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Jeffrey Nicholas Savas

  • 3462 Citations
20072023
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Personal profile

Research Interests

My research interests are centered on elucidating the pathogenic mechanisms which drive synaptopathies and proteinopathies in the mammalian nervous system. As a first step, we use reductionist biochemical approaches with discovery-based proteomic analysis to generate unbiased hypothesizes. Next, we test and characterize candidate proteins and pathways for potential functional relevance with molecular approaches. Ultimately, the goal of my research is to identify keystone proteins and proteomes as potential therapeutic targets to hopefully ameliorate neurodevelopmental and degenerative diseases.

Training Experience

2015Postdoctoral Fellowship, Scripps Research Institute

Education/Academic qualification

PhD, New York University, School of Medicine

… → 2009

Research interests

  • Alzheimer's Disease
  • Autism Spectrum Disorders
  • Biochemistry: Proteins
  • Neuroscience
  • Proteomics
  • Schizophrenia

Fingerprint Dive into the research topics where Jeffrey Nicholas Savas is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
Proteins Medicine & Life Sciences
Synapses Medicine & Life Sciences
Proteomics Medicine & Life Sciences
Neurons Medicine & Life Sciences
Proteome Medicine & Life Sciences
Brain Chemical Compounds
AMPA Receptors Medicine & Life Sciences
Huntington Disease Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2011 2023

Modulating the Cochlear Proteostasis Network to Prevent Hidden Hearing Loss

Cheatham, M. A., Kim, K. A. & Savas, J. N.

U.S. Army Medical Research and Materiel Command

9/1/19 → 8/31/22

Project: Research project

Noise-Induced Hearing Loss
Cochlea
Hearing Loss
Hearing Tests
Occupational Diseases

Understanding pathophysiological mechanisms underlying neurodegeneration

Goldman, R., Opal, P. & Savas, J. N.

National Institute of Neurological Disorders and Stroke

7/1/19 → 6/30/20

Project: Research project

Giant Axonal Neuropathy
Intermediate Filaments
Pathology
Proteins
Ubiquitin-Protein Ligases

Subproject for Institution # SP0048250

Savas, J. N.

National Institute of Child Health and Human Development

5/15/19 → 4/30/21

Project: Research project

Proteins
Oocytes
Ovary
Germ Cells
Meiotic Prophase I

Extremely Long Lived Proteins and Female Reproductive Aging

Duncan, F. E., Savas, J. N. & Savas, J. N.

National Institute of Child Health and Human Development

5/15/19 → 4/30/21

Project: Research project

Proteins
Oocytes
Ovary
Germ Cells
Meiotic Prophase I

Exploring ASD-related Synaptic Deficits in Direct Pathway Medium Spiny Neurons in Nucleus Accumbens

Savas, J. N. & Radulovic, J.

Brain & Behavior Research Foundation

1/15/19 → 1/14/21

Project: Research project

Nucleus Accumbens
Oxytocin
Neurons
Proteomics
Therapeutics

Research Output 2007 2019

  • 3462 Citations
  • 51 Article
  • 3 Comment/debate
  • 3 Review article
  • 1 Short survey
1 Citation (Scopus)

Catacomb: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

Piunti, A., Smith, E., Morgan, M. A., Ugarenko, M., Khaltyan, N., Helmin, K. A., Ryan, C. A., Murray, D. C., Rickels, R. A., Yilmaz, B. D., Rendleman, E. J., Savas, J. N., Singer, B., Bulun, S. E. & Shilatifard, A., Jan 1 2019, In : Science Advances. 5, 7, eaax2887.

Research output: Contribution to journal › Article

Open Access
methionine
methylation
genes
deoxyribonucleic acid
COMPASS (programming language)
5 Citations (Scopus)

Critical period inhibition of NKCC1 rectifies synapse plasticity in the somatosensory cortex and restores adult tactile response maps in fragile X mice

He, Q., Arroyo, E. D., Smukowski, S. N., Xu, J., Piochon, C., Savas, J. N., Portera-Cailliau, C. & Contractor, A., Nov 1 2019, In : Molecular Psychiatry. 24, 11, p. 1732-1747 16 p.

Research output: Contribution to journal › Article

Fragile X Syndrome
Somatosensory Cortex
Touch
Synapses
Chlorides

Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function

Kim, J. J., Savas, J. N., Miller, M. T., Hu, X., Carromeu, C., Lavallée-Adam, M., Freitas, B. C. G., Muotri, A. R., Yates, J. R. & Ghosh, A., Feb 2019, In : PloS one. 14, 2, e0212553.

Research output: Contribution to journal › Article

Open Access
neuroglia
Stem cells
Neuroglia
Induced Pluripotent Stem Cells
Proteomics
26 Citations (Scopus)

Secreted amyloid-b precursor protein functions as a GABA B R1a ligand to modulate synaptic transmission

Rice, H. C., De Malmazet, D., Schreurs, A., Frere, S., Van Molle, I., Volkov, A. N., Creemers, E., Vertkin, I., Nys, J., Ranaivoson, F. M., Comoletti, D., Savas, J. N., Remaut, H., Balschun, D., Wierda, K. D., Slutsky, I., Farrow, K., De Strooper, B. & De Wit, J., Jan 11 2019, In : Science. 363, 6423, eaao4827.

Research output: Contribution to journal › Article

Aminobutyrates
Amyloid beta-Protein Precursor
Synaptic Transmission
gamma-Aminobutyric Acid
Ligands
1 Citation (Scopus)

Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways

Ruhl, D. A., Bomba-Warczak, E., Watson, E. T., Bradberry, M. M., Peterson, T. A., Basu, T., Frelka, A., Evans, C. S., Briguglio, J. S., Basta, T., Stowell, M. H. B., Savas, J. N., Roopra, A., Pearce, R. A., Piper, R. C. & Chapman, E. R., Dec 1 2019, In : Nature communications. 10, 1, 3532.

Research output: Contribution to journal › Article

Open Access
Synaptotagmins
physiology
Physiology
neurons
membranes