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Research Output

  • 2342 Citations
  • 53 Article
  • 11 Comment/debate
  • 6 Review article
  • 1 Chapter
2020

Epilepsy Benchmarks Area IV: Limit or Prevent Adverse Consequence of Seizures and Their Treatment Across the Life Span

for the NINDS/AES Benchmarks Stewards Committee, Jan 1 2020, In : Epilepsy Currents. 20, 1_suppl, p. 31S-39S

Research output: Contribution to journalReview article

Open Access
2019
Open Access
1 Scopus citations

Gene expression profiling in a mouse model of Dravet syndrome

Hawkins, N. A., Calhoun, J. D., Huffman, A. M. & Kearney, J. A., Jan 2019, In : Experimental Neurology. 311, p. 247-256 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
2 Scopus citations

Spectrum of KV2.1 Dysfunction in KCNB1-Associated Neurodevelopmental Disorders

Kang, S. K., Vanoye, C. G., Misra, S. N., Echevarria, D. M., Calhoun, J. D., O'Connor, J. B., Fabre, K. L., McKnight, D., Demmer, L., Goldenberg, P., Grote, L. E., Thiffault, I., Saunders, C., Strauss, K. A., Torkamani, A., van der Smagt, J., van Gassen, K., Carson, R. P., Diaz, J., Leon, E. & 12 others, Jacher, J. E., Hannibal, M. C., Litwin, J., Friedman, N. R., Schreiber, A., Lynch, B., Poduri, A., Marsh, E. D., Goldberg, E. M., Millichap, J. J., George, A. L. & Kearney, J. A., Dec 1 2019, In : Annals of neurology. 86, 6, p. 899-912 14 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

A transient developmental window of fast-spiking interneuron dysfunction in a mouse model of dravet syndrome

Favero, M., Sotuyo, N. P., Lopez, E., Kearney, J. A. & Goldberg, E. M., Sep 5 2018, In : Journal of Neuroscience. 38, 36, p. 7912-7927 16 p.

Research output: Contribution to journalArticle

17 Scopus citations

Expanding the zebrafish toolkit for epilepsy research

Kearney, J. A., Jan 1 2018, In : Epilepsy Currents. 18, 1, p. 56-58 3 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy

Xu, D., Robinson, A. P., Ishii, T., Duncan, DA. S., Alden, T. D., Goings, G. E., Ifergan, I., Podojil, J. R., Penaloza-MacMaster, P., Kearney, J. A., Swanson, G. T., Miller, S. D. & Koh, S., Apr 1 2018, In : Journal of Experimental Medicine. 215, 4, p. 1169-1186 18 p.

Research output: Contribution to journalArticle

10 Scopus citations

The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy

Baker, E. M., Thompson, C. H., Hawkins, N. A., Wagnon, J. L., Wengert, E. R., Patel, M. K., George, A. L., Meisler, M. H. & Kearney, J. A., Jun 2018, In : Epilepsia. 59, 6, p. 1166-1176 11 p.

Research output: Contribution to journalArticle

15 Scopus citations
2017

A look behind the curtain: Epilepsy microarray consortium

Kearney, J. A., Jan 1 2017, In : Epilepsy Currents. 17, 6, p. 374-376 3 p.

Research output: Contribution to journalComment/debate

Cacna1g is a genetic modifier of epilepsy in a mouse model of Dravet syndrome

Calhoun, J. D., Hawkins, N. A., Zachwieja, N. J. & Kearney, J. A., Aug 1 2017, In : Epilepsia. 58, 8, p. e111-e115

Research output: Contribution to journalArticle

12 Scopus citations
10 Scopus citations

Precision medicine: NMDA receptor-targeted therapy for GRIN2D encephalopathy

Kearney, J. A., Jan 1 2017, In : Epilepsy Currents. 17, 2, p. 112-114 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

SCN3A deficiency associated with increased seizure susceptibility

Lamar, T., Vanoye, C. G., Calhoun, J., Wong, J. C., Dutton, S. B. B., Jorge, B. S., Velinov, M., Escayg, A. & Kearney, J. A., Jun 1 2017, In : Neurobiology of Disease. 102, p. 38-48 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Sodium channel β subunits in epilepsy: Location, location, location

Kearney, J. A., Jan 1 2017, In : Epilepsy Currents. 17, 1, p. 52-53 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

The big picture: Systems biology approach to antiepileptic drug discovery

Kearney, J. A., Jul 1 2017, In : Epilepsy Currents. 17, 4, p. 232-234 3 p.

