Personal profile

Research Interests

The lab is generally interested in the pathological mechanisms of kidney and vascular diseases. We take a proteomic approach to study molecules that serve structural or functional roles in kidney filtration. Particularly, we are trying to understand how the kidney podocytes maintain and regulate their slit diaphragm, as well as their interactions with the glomerular basement membrane.

Keywords

  • Hypertension
  • Angiogenesis
  • Cardiovascular Diseases
  • Nephrology
  • Vascular Biology
  • Proteomics
  • Biochemistry: Proteins

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Proteins Medicine & Life Sciences
Proto-Oncogene Proteins c-akt Medicine & Life Sciences
Protein Kinases Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
Phosphatidylinositol 3-Kinase Medicine & Life Sciences
Carcinogenesis Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences

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Research Output 1998 2017

  • 3511 Citations
  • 26 Article
  • 3 Review article
  • 1 Comment/debate

A Fluorometric Method of Measuring Carboxypeptidase Activities for Angiotensin II and Apelin-13

Liu, P., Wysocki, J., Serfozo, P., Ye, M., Souma, T., Batlle, D. & Jin, J. Apr 5 2017 In : Scientific Reports. 7, 45473

Research output: Research - peer-reviewArticle

Carboxypeptidases
Phenylalanine
Angiotensin II
Enzymes
apelin-13 peptide

Personalized peptide arrays for detection of HLA alloantibodies in organ transplantation

Liu, P., Souma, T., Wei, A. Z. S., Xie, X., Luo, X. & Jin, J. Sep 6 2017 In : Journal of Visualized Experiments. 2017, 127, e56278

Research output: Research - peer-reviewArticle

Isoantibodies
Organ Transplantation
HLA Antigens
Peptides
Transplantation (surgical)
17 Citations

Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity

Souma, T. , Tompson, S. W. , Thomson, B. R. , Siggs, O. M. , Kizhatil, K. , Yamaguchi, S. , Feng, L. , Limviphuvadh, V. , Whisenhunt, K. N. , Maurer-Stroh, S. , Yanovitch, T. L. , Kalaydjieva, L. , Azmanov, D. N. , Finzi, S. , Mauri, L. , Javadiyan, S. , Souzeau, E. , Zhou, T. , Hewitt, A. W. , Kloss, B. & 15 others Burdon, K. P., Mackey, D. A., Allen, K. F., Ruddle, J. B., Lim, S. H., Rozen, S., Tran-Viet, K. N., Liu, X., John, S., Wiggs, J. L., Pasutto, F., Craig, J. E., Jin, J., Quaggin, S. E. & Young, T. L. Jul 1 2016 In : Journal of Clinical Investigation. 126, 7, p. 2575-2587 13 p.

Research output: Research - peer-reviewArticle

Angiopoietins
Glaucoma
Mutation
Proteins
Anterior Chamber

A Novel Method for Anti-HLA Antibody Detection Using Personalized Peptide Arrays.

Liu, P., Souma, T., Wei, A. Z., Xie, X., Luo, X. & Jin, J. Oct 10 2016 In : Transplant Direct. 2, 11, p. 109 1 p.

Research output: ResearchArticle

3 Citations

Mutational analysis of glycogen synthase kinase 3β protein kinase together with kinome-wide binding and stability studies suggests context-dependent recognition of kinases by the chaperone heat shock protein 90

Jin, J., Tian, R., Pasculescu, A., Dai, A. Y., Williton, K., Taylor, L., Savitski, M. M., Bantscheff, M., Woodgett, J. R., Pawson, T. & Colwill, K. 2016 In : Molecular and Cellular Biology. 36, 6, p. 1007-1018 12 p.

Research output: Research - peer-reviewArticle

HSP90 Heat-Shock Proteins
Glycogen Synthase Kinases
Protein Kinases
Phosphotransferases
Protein Binding