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Jeremy Alastair O'Sullivan

  • 165 Citations
20112019
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Personal profile

Research Interests

My lab focuses on the regulation of immune responses, especially those involving eosinophils, mast cells, and basophils including asthma, allergic diseases, and systemic mastocytosis, by members of the siglec family of cell-surface receptors as well as the use of these receptors as therapeutic targets through which to deliver agents selectively to these cell types.

Education/Academic qualification

PhD, University of Chicago

… → 2011

Research interests

  • Allergies
  • Apoptosis
  • Asthma
  • Blood Cancer (leukemia and lymphomas)
  • Cell Adhesion Mechanisms
  • Immune Regulation
  • Immunology
  • Inflammation

Fingerprint Dive into the research topics where Jeremy Alastair O'Sullivan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
Sialic Acid Binding Immunoglobulin-like Lectins Medicine & Life Sciences
Eosinophils Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Mast Cells Medicine & Life Sciences
Transforming Growth Factors Medicine & Life Sciences
Lectins Medicine & Life Sciences
Saliva Medicine & Life Sciences
Ligands Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2017 2019

Identification of the Siglec-8-induced mode of eosinophil death and extracellular factors governing Siglec-6/8 expression and function

O'Sullivan, J. A.

University of California, San Diego, National Institute of Allergy and Infectious Diseases

9/1/18 → 8/31/19

Project: Research project

Sialic Acid Binding Immunoglobulin-like Lectins
Eosinophils
Mast Cells
Cell Death
Food

Targeting Mast Cells through Siglec-6

Bochner, B. S., Bochner, B. S. & O'Sullivan, J. A.

American Academy of Allergy, Asthma and Immunology

7/1/17 → 6/30/19

Project: Research project

Sialic Acid Binding Immunoglobulin-like Lectins
Mast Cells
Endocytosis
Systemic Mastocytosis
Cell Surface Receptors

Research Output 2011 2019

  • 165 Citations
  • 13 Article
  • 1 Review article

A Sulfonamide Sialoside Analogue for Targeting Siglec-8 and-F on Immune Cells

Nycholat, C. M., Duan, S., Knuplez, E., Worth, C., Elich, M., Yao, A., O'Sullivan, J., McBride, R., Wei, Y., Fernandes, S. M., Zhu, Z., Schnaar, R. L., Bochner, B. S. & Paulson, J. C., Sep 11 2019, In : Journal of the American Chemical Society. 141, 36, p. 14032-14037 6 p.

Research output: Contribution to journal › Article

Sialic Acid Binding Immunoglobulin-like Lectins
Sulfonamides
Ligands
Liposomes
Display devices
17 Citations (Scopus)

Eosinophils and eosinophil-associated diseases: An update

O'Sullivan, J. A. & Bochner, B. S., Feb 1 2018, In : Journal of Allergy and Clinical Immunology. 141, 2, p. 505-517 13 p.

Research output: Contribution to journal › Article

Eosinophils
Allergy and Immunology
6 Citations (Scopus)

Frontline Science: Characterization of a novel mouse strain expressing human Siglec-8 only on eosinophils

O'Sullivan, J. A., Wei, Y., Carroll, D. J., Moreno-Vinasco, L., Cao, Y., Zhang, F., Lee, J. J., Zhu, Z. & Bochner, B. S., Jul 1 2018, In : Journal of Leukocyte Biology. 104, 1, p. 11-19 9 p.

Research output: Contribution to journal › Article

Sialic Acid Binding Immunoglobulin-like Lectins
Eosinophils
Mast Cells
CXCR3 Receptors
Death Domain Receptors
2 Citations (Scopus)

Identification of a Siglec-F+ granulocyte-macrophage progenitor

Bolden, J. E., Lucas, E. C., Zhou, G., O'Sullivan, J. A., de Graaf, C. A., McKenzie, M. D., Di Rago, L., Baldwin, T. M., Shortt, J., Alexander, W. S., Bochner, B. S., Ritchie, M. E., Hilton, D. J. & Fairfax, K. A., Jul 2018, In : Journal of Leukocyte Biology. 104, 1, p. 123-133 11 p.

Research output: Contribution to journal › Article

Sialic Acid Binding Immunoglobulin-like Lectins
Granulocyte-Macrophage Progenitor Cells
Interleukin-5 Receptors
Eosinophils
Population
16 Citations (Scopus)

Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells

O'Sullivan, J. A., Carroll, D. J., Cao, Y., Salicru, A. N. & Bochner, B. S., May 2018, In : Journal of Allergy and Clinical Immunology. 141, 5, p. 1774-1785.e7

Research output: Contribution to journal › Article

Saliva
Eosinophils
Lectins
Mast Cells
Immunoglobulins