Grants per year
Personal profile
Research Interests
My lab focuses on the regulation of immune responses, especially those involving eosinophils, mast cells, and basophils including asthma, allergic diseases, and systemic mastocytosis, by members of the siglec family of cell-surface receptors as well as the use of these receptors as therapeutic targets through which to deliver agents selectively to these cell types.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Immunology, PhD, University of Chicago
… → 2011
Research interests keywords
- Allergies
- Apoptosis
- Asthma
- Blood Cancer (leukemia and lymphomas)
- Cell Adhesion Mechanisms
- Immune Regulation
- Immunology
- Inflammation
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Collaborations and top research areas from the last five years
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Determination of thd Efficacy of HistaQuel to Inhibit Mast Cell Responses In Vivo
O'Sullivan, J. A. (PD/PI)
4/15/24 → 4/14/25
Project: Research project
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Modulation and exploitation of Siglec-6 function to broadly impede mast cell activation
O'Sullivan, J. A. (PD/PI) & Bochner, B. S. (Other)
National Institute of Allergy and Infectious Diseases
3/7/24 → 1/31/29
Project: Research project
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Project 3 for Unraveling the Mechanisms of HIV Persistence and Rebound
Martinelli, E. (PD/PI), Martinelli, E. (PD/PI), Bochner, B. S. (Co-PD/PI), Martinelli, E. (Co-PD/PI), O'Sullivan, J. A. (Co-PD/PI), Bochner, B. S. (Co-Investigator), Bochner, B. S. (Co-Investigator) & O'Sullivan, J. A. (Co-Investigator)
National Institute of Allergy and Infectious Diseases
7/15/22 → 4/30/27
Project: Research project
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Targeting Mast Cells through Siglec-6
O'Sullivan, J. A. (PD/PI), Bochner, B. S. (Co-PD/PI) & Bochner, B. S. (Other)
American Academy of Allergy, Asthma and Immunology
7/1/17 → 6/30/19
Project: Research project
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Drug delivery targets and strategies to address mast cell diseases
Rische, C. H., Thames, A. N., Krier-Burris, R. A., O’Sullivan, J. A., Bochner, B. S. & Scott, E. A., 2023, In: Expert Opinion on Drug Delivery. 20, 2, p. 205-222 18 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Interactions between Siglec-8 and endogenous sialylated cis ligands restrain cell death induction in human eosinophils and mast cells
Cao, Y., Rische, C. H., Bochner, B. S. & O’Sullivan, J. A., 2023, In: Frontiers in immunology. 14, 1283370.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Memory Precursors and Short-Lived Effector T cell Subsets Have Different Sensitivities to TGFβ
O’Sullivan, J. A., Kohlhapp, F. J., Zloza, A., Plaza-Rojas, L., Burke, B., Dulin, N. O. & Guevara-Patiño, J. A., Feb 2023, In: International journal of molecular sciences. 24, 4, 3930.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
NKG2D signaling shifts the balance of CD8 T cells from single cytokine- to polycytokine-producing effector cells
Kohlhapp, F. J., O'Sullivan, J. A., Moore, T. V., Zloza, A. & Guevara-Patiño, J. A., Mar 2023, In: Molecular Immunology. 155, p. 1-6 6 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Siglecs as potential targets of therapy in human mast cell- and/or eosinophil-associated diseases
O'Sullivan, J. A., Youngblood, B. A., Schleimer, R. P. & Bochner, B. S., Sep 2023, In: Seminars in Immunology. 69, 101799.Research output: Contribution to journal › Review article › peer-review
Open Access8 Scopus citations