• 3278 Citations
20072023
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Research Output 2007 2019

  • 3278 Citations
  • 50 Article
  • 3 Comment/debate
  • 3 Review article
  • 1 Short survey
2019

Catacomb: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

Piunti, A., Smith, E., Morgan, M. A., Ugarenko, M., Khaltyan, N., Helmin, K. A., Ryan, C. A., Murray, D. C., Rickels, R. A., Yilmaz, B. D., Rendleman, E. J., Savas, J. N., Singer, B., Bulun, S. E. & Shilatifard, A., Jan 1 2019, In : Science Advances. 5, 7, eaax2887.

Research output: Contribution to journalArticle

Open Access
methionine
methylation
genes
deoxyribonucleic acid
COMPASS (programming language)

Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function

Kim, J. J., Savas, J. N., Miller, M. T., Hu, X., Carromeu, C., Lavallée-Adam, M., Freitas, B. C. G., Muotri, A. R., Yates, J. R. & Ghosh, A., Feb 1 2019, In : PloS one. 14, 2, e0212553.

Research output: Contribution to journalArticle

Open Access
neuroglia
Stem cells
Neuroglia
Induced Pluripotent Stem Cells
Proteomics
19 Citations (Scopus)

Secreted amyloid-b precursor protein functions as a GABA B R1a ligand to modulate synaptic transmission

Rice, H. C., De Malmazet, D., Schreurs, A., Frere, S., Van Molle, I., Volkov, A. N., Creemers, E., Vertkin, I., Nys, J., Ranaivoson, F. M., Comoletti, D., Savas, J. N., Remaut, H., Balschun, D., Wierda, K. D., Slutsky, I., Farrow, K., De Strooper, B. & De Wit, J., Jan 11 2019, In : Science. 363, 6423, eaao4827.

Research output: Contribution to journalArticle

Aminobutyrates
Amyloid beta-Protein Precursor
Synaptic Transmission
gamma-Aminobutyric Acid
Ligands

Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways

Ruhl, D. A., Bomba-Warczak, E., Watson, E. T., Bradberry, M. M., Peterson, T. A., Basu, T., Frelka, A., Evans, C. S., Briguglio, J. S., Basta, T., Stowell, M. H. B., Savas, J. N., Roopra, A., Pearce, R. A., Piper, R. C. & Chapman, E. R., Dec 1 2019, In : Nature communications. 10, 1, 3532.

Research output: Contribution to journalArticle

Open Access
Synaptotagmins
physiology
Physiology
neurons
membranes
2018
5 Citations (Scopus)

An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses

Condomitti, G., Wierda, K. D., Schroeder, A., Rubio, S. E., Vennekens, K. M., Orlandi, C., Martemyanov, K. A., Gounko, N. V., Savas, J. N. & de Wit, J., Oct 10 2018, In : Neuron. 100, 1, p. 201-215.e9

Research output: Contribution to journalArticle

Hippocampal Mossy Fibers
Heparan Sulfate Proteoglycans
Glypicans
Dendrites
Synapses
4 Citations (Scopus)

Critical period inhibition of NKCC1 rectifies synapse plasticity in the somatosensory cortex and restores adult tactile response maps in fragile X mice

He, Q., Arroyo, E. D., Smukowski, S. N., Xu, J., Piochon, C., Savas, J. N., Portera-Cailliau, C. & Contractor, A., Apr 27 2018, (Accepted/In press) In : Molecular Psychiatry. p. 1-16 16 p.

Research output: Contribution to journalArticle

Fragile X Syndrome
Somatosensory Cortex
Touch
Synapses
Chlorides
1 Citation (Scopus)

Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function

Wortham, M., Benthuysen, J. R., Wallace, M., Savas, J. N., Mulas, F., Divakaruni, A. S., Liu, F., Albert, V., Taylor, B. L., Sui, Y., Saez, E., Murphy, A. N., Yates, J. R., Metallo, C. M. & Sander, M., Dec 4 2018, In : Cell reports. 25, 10, p. 2904-2918.e8

Research output: Contribution to journalArticle

Proteomics
Nutrients
Glucose
Food
Cell Physiological Phenomena
20 Citations (Scopus)

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy

Wang, L., Zhao, Z., Ozark, P. A., Fantini, D., Marshall, S. A., Rendleman, E. J., Cozzolino, K. A., Louis, N., He, X., Morgan, M. A., Takahashi, Y., Collings, C. K., Smith, E., Ntziachristos, P., Savas, J. N., Zou, L., Hashizume, R., Meeks, J. J. & Shilatifard, A., Jun 1 2018, In : Nature Medicine. 24, 6, p. 758-769 12 p.

