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Research Output

2020

Correlation between retinal ganglion cell loss and nerve crush force-impulse established with instrumented tweezers in mice

Liu, X., Feng, L., Shinde, I., Cole, J. D., Troy, J. B. & Saggere, L., May 3 2020, In : Neurological research. 42, 5, p. 379-386 8 p.

Research output: Contribution to journalArticle

Investigation of Injection Depth for Subretinal Delivery of Exogenous Glutamate to Restore Vision via Biomimetic Chemical Neuromodulation

Rountree, C. M., Troy, J. B. & Saggere, L., Feb 2020, In : IEEE Transactions on Biomedical Engineering. 67, 2, p. 464-470 7 p., 8708301.

Research output: Contribution to journalArticle

2019
2018

Mechanical stimulation of the retina: Therapeutic feasibility and cellular mechanism

Rountree, C. M., Meng, C., Troy, J. B. & Saggere, L., May 1 2018, In : IEEE Transactions on Neural Systems and Rehabilitation Engineering. 26, 5, p. 1075-1083 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Microfluidics-based subretinal chemical neuromodulation of photoreceptor degenerated retinas

Rountree, C. M., Troy, J. B. & Saggere, L., Jan 2018, In : Investigative Ophthalmology and Visual Science. 59, 1, p. 418-430 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Nonselective wiring accounts for red-green opponency in midget ganglion cells of the primate retina

Wool, L. E., Crook, J. D., Troy, J. B., Packer, O. S., Zaidi, Q. & Dacey, D. M., Feb 7 2018, In : Journal of Neuroscience. 38, 6, p. 1520-1540 21 p.

Research output: Contribution to journalArticle

16 Scopus citations
2017

Different functional susceptibilities of mouse retinal ganglion cell subtypes to optic nerve crush injury

Puyang, Z., Gong, H. Q., He, S. G., Troy, J. B., Liu, X. & Liang, P. J., Sep 2017, In : Experimental eye research. 162, p. 97-103 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Methodology for biomimetic chemical neuromodulation of rat retinas with the neurotransmitter glutamate in vitro

Rountree, C. M., Troy, J. B. & Saggere, L., Dec 19 2017, In : Journal of Visualized Experiments. 2017, 130, e56645.

Research output: Contribution to journalArticle

1 Scopus citations

Overexpression of brain-derived neurotrophic factor protects large retinal ganglion cells after optic nerve crush in mice

Feng, L., Puyang, Z., Chen, H., Liang, P., Troy, J. B. & Liu, X., Jan 5 2017, In : eNeuro. 4, 1, 8 p., e0331.

Research output: Contribution to journalArticle

14 Scopus citations

Prototype chemical synapse chip for spatially patterned neurotransmitter stimulation of the retina ex vivo

Roundtree, C. M., Raghunathan, A., Troy, J. B. & Saggere, L., 2017, In : Microsystems & Nanoengineering. 3, 17052.

Research output: Contribution to journalArticle

Open Access

Visual prostheses—the past and the Future

Troy, J. B., Jan 1 2017, Biosystems and Biorobotics. Springer International Publishing, p. 111-113 3 p. (Biosystems and Biorobotics; vol. 15).

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Differential stimulation of the retina with subretinally injected exogenous neurotransmitter: A biomimetic alternative to electrical stimulation

Rountree, C. M., Inayat, S., Troy, J. B. & Saggere, L., Dec 8 2016, In : Scientific reports. 6, 38505.

Research output: Contribution to journalArticle

8 Scopus citations
20 Scopus citations

Receptive fields of retinal ganglion cells

Troy, J. B., Jan 1 2016, The Curated Reference Collection in Neuroscience and Biobehavioral Psychology. Elsevier Science Ltd., p. 219-223 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Receptive fields of retinal ganglion cells

Troy, J. B., Jan 1 2016, The Curated Reference Collection in Neuroscience and Biobehavioral Psychology. Elsevier Science Ltd., p. 219-223 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access

Retinal ganglion cell loss is delayed following optic nerve crush in nlrp3 knockout mice

Puyang, Z., Feng, L., Chen, H., Liang, P., Troy, J. B. & Liu, X., Feb 19 2016, In : Scientific reports. 6, 20998.

Research output: Contribution to journalArticle

22 Scopus citations

Thalamic visual prosthesis

Nguyen, H. T., Tangutooru, S. M., Rountree, C. M., Kantzos, A. J. K., Tarlochan, F., Yoon, W. J. & Troy, J. B., Aug 2016, In : IEEE Transactions on Biomedical Engineering. 63, 8, p. 1573-1580 8 p., 7470249.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Chemical stimulation of rat retinal neurons: Feasibility of an epiretinal neurotransmitter-based prosthesis

Inayat, S., Rountree, C. M., Troy, J. B. & Saggere, L., Feb 1 2015, In : Journal of Neural Engineering. 12, 1, 016010.

Research output: Contribution to journalArticle

11 Scopus citations

Progressive degeneration of retinal and superior collicular functions in mice with sustained ocular hypertension

Chen, H., Zhao, Y., Liu, M., Feng, L., Zhen, P., Yi, J., Liang, P., Zhang, H. F., Cang, J., Troy, J. B. & Liu, X., Feb 26 2015, In : Investigative Ophthalmology and Visual Science. 56, 3, p. 1971-1984 14 p.

