Grants per year
Personal profile
Research Interests
My research interests are centered on elucidating the pathogenic mechanisms which drive synaptopathies and proteinopathies in the mammalian nervous system. As a first step, we use reductionist biochemical approaches with discovery-based proteomic analysis to generate unbiased hypothesizes. Next, we test and characterize candidate proteins and pathways for potential functional relevance with molecular approaches. Ultimately, the goal of my research is to identify keystone proteins and proteomes as potential therapeutic targets to hopefully ameliorate neurodevelopmental and degenerative diseases.
Training Experience
2015 | Postdoctoral Fellowship, Scripps Research Institute |
Education/Academic qualification
PhD, New York University, School of Medicine
… → 2009
Research interests keywords
- Alzheimer's Disease
- Autism Spectrum Disorders
- Biochemistry: Proteins
- Neuroscience
- Proteomics
- Schizophrenia
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Collaborations and top research areas from the last five years
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CNS Demyelination: Initiation, Protection, and Correction
Popko, B. (PD/PI), Elbaz-Eilon, B. (Co-Investigator), Kiskinis, E. (Co-Investigator), Savas, J. N. (Co-Investigator) & Wong, Y. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
5/15/24 → 4/30/32
Project: Research project
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Improving Aged Neuromuscular Health and Function
Savas, J. N. (PD/PI) & Savas, J. N. (Other)
Rehabilitation Institute of Chicago, National Institute on Aging
7/1/23 → 3/31/25
Project: Research project
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Stable Isotope-based dating of the amyloid fibril proteome
Savas, J. N. (PD/PI)
7/1/23 → 6/30/25
Project: Research project
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A new biomarker for frontotemporal lobar degeneration with TDP-43 proteinopathy and Alzheimer's Disease
Savas, J. N. (PD/PI) & Savas, J. N. (PD/PI)
University of Utah, National Institute on Aging
1/1/23 → 12/31/24
Project: Research project
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Correction to: Neuron type-specific proteomics reveals distinct Shank3 proteoforms in iSPNs and dSPNs lead to striatal synaptopathy in Shank3B–/– mice (Molecular Psychiatry, (2024), 29, 8, (2372-2388), 10.1038/s41380-024-02493-w)
Wang, Y. Z., Perez-Rosello, T., Smukowski, S. N., Surmeier, D. J. & Savas, J. N., Sep 2024, In: Molecular Psychiatry. 29, 9, p. 2919 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Derailed protein turnover in the aging mammalian brain
Rao, N. R., Upadhyay, A. & Savas, J. N., Feb 2 2024, In: Molecular Systems Biology. 20, 2, p. 120-139 20 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Local mitochondrial replication in the periphery of neurons requires the eEF1A1 protein and thetranslation of nuclear-encoded proteins
Cardanho-Ramos, C., Simões, R. A., Wang, Y.-Z., Faria-Pereira, A., Bomba-Warczak, E., Craessaerts, K., Spinazzi, M., Savas, J. N. & Morais, V. A., Apr 19 2024, In: iScience. 27, 4, 109136.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Neuron type-specific proteomics reveals distinct Shank3 proteoforms in iSPNs and dSPNs lead to striatal synaptopathy in Shank3B–/– mice
Wang, Y. Z., Perez-Rosello, T., Smukowski, S. N., Surmeier, D. J. & Savas, J. N., Aug 2024, In: Molecular Psychiatry. 29, 8, p. 2372-2388 17 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Notch receptor-ligand binding facilitates extracellular vesicle-mediated neuron-to-neuron communication
Wang, Y. Z., Castillon, C. C. M., Gebis, K. K., Bartom, E. T., d'Azzo, A., Contractor, A. & Savas, J. N., Feb 27 2024, In: Cell reports. 43, 2, 113680.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Data from: Long-lived metabolic enzymes in the crystalline lens identified by pulse-labeling of mice and mass spectrometry
Liu, P. (Contributor), Ali, L. (Contributor), Thomson, B. R. (Contributor), Savas, J. N. (Contributor) & Jin, J. (Contributor), ZENODO, Dec 6 2019
DOI: 10.5061/dryad.r6h8dr2, https://zenodo.org/records/5017248
Dataset
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Crystal structure of the human neuroligin 1 cholinesterase domain containing spliced sequence B (SSB) (NL1(-A+B))
Elegheert, J. (Contributor), Cvetkovska, V. (Contributor), Clayton, A. J. (Contributor), Heroven, C. (Contributor), Vennekens, K. M. (Contributor), Smukowski, S. N. (Contributor), Regan, M. C. (Contributor), Jia, W. (Contributor), Smith, A. C. (Contributor), Furukawa, H. (Contributor), Savas, J. N. (Contributor), de Wit, J. (Contributor), Begbie, J. (Contributor), Craig, A. M. (Contributor) & Aricescu, A. R. (Contributor), Protein Data Bank (PDB), Aug 23 2017
DOI: 10.2210/pdb5OJK/pdb, https://www.wwpdb.org/pdb?id=pdb_00005ojk
Dataset
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Solution structure of the Sushi 1 domain of GABAbR1a
Rice, H. C. (Contributor), De Malmazet, D. (Contributor), Schreurs, A. (Contributor), Frere, S. (Contributor), Van Molle, I. (Contributor), Volkov, A. N. (Contributor), Creemers, E. (Contributor), Vertkin, I. (Contributor), Nys, J. (Contributor), Ranaivoson, F. M. (Contributor), Comoletti, D. (Contributor), Savas, J. N. (Contributor), Remaut, H. (Contributor), Balschun, D. (Contributor), Wierda, K. D. (Contributor), Slutsky, I. (Contributor), Farrow, K. (Contributor), De Strooper, B. (Contributor) & De Wit, J. (Contributor), Protein Data Bank (PDB), Jan 23 2019
DOI: 10.2210/pdb6HKC/pdb, https://www.wwpdb.org/pdb?id=pdb_00006hkc
Dataset
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Data from: Long-lived metabolic enzymes in the crystalline lens identified by pulse-labeling of mice and mass spectrometry
Liu, P. (Creator), Ali, L. (Creator), Thomson, B. R. (Creator), Savas, J. N. (Creator) & Jin, J. (Creator), Dryad, Dec 6 2019
DOI: 10.5061/dryad.r6h8dr2, https://datadryad.org/stash/dataset/doi:10.5061/dryad.r6h8dr2
Dataset
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Crystal structure of the chicken MDGA1 ectodomain in complex with the human neuroligin 1 (NL1(-A-B)) cholinesterase domain.
Elegheert, J. (Contributor), Cvetkovska, V. (Contributor), Clayton, A. J. (Contributor), Heroven, C. (Contributor), Vennekens, K. M. (Contributor), Smukowski, S. N. (Contributor), Regan, M. C. (Contributor), Jia, W. (Contributor), Smith, A. C. (Contributor), Furukawa, H. (Contributor), Savas, J. N. (Contributor), de Wit, J. (Contributor), Begbie, J. (Contributor), Craig, A. M. (Contributor) & Aricescu, A. R. (Contributor), Protein Data Bank (PDB), Aug 23 2017
DOI: 10.2210/pdb5OJ6/pdb, https://www.wwpdb.org/pdb?id=pdb_00005oj6
Dataset