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Research Output

  • 11540 Citations
  • 65 Article
  • 8 Review article
  • 3 Comment/debate
  • 2 Letter
2020

BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer

Zhu, S., Zhao, D., Li, C., Li, Q., Jiang, W., Liu, Q., Wang, R., Fazli, L., Li, Y., Zhang, L., Yi, Y., Meng, Q., Wang, W., Wang, G., Zhang, M., Zu, X., Zhao, W., Deng, T., Yu, J., Dong, X. & 2 others, Chen, K. & Cao, Q., Jan 2 2020, In : Oncogene. 39, 1, p. 17-29 13 p.

Research output: Contribution to journalArticle

2019

Activation of MAPK Signaling by CXCR7 leads to enzalutamide resistance in prostate cancer

Li, S., Fong, K. W., Gritsina, G., Zhang, A., Zhao, J. C., Kim, J., Sharp, A., Yuan, W., Aversa, C., Yang, X. J., Nelson, P. S., Feng, F. Y., Chinnaiyan, A. M., De Bono, J. S., Morrissey, C., Rettig, M. B. & Yu, J., Jan 1 2019, In : Cancer Research. 79, 10, p. 2580-2592 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Altered chromatin recruitment by FOXA1 mutations promotes androgen independence and prostate cancer progression

Xu, B., Song, B., Lu, X., Kim, J., Hu, M., Zhao, J. C. & Yu, J., Sep 1 2019, In : Cell Research. 29, 9, p. 773-775 3 p.

Research output: Contribution to journalLetter

1 Scopus citations

N-Myc-mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer

Berger, A., Brady, N. J., Bareja, R., Robinson, B., Conteduca, V., Augello, M. A., Puca, L., Ahmed, A., Dardenne, E., Lu, X., Hwang, I., Bagadion, A. M., Sboner, A., Elemento, O., Paik, J., Yu, J., Barbieri, C. E., Dephoure, N., Beltran, H. & Rickman, D. S., Sep 3 2019, In : Journal of Clinical Investigation. 129, 9, p. 3924-3940 17 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Targeting FOXA1-mediated repression of TGF-β signaling suppresses castration-resistant prostate cancer progression

Song, B., Park, S. H., Zhao, J. C., Fong, K. W., Li, S., Lee, Y., Yang, Y. A., Sridhar, S., Lu, X., Abdulkadir, S. A., Vessella, R. L., Morrissey, C., Kuzel, T. M., Catalona, W., Yang, X. & Yu, J., Feb 1 2019, In : Journal of Clinical Investigation. 129, 2, p. 569-582 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Transcriptional repression by androgen receptor: Roles in castration-resistant prostate cancer

Gritsina, G., Gao, W. Q. & Yu, J., May 1 2019, In : Asian Journal of Andrology. 21, 3, p. 215-223 9 p.

Research output: Contribution to journalReview article

1 Scopus citations
2018

BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1

Zhu, S., Zhao, D., Yan, L., Jiang, W., Kim, J. S., Gu, B., Liu, Q., Wang, R., Xia, B., Zhao, J. C., Song, G., Mi, W., Wang, R. F., Shi, X., Lam, H. M., Dong, X., Yu, J., Chen, K. & Cao, Q., Dec 1 2018, In : Nature communications. 9, 1, 500.

Research output: Contribution to journalArticle

18 Scopus citations

Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator

Kim, J., Lee, Y., Lu, X., Song, B., Fong, K. W., Cao, Q., Licht, J. D., Zhao, J. C. & Yu, J., Dec 4 2018, In : Cell reports. 25, 10, p. 2808-2820.e4

Research output: Contribution to journalArticle

19 Scopus citations

PRDM4 mediates YAP-induced cell invasion by activating leukocyte-specific integrin β2 expression

Liu, H., Dai, X., Cao, X., Yan, H., Ji, X., Zhang, H., Shen, S., Si, Y., Zhang, H., Chen, J., Li, L., Zhao, J. C., Yu, J., Feng, X. H. & Zhao, B., Jun 2018, In : EMBO Reports. 19, 6, e45180.

