Grants per year
Personal profile
Research Interests
We are using single photon confocal microscopy to measure intracellular Ca cycling in individual myocytes of intact rat and mouse hearts. Hearts are loaded with the Ca indicator fluo-4AM, allowing us to measure intracellular Ca at the submicron level. Ongoing projects include study of changes in Ca cycling in animal models of heart failure, catecholaminergic polymorphic ventricular tachycardia, spontaneous Ca release and cardiac arrhythmias.
Training Experience
| 1981 | Postdoctoral Fellowship, University of Chicago |
Education/Academic qualification
PhD, SUNY - Syracuse
… → 1978
Research interests
- Biophysics
- Cardiovascular Diseases
- Cell Imaging
- Pharmacology
- Physiology
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Grants
Determinants, Trajectories, and Consequences of Abnormal Cardiac Mechanics
Rasmussen-Torvik, L. J., Shah, S. J. & Wasserstrom, J. A.
National Heart, Lung, and Blood Institute
7/5/16 → 4/30/21
Project: Research project
Understanding Calmodulinopathies in an Animal Model
George Jr, A. L., Kearney, J. A. & Wasserstrom, J. A.
7/1/17 → 6/30/19
Project: Research project
Role of PIP2 and Bin1 in T-tubule Remodeling During Heart Failure Development
American Heart Association Midwest Affiliate
6/1/16 → 8/31/16
Project: Research project
Atrial arrhythmias and Ca2+ waves in HF: simulation and experimental studies
Aistrup, G. L. & Wasserstrom, J. A.
National Heart, Lung, and Blood Institute
9/1/14 → 5/31/20
Project: Research project
Cardiovascular Regenerative Medicine
Ardehali, H., Eren, M., Ghosh, A. K., Kume, T., Macrenaris, K. W., Meade, T. J., Perlman, H. R., Schumacker, P. T., Stupp, S., Vaughan, D. E., Vaughan, D. E. & Wasserstrom, J. A.
National Heart, Lung, and Blood Institute
9/7/11 → 4/30/16
Project: Research project
Research Output
Remodeling Promotes Proarrhythmic Disruption of Calcium Homeostasis in Failing Atrial Myocytes
Shiferaw, Y., Aistrup, G. L., Louch, W. E. & Wasserstrom, J. A., Jan 21 2020, In : Biophysical Journal. 118, 2, p. 476-491 16 p.Research output: Contribution to journal › Article
1
Scopus
citations
The sodium channel NaX: Possible player in excitation–contraction coupling
Bogdanovic, E., Potet, F., Marszalec, W., Iyer, H., Galiano, R., Hong, S. J., Leung, K. P., Wasserstrom, J. A., George, A. L. & Mustoe, T. A., Apr 1 2020, In : IUBMB Life. 72, 4, p. 601-606 6 p.Research output: Contribution to journal › Article
Triggered Ca2+ Waves Induce Depolarization of Maximum Diastolic Potential and Action Potential Prolongation in Dog Atrial Myocytes
Gussak, G., Marszalec, W., Yoo, S., Modi, R., O'Callaghan, C., Aistrup, G. L., Cordeiro, J. M., Goodrow, R., Kanaporis, G., Blatter, L. A., Shiferaw, Y., Arora, R., Zhou, J., Burrell, A. R. & Wasserstrom, J. A., Jun 1 2020, In : Circulation. Arrhythmia and electrophysiology. 13, 6, p. e008179Research output: Contribution to journal › Article
Oxidative stress creates a unique, CaMKII-mediated substrate for atrial fibrillation in heart failure
Yoo, S., Aistrup, G. L., Shiferaw, Y., Ng, J., Mohler, P. J., Hund, T. J., Waugh, T., Browne, S., Gussak, G., Gilani, M., Knight, B. P., Passman, R., Goldberger, J. J., Wasserstrom, J. A. & Arora, R., Nov 2 2018, In : JCI insight. 3, 21Research output: Contribution to journal › Article
Open Access
6
Scopus
citations
Synchronization of Triggered Waves in Atrial Tissue
Shiferaw, Y., Aistrup, G. L. & Wasserstrom, J. A., Sep 18 2018, In : Biophysical Journal. 115, 6, p. 1130-1141 12 p.Research output: Contribution to journal › Article
3
Scopus
citations