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Research Output

  • 3798 Citations
  • 52 Article
  • 3 Comment/debate
  • 3 Review article
  • 1 Short survey
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2019

Catacomb: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

Piunti, A., Smith, E. R., Morgan, M. A. J., Ugarenko, M., Khaltyan, N., Helmin, K. A., Ryan, C. A., Murray, D. C., Rickels, R. A., Yilmaz, B. D., Rendleman, E. J., Savas, J. N., Singer, B. D., Bulun, S. E. & Shilatifard, A., Jan 1 2019, In : Science Advances. 5, 7, eaax2887.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Critical period inhibition of NKCC1 rectifies synapse plasticity in the somatosensory cortex and restores adult tactile response maps in fragile X mice

He, Q., Arroyo, E. D., Smukowski, S. N., Xu, J., Piochon, C., Savas, J. N., Portera-Cailliau, C. & Contractor, A., Nov 1 2019, In : Molecular Psychiatry. 24, 11, p. 1732-1747 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

Long-lived metabolic enzymes in the crystalline lens identified by pulse-labeling of mice and mass spectrometry

Liu, P., Edassery, S. L., Ali, L., Thomson, B. R., Savas, J. N. & Jin, J., Dec 2019, In : eLife. 8, e50170.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function

Kim, J. J., Savas, J. N., Miller, M. T., Hu, X., Carromeu, C., Lavallée-Adam, M., Freitas, B. C. G., Muotri, A. R., Yates, J. R. & Ghosh, A., Feb 2019, In : PloS one. 14, 2, e0212553.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Secreted amyloid-b precursor protein functions as a GABA B R1a ligand to modulate synaptic transmission

Rice, H. C., De Malmazet, D., Schreurs, A., Frere, S., Van Molle, I., Volkov, A. N., Creemers, E., Vertkin, I., Nys, J., Ranaivoson, F. M., Comoletti, D., Savas, J. N., Remaut, H., Balschun, D., Wierda, K. D., Slutsky, I., Farrow, K., De Strooper, B. & De Wit, J., Jan 11 2019, In : Science. 363, 6423, eaao4827.

Research output: Contribution to journalArticle

44 Scopus citations

Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways

Ruhl, D. A., Bomba-Warczak, E., Watson, E. T., Bradberry, M. M., Peterson, T. A., Basu, T., Frelka, A., Evans, C. S., Briguglio, J. S., Basta, T., Stowell, M. H. B., Savas, J. N., Roopra, A., Pearce, R. A., Piper, R. C. & Chapman, E. R., Dec 1 2019, In : Nature communications. 10, 1, 3532.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

β-Catenin/Tcf7l2–dependent transcriptional regulation of GLUT1 gene expression by Zic family proteins in colon cancer

Zhao, Z., Wang, L., Bartom, E., Marshall, S., Rendleman, E., Ryan, C., Shilati, A., Savas, J., Chandel, N. & Shilatifard, A., Jul 31 2019, In : Science Advances. 5, 7, eaax0698.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses

Condomitti, G., Wierda, K. D., Schroeder, A., Rubio, S. E., Vennekens, K. M., Orlandi, C., Martemyanov, K. A., Gounko, N. V., Savas, J. N. & de Wit, J., Oct 10 2018, In : Neuron. 100, 1, p. 201-215.e9

Research output: Contribution to journalArticle

11 Scopus citations

Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function

Wortham, M., Benthuysen, J. R., Wallace, M., Savas, J. N., Mulas, F., Divakaruni, A. S., Liu, F., Albert, V., Taylor, B. L., Sui, Y., Saez, E., Murphy, A. N., Yates, J. R., Metallo, C. M. & Sander, M., Dec 4 2018, In : Cell reports. 25, 10, p. 2904-2918.e8

Research output: Contribution to journalArticle

4 Scopus citations

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy

Wang, L., Zhao, Z., Ozark, P. A., Fantini, D., Marshall, S. A., Rendleman, E. J., Cozzolino, K. A., Louis, N., He, X., Morgan, M. A., Takahashi, Y. H., Collings, C. K., Smith, E. R., Ntziachristos, P., Savas, J. N., Zou, L., Hashizume, R., Meeks, J. J. & Shilatifard, A., Jun 1 2018, In : Nature Medicine. 24, 6, p. 758-769 12 p.

Research output: Contribution to journalArticle

28 Scopus citations
4 Scopus citations
2017

A cryptic tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation

Morgan, M. A. J., Rickels, R. A., Collings, C. K., He, X., Cao, K., Herz, H. M., Cozzolino, K. A., Abshiru, N. A., Marshall, S. A., Rendleman, E. J., Sze, C. C., Piunti, A., Kelleher, N. L., Savas, J. N. & Shilatifard, A., Oct 1 2017, In : Genes and Development. 31, 19, p. 2003-2014 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

A cytoplasmic COMPASS is necessary for cell survival and triple-negative breast cancer pathogenesis by regulating metabolism

Wang, L., Collings, C. K., Zhao, Z., Cozzolino, K. A., Ma, Q., Liang, K., Marshall, S. A., Sze, C. C., Hashizume, R., Savas, J. N. & Shilatifard, A., Oct 15 2017, In : Genes and Development. 31, 20, p. 2056-2066 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer's Disease-like Pathology

Savas, J. N., Wang, Y. Z., DeNardo, L. A., Martinez-Bartolome, S., McClatchy, D. B., Hark, T. J., Shanks, N. F., Cozzolino, K. A., Lavallée-Adam, M., Smukowski, S. N., Park, S. K., Kelly, J. W., Koo, E. H., Nakagawa, T., Masliah, E., Ghosh, A. & Yates, J. R., Nov 28 2017, In : Cell reports. 21, 9, p. 2614-2627 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

Burbulla, L. F., Song, P., Mazzulli, J. R., Zampese, E., Wong, Y. C., Jeon, S., Santos, D. P., Blanz, J., Obermaier, C. D., Strojny, C., Savas, J. N., Kiskinis, E., Zhuang, X., Krüger, R., Surmeier, D. J. & Krainc, D., Sep 22 2017, In : Science. 357, 6357, p. 1255-1261 7 p.

Research output: Contribution to journalArticle

184 Scopus citations

Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E)

Park, J., Yang, J., Wenzel, A. T., Ramachandran, A., Lee, W. J., Daniels, J. C., Kim, J., Martinez-Escala, E., Amankulor, N., Pro, B., Guitart, J., Mendillo, M. L., Savas, J. N., Boggon, T. J. & Choi, J., Sep 21 2017, In : Blood. 130, 12, p. 1430-1440 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Global analysis of protein expression of inner ear hair cells

Hickox, A. E., Wong, A. C. Y., Pak, K., Strojny, C., Ramirez, M., Yates, J. R., Ryan, A. F. & Savas, J. N., Feb 1 2017, In : Journal of Neuroscience. 37, 5, p. 1320-1339 20 p.

Research output: Contribution to journalArticle

16 Scopus citations

Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification

Widjaja, C. E., Olvera, J. G., Metz, P. J., Phan, A. T., Savas, J. N., De Bruin, G., Leestemaker, Y., Berkers, C. R., De Jong, A., Florea, B. I., Fisch, K., Lopez, J., Kim, S. H., Garcia, D. A., Searles, S., Bui, J. D., Chang, A. N., Yates, J. R., Goldrath, A. W., Overkleeft, H. S. & 2 others, Ovaa, H. & Chang, J. T., Oct 2 2017, In : Journal of Clinical Investigation. 127, 10, p. 3609-3623 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins

Elegheert, J., Cvetkovska, V., Clayton, A. J., Heroven, C., Vennekens, K. M., Smukowski, S. N., Regan, M. C., Jia, W., Smith, A. C., Furukawa, H., Savas, J. N., de Wit, J., Begbie, J., Craig, A. M. & Aricescu, A. R., Aug 16 2017, In : Neuron. 95, 4, p. 896-913.e10

Research output: Contribution to journalArticle

19 Scopus citations

Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase

Jha, S., Rollins, M. G., Fuchs, G., Procter, D. J., Hall, E. A., Cozzolino, K., Sarnow, P., Savas, J. N. & Walsh, D., Jun 29 2017, In : Nature. 546, 7660, p. 651-655 5 p.

