Research Output per year
Research Output 2002 2019
2019
11
Citations
(Scopus)
Dysregulation of the autophagic-lysosomal pathway in Gaucher and Parkinson's disease
Pitcairn, C., Wani, W. Y. & Mazzulli, J., Feb 1 2019, In : Neurobiology of Disease. 122, p. 72-82 11 p.Research output: Contribution to journal › Review article
Gaucher Disease
Parkinson Disease
Induced Pluripotent Stem Cells
Lewy Bodies
Mutation
Increased Lysosomal Exocytosis Induced by Lysosomal Ca2+ Channel Agonists Protects Human Dopaminergic Neurons from α-Synuclein Toxicity
Tsunemi, T., Perez-Rosello, T., Ishiguro, Y., Yoroisaka, A., Jeon, S., Hamada, K., Rammonhan, M., Wong, Y. C., Xie, Z., Akamatsu, W., Mazzulli, J., Surmeier Jr, D. J., Hattori, N. & Krainc, D., Jul 17 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 29, p. 5760-5772 13 p.Research output: Contribution to journal › Article
Synucleins
Dopaminergic Neurons
Exocytosis
Parkinson Disease
Neurons
Modeling neuronopathic storage diseases with patient-derived culture systems
Zunke, F. & Mazzulli, J., Jul 1 2019, In : Neurobiology of Disease. 127, p. 147-162 16 p.Research output: Contribution to journal › Review article
Induced Pluripotent Stem Cells
Lysergic Acid Diethylamide
Neuroglia
Cell Differentiation
Pathology
2018
13
Citations
(Scopus)
Is Parkinson's disease a lysosomal disorder?
Klein, A. D. & Mazzulli, J., Jan 1 2018, In : Brain. 141, 8, p. 2255-2262 8 p.Research output: Contribution to journal › Article
Parkinson Disease
Synucleins
Molecular Biology
Mutation
Genes
6
Citations
(Scopus)
Molecular mechanisms of α-synuclein and GBA1 in Parkinson’s disease
Stojkovska, I., Krainc, D. & Mazzulli, J., Oct 24 2018, In : Cell and Tissue Research. 373, 1, p. 51-60 10 p.Research output: Contribution to journal › Review article
Synucleins
Glucosylceramidase
Parkinson Disease
Lewy Bodies
Gaucher Disease
28
Citations
(Scopus)
Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide
Zunke, F., Moise, A. C., Belur, N. R., Gelyana, E., Stojkovska, I., Dzaferbegovic, H., Toker, N. J., Jeon, S., Fredriksen, K. & Mazzulli, J., Jan 3 2018, In : Neuron. 97, 1, p. 92-107.e10Research output: Contribution to journal › Article
Synucleins
Glucosylceramides
Glycosphingolipids
Poisons
Parkinson Disease
2017
46
Citations
(Scopus)
Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration
Mor, D. E., Tsika, E., Mazzulli, J. R., Gould, N. S., Kim, H., Daniels, M. J., Doshi, S., Gupta, P., Grossman, J. L., Tan, V. X., Kalb, R. G., Caldwell, K. A., Caldwell, G. A., Wolfe, J. H. & Ischiropoulos, H., Jan 1 2017, In : Nature Neuroscience. 20, 11, p. 1560-1568 9 p.Research output: Contribution to journal › Article
Synucleins
Dopamine
Dopaminergic Neurons
Parkinson Disease
Cell Death
120
Citations
(Scopus)
Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease
Burbulla, L., Song, P., Mazzulli, J., Zampese, E., Wong, Y. C., Jeon, S., Santos, D. P., Blanz, J., Obermaier, C. D., Strojny, C., Savas, J. N., Kiskinis, E., Zhuang, X., Krüger, R., Surmeier Jr, D. J. & Krainc, D., Sep 22 2017, In : Science. 357, 6357, p. 1255-1261 7 p.Research output: Contribution to journal › Article
Parkinson Disease
Dopamine
Synucleins
Neurons
Glucosylceramidase
2016
64
Citations
(Scopus)
Activation of β-glucocerebrosidase reduces pathological α-synuclein and restores lysosomal function in Parkinson’s patient midbrain neurons
Mazzulli, J., Zunke, F., Tsunemi, T., Toker, N. J., Jeon, S., Burbulla, L., Patnaik, S., Sidransky, E., Marugan, J. J., Sue, C. M. & Krainc, D., Jul 20 2016, In : Journal of Neuroscience. 36, 29, p. 7693-7706 14 p.Research output: Contribution to journal › Article
Synucleins