Research output: Contribution to journalArticle

7 Scopus citations

TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression

Fong, K. W., Zhao, J. C., Song, B., Zheng, B. & Yu, J., Dec 1 2018, In : Nature communications. 9, 1, 5007.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Trinucleotide Repeat Expansion Diseases, RNAi, and Cancer

Murmann, A. E., Yu, J., Opal, P. & Peter, M. E., Oct 2018, In : Trends in Cancer. 4, 10, p. 684-700 17 p.

Research output: Contribution to journalReview article

5 Scopus citations

USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism

Melo-Cardenas, J., Xu, Y., Wei, J., Tan, C., Kong, S., Gao, B., Montauti, E., Kirsammer, G., Licht, J. D., Yu, J., Ji, P., Crispino, J. D. & Fang, D., Jul 26 2018, In : Blood. 132, 4, p. 423-434 12 p.

Research output: Contribution to journalArticle

7 Scopus citations
2017

CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response

Qadir, A. S., Ceppi, P., Brockway, S., Law, C., Mu, L., Khodarev, N. N., Kim, J., Zhao, J. C., Putzbach, W., Murmann, A. E., Chen, Z., Chen, W., Liu, X., Salomon, A. R., Liu, H., Weichselbaum, R. R., Yu, J. & Peter, M. E., Mar 7 2017, In : Cell reports. 18, 10, p. 2373-2386 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

FOXA1 inhibits prostate cancer neuroendocrine differentiation

Kim, J., Jin, H., Zhao, J. C., Yang, Y. A., Li, Y., Yang, X., Dong, X. & Yu, J., Jul 13 2017, In : Oncogene. 36, 28, p. 4072-4080 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

PADI2-mediated citrullination promotes prostate cancer progression

Wang, L., Song, G., Zhang, X., Feng, T., Pan, J., Chen, W., Yang, M., Bai, X., Pang, Y., Yu, J., Han, J. & Han, B., Nov 1 2017, In : Cancer Research. 77, 21, p. 5755-5768 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

Polycomb-mediated disruption of an androgen receptor feedback loop drives castration-resistant prostate cancer

Fong, K. W., Zhao, J. C., Kim, J., Li, S., Yang, Y. A., Song, B., Rittie, L., Hu, M., Yang, X., Perbal, B. & Yu, J., Jan 15 2017, In : Cancer Research. 77, 2, p. 412-422 11 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016

FOXA1 acts upstream of GATA2 and AR in hormonal regulation of gene expression

Zhao, J. C., Fong, K. W., Jin, H. J., Yang, Y. A., Kim, J. & Yu, J., Aug 18 2016, In : Oncogene. 35, 33, p. 4335-4344 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function

Yang, Y. A., Zhao, J. C., Fong, K. W., Kim, J., Li, S., Song, C., Song, B., Zheng, B., He, C. & Yu, J., Sep 30 2016, In : Nucleic acids research. 44, 17, p. 8153-8164 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

KAT8 regulates androgen signaling in prostate cancer cells

Kim, J. Y., Yu, J., Abdulkadir, S. A. & Chakravarti, D., Aug 2016, In : Molecular Endocrinology. 30, 8, p. 925-936 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer

Xue, X., Yang, Y. A., Zhang, A., Fong, K. W., Kim, J., Song, B., Li, S., Zhao, J. C. & Yu, J., May 1 2016, In : Oncogene. 35, 21, p. 2746-2755 10 p.

Research output: Contribution to journalArticle

151 Scopus citations

The common stress responsive transcription factor ATF3 binds genomic sites enriched with p300 and H3K27ac for transcriptional regulation

Zhao, J., Li, X., Guo, M., Yu, J. & Yan, C., May 4 2016, In : BMC Genomics. 17, 1, 335.

Research output: Contribution to journalArticle

23 Scopus citations
2015

A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis

Shen, S., Guo, X., Yan, H., Lu, Y., Ji, X., Li, L., Liang, T., Zhou, D., Feng, X. H., Zhao, J. C., Yu, J., Gong, X. G., Zhang, L. & Zhao, B., Sep 4 2015, In : Cell Research. 25, 9, p. 997-1012 16 p.