Research output: Contribution to journalArticle

The synthetic neuroactive steroid SGE-516 reduces seizure burden and improves survival in a Dravet syndrome mouse model

Hawkins, N. A., Lewis, M., Hammond, R. S., Doherty, J. J. & Kearney, J. A., Dec 1 2017, In : Scientific reports. 7, 1, 15327.

Research output: Contribution to journalArticle

2 Scopus citations

Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome

Anderson, L. L., Hawkins, N. A., Thompson, C. H., Kearney, J. A. & George, A. L., Dec 1 2017, In : Scientific reports. 7, 1, 1682.

Research output: Contribution to journalArticle

24 Scopus citations
2016

Cacna1g is a genetic modifier of epilepsy caused by mutation of voltage-gated sodium channel Scn2a

Calhoun, J. D., Hawkins, N. A., Zachwieja, N. J. & Kearney, J. A., Jun 1 2016, In : Epilepsia. 57, 6, p. e103-e107

Research output: Contribution to journalArticle

14 Scopus citations

Cannabidiol mellows out resurgent sodium current

Thompson, C. H. & Kearney, J. A., Jan 1 2016, In : Epilepsy Currents. 16, 6, p. 399-401 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Fine Mapping of a Dravet Syndrome Modifier Locus on Mouse Chromosome 5 and Candidate Gene Analysis by RNA-Seq

Hawkins, N. A., Zachwieja, N. J., Miller, A. R., Anderson, L. L. & Kearney, J. A., Oct 2016, In : PLoS genetics. 12, 10, e1006398.

Research output: Contribution to journalArticle

25 Scopus citations

Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations

Hawkins, N. A. & Kearney, J. A., Jan 1 2016, In : Epilepsy Research. 119, p. 20-23 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Locus heterogeneity in epilepsy of infancy with migrating focal seizures

Kearney, J. A., Jan 1 2016, In : Epilepsy Currents. 16, 1, p. 43-45 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

When inhibiting repetitive firing is pro-epileptic

Kearney, J. A., Mar 1 2016, In : Epilepsy Currents. 16, 2, p. 114-115 2 p.

Research output: Contribution to journalComment/debate

2015

Synaptopathies heat up: Mutations in STX1B in fever-associated epilepsies

Kearney, J. A., Jan 1 2015, In : Epilepsy Currents. 15, 3, p. 138-139 2 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

TALE of an SCN8A-associated epileptic encephalopathy mouse model

Kearney, J. A., Jan 1 2015, In : Epilepsy Currents. 15, 2, p. 83-84 2 p.

Research output: Contribution to journalComment/debate

Watch out, no brakes! impaired inhibition results in hyperexcitable networks

Thompson, C. H. & Kearney, J. A., Jan 1 2015, In : Epilepsy Currents. 15, 6, p. 342-343 2 p.

Research output: Contribution to journalArticle

2014

Antiepileptic activity of preferential inhibitors of persistent sodium current

Anderson, L. L., Thompson, C. H., Hawkins, N. A., Nath, R. D., Petersohn, A. A., Rajamani, S., Bush, W. S., Frankel, W. N., Vanoye, C. G., Kearney, J. A. & George, A. L., Aug 2014, In : Epilepsia. 55, 8, p. 1274-1283 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

De novo KCNB1 mutations in epileptic encephalopathy

Torkamani, A., Bersell, K., Jorge, B. S., Bjork, R. L., Friedman, J. R., Bloss, C. S., Cohen, J., Gupta, S., Naidu, S., Vanoye, C. G., George, A. L. & Kearney, J. A., Oct 1 2014, In : Annals of neurology. 76, 4, p. 529-540 12 p.

Research output: Contribution to journalArticle

63 Scopus citations

Double trouble: Impairment of two interneuron types in a dravet mouse model

Kearney, J. A., Jan 1 2014, In : Epilepsy Currents. 15, 1, p. 47-49 3 p.