Glucosylceramidase
Mesencephalon
Neurons
Parkinson Disease
19
Citations
(Scopus)
Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2
Zunke, F., Andresen, L., Wesseler, S., Groth, J., Arnold, P., Rothaug, M., Mazzulli, J. R., Krainc, D., Blanz, J., Saftig, P. & Schwake, M., Apr 5 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 14, p. 3791-3796 6 p.Research output: Contribution to journal › Article
Lysosome-Associated Membrane Glycoproteins
Glucosylceramidase
Gaucher Disease
Parkinson Disease
Peptides
12
Citations
(Scopus)
Detection of Free and Protein-Bound ortho-Quinones by Near-Infrared Fluorescence
Mazzulli, J., Burbulla, L., Krainc, D. & Ischiropoulos, H., Feb 16 2016, In : Analytical Chemistry. 88, 4, p. 2399-2405 7 p.Research output: Contribution to journal › Article
Quinones
Dopamine
Fluorescence
Infrared radiation
Proteins
52
Citations
(Scopus)
Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation
Chung, S. Y., Kishinevsky, S., Mazzulli, J., Graziotto, J., Mrejeru, A., Mosharov, E. V., Puspita, L., Valiulahi, P., Sulzer, D., Milner, T. A., Taldone, T., Krainc, D., Studer, L. & Shim, J. W., Oct 11 2016, In : Stem cell reports. 7, 4, p. 664-677 14 p.Research output: Contribution to journal › Article
Synucleins
Induced Pluripotent Stem Cells
Dopaminergic Neurons
Mesencephalon
Stem cells
92
Citations
(Scopus)
α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models
Mazzulli, J., Zunke, F., Isacson, O., Studer, L. & Krainc, D., Feb 16 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. 1931-1936 6 p.Research output: Contribution to journal › Article
Synucleins
Protein Transport
Mesencephalon
Parkinson Disease
Hydrolases
2014
50
Citations
(Scopus)
LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance
Rothaug, M., Zunke, F., Mazzulli, J. R., Schweizer, M., Altmeppen, H., Lüllmann-Rauche, R., Kallemeijn, W. W., Gaspar, P., Aerts, J. M., Glatzel, M., Saftig, P., Krainc, D., Schwake, M. & Blanz, J., Oct 28 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 43, p. 15573-15578 6 p.Research output: Contribution to journal › Article
Synucleins
Lysosome-Associated Membrane Glycoproteins
Glucosylceramidase
Gaucher Disease
Dopaminergic Neurons
27
Citations
(Scopus)
The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models
Knight, A. L., Yan, X., Hamamichi, S., Ajjuri, R. R., Mazzulli, J., Zhang, M. W., Daigle, J. G., Zhang, S., Borom, A. R., Roberts, L. R., Lee, S. K., DeLeon, S. M., Viollet-Djelassi, C., Krainc, D., O'Donnell, J. M., Caldwell, K. A. & Caldwell, G. A., Jul 1 2014, In : Cell Metabolism. 20, 1, p. 145-157 13 p.Research output: Contribution to journal › Article
Synucleins
Insulin-Like Growth Factor I
Enzymes
Insulin
Glucose
2013
69
Citations
(Scopus)
Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits
Schultheis, P. J., Fleming, S. M., Clippinger, A. K., Lewis, J., Tsunemi, T., Giasson, B., Dickson, D. W., Mazzulli, J. R., Bardgett, M. E., Haik, K. L., Ekhator, O., Chava, A. K., Howard, J., Gannon, M., Hoffman, E., Chen, Y., Prasad, V., Linn, S. C., Tamargo, R. J., Westbroek, W. & 3 others, , May 1 2013, In : Human molecular genetics. 22, 10, p. 2067-2082 16 p., ddt057.Research output: Contribution to journal › Article
Synucleins
Neuronal Ceroid-Lipofuscinoses
Lipofuscin
Cerebellum
Parkinson Disease
29
Citations
(Scopus)
Glucocerebrosidase mutations in a Serbian Parkinson's disease population
Kumar, K. R., Ramirez, A., Göbel, A., Kresojević, N., Svetel, M., Lohmann, K., M Sue, C., Rolfs, A., Mazzulli, J. R., Alcalay, R. N., Krainc, D., Klein, C., Kostic, V. & Grünewald, A., Feb 1 2013, In : European Journal of Neurology. 20, 2, p. 402-405 4 p.Research output: Contribution to journal › Article