Research output: Contribution to journalArticle

49 Scopus citations

Current perspectives on FOXA1 regulation of androgen receptor signaling and prostate cancer

Yang, Y. A. & Yu, J., Jun 1 2015, In : Genes and Diseases. 2, 2, p. 144-151 8 p.

Research output: Contribution to journalReview article

32 Scopus citations

LncRNA HOTAIR Enhances the Androgen-Receptor-Mediated Transcriptional Program and Drives Castration-Resistant Prostate Cancer

Zhang, A., Zhao, J. C., Kim, J., Fong, K. W., Yang, Y. A., Chakravarti, D., Mo, Y. Y. & Yu, J., Oct 6 2015, In : Cell reports. 13, 1, p. 209-221 13 p.

Research output: Contribution to journalArticle

128 Scopus citations

miR-573 inhibits prostate cancer metastasis by regulating epithelialmesenchymal transition

Wang, L., Song, G., Tan, W., Qi, M., Zhang, L., Chan, J., Yu, J., Han, J. & Han, B., Jan 1 2015, In : Oncotarget. 6, 34, p. 35978-35990 13 p.

Research output: Contribution to journalArticle

35 Scopus citations

The role of TXNDC5 in castration-resistant prostate cancer - Involvement of androgen receptor signaling pathway

Wang, L., Song, G., Chang, X., Tan, W., Pan, J., Zhu, X., Liu, Z., Qi, M., Yu, J. & Han, B., Sep 3 2015, In : Oncogene. 34, 36, p. 4735-4745 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
2014

CCN3/NOV gene expression in human prostate cancer is directly suppressed by the androgen receptor

Wu, L., Runkle, C., Jin, H. J., Yu, J., Li, J., Yang, X., Kuzel, T., Lee, C. & Yu, J., Jan 23 2014, In : Oncogene. 33, 4, p. 504-513 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Cooperativity and equilibrium with FOXA1 define the androgen receptor transcriptional program

Jin, H. J., Zhao, J. C., Wu, L., Kim, J. & Yu, J., May 29 2014, In : Nature communications. 5, 3972.

Research output: Contribution to journalArticle

75 Scopus citations

Influence of oncogenic transcription factors on chromatin conformation and implications in prostate cancer

Yang, Y. A., Kim, J. & Yu, J., May 12 2014, In : Application of Clinical Genetics. 7, p. 81-91 11 p.

Research output: Contribution to journalReview article

4 Scopus citations
2013

Androgen receptor genomic regulation

Jin, H. J., Kim, J. & Yu, J., Sep 2013, In : Translational Andrology and Urology. 2, 3, p. 158-177 20 p.

Research output: Contribution to journalReview article

27 Scopus citations

Androgen receptor-independent function of FoxA1 in prostate cancer metastasis

Jin, H. J., Zhao, J. C., Ogden, I., Bergan, R. C. & Yu, J., Jun 15 2013, In : Cancer Research. 73, 12, p. 3725-3736 12 p.

Research output: Contribution to journalArticle

71 Scopus citations

BRCA1 is a negative modulator of the PRC2 complex

Wang, L., Zeng, X., Chen, S., Ding, L., Zhong, J., Zhao, J. C., Wang, L., Sarver, A., Koller, A., Zhi, J., Ma, Y., Yu, J., Chen, J. & Huang, H., May 29 2013, In : EMBO Journal. 32, 11, p. 1584-1597 14 p.

Research output: Contribution to journalArticle

77 Scopus citations

ERG is a critical regulator of Wnt/LEF1 signaling in prostate cancer

Wu, L., Zhao, J. C., Kim, J., Jin, H. J., Wang, C. Y. & Yu, J., Oct 1 2013, In : Cancer Research. 73, 19, p. 6068-6079 12 p.

