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Research Output 1995 2019

  • 2129 Citations
  • 52 Article
  • 11 Comment/debate
  • 5 Review article
2019
Open Access
Myoclonic Epilepsy
Phenotype
Seizures
Inbred C57BL Mouse
Induced Hyperthermia
1 Citation (Scopus)

Gene expression profiling in a mouse model of Dravet syndrome

Hawkins, N. A., Calhoun, J. D., Huffman, A. M. & Kearney, J. A., Jan 1 2019, In : Experimental Neurology. 311, p. 247-256 10 p.

Research output: Contribution to journalArticle

Myoclonic Epilepsy
Gene Expression Profiling
Seizures
Gene Expression
Phenotype
Myoclonic Epilepsy
GABA-A Receptors
Seizures
Inhibitory Postsynaptic Potentials
Hypnotics and Sedatives
2018
Developmental Genes
Brain Diseases
Mutation
4 Citations (Scopus)

A transient developmental window of fast-spiking interneuron dysfunction in a mouse model of dravet syndrome

Favero, M., Sotuyo, N. P., Lopez, E., Kearney, J. A. & Goldberg, E. M., Sep 5 2018, In : Journal of Neuroscience. 38, 36, p. 7912-7927 16 p.

Research output: Contribution to journalArticle

Myoclonic Epilepsy
Interneurons
Epilepsy
Action Potentials
Voltage-Gated Sodium Channels
1 Citation (Scopus)

Expanding the zebrafish toolkit for epilepsy research

Kearney, J. A., Jan 1 2018, In : Epilepsy Currents. 18, 1, p. 56-58 3 p.

Research output: Contribution to journalComment/debate

Zebrafish
Epilepsy
Research
5 Citations (Scopus)

Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy

Xu, D., Robinson, A. P., Ishii, T., Duncan, DA. S., Alden, T. D., Goings, G. E., Ifergan, I., Podojil, J. R., Penaloza-MacMaster, P., Kearney, J. A., Swanson, G. T., Miller, S. D. & Koh, S., Apr 1 2018, In : Journal of Experimental Medicine. 215, 4, p. 1169-1186 18 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Interleukin-17
Granulocyte-Macrophage Colony-Stimulating Factor
Pediatrics
T-Lymphocytes
5 Citations (Scopus)

The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy

Baker, E. M., Thompson, C. H., Hawkins, N. A., Wagnon, J. L., Wengert, E. R., Patel, M. K., George Jr, A. L., Meisler, M. H. & Kearney, J. A., Jun 1 2018, In : Epilepsia. 59, 6, p. 1166-1176 11 p.

Research output: Contribution to journalArticle

Sodium Channels
Brain Diseases
Sodium
Seizures
Phenytoin
2017

A look behind the curtain: Epilepsy microarray consortium

Kearney, J. A., Jan 1 2017, In : Epilepsy Currents. 17, 6, p. 374-376 3 p.

Research output: Contribution to journalComment/debate

Status Epilepticus
Epilepsy
Pilocarpine
Kainic Acid
Amygdala
7 Citations (Scopus)

Cacna1g is a genetic modifier of epilepsy in a mouse model of Dravet syndrome

Calhoun, J. D., Hawkins, N. A., Zachwieja, N. J. & Kearney, J. A., Aug 1 2017, In : Epilepsia. 58, 8, p. e111-e115

Research output: Contribution to journalArticle

Myoclonic Epilepsy
Epilepsy
Phenotype
Seizures
T-Type Calcium Channels
9 Citations (Scopus)
Calcium-Calmodulin-Dependent Protein Kinases
Protein Kinases
Sodium
Epilepsy
Neurons
1 Citation (Scopus)

Precision medicine: NMDA receptor-targeted therapy for GRIN2D encephalopathy

Kearney, J. A., Jan 1 2017, In : Epilepsy Currents. 17, 2, p. 112-114 3 p.

Research output: Contribution to journalArticle

Precision Medicine
Brain Diseases
N-Methyl-D-Aspartate Receptors
Mutation
Epilepsy
8 Citations (Scopus)

SCN3A deficiency associated with increased seizure susceptibility

Lamar, T., Vanoye, C. G., Calhoun, J., Wong, J. C., Dutton, S. B. B., Jorge, B. S., Velinov, M., Escayg, A. & Kearney, J. A., Jun 1 2017, In : Neurobiology of Disease. 102, p. 38-48 11 p.