Research output: Contribution to journalArticle

24 Scopus citations
2016

Global quantitative analysis of phosphorylation underlying phencyclidine signaling and sensorimotor gating in the prefrontal cortex

McClatchy, D. B., Savas, J. N., Martínez-Bartolomé, S., Park, S. K., Maher, P., Powell, S. B. & Yates, J. R., Feb 1 2016, In : Molecular Psychiatry. 21, 2, p. 205-215 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Poly(ADP-ribose) polymerase 1 represses liver X receptor-mediated ABCA1 expression and cholesterol efflux in macrophages

Shrestha, E., Hussein, M. A., Savas, J. N., Ouimet, M., Barrett, T. J., Leone, S., Yates, J. R., Moore, K. J., Fisher, E. A. & Garabedian, M. J., May 20 2016, In : Journal of Biological Chemistry. 291, 21, p. 11172-11184 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Proteomic analysis of protein turnover by metabolic whole rodent pulse-chase isotopic labeling and shotgun mass spectrometry analysis

Savas, J. N., Park, S. K. & Yates, J. R., Feb 1 2016, In : Methods in Molecular Biology. 1410, p. 293-304 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation

Yonashiro, R., Tahara, E. B., Bengtson, M. H., Khokhrina, M., Lorenz, H., Chen, K. C., Kigoshi-Tansho, Y., Savas, J. N., Yates, J. R., Kay, S. A., Craig, E. A., Mogk, A., Bukau, B. & Joazeiro, C. A. P., Mar 4 2016, In : eLife. 5, MARCH2016, e11794.

Research output: Contribution to journalArticle

55 Scopus citations

URI regulates KAP1 phosphorylation and transcriptional repression via PP2A phosphatase in prostate cancer cells

Mita, P., Savas, J. N., Briggs, E. M., Ha, S., Gnanakkan, V., Yates, J. R., Robins, D. M., David, G., Boeke, J. D., Garabedian, M. J. & Logan, S. K., Dec 2 2016, In : Journal of Biological Chemistry. 291, 49, p. 25516-25528 13 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Increased abundance of translation machinery in stem cell-derived neural progenitor cells from four schizophrenia patients

Topol, A., English, J. A., Flaherty, E., Rajarajan, P., Hartley, B. J., Gupta, S., Desland, F., Zhu, S., Goff, T., Friedman, L., Rapoport, J., Felsenfeld, D., Cagney, G., Mackay-Sim, A., Savas, J. N., Aronow, B., Fang, G., Zhang, B., Cotter, D. & Brennand, K. J., Oct 20 2015, In : Translational psychiatry. 5, p. e662

Research output: Contribution to journalArticle

22 Scopus citations

Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia

Brennand, K., Savas, J. N., Kim, Y., Tran, N., Simone, A., Hashimoto-Torii, K., Beaumont, K. G., Kim, H. J., Topol, A., Ladran, I., Abdelrahim, M., Matikainen-Ankney, B., Chao, S. H., Mrksich, M., Rakic, P., Fang, G., Zhang, B., Yates, J. R. & Gage, F. H., Mar 12 2015, In : Molecular Psychiatry. 20, 3, p. 361-368 8 p.

Research output: Contribution to journalArticle

188 Scopus citations

The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors

Savas, J. N., Ribeiro, L. F., Wierda, K. D., Wright, R., DeNardo-Wilke, L. A., Rice, H. C., Chamma, I., Wang, Y. Z., Zemla, R., Lavallée-Adam, M., Vennekens, K. M., O'Sullivan, M. L., Antonios, J. K., Hall, E. A., Thoumine, O., Attie, A. D., Yates, J. R., Ghosh, A. & de Wit, J., Aug 19 2015, In : Neuron. 87, 4, p. 764-780 17 p.

