Jianbin Zheng

  • 188 Citations
20042019
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Personal profile

Education/Academic qualification

PhD, Fudan University

… → 2007

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  • 1 Similar Profiles
Glucosylceramidase Medicine & Life Sciences
Quinazolines Medicine & Life Sciences
Structure-Activity Relationship Medicine & Life Sciences
Non-Receptor Type 1 Protein Tyrosine Phosphatase Medicine & Life Sciences
Derivatives Chemical Compounds
Inhibitory Concentration 50 Medicine & Life Sciences
Caco-2 Cells Medicine & Life Sciences
Assays Chemical Compounds

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Grants 2017 2019

Glucosylceramidase
Parkinson Disease
alpha-Synuclein
Poisons
Pharmaceutical Databases

Research Output 2004 2019

  • 188 Citations
  • 16 Article
  • 1 Comment/debate

Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase

Zheng, J., Jeon, S., Jiang, W., Burbulla, L., Ysselstein, D., Oevel, K., Krainc, D. & Silverman, R. B., Feb 14 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1218-1230 13 p.

Research output: Contribution to journalArticle

Glucosylceramidase
Quinazolines
Parkinson Disease
Mutant Proteins
Structure-Activity Relationship
6 Citations (Scopus)

β-Glucocerebrosidase Modulators Promote Dimerization of β-Glucocerebrosidase and Reveal an Allosteric Binding Site

Zheng, J., Chen, L., Skinner, O. S., Ysselstein, D., Remis, J., Lansbury, P., Skerlj, R., Mrosek, M., Heunisch, U., Krapp, S., Charrow, J., Schwake, M., Kelleher, N. L., Silverman, R. B. & Krainc, D., May 9 2018, In : Journal of the American Chemical Society. 140, 18, p. 5914-5924 11 p.

Research output: Contribution to journalArticle

Glucosylceramidase
Allosteric Site
Dimerization
Binding sites
Modulators
4 Citations (Scopus)

Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators

Zheng, J., Chen, L., Schwake, M., Silverman, R. B. & Krainc, D., Sep 22 2016, In : Journal of Medicinal Chemistry. 59, 18, p. 8508-8520 13 p.

Research output: Contribution to journalArticle

Glucosylceramidase
Quinazolines
Gaucher Disease
Parkinson Disease
Lewy Body Disease
26 Citations (Scopus)

Characterization of a novel curcumin analog P1 as potent inhibitor of the NF-κB signaling pathway with distinct mechanisms

Peng, Y. M., Zheng, J. B., Zhou, Y. B. & Li, J., Jul 1 2013, In : Acta Pharmacologica Sinica. 34, 7, p. 939-950 12 p.

Research output: Contribution to journalArticle

Curcumin
HeLa Cells
Reactive Oxygen Species
lissamine rhodamine B
Apoptosis