Grants per year
Personal profile
Research Interests
We are using single photon confocal microscopy to measure intracellular Ca cycling in individual myocytes of intact rat and mouse hearts. Hearts are loaded with the Ca indicator fluo-4AM, allowing us to measure intracellular Ca at the submicron level. Ongoing projects include study of changes in Ca cycling in animal models of heart failure, catecholaminergic polymorphic ventricular tachycardia, spontaneous Ca release and cardiac arrhythmias.
Training Experience
| 1981 | Postdoctoral Fellowship, University of Chicago |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Pharmacology, SUNY - Syracuse
… → 1978
Research interests keywords
- Biophysics
- Cardiovascular Diseases
- Cell Imaging
- Pharmacology
- Physiology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Role of Endothelin-1 signaling in the development and progression of atrial fibrillation
Pfenniger, A. (PD/PI), Pfenniger, A. (PD/PI), Pfenniger, A. (Co-PD/PI), Arora, R. K. (Other), George, A. L. (Other), George, A. L. (Other), Lee, D. C. (Other), Lee, D. C. (Other), Passman, R. S. (Other), Passman, R. S. (Other), Roy-Puckelwartz, M. J. (Other), Roy-Puckelwartz, M. J. (Other), Shah, S. J. (Other), Shah, S. J. (Other), Vaughan, D. E. (Other), Vaughan, D. E. (Other), Wasserstrom, J. A. (Other) & Wasserstrom, J. A. (Other)
National Heart, Lung, and Blood Institute
9/1/23 → 8/31/28
Project: Research project
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New and Disruptive Therapeutic Approaches to Target Fundamental Molecular Mechanisms Underlying Atrial Fibrillation
Arora, R. K. (PD/PI), Arora, R. K. (PD/PI), Wasserstrom, J. A. (Co-Investigator), Wasserstrom, J. A. (Co-Investigator), Yoo, S. (Co-Investigator) & Yoo, S. (Co-Investigator)
National Heart, Lung, and Blood Institute
1/20/22 → 12/31/28
Project: Research project
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Understanding Calmodulinopathies in an Animal Model
George, A. L. (PD/PI), Kearney, J. A. (Other) & Wasserstrom, J. A. (Other)
7/1/17 → 6/30/19
Project: Research project
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Determinants, Trajectories, and Consequences of Abnormal Cardiac Mechanics
Shah, S. J. (PD/PI), Rasmussen-Torvik, L. J. (Co-Investigator) & Wasserstrom, J. A. (Co-Investigator)
National Heart, Lung, and Blood Institute
7/5/16 → 4/30/22
Project: Research project
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Role of PIP2 and Bin1 in T-tubule Remodeling During Heart Failure Development
Wasserstrom, J. A. (PD/PI)
American Heart Association Midwest Affiliate
6/1/16 → 8/31/16
Project: Research project
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Mitochondria regulate proliferation in adult cardiac myocytes
Waypa, G. B., Smith, K. A., Mungai, P. T., Dudley, V. J., Helmin, K. A., Singer, B. D., Peek, C. B., Bass, J., Nelson, L., Shah, S. J., Ofman, G., Wasserstrom, J. A., Muller, W. A., Misharin, A. V., Budinger, G. R. S., Abdala-Valencia, H., Chandel, N. S., Dokic, D., Bartom, E. & Zhang, S. & 5 others, , Jul 1 2024, In: Journal of Clinical Investigation. 134, 13, e165482.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes
Perdreau-Dahl, H., Lipsett, D. B., Frisk, M., Kermani, F., Carlson, C. R., Brech, A., Shen, X., Bergan-Dahl, A., Hou, Y., Tuomainen, T., Tavi, P., Jones, P. P., Lunde, M., Wasserstrom, J. A., Laporte, J., Ullrich, N. D., Christensen, G., Morth, J. P. & Louch, W. E., May 26 2023, In: Circulation research. 132, 11, p. E188-E205Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Myosin-binding protein H-like regulates myosin-binding protein distribution and function in atrial cardiomyocytes
Barefield, D. Y., Tonino, P., Woulfe, K. C., Rahmanseresht, S., O'Leary, T. S., Burnham, H. V., Wasserstrom, J. A., Kirk, J. A., Previs, M. J., Granzier, H. L. & McNally, E. M., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 51, e2314920120.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Regions of Highly Recurrent Electrogram Morphology With Low Cycle Length Reflect Substrate for Atrial Fibrillation
Yoo, S., Rottmann, M., Ng, J., Johnson, D., Shanab, B., Pfenniger, A., Geist, G. E., Mandava, S., Burrell, A., Zhang, W., Wasserstrom, J. A., Knight, B. P., Passman, R., Goldberger, J. J. & Arora, R., Jan 2023, In: JACC: Basic to Translational Science. 8, 1, p. 68-84 17 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Sex and Gene Influence Arrhythmia Susceptibility in Murine Models of Calmodulinopathy
Wren, L. M., Dekeyser, J. M., Barefield, D. Y., Hawkins, N. A., McNally, E. M., Kearney, J. A., Wasserstrom, J. A. & George, A. L., Sep 1 2023, In: Circulation: Arrhythmia and Electrophysiology. 16, 9, p. E010891Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations