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Research Output 1995 2019

  • 2232 Citations
  • 52 Article
  • 11 Comment/debate
  • 5 Review article
  • 1 Chapter
1995
22 Citations (Scopus)
Adenosine A2 Receptors
Metabotropic Glutamate Receptors
Adenosine
Theophylline
Adenosine A2 Receptor Agonists
1997
78 Citations (Scopus)

Metabotropic glutamate agonist-induced rotation: A pharmacological, FOS immunohistochemical, and [14C]-2- deoxyglucose autoradiographic study

Kearney, J. A. F., Frey, K. A. & Albin, R. L., Jun 7 1997, In : Journal of Neuroscience. 17, 11, p. 4415-4425 11 p.

Research output: Contribution to journalArticle

Excitatory Amino Acid Agonists
Deoxyglucose
Metabotropic Glutamate Receptors
Pharmacology
Corpus Striatum
1998
24 Citations (Scopus)

Calcium channel β4 (CACNB4): Human ortholog of the mouse epilepsy gene lethargic

Escayg, A., Jones, J. M., Kearney, J. A., Hitchcock, P. F. & Meisler, M. H., May 15 1998, In : Genomics. 50, 1, p. 14-22 9 p.

Research output: Contribution to journalArticle

Calcium Channels
Epilepsy
Chromosomes, Human, Pair 2
Genes
Exons
30 Citations (Scopus)

The role of nigrostriatal dopamine in metabotropic glutamate agonist- induced rotation

Feeley Kearney, J. A., Becker, J. B., Frey, K. A. & Albin, R. L., Aug 18 1998, In : Neuroscience. 87, 4, p. 881-891 11 p.

Research output: Contribution to journalArticle

Excitatory Amino Acid Agonists
Metabotropic Glutamate Receptors
Dopamine
Corpus Striatum
Oxidopamine
1999
12 Citations (Scopus)
Metabotropic Glutamate Receptors
Deoxyglucose
Subthalamic Nucleus
Excitatory Amino Acid Agonists
Basal Ganglia
2000

Models of basal ganglia dysfunction: Predictions and pitfalls

Albin, R. L. & Feeley Kearney, J. A., Jan 1 2000, In : Functional Neurology. 15, 3, p. 135-146 12 p.

Research output: Contribution to journalArticle

Secondary Parkinson Disease
Predictive Value of Tests
Corpus Striatum
Subthalamic Nucleus
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
2001
166 Citations (Scopus)

A gain-of-function mutation in the sodium channel gene Scn2a results in seizures and behavioral abnormalities

Kearney, J. A., Plummer, N. W., Smith, M. R., Kapur, J., Cummins, T. R., Waxman, S. G., Goldin, A. L. & Meisler, M. H., Jan 15 2001, In : Neuroscience. 102, 2, p. 307-317 11 p.

Research output: Contribution to journalArticle

Sodium Channels
Seizures
Hippocampus
Mutation
Transgenic Mice
113 Citations (Scopus)

Identification of epilepsy genes in human and mouse

Meisler, M. H., Kearney, J., Ottman, R. & Escayg, A., Dec 1 2001, In : Annual Review of Genetics. 35, p. 567-588 22 p.

Research output: Contribution to journalReview article

Epilepsy
Genes
Sodium Channels
Alleles
Mutation
48 Citations (Scopus)

Sodium channels and neurological disease: Insights from Scn8a mutations in the mouse

Meisler, M. H., Kearney, J., Escayg, A., MacDonald, B. T. & Sprunger, L. K., Jan 1 2001, In : Neuroscientist. 7, 2, p. 136-145 10 p.

Research output: Contribution to journalReview article

Sodium Channels
Mutation
Human Genome
Modifier Genes
High-Throughput Screening Assays
2002
77 Citations (Scopus)

Molecular and pathological effects of a modifier gene on deficiency of the sodium channel Scn8a (Nav1.6)

Kearney, J. A., Buchner, D. A., De Haan, G., Adamska, M., Levin, S. I., Furay, A. R., Albin, R. L., Jones, J. M., Montal, M., Stevens, M. J., Sprunger, L. K. & Meisler, M. H., Oct 15 2002, In : Human molecular genetics. 11, 22, p. 2765-2775 11 p.

