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Personal profile

Research Interests

The primary research focus of the lab is to understand aberrant transcriptional and epigenetic regulation of prostate cancer. We utilize high-throughput genomic techniques in combination with bioinformatics/statistical analysis to generate hypothetical concepts. We then test these hypotheses using traditional molecular or cellular biological approaches and examine the functional relevance of innovative mechanisms using in vitro cell line and in vivo mouse models. Transcription factors of particular interest to us include androgen receptor (AR), FoxA1, Polycomb group protein (EZH2), and the Ets family protein (ERG). Based on the genetics and epigenetics of the disease, we also pursue translational research to define diagnostic / prognostic biomarkers and to pursue novel therapeutics strategies for treating advanced prostate cancer.

Education/Academic qualification

PhD, University of Michigan

… → 2004

MD, Peking University

… → 1998

Research interests

  • Cancer Biology
  • Endocrinology
  • Genomics
  • Prostate Cancer

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Grants

  • Research Output

    • 11549 Citations
    • 65 Article
    • 8 Review article
    • 3 Comment/debate
    • 2 Letter

    BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer

    Zhu, S., Zhao, D., Li, C., Li, Q., Jiang, W., Liu, Q., Wang, R., Fazli, L., Li, Y., Zhang, L., Yi, Y., Meng, Q., Wang, W., Wang, G., Zhang, M., Zu, X., Zhao, W., Deng, T., Yu, J., Dong, X. & 2 others, Chen, K. & Cao, Q., Jan 2 2020, In : Oncogene. 39, 1, p. 17-29 13 p.

    Research output: Contribution to journalArticle

  • Activation of MAPK Signaling by CXCR7 leads to enzalutamide resistance in prostate cancer

    Li, S., Fong, K. W., Gritsina, G., Zhang, A., Zhao, J. C., Kim, J., Sharp, A., Yuan, W., Aversa, C., Yang, X. J., Nelson, P. S., Feng, F. Y., Chinnaiyan, A. M., De Bono, J. S., Morrissey, C., Rettig, M. B. & Yu, J., Jan 1 2019, In : Cancer Research. 79, 10, p. 2580-2592 13 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Altered chromatin recruitment by FOXA1 mutations promotes androgen independence and prostate cancer progression

    Xu, B., Song, B., Lu, X., Kim, J., Hu, M., Zhao, J. C. & Yu, J., Sep 1 2019, In : Cell Research. 29, 9, p. 773-775 3 p.

    Research output: Contribution to journalLetter

    1 Scopus citations

    N-Myc-mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer

    Berger, A., Brady, N. J., Bareja, R., Robinson, B., Conteduca, V., Augello, M. A., Puca, L., Ahmed, A., Dardenne, E., Lu, X., Hwang, I., Bagadion, A. M., Sboner, A., Elemento, O., Paik, J., Yu, J., Barbieri, C. E., Dephoure, N., Beltran, H. & Rickman, D. S., Sep 3 2019, In : Journal of Clinical Investigation. 129, 9, p. 3924-3940 17 p.

    Research output: Contribution to journalArticle

    Open Access
  • 11 Scopus citations

    Targeting FOXA1-mediated repression of TGF-β signaling suppresses castration-resistant prostate cancer progression

    Song, B., Park, S. H., Zhao, J. C., Fong, K. W., Li, S., Lee, Y., Yang, Y. A., Sridhar, S., Lu, X., Abdulkadir, S. A., Vessella, R. L., Morrissey, C., Kuzel, T. M., Catalona, W., Yang, X. & Yu, J., Feb 1 2019, In : Journal of Clinical Investigation. 129, 2, p. 569-582 14 p.

    Research output: Contribution to journalArticle

  • 14 Scopus citations