Glucosylceramidase
Parkinson Disease
Mutation
Population
Haplotypes
237
Citations
(Scopus)
Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons
Chung, C. Y., Khurana, V., Auluck, P. K., Tardiff, D. F., Mazzulli, J. R., Soldner, F., Baru, V., Lou, Y., Freyzon, Y., Cho, S., Mungenast, A. E., Muffat, J., Mitalipova, M., Pluth, M. D., Jui, N. T., Schul̈e, B., Lippard, S. J., Tsai, L. H., Krainc, D., Buchwald, S. L. & 2 others, , Jan 1 2013, In : Science. 342, 6161, p. 983-987 5 p.Research output: Contribution to journal › Article
Synucleins
Induced Pluripotent Stem Cells
Yeasts
Neurons
Parkinson Disease
2012
147
Citations
(Scopus)
Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity
Usenovic, M., Tresse, E., Mazzulli, J. R., Taylor, J. P. & Krainc, D., Mar 21 2012, In : Journal of Neuroscience. 32, 12, p. 4240-4246 7 p.Research output: Contribution to journal › Article
Synucleins
Neurons
Lysosome-Associated Membrane Glycoproteins
Lewy Bodies
Mutation
20
Citations
(Scopus)
Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease
Palada, V., Terzić, J., Mazzulli, J., Bwala, G., Hagenah, J., Peterlin, B., Hung, A. Y., Klein, C. & Krainc, D., Jan 1 2012, In : Neurobiology of Aging. 33, 4, p. 836.e1-836.e3Research output: Contribution to journal › Article
Histamine N-Methyltransferase
Parkinson Disease
Histamine
Neurotransmitter Agents
Meta-Analysis
270
Citations
(Scopus)
Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease
Cooper, O., Seo, H., Andrabi, S., Guardia-Laguarta, C., Graziotto, J., Sundberg, M., McLean, J. R., Carrillo-Reid, L., Xie, Z., Osborn, T., Hargus, G., Deleidi, M., Lawson, T., Bogetofte, H., Perez-Torres, E., Clark, L., Moskowitz, C., Mazzulli, J., Chen, L., Volpicelli-Daley, L. & 19 others, , Jul 4 2012, In : Science Translational Medicine. 4, 141, 141ra90.Research output: Contribution to journal › Article
Induced Pluripotent Stem Cells
Parkinson Disease
Pharmacology
Phosphotransferases
Leucine
197
Citations
(Scopus)
Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
Jeong, H., Cohen, D. E., Cui, L., Supinski, A., Savas, J. N., Mazzulli, J. R., Yates, J. R., Bordone, L., Guarente, L. & Krainc, D., Jan 1 2012, In : Nature Medicine. 18, 1, p. 159-165 7 p.Research output: Contribution to journal › Article
Huntington Disease
Chemical activation
Brain
Brain-Derived Neurotrophic Factor
Transcription
2011
587
Citations
(Scopus)
Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies
Mazzulli, J. R., Xu, Y. H., Sun, Y., Knight, A. L., McLean, P. J., Caldwell, G. A., Sidransky, E., Grabowski, G. A. & Krainc, D., Jul 8 2011, In : Cell. 146, 1, p. 37-52 16 p.Research output: Contribution to journal › Article
Synucleins
Glucosylceramidase
Gaucher Disease
Parkinson Disease
Neurons
200
Citations
(Scopus)
Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells
Cao, K., Graziotto, J. J., Blair, C. D., Mazzulli, J. R., Erdos, M. R., Krainc, D. & Collins, F. S., Jun 29 2011, In : Science translational medicine. 3, 89, 89ra58.Research output: Contribution to journal › Article
Progeria
Mutant Proteins
Sirolimus
Phenotype
Lamin Type A
2010
63
Citations
(Scopus)
Distinct region-specific α-synuclein oligomers in A53T transgenic mice: Implications for neurodegeneration
Tsika, E., Moysidou, M., Guo, J., Cushman, M., Gannon, P., Sandaltzopoulos, R., Giasson, B. I., Krainc, D., Ischiropoulos, H. & Mazzulli, J. R., Mar 3 2010, In : Journal of Neuroscience. 30, 9, p. 3409-3418 10 p.Research output: Contribution to journal › Article
Synucleins
Transgenic Mice
Neurons
Endopeptidase K
Nerve Degeneration
2009
256
Citations
(Scopus)
Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation
Jeong, H., Then, F., Melia, T. J., Mazzulli, J. R., Cui, L., Savas, J. N., Voisine, C., Paganetti, P., Tanese, N., Hart, A. C., Yamamoto, A. & Krainc, D., Apr 3 2009, In : Cell. 137, 1, p. 60-72 13 p.Research output: Contribution to journal › Article
Acetylation
Huntington Disease
Mutant Proteins
Degradation
Autophagy
43
Citations
(Scopus)
Characterization of hydrophobic residue requirements for α-synuclein fibrillization
Waxman, E. A., Mazzulli, J. R. & Giasson, B. I., Oct 22 2009, In : Biochemistry. 48, 40, p. 9427-9436 10 p.Research output: Contribution to journal › Article
Synucleins
Aptitude
Amyloid
Neurodegenerative diseases
Multiple System Atrophy
2008
406
Citations
(Scopus)
Dopamine-modified α-synuclein blocks chaperone-mediated autophagy
Martinez-Vicente, M., Talloczy, Z., Kaushik, S., Massey, A. C., Mazzulli, J., Mosharov, E. V., Hodara, R., Fredenburg, R., Wu, D. C., Follenzi, A., Dauer, W., Przedborski, S., Ischiropoulos, H., Lansbury, P. T., Sulzer, D. & Cuervo, A. M., Feb 1 2008, In : Journal of Clinical Investigation. 118, 2, p. 777-778 2 p.Research output: Contribution to journal › Article
Synucleins
Autophagy
Dopamine
Parkinson Disease
Post Translational Protein Processing
2007
55
Citations
(Scopus)
Cellular oligomerization of α-synuclein is determined by the interaction of oxidized catechols with a C-terminal sequence
Mazzulli, J. R., Armakola, M., Dumoulin, M., Parastatidis, I. & Ischiropoulos, H., Oct 26 2007, In : Journal of Biological Chemistry. 282, 43, p. 31621-31630 10 p.Research output: Contribution to journal › Article
Synucleins
Catechols
Oligomerization
Agglomeration
Parkinson Disease
2006
114
Citations
(Scopus)
Cytosolic catechols inhibit α-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates
Mazzulli, J. R., Mishizen, A. J., Giasson, B. I., Lynch, D. R., Thomas, S. A., Nakashima, A., Nagatsu, T., Ota, A. & Ischiropoulos, H., Sep 27 2006, In : Journal of Neuroscience. 26, 39, p. 10068-10078 11 p.Research output: Contribution to journal › Article
Synucleins
Catechols
Dopamine
Nerve Degeneration
Cell-Free System
Oxidative stress and protein deposition diseases
Mazzulli, JR., Hodara, R., Lind, S. & Ischiropoulos, H., 2006, Protein misfolding, aggregation and conformational diseases : Part A, protein aggregation and conformational diseases. Uversky, VN. & Fink, AL. (eds.). New York: Springer Science+Business Media, p. 123-136Research output: Chapter in Book/Report/Conference proceeding › Chapter
Reactive oxygen and nitrogen species: Weapons of neuronal destruction
Mazzulli, JR. & Ischiropoulos, H., 2006, Oxidative stress and age-related neurodegeneration. Luo, Y. & Packer, L. (eds.). Boca Raton: CRC/Taylor & Francis, p. 102-120Research output: Chapter in Book/Report/Conference proceeding › Chapter
2005
1
Citation
(Scopus)
Reactive oxygen and nitrogen species: Weapons of neuronal destruction
Mazzulli, J., Lind, S. & Ischiropoulos, H., Jan 1 2005, Oxidative Stress and Age-Related Neurodegeneration. CRC Press, p. 107-120 14 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
Reactive Nitrogen Species
Weapons
Reactive Oxygen Species
Macromolecules
Unsaturated Fatty Acids
2002
24
Citations
(Scopus)
Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in α1-adrenergic agonist-stimulated cardiac myocytes
Maeda, T., Mazzulli, J. R., Farrance, I. K. G. & Stewart, A. F. R., Jul 5 2002, In : Journal of Biological Chemistry. 277, 27, p. 24346-24352 7 p.Research output: Contribution to journal › Article
Adrenergic Agonists
Cardiac Myocytes
Adrenergic Agents
Muscle
Actins