Research output: Contribution to journalArticle

Modifier Genes
Sodium Channels
Alleles
Ranvier's Nodes
Voltage-Gated Sodium Channels
20 Citations (Scopus)

Mutations of voltage-gated sodium channels in movement disorders and epilepsy

Meisler, M. H., Kearney, J. A., Sprunger, L. K., MacDonald, B. T., Buchner, D. A. & Escayg, A., Dec 1 2002, In : Novartis Foundation Symposium. 241, p. 72-86 15 p.

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channels
Movement Disorders
Epilepsy
Mutation
Human Genome Project
2003
24 Citations (Scopus)

mGluRs: A target for pharmacotherapy in Parkinson disease

Kearney, J. A. F. & Albin, R. L., Nov 15 2003, In : Experimental Neurology. 184, SUPPL. 1, p. 30-36 7 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate Receptors
Parkinson Disease
Drug Therapy
Corpus Striatum
Glutamate Receptors
203 Citations (Scopus)

Sodium channels SCN1A, SCN2A and SCN3A in familial autism

Weiss, L. A., Escayg, A., Kearney, J. A., Trudeau, M., MacDonald, B. T., Mori, M., Reichert, J., Buxbaum, J. D. & Meisler, M. H., Mar 24 2003, In : Molecular Psychiatry. 8, 2, p. 186-194 9 p.

Research output: Contribution to journalArticle

Sodium Channels
Autistic Disorder
Calmodulin
Mutation
Single Nucleotide Polymorphism
2004
121 Citations (Scopus)

A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for β subunit interaction

Spampanato, J., Kearney, J. A., De Haan, G., McEwen, D. P., Escayg, A., Aradi, I., MacDonald, B. T., Levin, S. I., Soltesz, I., Benna, P., Montalenti, E., Isom, L. L., Goldin, A. L. & Meisler, M. H., Nov 3 2004, In : Journal of Neuroscience. 24, 44, p. 10022-10034 13 p.

Research output: Contribution to journalArticle

Sodium Channels
Epilepsy
Mutation
Action Potentials
Seizures
2005
44 Citations (Scopus)

Genetic modifiers affecting severity of epilepsy caused by mutation of sodium channel Scn2a

Bergren, S. K., Chen, S., Galecki, A. & Kearney, J. A., Sep 1 2005, In : Mammalian Genome. 16, 9, p. 683-690 8 p.

Research output: Contribution to journalArticle

Sodium Channels
Epilepsy
Mutation
Seizures
Phenotype
72 Citations (Scopus)

Sacred disease secrets revealed: The genetics of human epilepsy

Turnbull, J., Lohi, H., Kearney, J. A., Rouleau, G. A., Delgado-Escueta, A. V., Meisler, M. H., Cossette, P. & Minassian, B. A., Sep 1 2005, In : Human molecular genetics. 14, 17, p. 2491-2500 10 p.

Research output: Contribution to journalReview article

Medical Genetics
Epilepsy
Juvenile Myoclonic Epilepsy
Seizures
Genes
348 Citations (Scopus)

Sodium channel mutations in epilepsy and other neurological disorders

Meisler, M. H. & Kearney, J. A., Aug 1 2005, In : Journal of Clinical Investigation. 115, 8, p. 2010-2017 8 p.

