Jing Jin

  • 3874 Citations
19982023
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Research Output 1998 2018

  • 3874 Citations
  • 31 Article
  • 3 Review article
  • 1 Comment/debate
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Article
2018
9 Citations (Scopus)

Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP

Souma, T., Thomson, B. R., Heinen, S., Carota, I. A., Yamaguchi, S., Onay, T., Liu, P., Ghosh, A. K., Li, C., Eremina, V., Hong, Y. K., Economides, A. N., Vestweber, D., Peters, K. G., Jin, J. & Quaggina, S. E., Feb 6 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 6, p. 1298-1303 6 p.

Research output: Contribution to journalArticle

Class 3 Receptor-Like Protein Tyrosine Phosphatases
Angiopoietin-2
Phosphoric Monoester Hydrolases
Lymphatic Endothelium
Blood Vessels
4 Citations (Scopus)
Renin-Angiotensin System
Angiotensin II
Hypertension
Blood Pressure
Transgenic Mice
1 Citation (Scopus)

Selective permeability of mouse blood-aqueous barrier as determined by15N-heavy isotope tracing and mass spectrometry

Liu, P., Thomson, B. R., Khalatyan, N., Feng, L., Liu, X., Savas, J. N., Quaggin, S. E. & Jin, J., Sep 4 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 36, p. 9032-9037 6 p.

Research output: Contribution to journalArticle

Blood-Aqueous Barrier
Isotopes
Permeability
Mass Spectrometry
Blood Proteins
1 Citation (Scopus)

Transcription factor 21 is required for branching morphogenesis and regulates the Gdnf-Axis in kidney development

Ide, S., Finer, G., Maezawa, Y., Onay, T., Souma, T., Scott, R. P., Ide, K., Akimoto, Y., Li, C., Ye, M., Zhao, X., Baba, Y., Minamizuka, T., Jin, J., Takemoto, M., Yokote, K. & Quaggin, S. E., Dec 1 2018, In : Journal of the American Society of Nephrology. 29, 12, p. 2795-2808 14 p.

Research output: Contribution to journalArticle

Morphogenesis
Transcription Factors
Mesoderm
Kidney
Down-Regulation
2017
3 Citations (Scopus)

A Fluorometric Method of Measuring Carboxypeptidase Activities for Angiotensin II and Apelin-13

Liu, P., Wysocki, J., Serfozo, P., Ye, M., Souma, T., Batlle, D. & Jin, J., Apr 5 2017, In : Scientific reports. 7, 45473.

Research output: Contribution to journalArticle

Carboxypeptidases
Phenylalanine
Angiotensin II
Proline
Enzymes
10 Citations (Scopus)

Angiopoietin-1 is required for Schlemm’s canal development in mice and humans

Thomson, B. R., Souma, T., Tompson, S. W., Onay, T., Kizhatil, K., Siggs, O. M., Feng, L., Whisenhunt, K. N., Yanovitch, T. L., Kalaydjieva, L., Azmanov, D. N., Finzi, S., Tanna, C. E., Hewitt, A. W., Mackey, D. A., Bradfield, Y. S., Souzeau, E., Javadiyan, S., Wiggs, J. L., Pasutto, F. & 6 others, Liu, X., John, S. W. M., Craig, J. E., Jin, J., Young, T. L. & Quaggin, S. E., Dec 1 2017, In : Journal of Clinical Investigation. 127, 12, p. 4421-4436 16 p.

Research output: Contribution to journalArticle

Angiopoietin-1
Angiopoietins
Glaucoma
Trabecular Meshwork
Aqueous Humor

Personalized peptide arrays for detection of HLA alloantibodies in organ transplantation

Liu, P., Souma, T., Wei, A. Z. S., Xie, X., Luo, X. & Jin, J., Sep 6 2017, In : Journal of Visualized Experiments. 2017, 127, e56278.

Research output: Contribution to journalArticle

Transplantation (surgical)
Isoantibodies
Organ Transplantation
Antigens
HLA Antigens
2016
41 Citations (Scopus)

Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity

Souma, T., Tompson, S. W., Thomson, B. R., Siggs, O. M., Kizhatil, K., Yamaguchi, S., Feng, L., Limviphuvadh, V., Whisenhunt, K. N., Maurer-Stroh, S., Yanovitch, T. L., Kalaydjieva, L., Azmanov, D. N., Finzi, S., Mauri, L., Javadiyan, S., Souzeau, E., Zhou, T., Hewitt, A. W., Kloss, B. & 15 others, Burdon, K. P., Mackey, D. A., Allen, K. F., Ruddle, J. B., Lim, S. H., Rozen, S., Tran-Viet, K. N., Liu, X., John, S., Wiggs, J. L., Pasutto, F., Craig, J. E., Jin, J., Quaggin, S. E. & Young, T. L., Jul 1 2016, In : Journal of Clinical Investigation. 126, 7, p. 2575-2587 13 p.

Research output: Contribution to journalArticle

Angiopoietins
Glaucoma
Mutation
Anterior Chamber
Intraocular Pressure

A Novel Method for Anti-HLA Antibody Detection Using Personalized Peptide Arrays.

Liu, P., Souma, T., Wei, AZ., Xie, X., Luo, X. & Jin, J., Oct 10 2016, In : Transplant Direct. 2, 11, p. 109 1 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Mutational analysis of glycogen synthase kinase 3β protein kinase together with kinome-wide binding and stability studies suggests context-dependent recognition of kinases by the chaperone heat shock protein 90

Jin, J., Tian, R., Pasculescu, A., Dai, A. Y., Williton, K., Taylor, L., Savitski, M. M., Bantscheff, M., Woodgett, J. R., Pawson, T. & Colwill, K., Jan 1 2016, In : Molecular and cellular biology. 36, 6, p. 1007-1018 12 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
HSP90 Heat-Shock Proteins
Protein Kinases
Phosphotransferases
Protein Binding
2015
5 Citations (Scopus)

Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8

Nie, J., Xu, C., Jin, J., Aka, J. A., Tempel, W., Nguyen, V., You, L., Weist, R., Min, J., Pawson, T. & Yang, X. J., Apr 7 2015, In : Structure. 23, 4, p. 700-712 13 p.

Research output: Contribution to journalArticle

Ankyrin Repeat
Histone Deacetylases
Ligases
Low Density Lipoprotein Receptor-Related Protein-2
Severe Combined Immunodeficiency
2013
10 Citations (Scopus)

Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling

Louria-Hayon, I., Frelin, C., Ruston, J., Gish, G., Jin, J., Kofler, M. M., Lambert, J. P., Adissu, H. A., Milyavsky, M., Herrington, R., Minden, M. D., Dick, J. E., Gingras, A. C., Iscove, N. N. & Pawson, T., Dec 17 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 51, p. 20599-20604 6 p.

Research output: Contribution to journalArticle

Interleukin-11
src Homology Domains
B-Lymphocytes
SH2 Domain-Containing Protein Tyrosine Phosphatases
Radiation
7 Citations (Scopus)

Rapid and sensitive MRM-based mass spectrometry approach for systematically exploring ganglioside-protein interactions

Tian, R., Jin, J., Taylor, L., Larsen, B., Quaggin, S. E. & Pawson, T., Apr 1 2013, In : Proteomics. 13, 8, p. 1334-1338 5 p.

Research output: Contribution to journalArticle

Gangliosides
Mass spectrometry
Mass Spectrometry
Proteins
G(M1) Ganglioside
2012
25 Citations (Scopus)

Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock

Xu, C., Jin, J., Bian, C., Lam, R., Tian, R., Weist, R., You, L., Nie, J., Bochkarev, A., Tempel, W., Tan, C. S., Wasney, G. A., Vedadi, M., Gish, G. D., Arrowsmith, C. H., Pawson, T., Yang, X. J. & Min, J., May 29 2012, In : Science Signaling. 5, 226, ra39.