Research output: Contribution to journalArticle

Epigenomics
Tumors
Methyltransferases
Histones
Mutation
1 Citation (Scopus)

Selective permeability of mouse blood-aqueous barrier as determined by15N-heavy isotope tracing and mass spectrometry

Liu, P., Thomson, B. R., Khalatyan, N., Feng, L., Liu, X., Savas, J. N., Quaggin, S. E. & Jin, J., Sep 4 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 36, p. 9032-9037 6 p.

Research output: Contribution to journalArticle

Blood-Aqueous Barrier
Isotopes
Permeability
Mass Spectrometry
Blood Proteins
2 Citations (Scopus)

Uncovering discrete synaptic proteomes to understand neurological disorders

Wang, Y. Z. & Savas, J. N., Sep 1 2018, In : Proteomes. 6, 3, 30.

Research output: Contribution to journalReview article

Proteome
Nervous System Diseases
Synapses
Neurons
Proteins
2017
8 Citations (Scopus)

A cryptic tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation

Morgan, M. A., Rickels, R. A., Collings, C. K., He, X., Cao, K., Herz, H. M., Cozzolino, K. A., Abshiru, N. A., Marshall, S. A., Rendleman, E. J., Sze, C. C., Piunti, A., Kelleher, N. L., Savas, J. N. & Shilatifard, A., Oct 1 2017, In : Genes and Development. 31, 19, p. 2003-2014 12 p.

Research output: Contribution to journalArticle

Histones
Methylation
Chromatin
Drosophila
Clustered Regularly Interspaced Short Palindromic Repeats
12 Citations (Scopus)

A cytoplasmic COMPASS is necessary for cell survival and triple-negative breast cancer pathogenesis by regulating metabolism

Wang, L., Collings, C. K., Zhao, Z., Cozzolino, K. A., Ma, Q., Liang, K., Marshall, S. A., Sze, C. C., Hashizume, R., Savas, J. N. & Shilatifard, A., Oct 15 2017, In : Genes and Development. 31, 20, p. 2056-2066 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Cell Survival
Adiponectin Receptors
Proteins
Histone-Lysine N-Methyltransferase
8 Citations (Scopus)

Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer's Disease-like Pathology

Savas, J. N., Wang, Y. Z., DeNardo, L. A., Martinez-Bartolome, S., McClatchy, D. B., Hark, T. J., Shanks, N. F., Cozzolino, K. A., Lavallée-Adam, M., Smukowski, S. N., Park, S. K., Kelly, J. W., Koo, E. H., Nakagawa, T., Masliah, E., Ghosh, A. & Yates, J. R., Nov 28 2017, In : Cell reports. 21, 9, p. 2614-2627 14 p.

Research output: Contribution to journalArticle

Pathology
Proteome
Amyloid
Alzheimer Disease
Apolipoproteins E
120 Citations (Scopus)

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

Burbulla, L., Song, P., Mazzulli, J., Zampese, E., Wong, Y. C., Jeon, S., Santos, D. P., Blanz, J., Obermaier, C. D., Strojny, C., Savas, J. N., Kiskinis, E., Zhuang, X., Krüger, R., Surmeier Jr, D. J. & Krainc, D., Sep 22 2017, In : Science. 357, 6357, p. 1255-1261 7 p.

Research output: Contribution to journalArticle

Parkinson Disease
Dopamine
Synucleins
Neurons
Glucosylceramidase
3 Citations (Scopus)

Erratum: Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins (Journal Article (2017) 95(4) (896–913.e10) (S0896627317306888)(10.1016/j.neuron.2017.07.040))

Elegheert, J., Cvetkovska, V., Clayton, A. J., Heroven, C., Vennekens, K. M., Smukowski, S. N., Regan, M. C., Jia, W., Smith, A. C., Furukawa, H., Savas, J. N., de Wit, J., Begbie, J., Craig, A. M. & Aricescu, A. R., Sep 27 2017, In : Neuron. 96, 1, p. 242-244 3 p.

