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Research Output 1996 2019

  • 2339 Citations
  • 42 Article
  • 5 Review article
  • 2 Conference contribution
2019

Deletion of exons 17 and 18 in prestin’s STAS domain results in loss of function

Takahashi, S., Yamashita, T., Homma, K., Zhou, Y., Zuo, J., Zheng, J. & Cheatham, M. A., Dec 1 2019, In : Scientific Reports. 9, 1, 6874.

Research output: Contribution to journalArticle

Open Access
Exons
Outer Auditory Hair Cells
Calmodulin
Proteins
Messenger RNA
2018
1 Citation (Scopus)

Prestin contributes to membrane compartmentalization and is required for normal innervation of outer hair cells

Takahashi, S., Sun, W., Zhou, Y., Homma, K., Kachar, B., Cheatham, M. A. & Zheng, J., Jul 20 2018, In : Frontiers in Cellular Neuroscience. 12, 211.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Knockout Mice
Membranes
Synapses
Proteins
1 Citation (Scopus)

The extracellular loop of pendrin and prestin modulates their voltage-sensing property

Kuwabara, M. F., Wasano, K., Takahashi, S., Bodner, J., Komori, T., Uemura, S., Zheng, J., Shima, T. & Homma, K., Jan 1 2018, In : Journal of Biological Chemistry. 293, 26, p. 9970-9980 11 p.

Research output: Contribution to journalArticle

Anions
Capacitance
Electric Capacitance
Electric potential
Ion Transport

The susceptibility of cochlear outer hair cells to cyclodextrin is not related to their electromotile activity

Zhou, Y., Takahashi, S., Homma, K., Duan, C., Zheng, J., Cheatham, M. A. & Zheng, J., Sep 24 2018, In : Acta Neuropathologica Communications. 6, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Outer Auditory Hair Cells
Cyclodextrins
Cell Death
Knockout Mice
Cholesterol
2016
2 Citations (Scopus)

A comparison of classical histology to anatomy revealed by hard X-rays

Richter, C-P., Tan, X., Young, H., Stock, S. R., Robinson, A., Byskosh, O., Zheng, J., Soriano, C., Xiao, X. & Whitlon, D. S., Jan 1 2016, Developments in X-Ray Tomography X. Wang, G., Stock, S. R. & Muller, B. (eds.). SPIE, 99671I. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 9967).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Histology
Hard X-ray
histology
anatomy
Computed Tomography
8 Citations (Scopus)

Cadherin 23-C Regulates Microtubule Networks by Modifying CAMSAP3's Function

Takahashi, S., Mui, V. J., Rosenberg, S. K., Homma, K., Cheatham, M. A. & Zheng, J., Jun 28 2016, In : Scientific Reports. 6, 28706.

Research output: Contribution to journalArticle

Cadherins
Microtubules
Hearing
Carrier Proteins
Usher Syndromes
12 Citations (Scopus)

Susceptibility of outer hair cells to cholesterol chelator 2-hydroxypropyl-β-cyclodextrine is prestin-dependent

Takahashi, S., Homma, K., Zhou, Y., Nishimura, S., Duan, C., Chen, J., Ahmad, A., Cheatham, M. A. & Zheng, J., Feb 23 2016, In : Scientific Reports. 6, 21973.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Cyclodextrins
Chelating Agents
Cholesterol
Type C Niemann-Pick Disease
1 Citation (Scopus)

The R130S mutation significantly affects the function of prestin, the outer hair cell motor protein

Takahashi, S., Cheatham, M. A., Zheng, J. & Homma, K., Sep 1 2016, In : Journal of Molecular Medicine. 94, 9, p. 1053-1062 10 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Missense Mutation
Mutation
Hearing Loss
Proteins
2015

Examining the role of the tectorial membrane in otoacoustic emission generation

Cheatham, M. A., Goodyear, R. J., Charaziak, K. K., Conklin, T., Zheng, J., Dallos, P., Richardson, G. P. & Siegel, J. H., Dec 31 2015, Mechanics of Hearing: Protein to Perception - Proceedings of the 12th International Workshop on the Mechanics of Hearing. Corey, D. P. & Karavitaki, K. D. (eds.). American Institute of Physics Inc., Vol. 1703. 090005

Research output: Chapter in Book/Report/Conference proceedingConference contribution

membranes
mice
knockout mice
membrane structures
antigens
4 Citations (Scopus)