Research output: Contribution to journalArticle

Ankyrin Repeat
Factor X
Proteins
Low Density Lipoprotein Receptor-Related Protein-2
Ankyrins
87 Citations (Scopus)

Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function

Jin, J., Sison, K., Li, C., Tian, R., Wnuk, M., Sung, H. K., Jeansson, M., Zhang, C., Tucholska, M., Jones, N., Kerjaschki, D., Shibuya, M., Fantus, I. G., Nagy, A., Gerber, H. P., Ferrara, N., Pawson, T. & Quaggin, S. E., Oct 12 2012, In : Cell. 151, 2, p. 384-399 16 p.

Research output: Contribution to journalArticle

Podocytes
Pericytes
Lipids
Protein Isoforms
Glycosphingolipids
2011
12 Citations (Scopus)

Evolutionary versatility of eukaryotic protein domains revealed by their bigram networks

Xie, X., Jin, J. & Mao, Y., Aug 22 2011, In : BMC Evolutionary Biology. 11, 1, 242.

Research output: Contribution to journalArticle

genome
linkage (genetics)
networking
protein
proteins
2010
90 Citations (Scopus)

Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain

Liu, K., Chen, C., Guo, Y., Lam, R., Bian, C., Xu, C., Zhao, D. Y., Jin, J., MacKenzie, F., Pawson, T. & Min, J., Oct 26 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 43, p. 18398-18403 6 p.

Research output: Contribution to journalArticle

Micrococcal Nuclease
Arginine
Germ Cells
Methylation
Proteins
2009
89 Citations (Scopus)

Eukaryotic protein domains as functional units of cellular evolution

Jin, J., Xie, X., Chen, C., Park, J. G., Stark, C., James, D. A., Olhovsky, M., Linding, R., Mao, Y. & Pawson, T., Nov 24 2009, In : Science Signaling. 2, 98

Research output: Contribution to journalArticle

Protein Interaction Domains and Motifs
Biological Phenomena
Cellular Microenvironment
Chromatin Assembly and Disassembly
Proteome
108 Citations (Scopus)

Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi

Chen, C., Jin, J., James, D. A., Adams-Cioaba, M. A., Park, J. G., Guo, Y., Tenaglia, E., Xu, C., Gish, G., Min, J. & Pawson, T., Dec 1 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 48, p. 20336-20341 6 p.

Research output: Contribution to journalArticle

Arginine
Proteins
Germ Cells
Ligands
Small Interfering RNA
2007
519 Citations (Scopus)

Systematic Discovery of In Vivo Phosphorylation Networks

Linding, R., Jensen, L. J., Ostheimer, G. J., van Vugt, M. A. T. M., Jørgensen, C., Miron, I. M., Diella, F., Colwill, K., Taylor, L., Elder, K., Metalnikov, P., Nguyen, V., Pasculescu, A., Jin, J., Park, J. G., Samson, L. D., Woodgett, J. R., Russell, RB., Bork, P., Yaffe, M. B. & 1 others, Pawson, T., Jun 29 2007, In : Cell. 129, 7, p. 1415-1426 12 p.

Research output: Contribution to journalArticle

Phosphorylation
Phosphotransferases
Substrate Specificity
Substrates
Glycogen Synthase Kinase 3
2006
114 Citations (Scopus)

Genomic DNA functions as a universal external standard in quantitative real-time PCR

Yun, J. J., Heisler, L. E., Hwang, I. I. L., Wilkins, O., Lau, S. K., Hyrcza, M., Jayabalasingham, B., Jin, J., McLaurin, J. A., Tsao, M. S. & Der, S. D., Dec 1 2006, In : Nucleic Acids Research. 34, 12

Research output: Contribution to journalArticle

Real-Time Polymerase Chain Reaction
Gene Expression
DNA
Transgenic Mice
Genome
2005
29 Citations (Scopus)

Chronic activation of protein kinase Bβ/Akt2 leads to multinucleation and cell fusion in human epithelial kidney cells: Events associated with tumorigenesis

Jin, J. & Woodgett, J. R., Aug 18 2005, In : Oncogene. 24, 35, p. 5459-5470 12 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-akt
Cell Fusion
Carcinogenesis
Epithelial Cells
Kidney
2004
168 Citations (Scopus)

Activation of Akt-1 (PKB-α) Can Accelerate ErbB-2-Mediated Mammary Tumorigenesis but Suppresses Tumor Invasion

Hutchinson, J. N., Jin, J., Cardiff, R. D., Woodgett, J. R. & Muller, W. J., May 1 2004, In : Cancer Research. 64, 9, p. 3171-3178 8 p.