Research output: Contribution to journalArticle

31 Scopus citations
2014

Co-opting the Fanconi anemia genomic stability pathway enables herpesvirus DNA synthesis and productive growth

Karttunen, H., Savas, J. N., McKinney, C., Chen, Y. H., Yates, J. R., Hukkanen, V., Huang, T. T. & Mohr, I., Jul 3 2014, In : Molecular cell. 55, 1, p. 111-122 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Ecto-Fc MS identifies ligand-receptor interactions through extracellular domain Fc fusion protein baits and shotgun proteomic analysis

Savas, J. N., De Wit, J., Comoletti, D., Zemla, R., Ghosh, A. & Yates, J. R., Sep 2014, In : Nature Protocols. 9, 9, p. 2061-2074 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3

Shanks, N. F., Cais, O., Maruo, T., Savas, X. J. N., Zaika, E. I., Azumaya, C. M., Yates, J. R., Greger, I. & Nakagawa, T., Sep 3 2014, In : Journal of Neuroscience. 34, 36, p. 12104-12120 17 p.

Research output: Contribution to journalArticle

14 Scopus citations

Reelin induces Erk1/2 signaling in cortical neurons through a non-canonical pathway

Lee, G. H., Chhangawala, Z., Von Daake, S., Savas, J. N., Yates, J. R., Comoletti, D. & D'Arcangelo, G., Jan 1 2014, In : Journal of Biological Chemistry. 289, 29, p. 20307-20317 11 p.

Research output: Contribution to journalArticle

21 Scopus citations
2013

Analysis of URI Nuclear Interaction with RPB5 and Components of the R2TP/Prefoldin-Like Complex

Mita, P., Savas, J. N., Ha, S., Djouder, N., Yates, J. R. & Logan, S. K., May 10 2013, In : PloS one. 8, 5, e63879.

Research output: Contribution to journalArticle

33 Scopus citations

Identification of long-lived proteins reveals exceptional stability of essential cellular structures

Toyama, B. H., Savas, J. N., Park, S. K., Harris, M. S., Ingolia, N. T., Yates, J. R. & Hetzer, M. W., Aug 29 2013, In : Cell. 154, 5, p. 971-982 12 p.

Research output: Contribution to journalArticle

216 Scopus citations

In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation

Butko, M. T., Savas, J. N., Friedman, B., Delahunty, C., Ebner, F., Yates, J. R. & Tsien, R. Y., Feb 19 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 8

Research output: Contribution to journalArticle

39 Scopus citations

Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor

Parkhurst, C. N., Yang, G., Ninan, I., Savas, J. N., Yates, J. R., Lafaille, J. J., Hempstead, B. L., Littman, D. R. & Gan, W. B., Dec 19 2013, In : Cell. 155, 7, p. 1596-1609 14 p.

Research output: Contribution to journalArticle

886 Scopus citations

Tracking brain palmitoylation change: Predominance of glial change in a mouse model of Huntington's disease

Wan, J., Savas, J. N., Roth, A. F., Sanders, S. S., Singaraja, R. R., Hayden, M. R., Yates, J. R. & Davis, N. G., Nov 21 2013, In : Chemistry and Biology. 20, 11, p. 1421-1434 14 p.

Research output: Contribution to journalArticle

46 Scopus citations

Unbiased discovery of Glypican as a receptor for LRRTM4 in regulating excitatory synapse development

DeWit, J., O'Sullivan, M. L., Savas, J. N., Condomitti, G., Caccese, M. C., Vennekens, K. M., Yates, J. R. & Ghosh, A., Aug 21 2013, In : Neuron. 79, 4, p. 696-711 16 p.

Research output: Contribution to journalArticle

80 Scopus citations
2012

Differences in AMPA and Kainate Receptor Interactomes Facilitate Identification of AMPA Receptor Auxiliary Subunit GSG1L

Shanks, N. F., Savas, J. N., Maruo, T., Cais, O., Hirao, A., Oe, S., Ghosh, A., Noda, Y., Greger, I. H., Yates, J. R. & Nakagawa, T., Jun 28 2012, In : Cell reports. 1, 6, p. 590-598 9 p.

