John A Wasserstrom

Professor, Medicine, Cardiology Division

Phone+1 312 503 1384
Emailja-wasserstrom@northwestern.edu

Source: Scopus

Research activity per year

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Personal profile

Research Interests

We are using single photon confocal microscopy to measure intracellular Ca cycling in individual myocytes of intact rat and mouse hearts. Hearts are loaded with the Ca indicator fluo-4AM, allowing us to measure intracellular Ca at the submicron level. Ongoing projects include study of changes in Ca cycling in animal models of heart failure, catecholaminergic polymorphic ventricular tachycardia, spontaneous Ca release and cardiac arrhythmias.

Training Experience

1981	Postdoctoral Fellowship, University of Chicago

Education/Academic qualification

PhD, SUNY - Syracuse

… → 1978

Research interests

Biophysics
Cardiovascular Diseases
Cell Imaging
Pharmacology
Physiology

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1 Active
7 Finished

Determinants, Trajectories, and Consequences of Abnormal Cardiac Mechanics
Rasmussen-Torvik, L. J., Shah, S. J. & Wasserstrom, J. A.
National Heart, Lung, and Blood Institute
7/5/16 → 4/30/21
Project: Research project
Understanding Calmodulinopathies in an Animal Model
George Jr., A. L., Kearney, J. A. & Wasserstrom, J. A.
American Heart Association
7/1/17 → 6/30/19
Project: Research project
Role of PIP2 and Bin1 in T-tubule Remodeling During Heart Failure Development
Wasserstrom, J. A.
American Heart Association Midwest Affiliate
6/1/16 → 8/31/16
Project: Research project
Atrial arrhythmias and Ca2+ waves in HF: simulation and experimental studies
Aistrup, G. L. & Wasserstrom, J. A.
National Heart, Lung, and Blood Institute
9/1/14 → 5/31/20
Project: Research project
Cardiovascular Regenerative Medicine
Ardehali, H., Eren, M., Ghosh, A. K., Kume, T., Meade, T. J., Perlman, H. R., Schumacker, P. T., Stupp, S., Vaughan, D. E., Vaughan, D. E. & Wasserstrom, J. A.
National Heart, Lung, and Blood Institute
9/7/11 → 4/30/16
Project: Research project

2684 Citations
90 Article
6 Review article
3 Comment/debate

Altered enhancer and promoter usage leads to differential gene expression in the normal and failed human heart
Gacita, A. M., Castillo, L. M., Page, P. G. T., Barefield, D. Y., Wasserstrom, J. A., Roy-Puckelwartz, M. J., Nobrega, M. A. & McNally, E. M., 2020, (Accepted/In press) In: Circulation: Heart Failure. e006926.
Research output: Contribution to journal › Article › peer-review
Attenuation of Oxidative Injury with Targeted Expression of NADPH Oxidase 2 Short Hairpin RNA Prevents Onset and Maintenance of Electrical Remodeling in the Canine Atrium: A Novel Gene Therapy Approach to Atrial Fibrillation
Yoo, S., Pfenniger, A., Hoffman, J., Zhang, W., Ng, J., Burrell, A., Johnson, D. A., Gussak, G., Waugh, T., Bull, S., Benefield, B., Knight, B. P., Passman, R., Wasserstrom, J. A., Aistrup, G. L. & Arora, R., Sep 29 2020, In: Circulation. p. 1261-1278 18 p.
Research output: Contribution to journal › Article › peer-review
Remodeling Promotes Proarrhythmic Disruption of Calcium Homeostasis in Failing Atrial Myocytes
Shiferaw, Y., Aistrup, G. L., Louch, W. E. & Wasserstrom, J. A., Jan 21 2020, In: Biophysical Journal. 118, 2, p. 476-491 16 p.
Research output: Contribution to journal › Article › peer-review
3 Scopus citations
The sodium channel Na_X: Possible player in excitation–contraction coupling
Bogdanovic, E., Potet, F., Marszalec, W., Iyer, H., Galiano, R., Hong, S. J., Leung, K. P., Wasserstrom, J. A., George, A. L. & Mustoe, T. A., Apr 1 2020, In: IUBMB Life. 72, 4, p. 601-606 6 p.
Research output: Contribution to journal › Article › peer-review
Triggered Ca²⁺Waves Induce Depolarization of Maximum Diastolic Potential and Action Potential Prolongation in Dog Atrial Myocytes
Gussak, G., Marszalec, W., Yoo, S., Modi, R., O'Callaghan, C., Aistrup, G. L., Cordeiro, J. M., Goodrow, R., Kanaporis, G., Blatter, L. A., Shiferaw, Y., Arora, R., Zhou, J., Burrell, A. R. & Wasserstrom, J. A., Jun 1 2020, In: Circulation: Arrhythmia and Electrophysiology. p. 551-562 12 p.
Research output: Contribution to journal › Article › peer-review