Jing Jin

  • 3780 Citations
19982020
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Personal profile

Research Interests

The lab is generally interested in the pathological mechanisms of kidney and vascular diseases. We take a proteomic approach to study molecules that serve structural or functional roles in kidney filtration. Particularly, we are trying to understand how the kidney podocytes maintain and regulate their slit diaphragm, as well as their interactions with the glomerular basement membrane.

Education/Academic qualification

PhD, University of Toronto

… → 2003

MD, Peking University

… → 1992

Keywords

  • Angiogenesis
  • Biochemistry: Proteins
  • Cardiovascular Diseases
  • Hypertension
  • Nephrology
  • Proteomics
  • Vascular Biology

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Grants 2014 2020

Focal Segmental Glomerulosclerosis
Organoids
Kidney
Proteome
Proteomics
Autoantibodies
Arginine
Antigens
Protein Array Analysis
Immune Tolerance
Angiopoietins
Ocular Hypertension
Glaucoma
Intraocular Pressure
Drainage
Angiopoietins
Vascular Diseases
Blood Vessels
TIE-2 Receptor
Therapeutics
Insulin
Islets of Langerhans
Immune System
Antibodies
Poisons

Research Output 1998 2018

  • 3780 Citations
  • 31 Article
  • 3 Review article
  • 1 Comment/debate
5 Citations (Scopus)

Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP

Souma, T., Thomson, B. R., Heinen, S., Carota, I. A., Yamaguchi, S., Onay, T., Liu, P., Ghosh, A. K., Li, C., Eremina, V., Hong, Y. K., Economides, A. N., Vestweber, D., Peters, K. G., Jin, J. & Quaggina, S. E., Feb 6 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 6, p. 1298-1303 6 p.

Research output: Contribution to journalArticle

Class 3 Receptor-Like Protein Tyrosine Phosphatases
Angiopoietin-2
Phosphoric Monoester Hydrolases
Lymphatic Endothelium
Blood Vessels
Renin-Angiotensin System
Angiotensin II
Hypertension
Blood Pressure
Transgenic Mice
1 Citation (Scopus)

Selective permeability of mouse blood-aqueous barrier as determined by 15 N-heavy isotope tracing and mass spectrometry

Liu, P., Thomson, B. R., Khalatyan, N., Feng, L., Liu, X., Savas, J. N., Quaggin, S. E. & Jin, J., Sep 4 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 36, p. 9032-9037 6 p.

Research output: Contribution to journalArticle

Blood-Aqueous Barrier
Isotopes
Permeability
Mass Spectrometry
Blood Proteins

Transcription factor 21 is required for branching morphogenesis and regulates the Gdnf-Axis in kidney development

Ide, S., Finer, G., Maezawa, Y., Onay, T., Souma, T., Scott, R. P., Ide, K., Akimoto, Y., Li, C., Ye, M., Zhao, X., Baba, Y., Minamizuka, T., Jin, J., Takemoto, M., Yokote, K. & Quaggin, S. E., Dec 1 2018, In : Journal of the American Society of Nephrology. 29, 12, p. 2795-2808 14 p.

Research output: Contribution to journalArticle

Morphogenesis
Transcription Factors
Mesoderm
Kidney
Down-Regulation
1 Citation (Scopus)

A Fluorometric Method of Measuring Carboxypeptidase Activities for Angiotensin II and Apelin-13

Liu, P., Wysocki, J., Serfozo, P., Ye, M., Souma, T., Batlle, D. & Jin, J., Apr 5 2017, In : Scientific Reports. 7, 45473.

Research output: Contribution to journalArticle

Carboxypeptidases
Phenylalanine
Angiotensin II
Proline
Enzymes