• 2905 Citations
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Personal profile

Research Interests

My research interests are centered on elucidating the pathogenic mechanisms which drive synaptopathies and proteinopathies in the mammalian nervous system. As a first step, we use reductionist biochemical approaches with discovery-based proteomic analysis to generate unbiased hypothesizes. Next, we test and characterize candidate proteins and pathways for potential functional relevance with molecular approaches. Ultimately, the goal of my research is to identify keystone proteins and proteomes as potential therapeutic targets to hopefully ameliorate neurodevelopmental and degenerative diseases.

Training Experience

2015Postdoctoral Fellowship, Scripps Research Institute

Education/Academic qualification

PhD, New York University, School of Medicine

… → 2009


  • Alzheimer's Disease
  • Autism Spectrum Disorders
  • Biochemistry: Proteins
  • Neuroscience
  • Proteomics
  • Schizophrenia

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Grants 2011 2023

Cytomegalovirus Infections
Microtubule-Organizing Center
Cell Movement
Alzheimer Disease
Amyloid beta-Protein Precursor
Alzheimer Disease
Dendritic Spines
Glutamate Receptors
Amyotrophic Lateral Sclerosis
Motor Neurons

Research Output 2007 2019

  • 2905 Citations
  • 47 Article
  • 4 Review article
  • 3 Comment/debate
  • 1 Short survey
2 Citations

Secreted amyloid-b precursor protein functions as a GABA B R1a ligand to modulate synaptic transmission

Rice, H. C., De Malmazet, D., Schreurs, A., Frere, S., Van Molle, I., Volkov, A. N., Creemers, E., Vertkin, I., Nys, J., Ranaivoson, F. M., Comoletti, D., Savas, J. N., Remaut, H., Balschun, D., Wierda, K. D., Slutsky, I., Farrow, K., De Strooper, B. & De Wit, J., Jan 11 2019, In : Science. 363, 6423, eaao4827.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Synaptic Transmission
gamma-Aminobutyric Acid
1 Citations

An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses

Condomitti, G., Wierda, K. D., Schroeder, A., Rubio, S. E., Vennekens, K. M., Orlandi, C., Martemyanov, K. A., Gounko, N. V., Savas, J. N. & de Wit, J., Oct 10 2018, In : Neuron. 100, 1, p. 201-215.e9

Research output: Contribution to journalArticle

Hippocampal Mossy Fibers
Heparan Sulfate Proteoglycans
2 Citations

Critical period inhibition of NKCC1 rectifies synapse plasticity in the somatosensory cortex and restores adult tactile response maps in fragile X mice

He, Q., Arroyo, E. D., Smukowski, S. N., Xu, J., Piochon, C., Savas, J. N., Portera-Cailliau, C. & Contractor, A., Apr 27 2018, (Accepted/In press) In : Molecular Psychiatry. p. 1-16 16 p.

Research output: Contribution to journalArticle

Fragile X Syndrome
Somatosensory Cortex

Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function

Wortham, M., Benthuysen, J. R., Wallace, M., Savas, J. N., Mulas, F., Divakaruni, A. S., Liu, F., Albert, V., Taylor, B. L., Sui, Y., Saez, E., Murphy, A. N., Yates, J. R., Metallo, C. M. & Sander, M., Dec 4 2018, In : Cell reports. 25, 10, p. 2904-2918.e8

Research output: Contribution to journalArticle

Insulin-Secreting Cells
11 Citations

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy

Wang, L., Zhao, Z., Ozark, P. A., Fantini, D., Marshall, S. A., Rendleman, E. J., Cozzolino, K. A., Louis, N., He, X., Morgan, M. A., Takahashi, Y., Collings, C. K., Smith, E., Ntziachristos, P., Savas, J. N., Zou, L., Hashizume, R., Meeks, J. J. & Shilatifard, A., Jun 1 2018, In : Nature Medicine. 24, 6, p. 758-769 12 p.

Research output: Contribution to journalArticle