Research output: Contribution to journalArticle

Seizures
Partial Epilepsy
Mutation
Epilepsy
Flurothyl
Myoclonic Epilepsy
Genetic Models
Anticonvulsants
Epilepsy
Seizures
1 Citation (Scopus)

Sodium channel β subunits in epilepsy: Location, location, location

Kearney, J. A., Jan 1 2017, In : Epilepsy Currents. 17, 1, p. 52-53 2 p.

Research output: Contribution to journalArticle

Sodium Channels
Epilepsy

The big picture: Systems biology approach to antiepileptic drug discovery

Kearney, J. A., Jul 1 2017, In : Epilepsy Currents. 17, 4, p. 232-234 3 p.

Research output: Contribution to journalArticle

Systems Biology
Drug Discovery
Anticonvulsants
1 Citation (Scopus)

The synthetic neuroactive steroid SGE-516 reduces seizure burden and improves survival in a Dravet syndrome mouse model

Hawkins, N. A., Lewis, M., Hammond, R. S., Doherty, J. J. & Kearney, J. A., Dec 1 2017, In : Scientific Reports. 7, 1, 15327.

Research output: Contribution to journalArticle

Myoclonic Epilepsy
Seizures
Steroids
Benzodiazepines
Induced Hyperthermia
18 Citations (Scopus)

Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome

Anderson, L. L., Hawkins, N. A., Thompson, C. H., Kearney, J. A. & George Jr, A. L., Dec 1 2017, In : Scientific Reports. 7, 1, 1682.

Research output: Contribution to journalArticle

Myoclonic Epilepsy
Sodium Channels
Pyramidal Cells
Sodium Channel Blockers
Sodium
2016
12 Citations (Scopus)

Cacna1g is a genetic modifier of epilepsy caused by mutation of voltage-gated sodium channel Scn2a

Calhoun, J. D., Hawkins, N. A., Zachwieja, N. J. & Kearney, J. A., Jun 1 2016, In : Epilepsia. 57, 6, p. e103-e107

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channels
Modifier Genes
Epilepsy
Seizures
Mutation
1 Citation (Scopus)

Cannabidiol mellows out resurgent sodium current

Thompson, C. H. & Kearney, J. A., Jan 1 2016, In : Epilepsy Currents. 16, 6, p. 399-401 3 p.

Research output: Contribution to journalArticle

Cannabidiol
Sodium
19 Citations (Scopus)

Fine Mapping of a Dravet Syndrome Modifier Locus on Mouse Chromosome 5 and Candidate Gene Analysis by RNA-Seq

Hawkins, N. A., Zachwieja, N. J., Miller, A. R., Anderson, L. L. & Kearney, J. A., Oct 1 2016, In : PLoS Genetics. 12, 10, e1006398.

Research output: Contribution to journalArticle

Myoclonic Epilepsy
Chromosomes, Human, Pair 5
modifiers (genes)
epilepsy
Genetic Association Studies
13 Citations (Scopus)

Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations

Hawkins, N. A. & Kearney, J. A., Jan 1 2016, In : Epilepsy Research. 119, p. 20-23 4 p.

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channels
Epilepsy
Leukemia
Mutation
Liver
2 Citations (Scopus)

Locus heterogeneity in epilepsy of infancy with migrating focal seizures

Kearney, J. A., Jan 1 2016, In : Epilepsy Currents. 16, 1, p. 43-45 3 p.

Research output: Contribution to journalArticle

Epilepsy
Seizures
Brain Diseases
Sodium Channel Blockers
Phenytoin

When inhibiting repetitive firing is pro-epileptic

Kearney, J. A., Mar 1 2016, In : Epilepsy Currents. 16, 2, p. 114-115 2 p.

Research output: Contribution to journalComment/debate

2015
2 Citations (Scopus)

Synaptopathies heat up: Mutations in STX1B in fever-associated epilepsies

Kearney, J. A., Jan 1 2015, In : Epilepsy Currents. 15, 3, p. 138-139 2 p.

Research output: Contribution to journalComment/debate

Epilepsy
Fever
Hot Temperature
Mutation

TALE of an SCN8A-associated epileptic encephalopathy mouse model

Kearney, J. A., Jan 1 2015, In : Epilepsy Currents. 15, 2, p. 83-84 2 p.