Research output: Contribution to journalComment/debate

Epi4K phase I: Gene discovery in epileptic encephalopathies by exome sequencing

Kearney, J. A., Jan 1 2014, In : Epilepsy Currents. 14, 4, p. 208-210 3 p.

Research output: Contribution to journalArticle

6 Scopus citations

Mapping genetic modifiers of survival in a mouse model of Dravet syndrome

Miller, A. R., Hawkins, N. A., Mccollom, C. E. & Kearney, J. A., Feb 1 2014, In : Genes, Brain and Behavior. 13, 2, p. 163-172 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Novel SCN3A variants associated with focal epilepsy in children

Vanoye, C. G., Gurnett, C. A., Holland, K. D., George, A. L. & Kearney, J. A., Feb 2014, In : Neurobiology of Disease. 62, p. 313-322 10 p.

Research output: Contribution to journalArticle

41 Scopus citations
64 Scopus citations

The more, the better: Modeling dravet syndrome with induced pluripotent stem cell-derived neurons

Kearney, J., 2014, In : Epilepsy Currents. 14, 1, p. 33-34 2 p.

Research output: Contribution to journalComment/debate

2 Scopus citations
2013

A mutation hot-spot for benign infantile epilepsy

Kearney, J., Jan 1 2013, In : Epilepsy Currents. 13, 1, p. 20-21 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Cognitive and social impairment in mouse models mirrors dravet syndrome

Kearney, J. A., Jul 24 2013, In : Epilepsy Currents. 13, 2, p. 97-99 3 p.

Research output: Contribution to journalArticle

Less is more: Reducing tau ameliorates seizures in epilepsy models

Kearney, J. A., Nov 1 2013, In : Epilepsy Currents. 13, 4, p. 184-185 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Sudden unexpected death in Dravet syndrome

Kearney, J., Nov 1 2013, In : Epilepsy Currents. 13, 6, p. 264-265 2 p.

Research output: Contribution to journalComment/debate

3 Scopus citations

Voltage-gated ion channel accessory subunits: Sodium, potassium, or both?

Kearney, J., Jan 1 2013, In : Epilepsy Currents. 13, 1, p. 30-31 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations
2012

Advances in epilepsy genetics and genomics

Kearney, J. A., Jul 1 2012, In : Epilepsy Currents. 12, 4, p. 143-146 4 p.

Research output: Contribution to journalArticle

8 Scopus citations
17 Scopus citations
2011

Genetic modifiers of neurological disease

Kearney, J. A., Jun 1 2011, In : Current Opinion in Genetics and Development. 21, 3, p. 349-353 5 p.

Research output: Contribution to journalReview article

22 Scopus citations

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus

Hawkins, N. A., Martin, M. S., Frankel, W. N., Kearney, J. A. & Escayg, A., Mar 1 2011, In : Neurobiology of Disease. 41, 3, p. 655-660 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Voltage-gated potassium channel KCNV2 (Kv8.2) contributes to epilepsy susceptibility

Jorge, B. S., Campbell, C. M., Miller, A. R., Rutter, E. D., Gurnett, C. A., Vanoye, C. G., George, A. L. & Kearney, J. A., Mar 29 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 13, p. 5443-5448 6 p.

Research output: Contribution to journalArticle

37 Scopus citations
2010

Propranolol blocks cardiac and neuronal voltage-gated sodium channels

Wang, D. W., Mistry, A. M., Kahlig, K. M., Kearney, J. A., Xiang, J. & George, A. L., Dec 1 2010, In : Frontiers in Pharmacology. DEC, Article 144.

Research output: Contribution to journalArticle

47 Scopus citations
2009

Fine mapping of an epilepsy modifier gene on mouse Chromosome 19

Bergren, S. K., Rutter, E. D. & Kearney, J. A., Jun 1 2009, In : Mammalian Genome. 20, 6, p. 359-366 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Genetics: Single Gene Mutations in Inherited and Sporadic Epilepsy

Kearney, J. A. & Meisler, M., Jan 1 2009, Encyclopedia of Basic Epilepsy Research. Elsevier Inc, p. 369-374 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations