John A Wasserstrom

  • 2468 Citations
1979 …2020
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Personal profile

Research Interests

We are using single photon confocal microscopy to measure intracellular Ca cycling in individual myocytes of intact rat and mouse hearts. Hearts are loaded with the Ca indicator fluo-4AM, allowing us to measure intracellular Ca at the submicron level. Ongoing projects include study of changes in Ca cycling in animal models of heart failure, catecholaminergic polymorphic ventricular tachycardia, spontaneous Ca release and cardiac arrhythmias.

Training Experience

1981Postdoctoral Fellowship, University of Chicago

Education/Academic qualification

PhD, SUNY - Syracuse

… → 1978

Research interests

  • Biophysics
  • Cardiovascular Diseases
  • Cell Imaging
  • Pharmacology
  • Physiology

Fingerprint Dive into the research topics where John A Wasserstrom is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 10 Similar Profiles
Muscle Cells Medicine & Life Sciences
Sarcoplasmic Reticulum Medicine & Life Sciences
Heart Failure Medicine & Life Sciences
Purkinje Fibers Medicine & Life Sciences
Cardiac Myocytes Medicine & Life Sciences
Sodium Medicine & Life Sciences
Excitation Contraction Coupling Medicine & Life Sciences
Action Potentials Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2003 2020

Mechanics
Echocardiography
Myocardium
Heart Failure
Treatment Failure
Cardiac Arrhythmias
Atrial Fibrillation
Population Dynamics
Ion Channels
Lasers
Calmodulin
Animal Models
Sudden Cardiac Death
Phenotype
Long QT Syndrome
Protein Isoforms
Heart Failure
Phosphotransferases
Exons
Brain
Stem Cells
Cell- and Tissue-Based Therapy
Therapeutics
Ischemia
Extremities

Research Output 1979 2018

  • 2468 Citations
  • 86 Article
  • 7 Review article
  • 4 Comment/debate
2 Citations (Scopus)

Oxidative stress creates a unique, CaMKII-mediated substrate for atrial fibrillation in heart failure

Yoo, S., Aistrup, G., Shiferaw, Y., Ng, J., Mohler, P. J., Hund, T. J., Waugh, T., Browne, S., Gussak, G., Gilani, M., Knight, B. P., Passman, R. S., Goldberger, J. J., Wasserstrom, J. A. & Arora, R. K., Nov 2 2018, In : JCI insight. 3, 21

Research output: Contribution to journalArticle

Open Access
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Atrial Fibrillation
Heart Atria
Oxidative Stress
Heart Failure

Synchronization of Triggered Waves in Atrial Tissue

Shiferaw, Y., Aistrup, G. L. & Wasserstrom, J. A., Sep 18 2018, In : Biophysical Journal. 115, 6, p. 1130-1141 12 p.

Research output: Contribution to journalArticle

Action Potentials
Calcium
L-Type Calcium Channels
Calcium Signaling
Atrial Fibrillation
3 Citations (Scopus)

Abnormal sodium channel mRNA splicing in hypertrophic cardiomyopathy

Noyes, A. M., Zhou, A., Gao, G., Gu, L., Day, S., Wasserstrom, J. A. & Dudley, S. C., Dec 15 2017, In : International Journal of Cardiology. 249, p. 282-286 5 p.

Research output: Contribution to journalArticle

Sodium Channels
Hypertrophic Cardiomyopathy
Unfolded Protein Response
Messenger RNA
Real-Time Polymerase Chain Reaction
2 Citations (Scopus)

Mechanism for Triggered Waves in Atrial Myocytes

Shiferaw, Y., Aistrup, G. L. & Wasserstrom, J. A., Aug 8 2017, In : Biophysical Journal. 113, 3, p. 656-670 15 p.

Research output: Contribution to journalArticle

Muscle Cells
Calcium Signaling
Calcium
L-Type Calcium Channels
Ryanodine Receptor Calcium Release Channel
11 Citations (Scopus)

Regional distribution of T-tubule density in left and right atria in dogs

Arora, R. K., Aistrup, G. L., Supple, S., Frank, C., Singh, J., Tai, S., Zhao, A., Chicos, L., Marszalec, W., Guo, A., Song, L. S. & Wasserstrom, J. A., Feb 1 2017, In : Heart rhythm. 14, 2, p. 273-281 9 p.

Research output: Contribution to journalArticle

Heart Atria
Dogs
Muscle Cells
Atrial Appendage
Sarcomeres