleus Accumbens
Oxytocin
Neurons
Proteomics
Therapeutics
Research Output 2007 2019
Catacomb: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism
Piunti, A., Smith, E., Morgan, M. A., Ugarenko, M., Khaltyan, N., Helmin, K. A., Ryan, C. A., Murray, D. C., Rickels, R. A., Yilmaz, B. D., Rendleman, E. J., Savas, J. N., Singer, B., Bulun, S. E. & Shilatifard, A., Jan 1 2019, In : Science Advances. 5, 7, eaax2887.Research output: Contribution to journal › Article
Open Access
methionine
methylation
genes
deoxyribonucleic acid
COMPASS (programming language)
Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function
Kim, J. J., Savas, J. N., Miller, M. T., Hu, X., Carromeu, C., Lavallée-Adam, M., Freitas, B. C. G., Muotri, A. R., Yates, J. R. & Ghosh, A., Feb 1 2019, In : PloS one. 14, 2, e0212553.Research output: Contribution to journal › Article
Open Access
neuroglia
Stem cells
Neuroglia
Induced Pluripotent Stem Cells
Proteomics
21
Citations
(Scopus)
Secreted amyloid-b precursor protein functions as a GABA B R1a ligand to modulate synaptic transmission
Rice, H. C., De Malmazet, D., Schreurs, A., Frere, S., Van Molle, I., Volkov, A. N., Creemers, E., Vertkin, I., Nys, J., Ranaivoson, F. M., Comoletti, D., Savas, J. N., Remaut, H., Balschun, D., Wierda, K. D., Slutsky, I., Farrow, K., De Strooper, B. & De Wit, J., Jan 11 2019, In : Science. 363, 6423, eaao4827.Research output: Contribution to journal › Article
Aminobutyrates
Amyloid beta-Protein Precursor
Synaptic Transmission
gamma-Aminobutyric Acid
Ligands
Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways
Ruhl, D. A., Bomba-Warczak, E., Watson, E. T., Bradberry, M. M., Peterson, T. A., Basu, T., Frelka, A., Evans, C. S., Briguglio, J. S., Basta, T., Stowell, M. H. B., Savas, J. N., Roopra, A., Pearce, R. A., Piper, R. C. & Chapman, E. R., Dec 1 2019, In : Nature communications. 10, 1, 3532.Research output: Contribution to journal › Article
Open Access
Synaptotagmins
physiology
Physiology
neurons
membranes
1
Citation
(Scopus)
β-Catenin/Tcf7l2–dependent transcriptional regulation of GLUT1 gene expression by Zic family proteins in colon cancer
Zhao, Z., Wang, L., Bartom, E. T., Marshall, S., Rendleman, E., Ryan, C., Shilati, A., Savas, J. N., Chandel, N. & Shilatifard, A., Jul 31 2019, In : Science Advances. 5, 7, eaax0698.Research output: Contribution to journal › Article
Open Access
gene expression
cancer
proteins
glucose
chromatin