Grants per year
Personal profile
Research Interests
I grew up in Birmingham, MI. I attended Kenyon College from 2000-2004. I next earned my MD / PhD at the University of Wisconsin-Madison from 2004-2012, focusing upon the role of beta-cell mass dynamics during the pathogenesis of type 2 diabetes mellitus. I completed my internship at Aurora Medical Center from 2012-2013 and my residency in ophthalmology at the the University of Wisconsin from 2013-2016. I continued my training in surgical retina at the Cleveland Clinic from 2016-2018. I am now beginning my career as a clinician-scientist, practicing vitreoretinal surgery and running a basic science research lab.
My basic and clinic research focuses upon (1) the role of macrophages in macular degeneration, (2) mechanisms to inhibit angiogenesis independent of vascular endothelial growth factor (VEGF), and (3) the treatment of anti-VEGF resistant macular degeneration, retinal vein occlusion, and diabetic retinopathy.
My clinic focus includes the diagnosis, medical, and surgical management of retinal detachment, macular degeneration, diabetic retinopathy, retinal vein occlusion, and secondary intraocular lenses.
Training Experience
2013 | Residency, Aurora Saint Luke's Medical Center |
2016 | Residency, University of Wisconsin-Madison |
2018 | Fellowship, Cleveland Clinic |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, MD, PhD, University of Wisconsin
… → 2012
Research interests
- Angiogenesis
- Diabetes
- Eyes
- Inflammation
- Neuroinflammation
Fingerprint
- 1 Similar Profiles
Network
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Role of beta2-adrenergic receptor function in mouse models of neovascular age-related macular degeneration
1/1/23 → 12/31/23
Project: Research project
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Macrophage origin, heterogeneity, and function during experimental choroidal neovascularization in mice
7/1/21 → 6/30/24
Project: Research project
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Macrophage origin and function during experimental choroidal neovascularization in mice
1/1/21 → 12/31/24
Project: Research project
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The role of beta2-adrenergic receptor and interleukin-6 signaling in macrophage-driven choroidal neovascularization
2/1/20 → 1/31/25
Project: Research project
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Angiopoietin-1 Is Required for Vortex Vein and Choriocapillaris Development in Mice
Liu, P., Lavine, J. A., Fawzi, A., Quaggin, S. E. & Thomson, B. R., Nov 1 2022, In: Arteriosclerosis, thrombosis, and vascular biology. 42, 11, p. 1413-1427 15 p.Research output: Contribution to journal › Article › peer-review
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Macrophage-like cells are still detectable on the retinal surface after posterior vitreous detachment
Wang, J. M., Ong, J. X., Nesper, P. L., Fawzi, A. A. & Lavine, J. A., Dec 2022, In: Scientific reports. 12, 1, 12864.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Macrophages in close proximity to the vitreoretinal interface are potential biomarkers of inflammation during retinal vascular disease
Rajesh, A., Droho, S. & Lavine, J. A., Dec 2022, In: Journal of neuroinflammation. 19, 1, 203.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Use of Short-wave Blue Fundus Autofluorescence to Detect and Monitor Acute Regional Outer Retinopathy in Punctate Inner Choroidopathy
Minkus, C. L., Lavine, J. A., Lee, J., Skondra, D. & Goldstein, D. A., 2022, In: Ocular Immunology and Inflammation. 30, 4, p. 887-893 7 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Dendritic cells play no significant role in the laser-induced choroidal neovascularization model
Droho, S., Perlman, H. & Lavine, J. A., Dec 2021, In: Scientific reports. 11, 1, 17254.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Additional file 2 of Ocular macrophage origin and heterogeneity during steady state and experimental choroidal neovascularization
Droho, S. (Creator), Thomson, B. R. (Creator), Makinde, H. M. (Contributor), Cuda, C. M. (Creator), Perlman, H. R. (Creator) & Lavine, J. A. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.13237783.v1, https://springernature.figshare.com/articles/figure/Additional_file_2_of_Ocular_macrophage_origin_and_heterogeneity_during_steady_state_and_experimental_choroidal_neovascularization/13237783/1
Dataset
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Additional file 9 of Ocular macrophage origin and heterogeneity during steady state and experimental choroidal neovascularization
Droho, S. (Creator), Thomson, B. R. (Creator), Makinde, H. M. (Contributor), Cuda, C. M. (Creator), Perlman, H. R. (Creator) & Lavine, J. A. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.13237804.v1, https://springernature.figshare.com/articles/dataset/Additional_file_9_of_Ocular_macrophage_origin_and_heterogeneity_during_steady_state_and_experimental_choroidal_neovascularization/13237804/1
Dataset
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Additional file 8 of Ocular macrophage origin and heterogeneity during steady state and experimental choroidal neovascularization
Droho, S. (Creator), Thomson, B. R. (Creator), Makinde, H. M. (Contributor), Cuda, C. M. (Creator), Perlman, H. R. (Creator) & Lavine, J. A. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.13237801.v1, https://springernature.figshare.com/articles/dataset/Additional_file_8_of_Ocular_macrophage_origin_and_heterogeneity_during_steady_state_and_experimental_choroidal_neovascularization/13237801/1
Dataset
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Data for: Heterogeneity of Cultured Melanocyte Elongation and Proliferation Factor in Bilateral Diffuse Uveal Melanocytic Proliferation
Lavine, J. A. (Contributor), Ramos, M. S. (Contributor), Wolk, A. M. (Contributor), Baynes, K. (Contributor), Sharma, S. (Contributor), Rachitskaya, A. V. (Contributor), Anand-Apte, B. (Contributor), Srivastava, S. K. (Contributor) & Yuan, A. (Contributor), Mendeley Data, 2019
DOI: 10.17632/dfcrs5jyks.1, https://data.mendeley.com/datasets/dfcrs5jyks
Dataset
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Additional file 6 of Ocular macrophage origin and heterogeneity during steady state and experimental choroidal neovascularization
Droho, S. (Creator), Thomson, B. R. (Creator), Makinde, H. M. (Contributor), Cuda, C. M. (Creator), Perlman, H. R. (Creator) & Lavine, J. A. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.13237795.v1, https://springernature.figshare.com/articles/dataset/Additional_file_6_of_Ocular_macrophage_origin_and_heterogeneity_during_steady_state_and_experimental_choroidal_neovascularization/13237795/1
Dataset