Research output: Contribution to journalComment/debate

Manuscripts
Publications
Neurons
Proteins
methyl-N-dansylgalactosaminide
19 Citations (Scopus)

Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E)

Park, J., Yang, J., Wenzel, A. T., Ramachandran, A., Lee, W. J., Daniels, J. C., Kim, J., Martinez-Escala, E., Amankulor, N., Pro, B., Guitart, J., Mendillo, M. L., Savas, J. N., Boggon, T. J. & Choi, J., Sep 21 2017, In : Blood. 130, 12, p. 1430-1440 11 p.

Research output: Contribution to journalArticle

Cutaneous T-Cell Lymphoma
T-cells
NF-kappa B
T-Cell Antigen Receptor
T-Lymphocytes
13 Citations (Scopus)

Global analysis of protein expression of inner ear hair cells

Hickox, A. E., Wong, A. C. Y., Pak, K., Strojny, C., Ramirez, M., Yates, J. R., Ryan, A. F. & Savas, J. N., Feb 1 2017, In : Journal of Neuroscience. 37, 5, p. 1320-1339 20 p.

Research output: Contribution to journalArticle

Inner Auditory Hair Cells
Inner Ear
Proteins
Hair
Proteomics
6 Citations (Scopus)

Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification

Widjaja, C. E., Olvera, J. G., Metz, P. J., Phan, A. T., Savas, J. N., De Bruin, G., Leestemaker, Y., Berkers, C. R., De Jong, A., Florea, B. I., Fisch, K., Lopez, J., Kim, S. H., Garcia, D. A., Searles, S., Bui, J. D., Chang, A. N., Yates, J. R., Goldrath, A. W., Overkleeft, H. S. & 2 others, Ovaa, H. & Chang, J. T., Oct 2 2017, In : Journal of Clinical Investigation. 127, 10, p. 3609-3623 15 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
T-Lymphocytes
Lymphocytes
Glycolysis
Cell Division
16 Citations (Scopus)

Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins

Elegheert, J., Cvetkovska, V., Clayton, A. J., Heroven, C., Vennekens, K. M., Smukowski, S. N., Regan, M. C., Jia, W., Smith, A. C., Furukawa, H., Savas, J. N., de Wit, J., Begbie, J., Craig, A. M. & Aricescu, A. R., Aug 16 2017, In : Neuron. 95, 4, p. 896-913.e10

Research output: Contribution to journalArticle

Proteins
Autistic Disorder
Synaptic Transmission
Synapses
Psychiatry
10 Citations (Scopus)

Synapse biology in the ‘circuit-age’—paths toward molecular connectomics

Schreiner, D., Savas, J. N., Herzog, E., Brose, N. & de Wit, J., Feb 1 2017, In : Current opinion in neurobiology. 42, p. 102-110 9 p.

Research output: Contribution to journalReview article

Connectome
Synapses
Brain
Automatic Data Processing
Proteomics
18 Citations (Scopus)

Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase

Jha, S., Rollins, M. G., Fuchs, G., Procter, D. J., Hall, E. A., Cozzolino, K., Sarnow, P., Savas, J. N. & Walsh, D., Jun 29 2017, In : Nature. 546, 7660, p. 651-655 5 p.

Research output: Contribution to journalArticle

Poxviridae
Ribosomes
Phosphotransferases
Viral RNA
Adenosine
2016
5 Citations (Scopus)

Global quantitative analysis of phosphorylation underlying phencyclidine signaling and sensorimotor gating in the prefrontal cortex

McClatchy, D. B., Savas, J. N., Martínez-Bartolomé, S., Park, S. K., Maher, P., Powell, S. B. & Yates, J. R., Feb 1 2016, In : Molecular Psychiatry. 21, 2, p. 205-215 11 p.

Research output: Contribution to journalArticle

Sensory Gating
Phencyclidine
Prefrontal Cortex
Phosphorylation
Long-Term Potentiation
15 Citations (Scopus)

Poly(ADP-ribose) polymerase 1 represses liver X receptor-mediated ABCA1 expression and cholesterol efflux in macrophages

Shrestha, E., Hussein, M. A., Savas, J. N., Ouimet, M., Barrett, T. J., Leone, S., Yates, J. R., Moore, K. J., Fisher, E. A. & Garabedian, M. J., May 20 2016, In : Journal of Biological Chemistry. 291, 21, p. 11172-11184 13 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Macrophages
Liver
Cholesterol
Atherosclerosis
5 Citations (Scopus)

Proteomic analysis of protein turnover by metabolic whole rodent pulse-chase isotopic labeling and shotgun mass spectrometry analysis

Savas, J. N., Park, S. K. & Yates, J. R., Feb 1 2016, In : Methods in Molecular Biology. 1410, p. 293-304 12 p.