Research output: Contribution to journalArticle

95 Scopus citations

FLRT Proteins Are Endogenous Latrophilin Ligands and Regulate Excitatory Synapse Development

O'Sullivan, M. L., de Wit, J., Savas, J. N., Comoletti, D., Otto-Hitt, S., Yates, J. R. & Ghosh, A., Mar 8 2012, In : Neuron. 73, 5, p. 903-910 8 p.

Research output: Contribution to journalArticle

121 Scopus citations

Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis

Culver, B. P., Savas, J. N., Park, S. K., Choi, J. H., Zheng, S., Zeitlin, S. O., Yates, J. R. & Tanese, N., Jun 22 2012, In : Journal of Biological Chemistry. 287, 26, p. 21599-21614 16 p.

Research output: Contribution to journalArticle

57 Scopus citations

Quantitative analysis of BDNF/TrkB protein and mRNA in cortical and striatal neurons using α-tubulin as a normalization factor

Ma, B., Savas, J. N., Chao, M. V. & Tanese, N., Aug 1 2012, In : Cytometry Part A. 81 A, 8, p. 704-717 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway

Jeong, H., Cohen, D. E., Cui, L., Supinski, A., Savas, J. N., Mazzulli, J. R., Yates, J. R., Bordone, L., Guarente, L. & Krainc, D., Jan 1 2012, In : Nature Medicine. 18, 1, p. 159-165 7 p.

Research output: Contribution to journalArticle

205 Scopus citations
2011

Huntingtin mediates dendritic transport of β-actin mRNA in rat neurons

Ma, B., Savas, J. N., Yu, M. S., Culver, B. P., Chao, M. V. & Tanese, N., Dec 1 2011, In : Scientific reports. 1, 140.

Research output: Contribution to journalArticle

28 Scopus citations

Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP

Mita, P., Savas, J. N., Djouder, N., Yates, J. R., Ha, S., Ruoff, R., Schafler, E. D., Nwachukwu, J. C., Tanese, N., Cowan, N. J., Zavadil, J., Garabedian, M. J. & Logan, S. K., Sep 1 2011, In : Molecular and cellular biology. 31, 17, p. 3639-3652 14 p.

Research output: Contribution to journalArticle

26 Scopus citations
2010
3 Scopus citations

A role for Huntington disease protein in dendritic RNA granules

Savas, J. N., Ma, B., Deinhardt, K., Culver, B. P., Restituito, S., Wu, L., Belasco, J. G., Chao, M. V. & Tanese, N., Apr 23 2010, In : Journal of Biological Chemistry. 285, 17, p. 13142-13153 12 p.

Research output: Contribution to journalArticle

45 Scopus citations

Progressive accumulation of amyloid-β oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins

Pham, E., Crews, L., Ubhi, K., Hansen, L., Adame, A., Cartier, A., Salmon, D., Galasko, D., Michael, S., Savas, J. N., Yates, J. R., Glabe, C. & Masliah, E., Jul 1 2010, In : FEBS Journal. 277, 14, p. 3051-3067 17 p.

Research output: Contribution to journalArticle

133 Scopus citations
2009

Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation

Jeong, H., Then, F., Melia, T. J., Mazzulli, J. R., Cui, L., Savas, J. N., Voisine, C., Paganetti, P., Tanese, N., Hart, A. C., Yamamoto, A. & Krainc, D., Apr 3 2009, In : Cell. 137, 1, p. 60-72 13 p.

Research output: Contribution to journalArticle

266 Scopus citations

LRRTM2 Interacts with Neurexin1 and Regulates Excitatory Synapse Formation

de Wit, J., Sylwestrak, E., O'Sullivan, M. L., Otto, S., Tiglio, K., Savas, J. N., Yates, J. R., Comoletti, D., Taylor, P. & Ghosh, A., Dec 24 2009, In : Neuron. 64, 6, p. 799-806 8 p.

Research output: Contribution to journalArticle

256 Scopus citations