Research output: Contribution to journalReview article

Sodium Channels
Nervous System Diseases
Epilepsy
Mutation
Haploinsufficiency
2006
87 Citations (Scopus)
Sodium Channels
Purkinje Cells
Premature Mortality
Tetrodotoxin
Tremor
36 Citations (Scopus)

Recurrent de novo mutations of SCN1A in severe myoclonic epilepsy of infancy

Kearney, J. A., Wiste, A. K., Stephani, U., Trudeau, M. M., Siegel, A., Ramachandrannair, R., Elterman, R. D., Muhle, H., Reinsdorf, J., Shields, W. D., Meisler, M. H. & Escayg, A., Feb 1 2006, In : Pediatric neurology. 34, 2, p. 116-120 5 p.

Research output: Contribution to journalArticle

Myoclonic Epilepsy
Mutation
Voltage-Gated Sodium Channels
Deamination
Nucleic Acid Repetitive Sequences
49 Citations (Scopus)

Severe epilepsy resulting from genetic interaction between Scn2a and Kcnq2

Kearney, J. A., Yang, Y., Beyer, B., Bergren, S. K., Claes, L., DeJonghe, P. & Frankel, W. N., Mar 1 2006, In : Human molecular genetics. 15, 6, p. 1043-1048 6 p.

Research output: Contribution to journalArticle

Epilepsy
Seizures
Mutation
Sodium Channels
Missense Mutation
2008
102 Citations (Scopus)

Mutation of sodium channel SCN3A in a patient with cryptogenic pediatric partial epilepsy

Holland, K. D., Kearney, J. A., Glauser, T. A., Buck, G., Keddache, M., Blankston, J. R., Glaaser, I. W., Kass, R. S. & Meisler, M. H., Mar 5 2008, In : Neuroscience Letters. 433, 1, p. 65-70 6 p.

Research output: Contribution to journalArticle

Partial Epilepsy
Sodium Channels
Epilepsy
Pediatrics
Mutation
2009
19 Citations (Scopus)

Fine mapping of an epilepsy modifier gene on mouse Chromosome 19

Bergren, S. K., Rutter, E. D. & Kearney, J. A., Jun 1 2009, In : Mammalian Genome. 20, 6, p. 359-366 8 p.

Research output: Contribution to journalArticle

Modifier Genes
Chromosomes, Human, Pair 19
Epilepsy
Phenotype
Mutation
2 Citations (Scopus)

Genetics: Single Gene Mutations in Inherited and Sporadic Epilepsy

Kearney, J. A. & Meisler, M., Jan 1 2009, Encyclopedia of Basic Epilepsy Research. Elsevier Inc, p. 369-374 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Epilepsy
Mutation
Genes
Gene Components
Chloride Channels
2010
44 Citations (Scopus)

Propranolol blocks cardiac and neuronal voltage-gated sodium channels

Wang, D. W., Mistry, A. M., Kahlig, K. M., Kearney, J. A., Xiang, J. & George, A. L., Dec 1 2010, In : Frontiers in Pharmacology. DEC, Article 144.

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channels
Propranolol
Sodium Channels
Local Anesthetics
Nadolol
2011
22 Citations (Scopus)

Genetic modifiers of neurological disease

Kearney, J. A., Jun 1 2011, In : Current Opinion in Genetics and Development. 21, 3, p. 349-353 5 p.

Research output: Contribution to journalReview article

Phenotype
Therapeutics
42 Citations (Scopus)

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus

Hawkins, N. A., Martin, M. S., Frankel, W. N., Kearney, J. A. & Escayg, A., Mar 1 2011, In : Neurobiology of Disease. 41, 3, p. 655-660 6 p.

Research output: Contribution to journalArticle

Ion Channels
Seizures
Mutation
Epilepsy
Myoclonic Epilepsy
35 Citations (Scopus)

Voltage-gated potassium channel KCNV2 (Kv8.2) contributes to epilepsy susceptibility

Jorge, B. S., Campbell, C. M., Miller, A. R., Rutter, E. D., Gurnett, C. A., Vanoye, C. G., George, A. L. & Kearney, J. A., Mar 29 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 13, p. 5443-5448 6 p.

Research output: Contribution to journalArticle

Voltage-Gated Potassium Channels
Epilepsy
Mutation
Phenotype
Sodium Channels
2012
8 Citations (Scopus)

Advances in epilepsy genetics and genomics

Kearney, J. A., Jul 1 2012, In : Epilepsy Currents. 12, 4, p. 143-146 4 p.

Research output: Contribution to journalArticle

Genomics
Epilepsy
Technology
Mutation
Therapeutics
16 Citations (Scopus)
Chromosomes, Human, Pair 11
Genetic Association Studies
Epilepsy
RNA
Voltage-Gated Sodium Channels
2013
1 Citation (Scopus)

A mutation hot-spot for benign infantile epilepsy

Kearney, J., Jan 1 2013, In : Epilepsy Currents. 13, 1, p. 20-21 2 p.

Research output: Contribution to journalComment/debate

Epilepsy
Mutation

Cognitive and social impairment in mouse models mirrors dravet syndrome

Kearney, J. A., Jul 24 2013, In : Epilepsy Currents. 13, 2, p. 97-99 3 p.

Research output: Contribution to journalArticle

Myoclonic Epilepsy
Cognitive Dysfunction
1 Citation (Scopus)

Less is more: Reducing tau ameliorates seizures in epilepsy models

Kearney, J. A., Nov 1 2013, In : Epilepsy Currents. 13, 4, p. 184-185 2 p.

Research output: Contribution to journalComment/debate

Epilepsy
Seizures
3 Citations (Scopus)

Sudden unexpected death in Dravet syndrome

Kearney, J., Nov 1 2013, In : Epilepsy Currents. 13, 6, p. 264-265 2 p.

Research output: Contribution to journalComment/debate

Myoclonic Epilepsy
Sudden Death
1 Citation (Scopus)

Voltage-gated ion channel accessory subunits: Sodium, potassium, or both?

Kearney, J., Jan 1 2013, In : Epilepsy Currents. 13, 1, p. 30-31 2 p.

Research output: Contribution to journalComment/debate

Ion Channels
Potassium
Sodium
2014
25 Citations (Scopus)

Antiepileptic activity of preferential inhibitors of persistent sodium current

Anderson, L. L., Thompson, C. H., Hawkins, N. A., Nath, R. D., Petersohn, A. A., Rajamani, S., Bush, W. S., Frankel, W. N., Vanoye, C. G., Kearney, J. A. & George, A. L., Jan 1 2014, In : Epilepsia. 55, 8, p. 1274-1283 10 p.

Research output: Contribution to journalArticle

Anticonvulsants
Sodium
Seizures
Electroshock
Hippocampal Mossy Fibers
60 Citations (Scopus)

De novo KCNB1 mutations in epileptic encephalopathy

Torkamani, A., Bersell, K., Jorge, B. S., Bjork, R. L., Friedman, J. R., Bloss, C. S., Cohen, J., Gupta, S., Naidu, S., Vanoye, C. G., George Jr, A. L. & Kearney, J. A., Oct 1 2014, In : Annals of Neurology. 76, 4, p. 529-540 12 p.

Research output: Contribution to journalArticle

Brain Diseases
Exome
Mutation
Missense Mutation
Voltage-Gated Potassium Channels

Double trouble: Impairment of two interneuron types in a dravet mouse model

Kearney, J. A., Jan 1 2014, In : Epilepsy Currents. 15, 1, p. 47-49 3 p.

Research output: Contribution to journalComment/debate

Interneurons
5 Citations (Scopus)

Epi4K phase I: Gene discovery in epileptic encephalopathies by exome sequencing

Kearney, J. A., Jan 1 2014, In : Epilepsy Currents. 14, 4, p. 208-210 3 p.

Research output: Contribution to journalArticle

Exome
Genetic Association Studies
Brain Diseases
36 Citations (Scopus)

Mapping genetic modifiers of survival in a mouse model of Dravet syndrome

Miller, A. R., Hawkins, N. A., Mccollom, C. E. & Kearney, J. A., Feb 1 2014, In : Genes, Brain and Behavior. 13, 2, p. 163-172 10 p.