Research output: Contribution to journalArticle

Firearms
Proteomics
Rodentia
Mass Spectrometry
Proteins
46 Citations (Scopus)

The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation

Yonashiro, R., Tahara, E. B., Bengtson, M. H., Khokhrina, M., Lorenz, H., Chen, K. C., Kigoshi-Tansho, Y., Savas, J. N., Yates, J. R., Kay, S. A., Craig, E. A., Mogk, A., Bukau, B. & Joazeiro, C. A. P., Mar 4 2016, In : eLife. 5, MARCH2016, e11794.

Research output: Contribution to journalArticle

Ribosome Subunits
Ribosomes
Quality Control
Quality control
Agglomeration
8 Citations (Scopus)

URI regulates KAP1 phosphorylation and transcriptional repression via PP2A phosphatase in prostate cancer cells

Mita, P., Savas, J. N., Briggs, E. M., Ha, S., Gnanakkan, V., Yates, J. R., Robins, D. M., David, G., Boeke, J. D., Garabedian, M. J. & Logan, S. K., Dec 2 2016, In : Journal of Biological Chemistry. 291, 49, p. 25516-25528 13 p.

Research output: Contribution to journalArticle

Phosphorylation
Phosphoric Monoester Hydrolases
Prostatic Neoplasms
Cells
Proteins
2015
19 Citations (Scopus)

Increased abundance of translation machinery in stem cell-derived neural progenitor cells from four schizophrenia patients

Topol, A., English, J. A., Flaherty, E., Rajarajan, P., Hartley, B. J., Gupta, S., Desland, F., Zhu, S., Goff, T., Friedman, L., Rapoport, J., Felsenfeld, D., Cagney, G., Mackay-Sim, A., Savas, J. N., Aronow, B., Fang, G., Zhang, B., Cotter, D. & Brennand, K. J., Oct 20 2015, In : Translational psychiatry. 5, p. e662

Research output: Contribution to journalArticle

Neural Stem Cells
Induced Pluripotent Stem Cells
Schizophrenia
Stem Cells
Proteins
165 Citations (Scopus)

Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia

Brennand, K., Savas, J. N., Kim, Y., Tran, N., Simone, A., Hashimoto-Torii, K., Beaumont, K. G., Kim, H. J., Topol, A., Ladran, I., Abdelrahim, M., Matikainen-Ankney, B., Chao, S. H., Mrksich, M., Rakic, P., Fang, G., Zhang, B., Yates, J. R. & Gage, F. H., Mar 12 2015, In : Molecular Psychiatry. 20, 3, p. 361-368 8 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Schizophrenia
Stem Cells
Gene Expression
Neurons
24 Citations (Scopus)

The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors

Savas, J. N., Ribeiro, L. F., Wierda, K. D., Wright, R., DeNardo-Wilke, L. A., Rice, H. C., Chamma, I., Wang, Y. Z., Zemla, R., Lavallée-Adam, M., Vennekens, K. M., O'Sullivan, M. L., Antonios, J. K., Hall, E. A., Thoumine, O., Attie, A. D., Yates, J. R., Ghosh, A. & de Wit, J., Aug 19 2015, In : Neuron. 87, 4, p. 764-780 17 p.

Research output: Contribution to journalArticle

Neurotransmitter Receptor
AMPA Receptors
Glutamate Receptors
Synapses
Proteome
2014
15 Citations (Scopus)

Co-opting the Fanconi anemia genomic stability pathway enables herpesvirus DNA synthesis and productive growth

Karttunen, H., Savas, J. N., McKinney, C., Chen, Y. H., Yates, J. R., Hukkanen, V., Huang, T. T. & Mohr, I., Jul 3 2014, In : Molecular Cell. 55, 1, p. 111-122 12 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Genomic Instability
Herpesviridae
Viral DNA
Human Herpesvirus 1
9 Citations (Scopus)

Ecto-Fc MS identifies ligand-receptor interactions through extracellular domain Fc fusion protein baits and shotgun proteomic analysis

Savas, J. N., De Wit, J., Comoletti, D., Zemla, R., Ghosh, A. & Yates, J. R., Jan 1 2014, In : Nature Protocols. 9, 9, p. 2061-2074 14 p.

