Grants per year
Personal profile
Research Interests
My research interests are centered on elucidating the pathogenic mechanisms which drive synaptopathies and proteinopathies in the mammalian nervous system. As a first step, we use reductionist biochemical approaches with discovery-based proteomic analysis to generate unbiased hypothesizes. Next, we test and characterize candidate proteins and pathways for potential functional relevance with molecular approaches. Ultimately, the goal of my research is to identify keystone proteins and proteomes as potential therapeutic targets to hopefully ameliorate neurodevelopmental and degenerative diseases.
Training Experience
| 2015 | Postdoctoral Fellowship, Scripps Research Institute |
Education/Academic qualification
PhD, New York University, School of Medicine
… → 2009
Keywords
- Alzheimer's Disease
- Autism Spectrum Disorders
- Biochemistry: Proteins
- Neuroscience
- Proteomics
- Schizophrenia
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- 2 Similar Profiles
Synapses
Medicine & Life Sciences
Proteins
Medicine & Life Sciences
Proteomics
Medicine & Life Sciences
Neurons
Medicine & Life Sciences
Proteome
Medicine & Life Sciences
Brain
Chemical Compounds
AMPA Receptors
Medicine & Life Sciences
Huntington Disease
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2011 2023
Nuclear rotation and cellular reorganization during Cytomegalovirus infection
National Institute of Allergy and Infectious Diseases
11/1/18 → 10/31/23
Project: Research project
Cytomegalovirus Infections
Cytomegalovirus
Viruses
Microtubule-Organizing Center
Cell Movement
The role of activity induced exosome signaling in synaptic pathology of Alzheimer's Disease
9/30/18 → 4/30/23
Project: Research project
Exosomes
Alzheimer Disease
Pathology
Synapses
Amyloid beta-Protein Precursor
LOAD risk genes in postsynaptic endosomal trafficking
Penzes, P., Savas, J. N. & Vassar, R. J.
9/30/18 → 8/31/19
Project: Research project
Synapses
Genes
Alzheimer Disease
Dendritic Spines
Glutamate Receptors
Structural characterization of Aβ strain variation in AD mouse models
Sadleir, K. R., Savas, J. N. & Vassar, R. J.
University Of Southern California, National Institute on Aging
9/30/18 → 5/31/23
Project: Research project
Pathology
Brain
Nitrogen
Amyloid beta-Peptides
Amyloid
Defining The Impaired Proteostasis Network in ALS Patient Motor Neurons
National Institute of Neurological Disorders and Stroke
9/1/18 → 8/31/20
Project: Research project
Amyotrophic Lateral Sclerosis
Motor Neurons
Proteins
Mutation
Proteolysis
Research Output 2007 2019
Secreted amyloid-b precursor protein functions as a GABA B R1a ligand to modulate synaptic transmission
Rice, H. C., De Malmazet, D., Schreurs, A., Frere, S., Van Molle, I., Volkov, A. N., Creemers, E., Vertkin, I., Nys, J., Ranaivoson, F. M., Comoletti, D., Savas, J. N., Remaut, H., Balschun, D., Wierda, K. D., Slutsky, I., Farrow, K., De Strooper, B. & De Wit, J., Jan 11 2019, In : Science. 363, 6423, eaao4827.Research output: Contribution to journal › Article
Aminobutyrates
Amyloid beta-Protein Precursor
Synaptic Transmission
gamma-Aminobutyric Acid
Ligands
An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses
Condomitti, G., Wierda, K. D., Schroeder, A., Rubio, S. E., Vennekens, K. M., Orlandi, C., Martemyanov, K. A., Gounko, N. V., Savas, J. N. & de Wit, J., Oct 10 2018, In : Neuron. 100, 1, p. 201-215.e9Research output: Contribution to journal › Article
Hippocampal Mossy Fibers
Heparan Sulfate Proteoglycans
Glypicans
Dendrites
Synapses
Critical period inhibition of NKCC1 rectifies synapse plasticity in the somatosensory cortex and restores adult tactile response maps in fragile X mice
He, Q., Arroyo, E. D., Smukowski, S. N., Xu, J., Piochon, C., Savas, J. N., Portera-Cailliau, C. & Contractor, A., Apr 27 2018, (Accepted/In press) In : Molecular Psychiatry. p. 1-16 16 p.Research output: Contribution to journal › Article
Fragile X Syndrome
Somatosensory Cortex
Touch
Synapses
Chlorides
Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function
Wortham, M., Benthuysen, J. R., Wallace, M., Savas, J. N., Mulas, F., Divakaruni, A. S., Liu, F., Albert, V., Taylor, B. L., Sui, Y., Saez, E., Murphy, A. N., Yates, J. R., Metallo, C. M. & Sander, M., Dec 4 2018, In : Cell reports. 25, 10, p. 2904-2918.e8Research output: Contribution to journal › Article
Insulin-Secreting Cells
Proteomics
Nutrients
Glucose
Food
Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy
Wang, L., Zhao, Z., Ozark, P. A., Fantini, D., Marshall, S. A., Rendleman, E. J., Cozzolino, K. A., Louis, N., He, X., Morgan, M. A., Takahashi, Y., Collings, C. K., Smith, E., Ntziachristos, P., Savas, J. N., Zou, L., Hashizume, R., Meeks, J. J. & Shilatifard, A., Jun 1 2018, In : Nature Medicine. 24, 6, p. 758-769 12 p.Research output: Contribution to journal › Article
Epigenomics
Tumors
Methyltransferases
Histones
Mutation