No photo of Jennifer A Kearney

View Scopus Profile

Jennifer A Kearney

  • 2333 Citations
1995 …2024

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research Interests

Research in my laboratory is focused on studying genetic modifiers that influence the clinical severity of epilepsy. Variable expressivity is a common feature in patients with epilepsy caused by sodium channel mutations, and family members carrying the same mutation often exhibit differences in the clinical severity of epilepsy. Similarly, mouse models with mutations in voltage-gated sodium channels have a variable epilepsy phenotype depending on their genetic background. We use genetic and genomic approaches to identify modifier genes that contribute to phenotype variability in mouse models and also investigate whether the same genes contribute to epilepsy risk in patients. We then use neurophysiological approaches to study the mechanisms underlying phenotype modification. Isolation of epilepsy modifier genes will contribute to our understanding of the molecular basis of epilepsy and may suggest novel targets for improved treatment of human epilepsy.

Training Experience

2002Postdoctoral Fellowship, University of Michigan

Education/Academic qualification

PhD, University of Michigan

… → 1997

Research interests

  • Epilepsy
  • Genetics
  • Genomics
  • Neuroscience
  • Pharmacology

Fingerprint Dive into the research topics where Jennifer A Kearney is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 20 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants

MicroRNA-mediated modification of Dravet syndrome

Kearney, J. A.

Dravet Syndrome Foundation, Inc.

1/1/20 → 12/31/21

Project: Research project

    • Cajal-Retzius cells and neuronal signaling in postnatal cortical networks

    Kearney, J. A. & Maccaferri, G.

    National Institute of Neurological Disorders and Stroke

    4/15/19 → 3/31/24

    Project: Research project

    • Compound Evaluation in Scn2aQ54 Mice

    Hawkins, N. A. & Kearney, J. A.

    Praxis Precision Medicines, Inc.

    12/9/18 → 6/12/20

    Project: Research project

    • Development and investigation of murine models of channelopathy-associated epilepsy

    Hawkins, N. A., Kearney, J. A. & Thompson, C. H.

    National Institute of Neurological Disorders and Stroke

    9/30/18 → 8/31/23

    Project: Research project

    • Animal Models for SCN2A Neurodevelopmental Disorders

    Hawkins, N. A., Kearney, J. A. & Thompson, C. H.

    Office of the Director, National Institutes of Health

    8/1/18 → 7/31/20

    Project: Research project

    • Research Output

    • 2333 Citations
    • 53 Article
    • 11 Comment/debate
    • 6 Review article
    • 1 Chapter

    Epilepsy Benchmarks Area IV: Limit or Prevent Adverse Consequence of Seizures and Their Treatment Across the Life Span

    for the NINDS/AES Benchmarks Stewards Committee, Jan 1 2020, In : Epilepsy Currents. 20, 1_suppl, p. 31S-39S

    Research output: Contribution to journal › Review article

    Open Access

    • C57BL/6J and C57BL/6N substrains differentially influence phenotype severity in the Scn1a+/− mouse model of Dravet syndrome

    Kang, S. K., Hawkins, N. A. & Kearney, J. A., Mar 2019, In : Epilepsia Open. 4, 1, p. 164-169 6 p.

    Research output: Contribution to journal › Article

    Open Access

    • Gene expression profiling in a mouse model of Dravet syndrome

    Hawkins, N. A., Calhoun, J. D., Huffman, A. M. & Kearney, J. A., Jan 2019, In : Experimental Neurology. 311, p. 247-256 10 p.

    Research output: Contribution to journal › Article

    • 4 Scopus citations

    Potentiating a2 subunit containing perisomatic GABAA receptors protects against seizures in a mouse model of Dravet syndrome

    Nomura, T., Hawkins, N. A., Kearney, J. A., George, A. L. & Contractor, A., Jan 1 2019, In : Journal of Physiology. 597, 16, p. 4293-4307 15 p.

    Research output: Contribution to journal › Article

    • 2 Scopus citations

    Spectrum of KV2.1 Dysfunction in KCNB1-Associated Neurodevelopmental Disorders

    Kang, S. K., Vanoye, C. G., Misra, S. N., Echevarria, D. M., Calhoun, J. D., O'Connor, J. B., Fabre, K. L., McKnight, D., Demmer, L., Goldenberg, P., Grote, L. E., Thiffault, I., Saunders, C., Strauss, K. A., Torkamani, A., van der Smagt, J., van Gassen, K., Carson, R. P., Diaz, J., Leon, E. & 12 others, Jacher, J. E., Hannibal, M. C., Litwin, J., Friedman, N. R., Schreiber, A., Lynch, B., Poduri, A., Marsh, E. D., Goldberg, E. M., Millichap, J. J., George, A. L. & Kearney, J. A., Dec 1 2019, In : Annals of neurology. 86, 6, p. 899-912 14 p.

    Research output: Contribution to journal › Article

    • 2 Scopus citations