Research output: Contribution to journalComment/debate

Brain Diseases

Watch out, no brakes! impaired inhibition results in hyperexcitable networks

Thompson, C. H. & Kearney, J. A., Jan 1 2015, In : Epilepsy Currents. 15, 6, p. 342-343 2 p.

Research output: Contribution to journalArticle

2014
21 Citations (Scopus)

Antiepileptic activity of preferential inhibitors of persistent sodium current

Anderson, L. L., Thompson, C. H., Hawkins, N. A., Nath, R. D., Petersohn, A. A., Rajamani, S., Bush, W. S., Frankel, W. N., Vanoye, C. G., Kearney, J. A. & George, A. L., Jan 1 2014, In : Epilepsia. 55, 8, p. 1274-1283 10 p.

Research output: Contribution to journalArticle

Anticonvulsants
Sodium
Seizures
Electroshock
Hippocampal Mossy Fibers
54 Citations (Scopus)

De novo KCNB1 mutations in epileptic encephalopathy

Torkamani, A., Bersell, K., Jorge, B. S., Bjork, R. L., Friedman, J. R., Bloss, C. S., Cohen, J., Gupta, S., Naidu, S., Vanoye, C. G., George Jr, A. L. & Kearney, J. A., Oct 1 2014, In : Annals of Neurology. 76, 4, p. 529-540 12 p.

Research output: Contribution to journalArticle

Brain Diseases
Exome
Mutation
Missense Mutation
Voltage-Gated Potassium Channels

Double trouble: Impairment of two interneuron types in a dravet mouse model

Kearney, J. A., Jan 1 2014, In : Epilepsy Currents. 15, 1, p. 47-49 3 p.

Research output: Contribution to journalComment/debate

Interneurons
5 Citations (Scopus)

Epi4K phase I: Gene discovery in epileptic encephalopathies by exome sequencing

Kearney, J. A., Jan 1 2014, In : Epilepsy Currents. 14, 4, p. 208-210 3 p.

Research output: Contribution to journalArticle

Exome
Genetic Association Studies
Brain Diseases
31 Citations (Scopus)

Mapping genetic modifiers of survival in a mouse model of Dravet syndrome

Miller, A. R., Hawkins, N. A., Mccollom, C. E. & Kearney, J. A., Feb 1 2014, In : Genes, Brain and Behavior. 13, 2, p. 163-172 10 p.

Research output: Contribution to journalArticle

Myoclonic Epilepsy
Survival
Voltage-Gated Sodium Channels
Epilepsy
Mutation
36 Citations (Scopus)

Novel SCN3A variants associated with focal epilepsy in children

Vanoye, C. G., Gurnett, C. A., Holland, K. D., George, A. L. & Kearney, J. A., Jan 1 2014, In : Neurobiology of Disease. 62, p. 313-322 10 p.

Research output: Contribution to journalArticle

Partial Epilepsy
Epilepsy
Mutation
Pediatrics
Voltage-Gated Sodium Channels
49 Citations (Scopus)
Myoclonic Epilepsy
Epilepsy
Sodium
Neurons
Pyramidal Cells
2 Citations (Scopus)

The more, the better: Modeling dravet syndrome with induced pluripotent stem cell-derived neurons

Kearney, J., Jan 1 2014, In : Epilepsy Currents. 14, 1, p. 33-34 2 p.

Research output: Contribution to journalComment/debate

Myoclonic Epilepsy
Induced Pluripotent Stem Cells
Neurons
2013
1 Citation (Scopus)

A mutation hot-spot for benign infantile epilepsy

Kearney, J., Jan 1 2013, In : Epilepsy Currents. 13, 1, p. 20-21 2 p.

Research output: Contribution to journalComment/debate

Epilepsy
Mutation

Cognitive and social impairment in mouse models mirrors dravet syndrome

Kearney, J. A., Jul 24 2013, In : Epilepsy Currents. 13, 2, p. 97-99 3 p.

Research output: Contribution to journalArticle

Myoclonic Epilepsy
Cognitive Dysfunction
1 Citation (Scopus)

Less is more: Reducing tau ameliorates seizures in epilepsy models

Kearney, J. A., Nov 1 2013, In : Epilepsy Currents. 13, 4, p. 184-185 2 p.

Research output: Contribution to journalComment/debate

Epilepsy
Seizures
2 Citations (Scopus)

Sudden unexpected death in Dravet syndrome

Kearney, J., Nov 1 2013, In : Epilepsy Currents. 13, 6, p. 264-265 2 p.

