Grants per year
Personal profile
Research Interests
We are using single photon confocal microscopy to measure intracellular Ca cycling in individual myocytes of intact rat and mouse hearts. Hearts are loaded with the Ca indicator fluo-4AM, allowing us to measure intracellular Ca at the submicron level. Ongoing projects include study of changes in Ca cycling in animal models of heart failure, catecholaminergic polymorphic ventricular tachycardia, spontaneous Ca release and cardiac arrhythmias.
Training Experience
| 1981 | Postdoctoral Fellowship, University of Chicago |
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, SUNY - Syracuse
… → 1978
Research interests
- Biophysics
- Cardiovascular Diseases
- Cell Imaging
- Pharmacology
- Physiology
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Determinants, Trajectories, and Consequences of Abnormal Cardiac Mechanics
Shah, S. J., Rasmussen-Torvik, L. J. & Wasserstrom, J. A.
National Heart, Lung, and Blood Institute
7/5/16 → 4/30/22
Project: Research project
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Understanding Calmodulinopathies in an Animal Model
George Jr., A. L., Kearney, J. A. & Wasserstrom, J. A.
7/1/17 → 6/30/19
Project: Research project
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Role of PIP2 and Bin1 in T-tubule Remodeling During Heart Failure Development
American Heart Association Midwest Affiliate
6/1/16 → 8/31/16
Project: Research project
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Atrial arrhythmias and Ca2+ waves in HF: simulation and experimental studies
National Heart, Lung, and Blood Institute
9/1/14 → 5/31/20
Project: Research project
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Project 4 - Kishore
Vaughan, D. E. & Wasserstrom, J. A.
National Heart, Lung, and Blood Institute
9/7/11 → 4/30/16
Project: Research project
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Altered enhancer and promoter usage leads to differential gene expression in the normal and failed human heart
Gacita, A. M., Dellefave-Castillo, L., Page, P. G. T., Barefield, D. Y., Wasserstrom, J. A., Puckelwartz, M. J., Nobrega, M. A. & McNally, E. M., 2020, (Accepted/In press) In: Circulation: Heart Failure. e006926.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Attenuation of Oxidative Injury with Targeted Expression of NADPH Oxidase 2 Short Hairpin RNA Prevents Onset and Maintenance of Electrical Remodeling in the Canine Atrium: A Novel Gene Therapy Approach to Atrial Fibrillation
Yoo, S., Pfenniger, A., Hoffman, J., Zhang, W., Ng, J., Burrell, A., Johnson, D. A., Gussak, G., Waugh, T., Bull, S., Benefield, B., Knight, B. P., Passman, R., Wasserstrom, J. A., Aistrup, G. L. & Arora, R., Sep 29 2020, In: Circulation. p. 1261-1278 18 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Remodeling Promotes Proarrhythmic Disruption of Calcium Homeostasis in Failing Atrial Myocytes
Shiferaw, Y., Aistrup, G. L., Louch, W. E. & Wasserstrom, J. A., Jan 21 2020, In: Biophysical Journal. 118, 2, p. 476-491 16 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
The sodium channel NaX: Possible player in excitation–contraction coupling
Bogdanovic, E., Potet, F., Marszalec, W., Iyer, H., Galiano, R., Hong, S. J., Leung, K. P., Wasserstrom, J. A., George, A. L. & Mustoe, T. A., Apr 1 2020, In: IUBMB Life. 72, 4, p. 601-606 6 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Triggered Ca2+Waves Induce Depolarization of Maximum Diastolic Potential and Action Potential Prolongation in Dog Atrial Myocytes
Gussak, G., Marszalec, W., Yoo, S., Modi, R., O'Callaghan, C., Aistrup, G. L., Cordeiro, J. M., Goodrow, R., Kanaporis, G., Blatter, L. A., Shiferaw, Y., Arora, R., Zhou, J., Burrell, A. R. & Wasserstrom, J. A., Jun 1 2020, In: Circulation: Arrhythmia and Electrophysiology. p. 551-562 12 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations