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Personal profile

Research Interests

Research in my laboratory is focused on studying genetic modifiers that influence the clinical severity of epilepsy. Variable expressivity is a common feature in patients with epilepsy caused by sodium channel mutations, and family members carrying the same mutation often exhibit differences in the clinical severity of epilepsy. Similarly, mouse models with mutations in voltage-gated sodium channels have a variable epilepsy phenotype depending on their genetic background. We use genetic and genomic approaches to identify modifier genes that contribute to phenotype variability in mouse models and also investigate whether the same genes contribute to epilepsy risk in patients. We then use neurophysiological approaches to study the mechanisms underlying phenotype modification. Isolation of epilepsy modifier genes will contribute to our understanding of the molecular basis of epilepsy and may suggest novel targets for improved treatment of human epilepsy.

Training Experience

2002Postdoctoral Fellowship, University of Michigan

Education/Academic qualification

PhD, University of Michigan

… → 1997

Research interests

  • Epilepsy
  • Genetics
  • Genomics
  • Neuroscience
  • Pharmacology

Fingerprint Dive into the research topics where Jennifer A Kearney is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 20 Similar Profiles
Epilepsy Medicine & Life Sciences
Myoclonic Epilepsy Medicine & Life Sciences
Sodium Channels Medicine & Life Sciences
Mutation Medicine & Life Sciences
Seizures Medicine & Life Sciences
Voltage-Gated Sodium Channels Medicine & Life Sciences
Brain Diseases Medicine & Life Sciences
Phenotype Medicine & Life Sciences

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Grants 2014 2024

Febrile Seizures
Hippocampus
Vesicular Glutamate Transport Proteins
Physiological Phenomena
Temperature
Epilepsy
Seizures
Sodium
Mutation
Animal Models
Epilepsy
Phenotype
Intellectual Disability
Brain Diseases
Therapeutic Uses
Brain Stem
Seizures

Research Output 1995 2019

  • 2233 Citations
  • 52 Article
  • 11 Comment/debate
  • 5 Review article
  • 1 Chapter
Open Access
Myoclonic Epilepsy
Phenotype
Seizures
Inbred C57BL Mouse
Induced Hyperthermia
2 Citations (Scopus)

Gene expression profiling in a mouse model of Dravet syndrome

Hawkins, N. A., Calhoun, J. D., Huffman, A. M. & Kearney, J. A., Jan 1 2019, In : Experimental Neurology. 311, p. 247-256 10 p.

Research output: Contribution to journalArticle

Myoclonic Epilepsy
Gene Expression Profiling
Seizures
Gene Expression
Phenotype
1 Citation (Scopus)
Myoclonic Epilepsy
GABA-A Receptors
Seizures
Inhibitory Postsynaptic Potentials
Hypnotics and Sedatives
Developmental Genes
Brain Diseases
Mutation
10 Citations (Scopus)

A transient developmental window of fast-spiking interneuron dysfunction in a mouse model of dravet syndrome

Favero, M., Sotuyo, N. P., Lopez, E., Kearney, J. A. & Goldberg, E. M., Sep 5 2018, In : Journal of Neuroscience. 38, 36, p. 7912-7927 16 p.

Research output: Contribution to journalArticle

Myoclonic Epilepsy
Interneurons
Epilepsy
Action Potentials
Voltage-Gated Sodium Channels