Research output: Contribution to journalArticle

Firearms
Proteomics
Fusion reactions
Ligands
Proteins
10 Citations (Scopus)

Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3

Shanks, N. F., Cais, O., Maruo, T., Savas, X. J. N., Zaika, E. I., Azumaya, C. M., Yates, J. R., Greger, I. & Nakagawa, T., Sep 3 2014, In : Journal of Neuroscience. 34, 36, p. 12104-12120 17 p.

Research output: Contribution to journalArticle

AMPA Receptors
Glutamate Receptors
Dissection
Membranes
Ligands
21 Citations (Scopus)

Reelin induces Erk1/2 signaling in cortical neurons through a non-canonical pathway

Lee, G. H., Chhangawala, Z., Von Daake, S., Savas, J. N., Yates, J. R., Comoletti, D. & D'Arcangelo, G., Jan 1 2014, In : Journal of Biological Chemistry. 289, 29, p. 20307-20317 11 p.

Research output: Contribution to journalArticle

Neurons
Brain
Signal transduction
Neuronal Plasticity
Signal Transduction
2013
29 Citations (Scopus)

Analysis of URI Nuclear Interaction with RPB5 and Components of the R2TP/Prefoldin-Like Complex

Mita, P., Savas, J. N., Ha, S., Djouder, N., Yates, J. R. & Logan, S. K., May 10 2013, In : PLoS One. 8, 5, e63879.

Research output: Contribution to journalArticle

DNA-directed RNA polymerase
DNA damage
amanitins
proteins
transcription (genetics)
186 Citations (Scopus)

Identification of long-lived proteins reveals exceptional stability of essential cellular structures

Toyama, B. H., Savas, J. N., Park, S. K., Harris, M. S., Ingolia, N. T., Yates, J. R. & Hetzer, M. W., Aug 29 2013, In : Cell. 154, 5, p. 971-982 12 p.

Research output: Contribution to journalArticle

Cellular Structures
Nuclear Pore Complex Proteins
Nuclear Pore
Proteins
Aging of materials
36 Citations (Scopus)

In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation

Butko, M. T., Savas, J. N., Friedman, B., Delahunty, C., Ebner, F., Yates, J. R. & Tsien, R. Y., Feb 19 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 8

Research output: Contribution to journalArticle

Sensory Deprivation
Proteomics
Synapses
Proteins
Proteome
739 Citations (Scopus)

Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor

Parkhurst, C. N., Yang, G., Ninan, I., Savas, J. N., Yates, J. R., Lafaille, J. J., Hempstead, B. L., Littman, D. R. & Gan, W. B., Dec 19 2013, In : Cell. 155, 7, p. 1596-1609 14 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Microglia
Synapses
Learning
Brain
44 Citations (Scopus)

Tracking brain palmitoylation change: Predominance of glial change in a mouse model of Huntington's disease

Wan, J., Savas, J. N., Roth, A. F., Sanders, S. S., Singaraja, R. R., Hayden, M. R., Yates, J. R. & Davis, N. G., Nov 21 2013, In : Chemistry and Biology. 20, 11, p. 1421-1434 14 p.

Research output: Contribution to journalArticle

Lipoylation
Huntington Disease
Neuroglia
Brain
Rodent Diseases
74 Citations (Scopus)

Unbiased discovery of Glypican as a receptor for LRRTM4 in regulating excitatory synapse development

DeWit, J., O'Sullivan, M. L., Savas, J. N., Condomitti, G., Caccese, M. C., Vennekens, K. M., Yates, J. R. & Ghosh, A., Aug 21 2013, In : Neuron. 79, 4, p. 696-711 16 p.

Research output: Contribution to journalArticle

Glypicans
Synapses
Heparitin Sulfate
Cluster Analysis
Heparan Sulfate Proteoglycans
2012
87 Citations (Scopus)

Differences in AMPA and Kainate Receptor Interactomes Facilitate Identification of AMPA Receptor Auxiliary Subunit GSG1L

Shanks, N. F., Savas, J. N., Maruo, T., Cais, O., Hirao, A., Oe, S., Ghosh, A., Noda, Y., Greger, I. H., Yates, J. R. & Nakagawa, T., Jun 28 2012, In : Cell Reports. 1, 6, p. 590-598 9 p.

