Grants per year
Personal profile
Research Interests
My research interests are centered on elucidating the pathogenic mechanisms which drive synaptopathies and proteinopathies in the mammalian nervous system. As a first step, we use reductionist biochemical approaches with discovery-based proteomic analysis to generate unbiased hypothesizes. Next, we test and characterize candidate proteins and pathways for potential functional relevance with molecular approaches. Ultimately, the goal of my research is to identify keystone proteins and proteomes as potential therapeutic targets to hopefully ameliorate neurodevelopmental and degenerative diseases.
Training Experience
| 2015 | Postdoctoral Fellowship, Scripps Research Institute |
Education/Academic qualification
PhD, New York University, School of Medicine
… → 2009
Keywords
- Alzheimer's Disease
- Autism Spectrum Disorders
- Biochemistry: Proteins
- Neuroscience
- Proteomics
- Schizophrenia
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Proteins
Medicine & Life Sciences
Synapses
Medicine & Life Sciences
Proteomics
Medicine & Life Sciences
Neurons
Medicine & Life Sciences
Proteome
Medicine & Life Sciences
Brain
Chemical Compounds
AMPA Receptors
Medicine & Life Sciences
Huntington Disease
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2011 2023
Postdoc Fellowship for Yi-Zhi Wang in support of: Explore ASD-related synaptic deficits in Drd1-positve MSN
Brain & Behavior Research Foundation
1/15/19 → 1/14/21
Project: Research project
Nucleus Accumbens
Oxytocin
Neurons
Proteomics
Therapeutics
The role of impaired SV machinery proteostasis in AD pathogenesis
Alzheimer's Disease Research Foundation
1/1/19 → 12/31/19
Project: Research project
Synaptic Vesicles
Proteins
Research
tau Proteins
Neurofibrillary Tangles
Nuclear rotation and cellular reorganization during Cytomegalovirus infection
National Institute of Allergy and Infectious Diseases
11/1/18 → 10/31/23
Project: Research project
Cytomegalovirus Infections
Cytomegalovirus
Viruses
Microtubule-Organizing Center
Cell Movement
LOAD risk genes in postsynaptic endosomal trafficking
Penzes, P., Savas, J. N. & Vassar, R. J.
9/30/18 → 8/31/19
Project: Research project
Synapses
Alzheimer Disease
Genes
Dendritic Spines
Glutamate Receptors
Structural characterization of Aβ strain variation in AD mouse models
Sadleir, K. R., Savas, J. N. & Vassar, R. J.
University Of Southern California, National Institute on Aging
9/30/18 → 5/31/23
Project: Research project
Pathology
Brain
Nitrogen
Amyloid beta-Peptides
Amyloid
Research Output 2007 2019
Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function
Kim, J. J., Savas, J. N., Miller, M. T., Hu, X., Carromeu, C., Lavallée-Adam, M., Freitas, B. C. G., Muotri, A. R., Yates, J. R. & Ghosh, A., Feb 1 2019, In : PloS one. 14, 2, e0212553.Research output: Contribution to journal › Article
Open Access
neuroglia
Stem cells
Neuroglia
Induced Pluripotent Stem Cells
Proteomics
11
Citations
(Scopus)
Secreted amyloid-b precursor protein functions as a GABA B R1a ligand to modulate synaptic transmission
Rice, H. C., De Malmazet, D., Schreurs, A., Frere, S., Van Molle, I., Volkov, A. N., Creemers, E., Vertkin, I., Nys, J., Ranaivoson, F. M., Comoletti, D., Savas, J. N., Remaut, H., Balschun, D., Wierda, K. D., Slutsky, I., Farrow, K., De Strooper, B. & De Wit, J., Jan 11 2019, In : Science. 363, 6423, eaao4827.Research output: Contribution to journal › Article
Aminobutyrates
Amyloid beta-Protein Precursor
Synaptic Transmission
gamma-Aminobutyric Acid
Ligands
2
Citations
(Scopus)
An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses
Condomitti, G., Wierda, K. D., Schroeder, A., Rubio, S. E., Vennekens, K. M., Orlandi, C., Martemyanov, K. A., Gounko, N. V., Savas, J. N. & de Wit, J., Oct 10 2018, In : Neuron. 100, 1, p. 201-215.e9Research output: Contribution to journal › Article
Hippocampal Mossy Fibers
Heparan Sulfate Proteoglycans
Glypicans
Dendrites
Synapses
3
Citations
(Scopus)
Critical period inhibition of NKCC1 rectifies synapse plasticity in the somatosensory cortex and restores adult tactile response maps in fragile X mice
He, Q., Arroyo, E. D., Smukowski, S. N., Xu, J., Piochon, C., Savas, J. N., Portera-Cailliau, C. & Contractor, A., Apr 27 2018, (Accepted/In press) In : Molecular Psychiatry. p. 1-16 16 p.Research output: Contribution to journal › Article
Fragile X Syndrome
Somatosensory Cortex
Touch
Synapses
Chlorides
Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function
Wortham, M., Benthuysen, J. R., Wallace, M., Savas, J. N., Mulas, F., Divakaruni, A. S., Liu, F., Albert, V., Taylor, B. L., Sui, Y., Saez, E., Murphy, A. N., Yates, J. R., Metallo, C. M. & Sander, M., Dec 4 2018, In : Cell reports. 25, 10, p. 2904-2918.e8Research output: Contribution to journal › Article
Proteomics
Nutrients
Glucose
Food
Cell Physiological Phenomena