Grants per year
Personal profile
Research Interests
I grew up in Birmingham, MI. I attended Kenyon College from 2000-2004. I next earned my MD / PhD at the University of Wisconsin-Madison from 2004-2012, focusing upon the role of beta-cell mass dynamics during the pathogenesis of type 2 diabetes mellitus. I completed my internship at Aurora Medical Center from 2012-2013 and my residency in ophthalmology at the the University of Wisconsin from 2013-2016. I continued my training in surgical retina at the Cleveland Clinic from 2016-2018. I am now beginning my career as a clinician-scientist, practicing vitreoretinal surgery and running a basic science research lab.
My basic and clinic research focuses upon (1) the role of macrophages in macular degeneration, (2) mechanisms to inhibit angiogenesis independent of vascular endothelial growth factor (VEGF), and (3) the treatment of anti-VEGF resistant macular degeneration, retinal vein occlusion, and diabetic retinopathy.
My clinic focus includes the diagnosis, medical, and surgical management of retinal detachment, macular degeneration, diabetic retinopathy, retinal vein occlusion, and secondary intraocular lenses.
Training Experience
2013 | Residency, Aurora Saint Luke's Medical Center |
2016 | Residency, University of Wisconsin-Madison |
2018 | Fellowship, Cleveland Clinic |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, MD, PhD, University of Wisconsin
… → 2012
Research interests keywords
- Angiogenesis
- Diabetes
- Eyes
- Inflammation
- Neuroinflammation
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Retinal perivascular macrophages: ontology and function during neuroinflammation
Lavine, J. A. (PD/PI)
1/1/25 → 12/31/29
Project: Research project
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Health Equity and Access to Leverage Technology for Improved Diabetic Retinopathy Outcomes (HEAL-DR)
French, D. D. (PD/PI), Bryar, P. (Co-Investigator), Evans, C. T. (Co-Investigator), Kho, A. N. (Co-Investigator) & Lavine, J. A. (Co-Investigator)
8/1/24 → 4/30/29
Project: Research project
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The Role of Pigmentation and L-DOPA in Choroidal Angiogenesis
Lavine, J. A. (PD/PI)
7/1/24 → 6/30/27
Project: Research project
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Using spatial transcriptomics to resolve human pro-angiogenic macrophages in neovascular age-related macular degeneration
Lavine, J. A. (PD/PI)
Illinois Society for the Prevention of Blindness
7/1/24 → 6/30/25
Project: Research project
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Exploring Diagnostic Precision and Triage Proficiency: A Comparative Study of GPT-4 and Bard in Addressing Common Ophthalmic Complaints
Zandi, R., Fahey, J. D., Drakopoulos, M., Bryan, J. M., Dong, S., Bryar, P. J., Bidwell, A. E., Bowen, R. C., Lavine, J. A. & Mirza, R. G., Feb 2024, In: Bioengineering. 11, 2, 120.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Intravitreal Metformin Protects Against Choroidal Neovascularization and Light-Induced Retinal Degeneration
Xiao, J. F., Luo, W., Mani, A., Barba, H., Solanki, A., Droho, S., Lavine, J. A. & Skondra, D., Nov 2024, In: International journal of molecular sciences. 25, 21, 11357.Research output: Contribution to journal › Article › peer-review
Open Access -
Levodopa is associated with reduced development of new-onset geographic atrophy in patients with age-related macular degeneration
Chan, K. S., Aggarwal, N., Lawson, S., Boucher, N., MacCumber, M. W. & Lavine, J. A., Dec 2024, In: Eye and Vision. 11, 1, 44.Research output: Contribution to journal › Article › peer-review
Open Access -
Prevalence of Retinal Venous Malformations in Patients With Cerebral Cavernous or Arteriovenous Malformations
Chan, K. S., Daulton, M. R., Reddy, V. D., McComb, E. N. & Lavine, J. A., Jun 1 2024, In: Journal of Neuro-Ophthalmology. 44, 2, p. 226-231 6 p.Research output: Contribution to journal › Article › peer-review
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Retinal microglia express more MHC class I and promote greater T-cell-driven inflammation than brain microglia
Bloomfield, C. L., Gong, J., Droho, S., Makinde, H. M., Gurra, M. G., Stumpf, C. H., Kharel, A., Gadhvi, G., Winter, D. R., Cui, W., Cuda, C. M. & Lavine, J. A., 2024, In: Frontiers in immunology. 15, 1399989.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations
Datasets
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Additional file 8 of Ocular macrophage origin and heterogeneity during steady state and experimental choroidal neovascularization
Droho, S. (Creator), Thomson, B. R. (Creator), Makinde, H. M. (Contributor), Cuda, C. M. (Creator), Perlman, H. (Creator) & Lavine, J. A. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.13237801, https://springernature.figshare.com/articles/dataset/Additional_file_8_of_Ocular_macrophage_origin_and_heterogeneity_during_steady_state_and_experimental_choroidal_neovascularization/13237801
Dataset
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Additional file 4 of Ocular macrophage origin and heterogeneity during steady state and experimental choroidal neovascularization
Droho, S. (Creator), Thomson, B. R. (Creator), Makinde, H. M. (Contributor), Cuda, C. M. (Creator), Perlman, H. (Creator) & Lavine, J. A. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.13237789, https://springernature.figshare.com/articles/figure/Additional_file_4_of_Ocular_macrophage_origin_and_heterogeneity_during_steady_state_and_experimental_choroidal_neovascularization/13237789
Dataset
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Data for: Heterogeneity of Cultured Melanocyte Elongation and Proliferation Factor in Bilateral Diffuse Uveal Melanocytic Proliferation
Lavine, J. A. (Contributor), Ramos, M. S. (Contributor), Wolk, A. M. (Contributor), Baynes, K. (Contributor), Sharma, S. (Contributor), Rachitskaya, A. V. (Contributor), Anand-Apte, B. (Contributor), Srivastava, S. K. (Contributor) & Yuan, A. (Contributor), Mendeley Data, Apr 19 2019
DOI: 10.17632/dfcrs5jyks.1, https://data.mendeley.com/datasets/dfcrs5jyks
Dataset
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Additional file 10 of Ocular macrophage origin and heterogeneity during steady state and experimental choroidal neovascularization
Droho, S. (Creator), Thomson, B. R. (Creator), Makinde, H. M. (Contributor), Cuda, C. M. (Creator), Perlman, H. (Creator) & Lavine, J. A. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.13237777, https://springernature.figshare.com/articles/dataset/Additional_file_10_of_Ocular_macrophage_origin_and_heterogeneity_during_steady_state_and_experimental_choroidal_neovascularization/13237777
Dataset
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Additional file 7 of Ocular macrophage origin and heterogeneity during steady state and experimental choroidal neovascularization
Droho, S. (Creator), Thomson, B. R. (Creator), Makinde, H. M. (Contributor), Cuda, C. M. (Creator), Perlman, H. (Creator) & Lavine, J. A. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.13237798, https://springernature.figshare.com/articles/dataset/Additional_file_7_of_Ocular_macrophage_origin_and_heterogeneity_during_steady_state_and_experimental_choroidal_neovascularization/13237798
Dataset