Research output: Contribution to journalArticle

Kainic Acid Receptors
AMPA Receptors
Ionotropic Glutamate Receptors
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Proteins
137 Citations (Scopus)

Extremely long-lived nuclear pore proteins in the rat brain

Savas, J. N., Toyama, B. H., Xu, T., Yates, J. R. & Hetzer, M. W., Feb 24 2012, In : Science. 335, 6071, 1 p.

Research output: Contribution to journalShort survey

neurology
Nuclear Pore
Porins
Neurology
Nuclear Proteins
109 Citations (Scopus)

FLRT Proteins Are Endogenous Latrophilin Ligands and Regulate Excitatory Synapse Development

O'Sullivan, M. L., de Wit, J., Savas, J. N., Comoletti, D., Otto-Hitt, S., Yates, J. R. & Ghosh, A., Mar 8 2012, In : Neuron. 73, 5, p. 903-910 8 p.

Research output: Contribution to journalArticle

Synapses
Ligands
Small Interfering RNA
Proteins
Neurons
53 Citations (Scopus)

Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis

Culver, B. P., Savas, J. N., Park, S. K., Choi, J. H., Zheng, S., Zeitlin, S. O., Yates, J. R. & Tanese, N., Jun 22 2012, In : Journal of Biological Chemistry. 287, 26, p. 21599-21614 16 p.

Research output: Contribution to journalArticle

Mutant Proteins
Proteomics
Brain
Proteins
Huntington Disease
9 Citations (Scopus)

Quantitative analysis of BDNF/TrkB protein and mRNA in cortical and striatal neurons using α-tubulin as a normalization factor

Ma, B., Savas, J. N., Chao, M. V. & Tanese, N., Aug 1 2012, In : Cytometry Part A. 81 A, 8, p. 704-717 14 p.

Research output: Contribution to journalArticle

Corpus Striatum
Brain-Derived Neurotrophic Factor
Tubulin
Neurons
Messenger RNA
197 Citations (Scopus)

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway

Jeong, H., Cohen, D. E., Cui, L., Supinski, A., Savas, J. N., Mazzulli, J. R., Yates, J. R., Bordone, L., Guarente, L. & Krainc, D., Jan 1 2012, In : Nature Medicine. 18, 1, p. 159-165 7 p.

Research output: Contribution to journalArticle

Huntington Disease
Chemical activation
Brain
Brain-Derived Neurotrophic Factor
Transcription
20 Citations (Scopus)

Toward objective evaluation of proteomic algorithms

Yates, J. R., Park, S. K. R., Delahunty, C. M., Xu, T., Savas, J. N., Cociorva, D. & Carvalho, P. C., May 1 2012, In : Nature Methods. 9, 5, p. 455-456 2 p.

Research output: Contribution to journalComment/debate

Tandem Mass Spectrometry
Proteomics
2011
24 Citations (Scopus)

Huntingtin mediates dendritic transport of β-actin mRNA in rat neurons

Ma, B., Savas, J. N., Yu, M. S., Culver, B. P., Chao, M. V. & Tanese, N., Dec 1 2011, In : Scientific Reports. 1, 140.

Research output: Contribution to journalArticle

Dyneins
Actins
Neurons
Messenger RNA
RNA
61 Citations (Scopus)

Mass spectrometry accelerates membrane protein analysis

Savas, J. N., Stein, B. D., Wu, C. C. & Yates, J. R., Jul 1 2011, In : Trends in Biochemical Sciences. 36, 7

Research output: Contribution to journalReview article

Mass spectrometry
Mass Spectrometry
Membrane Proteins
Proteome
Cell membranes
23 Citations (Scopus)

Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP

Mita, P., Savas, J. N., Djouder, N., Yates, J. R., Ha, S., Ruoff, R., Schafler, E. D., Nwachukwu, J. C., Tanese, N., Cowan, N. J., Zavadil, J., Garabedian, M. J. & Logan, S. K., Sep 1 2011, In : Molecular and Cellular Biology. 31, 17, p. 3639-3652 14 p.

Research output: Contribution to journalArticle

Androgen Receptors
Carrier Proteins
Clone Cells
prefoldin
Prostatic Neoplasms
2010
3 Citations (Scopus)
Gene Regulatory Networks
MicroRNAs
Immunoprecipitation
Gene expression
Nucleic Acids