Research output: Contribution to journalComment/debate

Myoclonic Epilepsy
Sudden Death
1 Citation (Scopus)

Voltage-gated ion channel accessory subunits: Sodium, potassium, or both?

Kearney, J., Jan 1 2013, In : Epilepsy Currents. 13, 1, p. 30-31 2 p.

Research output: Contribution to journalComment/debate

Ion Channels
Potassium
Sodium
2012
8 Citations (Scopus)

Advances in epilepsy genetics and genomics

Kearney, J. A., Jul 1 2012, In : Epilepsy Currents. 12, 4, p. 143-146 4 p.

Research output: Contribution to journalArticle

Genomics
Epilepsy
Technology
Mutation
Therapeutics
15 Citations (Scopus)
Chromosomes, Human, Pair 11
Genetic Association Studies
Epilepsy
RNA
Voltage-Gated Sodium Channels
2011
22 Citations (Scopus)

Genetic modifiers of neurological disease

Kearney, J. A., Jun 1 2011, In : Current Opinion in Genetics and Development. 21, 3, p. 349-353 5 p.

Research output: Contribution to journalReview article

Phenotype
Therapeutics
41 Citations (Scopus)

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus

Hawkins, N. A., Martin, M. S., Frankel, W. N., Kearney, J. A. & Escayg, A., Mar 1 2011, In : Neurobiology of Disease. 41, 3, p. 655-660 6 p.

Research output: Contribution to journalArticle

Ion Channels
Seizures
Mutation
Epilepsy
Myoclonic Epilepsy
32 Citations (Scopus)

Voltage-gated potassium channel KCNV2 (Kv8.2) contributes to epilepsy susceptibility

Jorge, B. S., Campbell, C. M., Miller, A. R., Rutter, E. D., Gurnett, C. A., Vanoye, C. G., George, A. L. & Kearney, J. A., Mar 29 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 13, p. 5443-5448 6 p.

Research output: Contribution to journalArticle

Voltage-Gated Potassium Channels
Epilepsy
Mutation
Phenotype
Sodium Channels
2010
42 Citations (Scopus)

Propranolol blocks cardiac and neuronal voltage-gated sodium channels

Wang, D. W., Mistry, A. M., Kahlig, K. M., Kearney, J. A., Xiang, J. & George, A. L., Dec 1 2010, In : Frontiers in Pharmacology. DEC, Article 144.

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channels
Propranolol
Sodium Channels
Local Anesthetics
Nadolol
2009
18 Citations (Scopus)

Fine mapping of an epilepsy modifier gene on mouse Chromosome 19

Bergren, S. K., Rutter, E. D. & Kearney, J. A., Jun 1 2009, In : Mammalian Genome. 20, 6, p. 359-366 8 p.

Research output: Contribution to journalArticle

Modifier Genes
Chromosomes, Human, Pair 19
Epilepsy
Phenotype
Mutation
2008
98 Citations (Scopus)

Mutation of sodium channel SCN3A in a patient with cryptogenic pediatric partial epilepsy

Holland, K. D., Kearney, J. A., Glauser, T. A., Buck, G., Keddache, M., Blankston, J. R., Glaaser, I. W., Kass, R. S. & Meisler, M. H., Mar 5 2008, In : Neuroscience Letters. 433, 1, p. 65-70 6 p.

Research output: Contribution to journalArticle

Partial Epilepsy
Sodium Channels
Epilepsy
Pediatrics
Mutation
2006
86 Citations (Scopus)
Sodium Channels
Purkinje Cells
Premature Mortality
Tetrodotoxin
Tremor
36 Citations (Scopus)

Recurrent de novo mutations of SCN1A in severe myoclonic epilepsy of infancy

Kearney, J. A., Wiste, A. K., Stephani, U., Trudeau, M. M., Siegel, A., Ramachandrannair, R., Elterman, R. D., Muhle, H., Reinsdorf, J., Shields, W. D., Meisler, M. H. & Escayg, A., Feb 1 2006, In : Pediatric neurology. 34, 2, p. 116-120 5 p.

Research output: Contribution to journalArticle

Myoclonic Epilepsy
Mutation
Voltage-Gated Sodium Channels
Deamination
Nucleic Acid Repetitive Sequences