Prestin-Dependence of Outer Hair Cell Survival and Partial Rescue of Outer Hair Cell Loss in PrestinV499G/Y501H Knockin Mice

Cheatham, M. A., Edge, R. M., Homma, K., Leserman, E. L., Dallos, P. & Zheng, J., Dec 1 2015, In : PLoS One. 10, 12, e0145428.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Alopecia
Audition
hairs
cell viability
2014
7 Citations (Scopus)

Functional regulation of the SLC26-family protein prestin by calcium/calmodulin

Keller, J. P., Homma, K., Duan, C., Zheng, J., Cheatham, M. A. & Dallos, P., Jan 27 2014, In : Journal of Neuroscience. 34, 4, p. 1325-1332 8 p.

Research output: Contribution to journalArticle

Calmodulin
Outer Auditory Hair Cells
Calcium
Genes
Proteins
22 Citations (Scopus)

Loss of the tectorial membrane protein CEACAM16 enhances spontaneous, stimulus-frequency, and transiently evoked otoacoustic emissions

Cheatham, M. A., Goodyear, R. J., Homma, K., Kevin Legan, P., Korchagina, J., Naskar, S., Siegel, J. H., Dallos, P., Zheng, J. & Richardson, G. P., Jan 1 2014, In : Journal of Neuroscience. 34, 31, p. 10325-10338 14 p.

Research output: Contribution to journalArticle

Tectorial Membrane
Membrane Proteins
Organ of Corti
Spontaneous Otoacoustic Emissions
Carcinoembryonic Antigen
2013
19 Citations (Scopus)

Linguistic Grammar Learning and DRD2-TAQ-IA Polymorphism

Wong, P. C. M., Ettlinger, M. & Zheng, J., May 31 2013, In : PLoS One. 8, 5, e64983.

Research output: Contribution to journalArticle

Dopamine D2 Receptors
Linguistics
Polymorphism
learning
Genes
9 Citations (Scopus)

Marshalin, a microtubule minus-end binding protein, regulates cytoskeletal structure in the organ of Corti

Zheng, J., Furness, D., Duan, C., Miller, K. K., Edge, R. M., Chen, J., Homma, K., Hackney, C. M., Dallos, P. & Cheatham, M. A., Nov 15 2013, In : Biology Open. 2, 11, p. 1192-1202 11 p.

Research output: Contribution to journalArticle

Organ of Corti
Microtubules
microtubules
binding proteins
Carrier Proteins
12 Citations (Scopus)

The V499G/Y501H mutation impairs fast motor kinetics of prestin and has significance for defining functional independence of individual prestin subunits

Homma, K., Duan, C., Zheng, J., Cheatham, M. A. & Dallos, P., Jan 25 2013, In : Journal of Biological Chemistry. 288, 4, p. 2452-2463 12 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Cochlea
Mutation
Kinetics
Mutagenesis
2012
29 Citations (Scopus)

Linking neurogenetics and individual differences in language learning: The dopamine hypothesis

Wong, P. C. M., Morgan-Short, K., Ettlinger, M. & Zheng, J., Jan 1 2012, In : Cortex. 48, 9, p. 1091-1102 12 p.

Research output: Contribution to journalReview article

Individuality
Dopamine
Language
Learning
Neuronal Plasticity
12 Citations (Scopus)

The derived allele of ASPM is associated with lexical tone perception

Wong, P. C. M., Chandrasekaran, B. & Zheng, J., Apr 17 2012, In : PloS one. 7, 4, e34243.

Research output: Contribution to journalArticle

Brain
Alleles
alleles
brain
Genes
2011
61 Citations (Scopus)

Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with α-tectorin and is mutated in autosomal dominant hearing loss (DFNA4)

Zheng, J., Miller, K. K., Yang, T., Hildebrand, M. S., Shearer, A. E., DeLuca, A. P., Scheetz, T. E., Drummond, J., Scherer, S. E., Legan, P. K., Goodyear, R. J., Richardson, G. P., Cheatham, M. A., Smith, R. J. & Dallos, P., Mar 8 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 10, p. 4218-4223 6 p.

Research output: Contribution to journalArticle

Tectorial Membrane
Outer Auditory Hair Cells
Carcinoembryonic Antigen
Cell Adhesion Molecules
Hearing Loss
2010
31 Citations (Scopus)

Interaction between CFTR and prestin (SLC26A5)

Homma, K., Miller, K. K., Anderson, C. T., Sengupta, S., Du, G. G., Aguiñaga, S., Cheatham, M. A., Dallos, P. & Zheng, J., Jun 1 2010, In : Biochimica et Biophysica Acta - Biomembranes. 1798, 6, p. 1029-1040 12 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Outer Auditory Hair Cells
Membranes
Chloride Channels
Inner Auditory Hair Cells
7 Citations (Scopus)

Interaction between the motor protein prestin and the transporter protein VAPA

Sengupta, S., Miller, K. K., Homma, K., Edge, R., Cheatham, M. A., Dallos, P. & Zheng, J., Jul 1 2010, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1803, 7, p. 796-804 9 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Proteins
Membrane Proteins
R-SNARE Proteins
Cell Membrane
25 Citations (Scopus)
Cadherins
Myosins
Epithelial Cells
Stereocilia
Microvilli
2009
8 Citations (Scopus)

A chimera analysis of prestin knock-out mice

Cheatham, M. A., Low-Zeddies, S., Naik, K., Edge, R., Zheng, J., Anderson, C. T. & Dallos, P., Sep 23 2009, In : Journal of Neuroscience. 29, 38, p. 12000-12008 9 p.

Research output: Contribution to journalArticle

Knockout Mice
Cochlea
Genotype
Phenotype
Outer Auditory Hair Cells
16 Citations (Scopus)

EHD4 and CDH23 are interacting partners in cochlear hair cells

Sengupta, S., George, M., Miller, K. K., Naik, K., Chou, J., Cheatham, M. A., Dallos, P., Naramura, M., Band, H. & Zheng, J., Jul 24 2009, In : Journal of Biological Chemistry. 284, 30, p. 20121-20129 9 p.

Research output: Contribution to journalArticle

Auditory Hair Cells
Cadherins
Cells
Audition
Knockout Mice
8 Citations (Scopus)

Identifying components of the hair-cell interactome involved in cochlear amplification

Zheng, J., Anderson, C. T., Miller, K. K., Cheatham, M. A. & Dallos, P., Mar 25 2009, In : BMC Genomics. 10, 127.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Cochlea
Cellular Structures
Cadherins
Proteins
2008
10 Citations (Scopus)

Glucose transporter 5 is undetectable in outer hair cells and does not contribute to cochlear amplification

Wu, X., Wang, X., Gao, J., Yu, Y., Jia, S., Zheng, J., Dallos, P., He, D. Z. Z., Cheatham, M. A. & Zuo, J., May 19 2008, In : Brain Research. 1210, p. 20-28 9 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Facilitative Glucose Transport Proteins
Cochlea
Fructose
Cell Movement
208 Citations (Scopus)

Prestin-Based Outer Hair Cell Motility Is Necessary for Mammalian Cochlear Amplification

Dallos, P., Wu, X., Cheatham, M. A., Gao, J., Zheng, J., Anderson, C. T., Jia, S., Wang, X., Cheng, W. H. Y., Sengupta, S., He, D. Z. Z. & Zuo, J., May 8 2008, In : Neuron. 58, 3, p. 333-339 7 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Cochlea
Knockout Mice
Cell Movement
Mechanical Phenomena
2007
16 Citations (Scopus)

A new mutation in the human pres gene and its effect on prestin function

Toth, T., Deak, L., Fazakas, F., Zheng, J., Muszbek, L. & Sziklai, I., Oct 1 2007, In : International Journal of Molecular Medicine. 20, 4, p. 545-550 6 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Mutation
Hearing
Genes
Cochlea
18 Citations (Scopus)

Evaluation of an independent prestin mouse model derived from the 129S1 strain

Cheatham, M. A., Zheng, J., Huynh, K. H., Du, G. G., Edge, R. M., Anderson, C. T., Zuo, J., Ryan, A. F. & Dallos, P., Oct 1 2007, In : Audiology and Neurotology. 12, 6, p. 378-390 13 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Cochlea
Action Potentials
Proteins
Phenotype
6 Citations (Scopus)

Isolation of outer hair cells from the cochlear sensory epithelium in whole-mount preparation using laser capture microdissection

Anderson, C. T. & Zheng, J., May 15 2007, In : Journal of Neuroscience Methods. 162, 1-2, p. 229-236 8 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Laser Capture Microdissection
Cochlea
Epithelium
Inner Auditory Hair Cells
26 Citations (Scopus)

