Jennifer Donglan Wu

  • 3314 Citations
1990 …2023
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Personal profile

Research Interests

I joined Northwestern University in August 2017 as a tenured Professor in Urology. I previously served as a Professor of Microbiology and Immunology at the Medical University of South Carolina and the University of Washington. I obtained a PhD from the University of British Columbia in Canada followed by post-doctoral training in Fred Hutchinson Cancer Research Center (FHCRC) and a faculty position at the University of Washington. My research focuses on understanding how cancer cells edit the immune system with the ultimate goal to develop effective immune therapy to control cancers.

Research in my laboratory include these specific aspects: 1) mechanisms of cancer immune evasion; 2) development of novel cancer immunotherapy; 3) Immune therapy-related mucosal toxicity; 4) mechanisms of cancer therapeutic resistance; 4) cancer biomarker discovery. Prostate Cancer is one of my lab's main focus areas. I am also researching the NKG2D axis in tumors which can be applied to a broad spectrum of cancer types and autoimmunity.

Training Experience

2002Postdoctoral Fellowship, Fred Hutchinson Cancer Research Center

Education/Academic qualification

PhD, University of British Columbia

… → 2000

MSc, Peking University

… → 1991

Research interests

  • Cancer Biology
  • Immune Regulation
  • Inflammation
  • Inflammatory Bowel Disease
  • Interdisciplinary Research
  • Prostate Cancer

Fingerprint Dive into the research topics where Jennifer Donglan Wu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Neoplasms Medicine & Life Sciences
Prostatic Neoplasms Medicine & Life Sciences
Ligands Medicine & Life Sciences
IGF Type 1 Receptor Medicine & Life Sciences
Prostate Medicine & Life Sciences
Natural Killer Cells Medicine & Life Sciences
Androgens Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2017 2023

Allergy and Immunology
Prostatic Neoplasms
Ligands
Prostate
Hormones
Neoplasms
Medicine
Research
Population
Immunity
Neoplasms
T-Lymphocytes
Immune System
NK Cell Lectin-Like Receptor Subfamily K
Polysaccharides
Prostatic Neoplasms
Biomarkers
Neoplasms
Serum
Prostatic Neoplasms
Biomarkers
Serum
Polysaccharides
Validation Studies

Research Output 1990 2019

  • 3314 Citations
  • 45 Article
  • 6 Review article
  • 1 Comment/debate
  • 1 Editorial
1 Citation (Scopus)
Open Access
Neoplasm Antibodies
Ligands
T-Lymphocytes
CD8 Antigens
Neoplasms
2 Citations (Scopus)

CD73: An emerging checkpoint for cancer immunotherapy

Chen, S., Wainwright, D. A., Wu, J. D., Wan, Y., Matei, D. E., Zhang, Y. & Zhang, B., Jan 1 2019, In : Immunotherapy. 11, 11, p. 983-997 15 p.

Research output: Contribution to journalReview article

Immunotherapy
Neoplasms
Adenosine
Immunity
Carcinogenesis

Commentary: preclinical efficacy of immune-checkpoint monotherapy does not recapitulate corresponding biomarkers-based clinical predictions in glioblastoma by Garg et al. (2017)

Zhai, L., Ladomersky, E., Lauing, K. L., Wu, M., Scholtens, D. M., Savoor, R., Zhang, B., Wu, J. D., Horbinski, C., Lukas, R. V., Binder, D. C. & Wainwright, D. A., Mar 4 2019, In : OncoImmunology. 8, 3, 1548242.

Research output: Contribution to journalComment/debate

Glioblastoma
Biomarkers
Computational Biology
Gene Expression
1 Citation (Scopus)

How else can we approach prostate cancer biomarker discovery?

Drake, R. R., Angel, P. M., Wu, J., Pachynski, R. K. & Ippolito, J. E., Jan 1 2019, (Accepted/In press) In : Expert Review of Molecular Diagnostics.

Research output: Contribution to journalEditorial

Open Access
1 Citation (Scopus)

Past, Current, and Future of Immunotherapies for Prostate Cancer

Boettcher, A. N., Usman, A., Morgans, A., VanderWeele, D. J., Sosman, J. & Wu, J. D., Sep 11 2019, In : Frontiers in Oncology. 9, 884.

Research output: Contribution to journalReview article

Open Access
Immunotherapy
Prostatic Neoplasms
Oncolytic Viruses
Androgens
Tumor Microenvironment