Research output: Contribution to journalArticle

Myoclonic Epilepsy
Survival
Voltage-Gated Sodium Channels
Epilepsy
Mutation
39 Citations (Scopus)

Novel SCN3A variants associated with focal epilepsy in children

Vanoye, C. G., Gurnett, C. A., Holland, K. D., George, A. L. & Kearney, J. A., Jan 1 2014, In : Neurobiology of Disease. 62, p. 313-322 10 p.

Research output: Contribution to journalArticle

Partial Epilepsy
Epilepsy
Mutation
Pediatrics
Voltage-Gated Sodium Channels
55 Citations (Scopus)
Myoclonic Epilepsy
Epilepsy
Sodium
Neurons
Pyramidal Cells
2 Citations (Scopus)

The more, the better: Modeling dravet syndrome with induced pluripotent stem cell-derived neurons

Kearney, J., Jan 1 2014, In : Epilepsy Currents. 14, 1, p. 33-34 2 p.

Research output: Contribution to journalComment/debate

Myoclonic Epilepsy
Induced Pluripotent Stem Cells
Neurons
2015
2 Citations (Scopus)

Synaptopathies heat up: Mutations in STX1B in fever-associated epilepsies

Kearney, J. A., Jan 1 2015, In : Epilepsy Currents. 15, 3, p. 138-139 2 p.

Research output: Contribution to journalComment/debate

Epilepsy
Fever
Hot Temperature
Mutation

TALE of an SCN8A-associated epileptic encephalopathy mouse model

Kearney, J. A., Jan 1 2015, In : Epilepsy Currents. 15, 2, p. 83-84 2 p.

Research output: Contribution to journalComment/debate

Brain Diseases

Watch out, no brakes! impaired inhibition results in hyperexcitable networks

Thompson, C. H. & Kearney, J. A., Jan 1 2015, In : Epilepsy Currents. 15, 6, p. 342-343 2 p.

Research output: Contribution to journalArticle

2016
14 Citations (Scopus)

Cacna1g is a genetic modifier of epilepsy caused by mutation of voltage-gated sodium channel Scn2a

Calhoun, J. D., Hawkins, N. A., Zachwieja, N. J. & Kearney, J. A., Jun 1 2016, In : Epilepsia. 57, 6, p. e103-e107

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channels
Modifier Genes
Epilepsy
Seizures
Mutation
3 Citations (Scopus)

Cannabidiol mellows out resurgent sodium current

Thompson, C. H. & Kearney, J. A., Jan 1 2016, In : Epilepsy Currents. 16, 6, p. 399-401 3 p.

Research output: Contribution to journalArticle

Cannabidiol
Sodium
22 Citations (Scopus)

Fine Mapping of a Dravet Syndrome Modifier Locus on Mouse Chromosome 5 and Candidate Gene Analysis by RNA-Seq

Hawkins, N. A., Zachwieja, N. J., Miller, A. R., Anderson, L. L. & Kearney, J. A., Oct 1 2016, In : PLoS genetics. 12, 10, e1006398.

Research output: Contribution to journalArticle

Myoclonic Epilepsy
Chromosomes, Human, Pair 5
modifiers (genes)
epilepsy
Genetic Association Studies
13 Citations (Scopus)

Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations

Hawkins, N. A. & Kearney, J. A., Jan 1 2016, In : Epilepsy Research. 119, p. 20-23 4 p.

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channels
Epilepsy
Leukemia
Mutation
Liver
2 Citations (Scopus)

Locus heterogeneity in epilepsy of infancy with migrating focal seizures

Kearney, J. A., Jan 1 2016, In : Epilepsy Currents. 16, 1, p. 43-45 3 p.

Research output: Contribution to journalArticle

Epilepsy
Seizures
Brain Diseases
Sodium Channel Blockers
Phenytoin