Grants per year
Personal profile
Research Interests
Research in my laboratory is focused on studying genetic modifiers that influence the clinical severity of epilepsy. Variable expressivity is a common feature in patients with epilepsy caused by sodium channel mutations, and family members carrying the same mutation often exhibit differences in the clinical severity of epilepsy. Similarly, mouse models with mutations in voltage-gated sodium channels have a variable epilepsy phenotype depending on their genetic background. We use genetic and genomic approaches to identify modifier genes that contribute to phenotype variability in mouse models and also investigate whether the same genes contribute to epilepsy risk in patients. We then use neurophysiological approaches to study the mechanisms underlying phenotype modification. Isolation of epilepsy modifier genes will contribute to our understanding of the molecular basis of epilepsy and may suggest novel targets for improved treatment of human epilepsy.
Training Experience
2002 | Postdoctoral Fellowship, University of Michigan |
Education/Academic qualification
PhD, Neuroscience, University of Michigan
… → 1997
Research interests keywords
- Epilepsy
- Genetics
- Genomics
- Neuroscience
- Pharmacology
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
Genetic Mapping of Modifier Loci in a Mouse Model KCNB1 Encephalopathy
Kearney, J. A. & Hawkins, N. A.
National Institute of Neurological Disorders and Stroke
7/15/23 → 6/30/25
Project: Research project
-
SyncroPatch 384 Automated Patch Clamp Instrument
George, A. L., Burridge, P., DeCaen, P. G., Horvath, C. M., Kearney, J. A., Kiskinis, E., McNally, E. M., Miller, R. J., Prakriya, M., Smith, R. S., Surmeier Jr, D. J. & Vanoye, C. G.
Office of the Director, National Institutes of Health
3/1/23 → 2/29/24
Project: Research project
-
-
Subacute Dosing - Effect on spontaneous seizures and survival in Scn1a+/- Dravet Mice
Kearney, J. A. & Kearney, J. A.
Praxis Precision Medicines, Inc.
10/1/21 → 4/30/24
Project: Research project
-
Heterozygous deletion of Gpr55 does not affect a hyperthermia-induced seizure, spontaneous seizures or survival in the Scn1a+/- mouse model of Dravet syndrome
Anderson, L. L., Bahceci, D. A., Hawkins, N. A., Everett-Morgan, D., Banister, S. D., Kearney, J. A. & Arnold, J. C., Jan 2023, In: PloS one. 18, 1 January, e0280842.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Sex and Gene Influence Arrhythmia Susceptibility in Murine Models of Calmodulinopathy
Wren, L. M., Dekeyser, J. M., Barefield, D. Y., Hawkins, N. A., McNally, E. M., Kearney, J. A., Wasserstrom, J. A. & George, A. L., Sep 1 2023, In: Circulation: Arrhythmia and Electrophysiology. 16, 9, p. E010891Research output: Contribution to journal › Article › peer-review
-
Cell-Selective Adeno-Associated Virus-Mediated SCN1A Gene Regulation Therapy Rescues Mortality and Seizure Phenotypes in a Dravet Syndrome Mouse Model and Is Well Tolerated in Nonhuman Primates
Tanenhaus, A., Stowe, T., Young, A., McLaughlin, J., Aeran, R., Lin, I. W., Li, J., Hosur, R., Chen, M., Leedy, J., Chou, T., Pillay, S., Vila, M. C., Kearney, J. A., Moorhead, M., Belle, A. & Tagliatela, S., Jun 1 2022, In: Human Gene Therapy. 33, 11-12, p. 579-597 19 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Cellular and behavioral effects of altered NaV1.2 sodium channel ion permeability in Scn2aK1422Emice
Echevarria-Cooper, D. M., Hawkins, N. A., Misra, S. N., Huffman, A. M., Thaxton, T., Thompson, C. H., Ben-Shalom, R., Nelson, A. D., Lipkin, A. M., George, A. L., Bender, K. J. & Kearney, J. A., Sep 1 2022, In: Human molecular genetics. 31, 17, p. 2964-2988 25 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Fine mapping and candidate gene analysis of a dravet syndrome modifier locus on mouse chromosome 11
Kearney, J. A., Copeland-Hardin, L. D., Duarte, S., Zachwieja, N. A., Eckart-Frank, I. K. & Hawkins, N. A., Dec 2022, In: Mammalian Genome. 33, 4, p. 565-574 10 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Datasets
-
Evaluating the interplay between estrous cyclicity and flurothyl-induced seizure susceptibility in Scn2aK1422E mice - Supplementary Table S1
Echevarria-Cooper, D. M. (Creator) & Kearney, J. A. (Creator), Prism. Galter Health Sciences Library. Northwestern University, 2023
DOI: 10.18131/pvcx7-p9x63, https://prism.northwestern.edu/doi/10.18131/pvcx7-p9x63
Dataset
-
Strain-dependent effects on neurobehavioral and seizure phenotypes in Scn2a-K1422E mice
Echevarria-Cooper, D. M. (Creator), Hawkins, N. A. (Creator) & Kearney, J. A. (Creator), Prism. Galter Health Sciences Library. Northwestern University, 2023
DOI: 10.18131/wvn4p-y4z74, https://prism.northwestern.edu/doi/10.18131/wvn4p-y4z74
Dataset
-
Evaluating the interplay between estrous cyclicity and induced seizure susceptibility in Scn2aK1422E mice - Supplementary Table S1
Echevarria-Cooper, D. M. (Creator) & Kearney, J. A. (Creator), Prism. Galter Health Sciences Library. Northwestern University, 2023
DOI: 10.18131/ft2vx-bw849, https://prism.northwestern.edu/doi/10.18131/ft2vx-bw849
Dataset