• 3126 Citations
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Personal profile

Research Interests

My research interests are centered on elucidating the pathogenic mechanisms which drive synaptopathies and proteinopathies in the mammalian nervous system. As a first step, we use reductionist biochemical approaches with discovery-based proteomic analysis to generate unbiased hypothesizes. Next, we test and characterize candidate proteins and pathways for potential functional relevance with molecular approaches. Ultimately, the goal of my research is to identify keystone proteins and proteomes as potential therapeutic targets to hopefully ameliorate neurodevelopmental and degenerative diseases.

Training Experience

2015Postdoctoral Fellowship, Scripps Research Institute

Education/Academic qualification

PhD, New York University, School of Medicine

… → 2009


  • Alzheimer's Disease
  • Autism Spectrum Disorders
  • Biochemistry: Proteins
  • Neuroscience
  • Proteomics
  • Schizophrenia

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  • 3 Similar Profiles
Proteins Medicine & Life Sciences
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Proteome Medicine & Life Sciences
Brain Chemical Compounds
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Huntington Disease Medicine & Life Sciences

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Grants 2011 2023

Germ Cells
Meiotic Prophase I
Nucleus Accumbens
Synaptic Vesicles
tau Proteins
Neurofibrillary Tangles
Cytomegalovirus Infections
Microtubule-Organizing Center
Cell Movement
Alzheimer Disease
Amyloid beta-Protein Precursor

Research Output 2007 2019

  • 3126 Citations
  • 48 Article
  • 3 Comment/debate
  • 3 Review article
  • 1 Short survey

Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function

Kim, J. J., Savas, J. N., Miller, M. T., Hu, X., Carromeu, C., Lavallée-Adam, M., Freitas, B. C. G., Muotri, A. R., Yates, J. R. & Ghosh, A., Feb 1 2019, In : PloS one. 14, 2, e0212553.

Research output: Contribution to journalArticle

Open Access
Stem cells
Induced Pluripotent Stem Cells
15 Citations (Scopus)

Secreted amyloid-b precursor protein functions as a GABA B R1a ligand to modulate synaptic transmission

Rice, H. C., De Malmazet, D., Schreurs, A., Frere, S., Van Molle, I., Volkov, A. N., Creemers, E., Vertkin, I., Nys, J., Ranaivoson, F. M., Comoletti, D., Savas, J. N., Remaut, H., Balschun, D., Wierda, K. D., Slutsky, I., Farrow, K., De Strooper, B. & De Wit, J., Jan 11 2019, In : Science. 363, 6423, eaao4827.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Synaptic Transmission
gamma-Aminobutyric Acid
2 Citations (Scopus)

An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses

Condomitti, G., Wierda, K. D., Schroeder, A., Rubio, S. E., Vennekens, K. M., Orlandi, C., Martemyanov, K. A., Gounko, N. V., Savas, J. N. & de Wit, J., Oct 10 2018, In : Neuron. 100, 1, p. 201-215.e9

Research output: Contribution to journalArticle

Hippocampal Mossy Fibers
Heparan Sulfate Proteoglycans
3 Citations (Scopus)

Critical period inhibition of NKCC1 rectifies synapse plasticity in the somatosensory cortex and restores adult tactile response maps in fragile X mice

He, Q., Arroyo, E. D., Smukowski, S. N., Xu, J., Piochon, C., Savas, J. N., Portera-Cailliau, C. & Contractor, A., Apr 27 2018, (Accepted/In press) In : Molecular Psychiatry. p. 1-16 16 p.

Research output: Contribution to journalArticle

Fragile X Syndrome
Somatosensory Cortex

Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function

Wortham, M., Benthuysen, J. R., Wallace, M., Savas, J. N., Mulas, F., Divakaruni, A. S., Liu, F., Albert, V., Taylor, B. L., Sui, Y., Saez, E., Murphy, A. N., Yates, J. R., Metallo, C. M. & Sander, M., Dec 4 2018, In : Cell reports. 25, 10, p. 2904-2918.e8

Research output: Contribution to journalArticle

Cell Physiological Phenomena