Research output: Contribution to journalArticle

44 Scopus citations

Erratum: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression (Nature (2009) 457 (910-914) DOI: 10.1038/nature07762)

Sreekumar, A., Poisson, L. M., Rajendiran, T. M., Khan, A. P., Cao, Q., Yu, J., Laxman, B., Mehra, R., Lonigro, R. J., Li, Y., Nyati, M. K., Ahsan, A., Kalyana-Sundaram, S., Han, B., Cao, X., Byun, J., Omenn, G. S., Ghosh, D., Pennathur, S., Alexander, D. C. & 6 others, Berger, A., Shuster, J. R., Wei, J. T., Varambally, S., Beecher, C. & Chinnaiyan, A. M., Jun 7 2013, In : Nature. 499, 7459, 1 p.

Research output: Contribution to journalComment/debate

3 Scopus citations

Erratum to Mechanistic rationale for inhibition of poly(ADP-Ribose) polymerase in ETS gene fusion-positive prostate cancer [Cancer Cell, 19 (2011) 664-678]

Brenner, J. C., Ateeq, B., Li, Y., Yocum, A. K., Cao, Q., Asangani, I. A., Patel, S., Wang, X., Liang, H., Yu, J., Palanisamy, N., Siddiqui, J., Yan, W., Cao, X., Mehra, R., Sabolch, A., Basrur, V., Lonigro, R. J., Yang, J., Tomlins, S. A. & 8 others, Maher, C. A., Elenitoba-Johnson, K. S. J., Hussain, M., Navone, N. M., Pienta, K. J., Varambally, S., Feng, F. Y. & Chinnaiyan, A. M., Apr 15 2013, In : Cancer Cell. 23, 4, 1 p.

Research output: Contribution to journalComment/debate

EZH2, an epigenetic driver of prostate cancer

Yang, Y. A. & Yu, J., 2013, In : Protein and Cell. 4, 5, p. 331-341 11 p.

Research output: Contribution to journalReview article

73 Scopus citations

The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer

Ezponda, T., Popovic, R., Shah, M. Y., Martinez-Garcia, E., Zheng, Y., Min, D. J., Will, C., Neri, A., Kelleher, N. L., Yu, J. & Licht, J. D., Jun 6 2013, In : Oncogene. 32, 23, p. 2882-2890 9 p.

Research output: Contribution to journalArticle

76 Scopus citations

TMPRSS2-ERG gene fusions induce prostate tumorigenesis by modulating microRNA miR-200c

Kim, J., Wu, L., Zhao, J. C., Jin, H. J. & Yu, J., Nov 4 2013, In : Oncogene. 33, 44, p. 5183-5192 10 p.

Research output: Contribution to journalArticle

32 Scopus citations
2012

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

Zhao, B., Li, L., Wang, L., Wang, C. Y., Yu, J. & Guan, K. L., Jan 1 2012, In : Genes and Development. 26, 1, p. 54-68 15 p.

Research output: Contribution to journalArticle

403 Scopus citations

Cooperation between Polycomb and androgen receptor during oncogenic transformation

Zhao, J. C., Yu, J., Runkle, C., Wu, L., Hu, M., Wu, D., Liu, J. S., Wang, Q., Qin, Z. S. & Yu, J., Feb 1 2012, In : Genome research. 22, 2, p. 322-331 10 p.

Research output: Contribution to journalArticle

70 Scopus citations

Interrogating genomic and epigenomic data to understand prostate cancer

Kim, J. & Yu, J., Apr 1 2012, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1825, 2, p. 186-196 11 p.

Research output: Contribution to journalReview article

15 Scopus citations
2011

Cancer cell migration: When red light switched to green

Corey, S. J. & Yu, J., Mar 1 2011, In : Asian Journal of Andrology. 13, 2, p. 177-178 2 p.

Research output: Contribution to journalReview article

1 Scopus citations

Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer

Cao, Q., Mani, R. S., Ateeq, B., Dhanasekaran, S. M., Asangani, I. A., Prensner, J. R., Kim, J. H., Brenner, J. C., Jing, X., Cao, X., Wang, R., Li, Y., Dahiya, A., Wang, L., Pandhi, M., Lonigro, R. J., Wu, Y. M., Tomlins, S. A., Palanisamy, N., Qin, Z. & 4 others, Yu, J., Maher, C. A., Varambally, S. & Chinnaiyan, A. M., Aug 16 2011, In : Cancer Cell. 20, 2, p. 187-199 13 p.

