Grants per year
Personal profile
Research Interests
I have studied skin carcinogenesis and the biology of keratinocytes in response to DNA damaging agents like ultraviolet (UV) light for more than 12 years. I have made several key contributions to understanding the process of skin carcinogenesis by studying how the p53 family of tumor suppressors is involved in transcriptional regulation and coordinating keratinocyte responses to DNA damaging agents. By delivering a nuclear-targeted DNA repair protein through the epidermis to increase the rate of repair of UV-induced DNA damage in basal keratinocytes, I demonstrated the feasibility of a potential clinical strategy for prevention of SCC, which may one day be of use for patients such as organ transplant recipients who are at up to 100 fold increased risk of developing SCC compared to the general population. My current research aims to understand how and why UV-damaged keratinocytes remain within the skin structure to later become cancerous rather than undergoing apoptosis or exiting the skin through differentiation. I am studying the roles of cell-cell adhesion desmosomal proteins in coordinating global keratinocyte responses to UV exposure within the 3D skin structure, including cell cycle arrest, proliferation, apoptosis, and differentiation. My research offers novel and unique perspectives about epidermal recovery in response to environmental injury, a topic on which very little is currently known.
Training Experience
2010 | Postdoctoral Fellowship, Oregon Health & Science University |
2011 | Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine |
Education/Academic qualification
PhD, Oregon Health and Science University
… → 2007
Molecular Genetics, PhD, Oregon Health and Science University
… → 2007
Research interests
- Cell Biology
- DNA Repair
- Genetics
- Skin
- Skin Cancer
- Transplant Pathology
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Grants
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Role of Desmoglein 1 in Keratinocyte-Melanocyte Communication and Melanoma
Johnson, J. L. P., Godsel, L. M. & Green, K. J.
2/1/19 → 1/31/24
Project: Research project
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Function of Desmoglein 1/Pemphigus Foliaceus Antigen
Johnson, J. L. P., Nekrasova, O. & Green, K. J.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/1/17 → 8/31/22
Project: Research project
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P&F 9: Study of Keratinocyte B: Jodi Johnson
Johnson, J. L. P. & Johnson, J. L. P.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
8/1/14 → 1/31/20
Project: Research project
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Role of Cell Anchoring Desmosomal Proteins in Epidermal Responses to UV Exposure
Johnson, J. L. P. & Green, K. J.
7/1/12 → 6/30/15
Project: Research project
Research Output
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Keratinocyte cadherin desmoglein 1 controls melanocyte behavior through paracrine signaling
Arnette, C. R., Roth-Carter, Q. R., Koetsier, J. L., Broussard, J. A., Burks, H. E., Cheng, K., Amadi, C., Gerami, P., Johnson, J. L. & Green, K. J., Mar 1 2020, In: Pigment Cell and Melanoma Research. 33, 2, p. 305-317 13 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Sarecycline: A review of preclinical and clinical evidence
Moore, A. Y., Del Rosso, J., Johnson, J. L. & Grada, A., 2020, In: Clinical, Cosmetic and Investigational Dermatology. 13, p. 553-560 8 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
The Role of Desmoglein 1 in Gap Junction Turnover Revealed through the Study of SAM Syndrome
Cohen-Barak, E., Godsel, L. M., Koetsier, J. L., Hegazy, M., Kushnir-Grinbaum, D., Hammad, H., Danial-Farran, N., Harmon, R., Khayat, M., Bochner, R., Peled, A., Rozenblat, M., Krausz, J., Sarig, O., Johnson, J. L., Ziv, M., Shalev, S. A., Sprecher, E. & Green, K. J., Mar 2020, In: Journal of Investigative Dermatology. 140, 3, p. 556-567.e9Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Putting “Research Techniques Made Simple” Articles to Work for You and for the Future of Investigative Dermatology
Johnson, J. L., Sep 2019, In: Journal of Investigative Dermatology. 139, 9, p. 1841-1842 2 p.Research output: Contribution to journal › Editorial › peer-review
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Keratinocyte desmoglein 1 regulates the epidermal microenvironment and tanning response
Arnette, C. R., Koetsier, J. L., Broussard, J. A., Gerami, P., Johnson, J. L. & Green, K. J., Sep 20 2018, In: Unknown Journal.Research output: Contribution to journal › Article › peer-review