Grants per year
Personal profile
Research Interests
Research in my laboratory is focused on studying genetic modifiers that influence the clinical severity of epilepsy. Variable expressivity is a common feature in patients with epilepsy caused by sodium channel mutations, and family members carrying the same mutation often exhibit differences in the clinical severity of epilepsy. Similarly, mouse models with mutations in voltage-gated sodium channels have a variable epilepsy phenotype depending on their genetic background. We use genetic and genomic approaches to identify modifier genes that contribute to phenotype variability in mouse models and also investigate whether the same genes contribute to epilepsy risk in patients. We then use neurophysiological approaches to study the mechanisms underlying phenotype modification. Isolation of epilepsy modifier genes will contribute to our understanding of the molecular basis of epilepsy and may suggest novel targets for improved treatment of human epilepsy.
Training Experience
| 2002 | Postdoctoral Fellowship, University of Michigan |
Education/Academic qualification
PhD, University of Michigan
… → 1997
Research interests
- Epilepsy
- Genetics
- Genomics
- Neuroscience
- Pharmacology
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Grants
CardioExcyte 96 System for Pharmacology Research at Northwestern University
Abdulkadir, S. A., Ardehali, H., Arora, R. K., Burridge, P., George Jr, A. L., Kearney, J. A., McNally, E. M., Schiltz, G. E., Silverman, R. B., Watterson, D. M. & Wilsbacher, L. D.
6/15/20 → 6/14/21
Project: Research project
Genetic Modifiers of Childhood Epilepsy
Hawkins, N. A. & Kearney, J. A.
National Institute of Neurological Disorders and Stroke
4/1/20 → 12/31/24
Project: Research project
MicroRNA-mediated modification of Dravet syndrome
Dravet Syndrome Foundation, Inc.
1/1/20 → 12/31/21
Project: Research project
Cajal-Retzius cells and neuronal signaling in postnatal cortical networks
Kearney, J. A. & Maccaferri, G.
National Institute of Neurological Disorders and Stroke
4/15/19 → 3/31/24
Project: Research project
Compound Evaluation in Scn2aQ54 Mice
Hawkins, N. A. & Kearney, J. A.
Praxis Precision Medicines, Inc.
12/9/18 → 6/12/20
Project: Research project
Research Output
CACNA1H variants are not a cause of monogenic epilepsy
Calhoun, J. D., Huffman, A. M., Bellinski, I., Kinsley, L., Bachman, E., Gerard, E., Kearney, J. A. & Carvill, G. L., Jun 1 2020, In : Human mutation. 41, 6, p. 1138-1144 7 p.Research output: Contribution to journal › Article
Open Access
Epilepsy Benchmarks Area IV: Limit or Prevent Adverse Consequence of Seizures and Their Treatment Across the Life Span
for the NINDS/AES Benchmarks Stewards Committee, Jan 1 2020, In : Epilepsy Currents. 20, 1_suppl, p. 31S-39SResearch output: Contribution to journal › Review article
Open Access
C57BL/6J and C57BL/6N substrains differentially influence phenotype severity in the Scn1a+/− mouse model of Dravet syndrome
Kang, S. K., Hawkins, N. A. & Kearney, J. A., Mar 2019, In : Epilepsia Open. 4, 1, p. 164-169 6 p.Research output: Contribution to journal › Article
Open Access
2
Scopus
citations
Gene expression profiling in a mouse model of Dravet syndrome
Hawkins, N. A., Calhoun, J. D., Huffman, A. M. & Kearney, J. A., Jan 2019, In : Experimental Neurology. 311, p. 247-256 10 p.Research output: Contribution to journal › Article
5
Scopus
citations
Potentiating a2 subunit containing perisomatic GABAA receptors protects against seizures in a mouse model of Dravet syndrome
Nomura, T., Hawkins, N. A., Kearney, J. A., George, A. L. & Contractor, A., Jan 1 2019, In : Journal of Physiology. 597, 16, p. 4293-4307 15 p.Research output: Contribution to journal › Article
3
Scopus
citations