Research output: Contribution to journalArticle

157 Scopus citations

Deep sequencing reveals distinct patterns of DNA methylation in prostate cancer

Kim, J. H., Dhanasekaran, S. M., Prensner, J. R., Cao, X., Robinson, D., Kalyana-Sundaram, S., Huang, C., Shankar, S., Jing, X., Iyer, M., Hu, M., Sam, L., Grasso, C., Maher, C. A., Palanisamy, N., Mehra, R., Kominsky, H. D., Siddiqui, J., Yu, J., Qin, Z. S. & 1 others, Chinnaiyan, A. M., Jul 1 2011, In : Genome research. 21, 7, p. 1028-1041 14 p.

Research output: Contribution to journalArticle

130 Scopus citations

Definition of a FoxA1 cistrome that is crucial for G 1 to S-phase cell-cycle transit in castration-resistant prostate cancer

Zhang, C., Wang, L., Wu, D., Chen, H., Chen, Z., Thomas-Ahner, J. M., Zynger, D. L., Eeckhoute, J., Yu, J., Luo, J., Brown, M., Clinton, S. K., Nephew, K. P., Huang, T. H. M., Li, W. & Wang, Q., Nov 1 2011, In : Cancer Research. 71, 21, p. 6738-6748 11 p.

Research output: Contribution to journalArticle

63 Scopus citations

Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer

Brenner, J. C., Ateeq, B., Li, Y., Yocum, A. K., Cao, Q., Asangani, I. A., Patel, S., Wang, X., Liang, H., Yu, J., Palanisamy, N., Siddiqui, J., Yan, W., Cao, X., Mehra, R., Sabolch, A., Basrur, V., Lonigro, R. J., Yang, J., Tomlins, S. A. & 8 others, Maher, C. A., Elenitoba-Johnson, K. S. J., Hussain, M., Navone, N. M., Pienta, K. J., Varambally, S., Feng, F. Y. & Chinnaiyan, A. M., May 17 2011, In : Cancer Cell. 19, 5, p. 664-678 15 p.

Research output: Contribution to journalArticle

290 Scopus citations

The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity

Kappes, F., Waldmann, T., Mathew, V., Yu, J., Zhang, L., Khodadoust, M. S., Chinnaiyan, A. M., Luger, K., Erhardt, S., Schneider, R. & Markovitz, D. M., Apr 1 2011, In : Genes and Development. 25, 7, p. 673-678 6 p.

Research output: Contribution to journalArticle

50 Scopus citations
2010

An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression

Yu, J., Yu, J., Mani, R. S., Cao, Q., Brenner, C. J., Cao, X., Wang, X., Wu, L., Li, J., Hu, M., Gong, Y., Cheng, H., Laxman, B., Vellaichamy, A., Shankar, S., Li, Y., Dhanasekaran, S. M., Morey, R., Barrette, T., Lonigro, R. J. & 4 others, Tomlins, S. A., Varambally, S., Qin, Z. S. & Chinnaiyan, A. M., May 18 2010, In : Cancer Cell. 17, 5, p. 443-454 12 p.

Research output: Contribution to journalArticle

516 Scopus citations

Cdc42-interacting protein 4 promotes breast cancer cell invasion and formation of invadopodia through activation of N-WASp

Pichot, C. S., Arvanitis, C., Hartig, S. M., Jensen, S. A., Bechill, J., Marzouk, S., Yu, J., Frost, J. A. & Corey, S. J., Nov 1 2010, In : Cancer Research. 70, 21, p. 8347-8356 10 p.

Research output: Contribution to journalArticle

67 Scopus citations

ERG cooperates with androgen receptor in regulating trefoil factor 3 in prostate cancer disease progression

Rickman, D. S., Chen, Y. B., Banerjee, S., Pan, Y., Yu, J., Vuong, T., Perner, S., Lafargue, C. J., Mertz, K. D., Setlur, S. R., Sircar, K., Chinnaiyan, A. M., Bismar, T. A., Rubin, M. A. & Demichelis, F., Jan 1 2010, In : Neoplasia. 12, 12, p. 1031-1040 10 p.

Research output: Contribution to journalArticle

47 Scopus citations