Prestin-based outer hair cell electromotility in knockin mice does not appear to adjust the operating point of a cilia-based amplifier

Gao, J., Wang, X., Wu, X., Aguinaga, S., Huynh, K., Jia, S., Matsuda, K., Patel, M., Zheng, J., Cheatham, M. A., He, D. Z., Dallos, P. & Zuo, J., Jul 24 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 30, p. 12542-12547 6 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Cilia
Cochlea
Stereocilia
Cell Movement
2006
68 Citations (Scopus)

Analysis of the oligomeric structure of the motor protein prestin

Zheng, J., Du, G. G., Anderson, C. T., Keller, J. P., Orem, A., Dallos, P. & Cheatham, M. A., Jul 21 2006, In : Journal of Biological Chemistry. 281, 29, p. 19916-19924 9 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Cells
Oligomers
Yeast
Membranes
90 Citations (Scopus)

Prestin and the cochlear amplifier

Dallos, P., Zheng, J. & Cheatham, M. A., Oct 1 2006, In : Journal of Physiology. 576, 1, p. 37-42 6 p.

Research output: Contribution to journalReview article

Stereocilia
Cochlea
Outer Auditory Hair Cells
Sense Organs
Transducers
39 Citations (Scopus)

Tuning in to the amazing outer hair cell: Membrane wizardry with a twist and shout

He, D. Z. Z., Zheng, J., Kalinec, F., Kakehata, S. & Santos-Sacchi, J., Jan 1 2006, In : Journal of Membrane Biology. 209, 2-3, p. 119-134 16 p.

Research output: Contribution to journalReview article

Outer Auditory Hair Cells
Cell Membrane
Cochlea
Hearing
Cations
2005
36 Citations (Scopus)

Cochlear function in mice with only one copy of the prestin gene

Cheatham, M. A., Zheng, J., Huynh, K. H., Du, G. G., Gao, J., Zuo, J., Navarrete, E. & Dallos, P., Nov 15 2005, In : Journal of Physiology. 569, 1, p. 229-241 13 p.

Research output: Contribution to journalArticle

Cochlea
Heterozygote
Genes
Outer Auditory Hair Cells
Electrophysiology
63 Citations (Scopus)

Effects of cyclic nucleotides on the function of prestin

Deák, L., Zheng, J., Orem, A., Du, G. G., Aguiñaga, S., Matsuda, K. & Dallos, P., Mar 1 2005, In : Journal of Physiology. 563, 2, p. 483-496 14 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Cyclic Nucleotides
Cyclic GMP-Dependent Protein Kinases
Phosphorylation
Neutral Amino Acids
48 Citations (Scopus)

The C-terminus of prestin influences nonlinear capacitance and plasma membrane targeting

Zheng, J., Du, G. G., Matsuda, K., Orem, A., Aguiñaga, S., Deák, L., Navarrete, E., Madison, L. D. & Dallos, P., Jul 1 2005, In : Journal of Cell Science. 118, 13, p. 2987-2996 10 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Cell Membrane
Cochlea
Amino Acids
Membrane Potentials
2004
51 Citations (Scopus)

N-linked glycosylation sites of the motor protein prestin: Effects on membrane targeting and electrophysiological function

Matsuda, K., Zheng, J., Du, G. G., Klöcker, N., Madison, L. D. & Dallos, P., May 1 2004, In : Journal of Neurochemistry. 89, 4, p. 928-938 11 p.

Research output: Contribution to journalArticle

Glycosylation
Membranes
Proteins
Outer Auditory Hair Cells
Glycoproteins
2003
46 Citations (Scopus)

Genomic characterization and expression of mouse prestin, the motor protein of outer hair cells

Zheng, J., Long, K. B., Matsuda, K., Madison, L. D., Ryan, A. & Dallos, P., Feb 1 2003, In : Mammalian Genome. 14, 2, p. 87-96 10 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Exons
Genes
Gerbillinae
Binding Sites
130 Citations (Scopus)

Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss

Liu, X. Z., Ouyang, X. M., Xia, X. J., Zheng, J., Pandya, A., Li, F., Du, L. L., Welch, K. O., Petit, C., Smith, R. J. H., Webb, B. T., Yan, D., Arnos, K. S., Corey, D., Dallos, P., Nance, W. E. & Chen, Z. Y., May 15 2003, In : Human molecular genetics. 12, 10, p. 1155-1162 8 p.

