Grants per year
Personal profile
Research Interests
We are using single photon confocal microscopy to measure intracellular Ca cycling in individual myocytes of intact rat and mouse hearts. Hearts are loaded with the Ca indicator fluo-4AM, allowing us to measure intracellular Ca at the submicron level. Ongoing projects include study of changes in Ca cycling in animal models of heart failure, catecholaminergic polymorphic ventricular tachycardia, spontaneous Ca release and cardiac arrhythmias.
Training Experience
| 1981 | Postdoctoral Fellowship, University of Chicago |
Education/Academic qualification
PhD, SUNY - Syracuse
… → 1978
Research interests
- Biophysics
- Cardiovascular Diseases
- Cell Imaging
- Pharmacology
- Physiology
Fingerprint Dive into the research topics where John A Wasserstrom is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Muscle Cells
Medicine & Life Sciences
Sarcoplasmic Reticulum
Medicine & Life Sciences
Heart Failure
Medicine & Life Sciences
Purkinje Fibers
Medicine & Life Sciences
Cardiac Myocytes
Medicine & Life Sciences
Sodium
Medicine & Life Sciences
Excitation Contraction Coupling
Medicine & Life Sciences
Action Potentials
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2003 2020
Determinants, Trajectories, and Consequences of Abnormal Cardiac Mechanics
Rasmussen-Torvik, L. J., Shah, S. J. & Wasserstrom, J. A.
National Heart, Lung, and Blood Institute
7/5/16 → 4/30/20
Project: Research project
Mechanics
Echocardiography
Myocardium
Heart Failure
Treatment Failure
Atrial arrhythmias and Ca2+ waves in HF: simulation and experimental studies
Aistrup, G. L. & Wasserstrom, J. A.
National Heart, Lung, and Blood Institute
9/1/14 → 5/31/20
Project: Research project
Cardiac Arrhythmias
Atrial Fibrillation
Population Dynamics
Ion Channels
Lasers
Understanding Calmodulinopathies in an Animal Model
George Jr, A. L., Kearney, J. A. & Wasserstrom, J. A.
7/1/17 → 6/30/19
Project: Research project
Calmodulin
Animal Models
Sudden Cardiac Death
Phenotype
Long QT Syndrome
Role of PIP2 and Bin1 in T-tubule Remodeling During Heart Failure Development
American Heart Association Midwest Affiliate
6/1/16 → 8/31/16
Project: Research project
Protein Isoforms
Heart Failure
Phosphotransferases
Exons
Brain
Project 4 - Kishore
Vaughan, D. E. & Wasserstrom, J. A.
National Heart, Lung, and Blood Institute
9/7/11 → 4/30/16
Project: Research project
Stem Cells
Cell- and Tissue-Based Therapy
Therapeutics
Ischemia
Extremities
Research Output 1979 2018
3
Citations
(Scopus)
Oxidative stress creates a unique, CaMKII-mediated substrate for atrial fibrillation in heart failure
Yoo, S., Aistrup, G., Shiferaw, Y., Ng, J., Mohler, P. J., Hund, T. J., Waugh, T., Browne, S., Gussak, G., Gilani, M., Knight, B. P., Passman, R. S., Goldberger, J. J., Wasserstrom, J. A. & Arora, R. K., Nov 2 2018, In : JCI insight. 3, 21Research output: Contribution to journal › Article
Open Access
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Atrial Fibrillation
Heart Atria
Oxidative Stress
Heart Failure
Synchronization of Triggered Waves in Atrial Tissue
Shiferaw, Y., Aistrup, G. L. & Wasserstrom, J. A., Sep 18 2018, In : Biophysical Journal. 115, 6, p. 1130-1141 12 p.Research output: Contribution to journal › Article
Action Potentials
Calcium
L-Type Calcium Channels
Calcium Signaling
Atrial Fibrillation
3
Citations
(Scopus)
Abnormal sodium channel mRNA splicing in hypertrophic cardiomyopathy
Noyes, A. M., Zhou, A., Gao, G., Gu, L., Day, S., Wasserstrom, J. A. & Dudley, S. C., Dec 15 2017, In : International Journal of Cardiology. 249, p. 282-286 5 p.Research output: Contribution to journal › Article
Sodium Channels
Hypertrophic Cardiomyopathy
Unfolded Protein Response
Messenger RNA
Real-Time Polymerase Chain Reaction
2
Citations
(Scopus)
Mechanism for Triggered Waves in Atrial Myocytes
Shiferaw, Y., Aistrup, G. L. & Wasserstrom, J. A., Aug 8 2017, In : Biophysical Journal. 113, 3, p. 656-670 15 p.Research output: Contribution to journal › Article
Muscle Cells
Calcium Signaling
Calcium
L-Type Calcium Channels
Ryanodine Receptor Calcium Release Channel
11
Citations
(Scopus)
Regional distribution of T-tubule density in left and right atria in dogs
Arora, R. K., Aistrup, G. L., Supple, S., Frank, C., Singh, J., Tai, S., Zhao, A., Chicos, L., Marszalec, W., Guo, A., Song, L. S. & Wasserstrom, J. A., Feb 1 2017, In : Heart rhythm. 14, 2, p. 273-281 9 p.Research output: Contribution to journal › Article
Heart Atria
Dogs
Muscle Cells
Atrial Appendage
Sarcomeres