Research output: Contribution to journalArticle

Carcinogenesis
Breast
Breast Neoplasms
Mouse mammary tumor virus
Neoplasms
349 Citations (Scopus)

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization

Jin, J., Smith, F. D., Stark, C., Wells, C. D., Fawcett, J. P., Kulkarni, S., Metalnikov, P., O'Donnell, P., Taylor, P., Taylor, L., Zougman, A., Woodgett, J. R., Langeberg, L. K., Scott, J. D. & Pawson, T., Aug 24 2004, In : Current Biology. 14, 16, p. 1436-1450 15 p.

Research output: Contribution to journalArticle

14-3-3 Proteins
Proteomics
proteomics
Protein Kinases
binding proteins
2001
214 Citations (Scopus)

Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

Hutchinson, J., Jin, J., Cardiff, R. D., Woodgett, J. R. & Muller, W. J., Mar 1 2001, In : Molecular and Cellular Biology. 21, 6, p. 2203-2212 10 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-akt
Phosphatidylinositol 3-Kinases
Transgenic Mice
Polyomavirus Transforming Antigens
Cell Survival
30 Citations (Scopus)

Regulation of Drosophila Tracheal System Development by Protein Kinase B

Jin, J., Anthopoulos, N., Wetsch, B., Binari, R. C., Isaac, D. D., Andrew, D. J., Woodgett, J. R. & Manoukian, A. S., Dec 1 2001, In : Developmental Cell. 1, 6, p. 817-827 11 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Fibroblast Growth Factor Receptors
Proto-Oncogene Proteins c-akt
Phosphorylation
Trachea
14 Citations (Scopus)

The role of protein kinase B (PKB) in modulating heat sensitivity in a human breast cancer cell line

Ma, N., Jin, J., Lu, F., Woodgett, J. & Liu, F. F., Jul 15 2001, In : International Journal of Radiation Oncology Biology Physics. 50, 4, p. 1041-1050 10 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-akt
cultured cells
breast
apoptosis
Hot Temperature
1999
122 Citations (Scopus)
TOR Serine-Threonine Kinases
Phosphatidylinositol 3-Kinase
Proto-Oncogene Proteins c-akt
Facilitative Glucose Transport Proteins
Protein Biosynthesis
479 Citations (Scopus)

Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts

Wang, Q., Somwar, R., Bilan, P. J., Liu, Z., Jin, J., Woodgett, J. R. & Klip, A., Jan 1 1999, In : Molecular and Cellular Biology. 19, 6, p. 4008-4018 11 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-akt
Myoblasts
Insulin
Phosphatidylinositol 3-Kinase
Hemagglutinins
1998
64 Citations (Scopus)

Downregulation of the pro-apoptotic protein Bak is required for the ras-induced transformation of intestinal epithelial cells

Rosen, K., Rak, J., Jin, J., Kerbel, R. S., Newman, M. J. & Filmus, J., Dec 3 1998, In : Current Biology. 8, 24, p. 1331-1334 4 p.

Research output: Contribution to journalArticle

Anoikis
Apoptosis Regulatory Proteins
epithelial cells
Down-Regulation
Epithelial Cells
108 Citations (Scopus)

Genetic analysis of protein kinase B (AKT) in Drosophila

Staveley, B. E., Ruel, L., Jin, J., Stambolic, V., Mastronardi, F. G., Heitzler, P., Woodgett, J. R. & Manoukian, A. S., May 7 1998, In : Current Biology. 8, 10, p. 599-603 5 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-akt
Phosphatidylinositol 3-Kinase
protein kinases
Drosophila
genetic techniques and protocols