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Personal profile

Research Interests

The primary research focus of the lab is to understand aberrant transcriptional and epigenetic regulation of prostate cancer. We utilize high-throughput genomic techniques in combination with bioinformatics/statistical analysis to generate hypothetical concepts. We then test these hypotheses using traditional molecular or cellular biological approaches and examine the functional relevance of innovative mechanisms using in vitro cell line and in vivo mouse models. Transcription factors of particular interest to us include androgen receptor (AR), FoxA1, Polycomb group protein (EZH2), and the Ets family protein (ERG). Based on the genetics and epigenetics of the disease, we also pursue translational research to define diagnostic / prognostic biomarkers and to pursue novel therapeutics strategies for treating advanced prostate cancer.

Education/Academic qualification

PhD, University of Michigan

… → 2004

MD, Peking University

… → 1998

Research interests

  • Cancer Biology
  • Endocrinology
  • Genomics
  • Prostate Cancer

Fingerprint Dive into the research topics where Jindan Yu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 25 Similar Profiles
Prostatic Neoplasms Medicine & Life Sciences
Androgen Receptors Medicine & Life Sciences
Castration Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Gene Fusion Medicine & Life Sciences
Androgens Medicine & Life Sciences
Genes Medicine & Life Sciences
Epigenomics Medicine & Life Sciences

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Grants 2009 2023

Prostatic Neoplasms
Androgen Receptors
Androgens
Polycomb Repressive Complex 2
Transcriptional Activation
CXC Chemokines
MAP Kinase Signaling System
Chemokine Receptors
Chemokines
Prostatic Neoplasms
Prostatic Neoplasms
Lysine
Polycomb-Group Proteins
Proteins
Castration
Astemizole
Castration
Nuclear Factor 90 Proteins
Prostatic Neoplasms
Zinc Compounds
Lipoylation
Cell Polarity
Prostatic Neoplasms
Neoplasm Metastasis
Acyltransferases

Research Output 2002 2019

  • 11042 Citations
  • 65 Article
  • 8 Review article
  • 3 Comment/debate
  • 3 Letter
4 Citations (Scopus)

Activation of MAPK Signaling by CXCR7 leads to enzalutamide resistance in prostate cancer

Li, S., Fong, K. W., Gritsina, G., Zhang, A., Zhao, C., Kim, J., Sharp, A., Yuan, W., Aversa, C., Yang, X. J., Nelson, P. S., Feng, F. Y., Chinnaiyan, A. M., De Bono, J. S., Morrissey, C., Rettig, M. B. & Yu, J., Jan 1 2019, In : Cancer Research. 79, 10, p. 2580-2592 13 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Castration
Androgen Receptor Antagonists
MDV 3100
Androgen Antagonists
1 Citation (Scopus)

Altered chromatin recruitment by FOXA1 mutations promotes androgen independence and prostate cancer progression

Xu, B., Song, B., Lu, X., Kim, J., Hu, M., Zhao, C. & Yu, J., Sep 1 2019, In : Cell Research. 29, 9, p. 773-775 3 p.

Research output: Contribution to journalLetter

Androgens
Chromatin
Prostatic Neoplasms
Mutation

BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer

Zhu, S., Zhao, D., Li, C., Li, Q., Jiang, W., Liu, Q., Wang, R., Fazli, L., Li, Y., Zhang, L., Yi, Y., Meng, Q., Wang, W., Wang, G., Zhang, M., Zu, X., Zhao, W., Deng, T., Yu, J., Dong, X. & 2 others, Chen, K. & Cao, Q., Jan 1 2019, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Castration
Androgen Receptors
Lymphoma
Prostatic Neoplasms
Neoplasms
1 Citation (Scopus)

N-Myc-mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer

Berger, A., Brady, N. J., Bareja, R., Robinson, B., Conteduca, V., Augello, M. A., Puca, L., Ahmed, A., Dardenne, E., Lu, X., Hwang, I., Bagadion, A. M., Sboner, A., Elemento, O., Paik, J., Yu, J., Barbieri, C. E., Dephoure, N., Beltran, H. & Rickman, D. S., Sep 3 2019, In : Journal of Clinical Investigation. 129, 9, p. 3924-3940 17 p.

Research output: Contribution to journalArticle

Open Access
Epigenomics
Prostatic Neoplasms
Androgen Receptors
Histone Code
Organoids
10 Citations (Scopus)

Targeting FOXA1-mediated repression of TGF-β signaling suppresses castration-resistant prostate cancer progression

Song, B., Park, S. H., Zhao, C., Fong, K. W., Li, S., Lee, Y., Yang, Y. A., Sridhar, S., Lu, X., Abdulkadir, S. A., Vessella, R. L., Morrissey, C., Kuzel, T. M., Catalona, W. J., Yang, X. J. & Yu, J., Feb 1 2019, In : Journal of Clinical Investigation. 129, 2, p. 569-582 14 p.

Research output: Contribution to journalArticle

LY-2157299
Castration
Androgen Antagonists
Prostatic Neoplasms
Epithelial-Mesenchymal Transition