Research output: Contribution to journalArticle

Cochlea
Hearing Loss
Outer Auditory Hair Cells
Mutation
Genes
9 Citations (Scopus)

Prestin expression in the cochlea of the reeler mouse

Zheng, J., Richter, C. P. & Cheatham, M. A., Aug 14 2003, In : Neuroscience Letters. 347, 1, p. 13-16 4 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Cochlea
Outer Auditory Hair Cells
Chromosomes, Human, Pair 5
Brain Stem Auditory Evoked Potentials
2002
8 Citations (Scopus)

Identification of differentially expressed cDNA clones from gerbil cochlear outer hair cells

Zheng, J., Long, K. B., Robison, D. E., He, D. Z. Z., Cheng, J., Dallos, P. & Madison, L. D., Oct 9 2002, In : Audiology and Neuro-Otology. 7, 5, p. 277-288 12 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Gerbillinae
Inner Auditory Hair Cells
Complementary DNA
Clone Cells
50 Citations (Scopus)

Prestin, the motor protein of outer hair cells

Zheng, J., Madison, L. D., Oliver, D., Fakler, B. & Dallos, P., Apr 6 2002, In : Audiology and Neuro-Otology. 7, 1, p. 9-12 4 p.

Research output: Contribution to journalReview article

Outer Auditory Hair Cells
Anions
Inner Auditory Hair Cells
Chlorides
Chloride-Bicarbonate Antiporters
2001
12 Citations (Scopus)

Development of acetylcholine receptors in cultured outer hair cells

He, D. Z. Z., Zheng, J. & Dallos, P., Nov 28 2001, In : Hearing Research. 162, 1-2, p. 113-125 13 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Cholinergic Receptors
Cultured Cells
Acetylcholine
Cochlea
64 Citations (Scopus)

Effects of membrane potential and tension on prestin, the outer hair cell lateral membrane motor protein

Santos-Sacchi, J., Shen, W., Zheng, J. & Dallos, P., Mar 15 2001, In : Journal of Physiology. 531, 3, p. 661-666 6 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Membrane Potentials
Membrane Proteins
Cell Membrane
Membranes
81 Citations (Scopus)

Prestin topology: Localization of protein epitopes in relation to the plasma membrane

Zheng, J., Long, K. B., Shen, W., Madison, L. D. & Dallos, P., Jul 3 2001, In : NeuroReport. 12, 9, p. 1929-1935 7 p.

Research output: Contribution to journalArticle

Epitopes
Cell Membrane
Outer Auditory Hair Cells
Proteins
Fluorescent Antibody Technique
2000
32 Citations (Scopus)

Isolation of cochlear inner hair cells

He, D. Z. Z., Zheng, J., Edge, R. & Dallos, P., Jun 27 2000, In : Hearing Research. 145, 1-2, p. 156-160 5 p.

Research output: Contribution to journalArticle

Inner Auditory Hair Cells
Gerbillinae
Patch-Clamp Techniques
Genes
Molecular Biology
814 Citations (Scopus)

Prestin is the motor protein of cochlear outer hair cells

Zheng, J., Shen, W., He, D. Z. Z., Long, K. B., Madison, L. D. & Dallos, P., May 11 2000, In : Nature. 405, 6783, p. 149-155 7 p.

Research output: Contribution to journalReview article

Outer Auditory Hair Cells
Inner Auditory Hair Cells
Cochlea
Proteins
Anion Transport Proteins
84 Citations (Scopus)

Regulation of the pituitary somatotroph cell by GHRH and its receptor

Mayo, K. E., Miller, T., DeAlmeida, V., Godfrey, P., Zheng, J., Cunha, S. R., Cutler, G., Carter-Su, C. & Frohman, L., Dec 1 2000, In : Recent Progress in Hormone Research. 55, p. 237-267 31 p.

Research output: Contribution to journalArticle

Somatotrophs
Growth Hormone-Releasing Hormone
Hormones
Transcription Factor Pit-1
Gene Expression
1996
35 Citations (Scopus)

The growth-hormone-releasing hormone receptor: Signal transduction, gene expression, and physiological function in growth regulation

Mayo, K. E., Miller, T. L., DeAlmeida, V., Zheng, J. & Godfrey, P. A., Jan 1 1996, In : Annals of the New York Academy of Sciences. 805, p. 184-203 20 p.

Research output: Contribution to journalArticle

Signal transduction
Gene expression
Growth Hormone
Signal Transduction
Gene Expression