Research output: Contribution to journalArticle

28 Scopus citations

Visual Prostheses: Technological and Socioeconomic Challenges

Troy, J. B., Sep 1 2015, In : Engineering. 1, 3, p. 288-291 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
2014

Biomimetic stimulation of rat retinal ganglion cells with the neurotransmitter glutamate

Rountree, C. M., Inayat, S., Saggere, L. & Troy, J. B., Jan 1 2014, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc., p. 2593-2596 4 p. 6944153

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Early design considerations for a thalamic visual prosthesis to treat blindness resulting from glaucoma

Tangutooru, S. M., Yoon, W. J. & Troy, J. B., Jan 1 2014, 2014 Middle East Conference on Biomedical Engineering, MECBME 2014. IEEE Computer Society, p. 249-252 4 p. 6783251

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations
2013

Development of a chemical retinal prosthesis: Stimulation of rat retina with glutamate

Rountree, C. M., Inayat, S., Troy, J. B. & Saggere, L., Oct 31 2013, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. p. 3134-3137 4 p. 6610205. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Minimizing cytosol dilution in whole-cell patch-clamp experiments

Inayat, S., Pinto, L. H. & Troy, J. B., Jul 17 2013, In : IEEE Transactions on Biomedical Engineering. 60, 7, p. 2042-2051 10 p., 6468078.

Research output: Contribution to journalArticle

1 Scopus citations

Retinal bioengineering

Linsenmeier, R. A. & Troy, J. B., Jan 1 2013, Neural Engineering: Second Edition. Springer US, p. 565-634 70 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sustained ocular hypertension induces dendritic degeneration of mouse retinal ganglion cells that depends on cell type and location

Feng, L., Zhao, Y., Yoshida, M., Chen, H., Yang, J. F., Kim, T. S., Cang, J., Troy, J. B. & Liu, X., Feb 1 2013, In : Investigative Ophthalmology and Visual Science. 54, 2, p. 1106-1117 12 p.

Research output: Contribution to journalArticle

60 Scopus citations

Synaptic Mechanisms of Color and Luminance Coding: Rediscovering the X-Y-cell dichotomy in primate retinal ganglion cells

Crook, J. D., Packer, O. S., Troy, J. B. & Dacey, D. M., Oct 2013, The New Visual Neurosciences. Werner, J. S. & Chalupa, L. M. (eds.). 1 ed. The MIT Press, p. 123-144

Research output: Chapter in Book/Report/Conference proceedingChapter

2012

Electrode for Whole Cell and Other Testing

Troy, J., Jan 12 2012, Patent No. 8557095

Research output: Patent

Parasol cell mosaics are unlikely to drive the formation of structured orientation maps in primary visual cortex

Hore, V. R. A., Troy, J. B. & Eglen, S. J., Nov 1 2012, In : Visual Neuroscience. 29, 6, p. 283-299 17 p.

Research output: Contribution to journalReview article

15 Scopus citations

The uniqueness of the message in a retinal ganglion cell spike train and its implication for retinal prostheses

Troy, J. B., Yrazu, F. M. & Passaglia, C. L., Dec 14 2012, 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012. p. 312-313 2 p. 6345931. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2010

A novel way to go whole cell in patch-clamp experiments

Inayat, S., Zhao, Y., Cantrell, D. R., Dikin, D. A., Pinto, L. H. & Troy, J. B., Nov 2010, In : IEEE Transactions on Biomedical Engineering. 57, 11, p. 2764-2770 7 p., 5497104.

Research output: Contribution to journalArticle

4 Scopus citations

Considerations in Designing Optimal Stimulation Electrodes for Retinal Prostheses

Troy, J. B., 2010, Nova Acta Leopoldina NF 111, No. 379. Leopoldina, p. 197-204

Research output: Chapter in Book/Report/Conference proceedingChapter

Impedance characterization and modelling of an improved patch clamp device

Zhao, Y., Inayat, S., Dikin, D. A., Ruoff, R. S. & Troy, J. B., Jan 1 2010, In : Proceedings of the Institution of Mechanical Engineers, Part N: Journal of Nanoengineering and Nanosystems. 223, 3, p. 1-11 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
28 Scopus citations
2009

Effects of remote stimulation on the modulated activity of cat retinal ganglion cells

Passaglia, C. L., Freeman, D. K. & Troy, J. B., Feb 25 2009, In : Journal of Neuroscience. 29, 8, p. 2467-2476 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Extracellular stimulation of mouse retinal ganglion cells with non-rectangular voltage-controlled waveforms

Cantrell, D. R. & Troy, J. B., Jan 1 2009, Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, p. 642-645 4 p. 5333464. (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations

Retinal ganglion cells: Receptive fields

Troy, J. B., Jan 1 2009, Encyclopedia of Neuroscience. Elsevier Ltd, p. 219-223 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Retinal ganglion cells: Receptive fields: Encyclopedia of Neuroscience

Troy, J. B. & Squire, L. R. (ed.), 2009, Oxford : Academic Press.

Research output: Other contribution

2008

Allelic variance between GRM6 mutants, Grm6 nob3 and Grm6 nob4 results in differences in retinal ganglion cell visual responses

Maddox, D. M., Vessey, K. A., Yarbrough, G. L., Invergo, B. M., Cantrell, D. R., Inayat, S., Balannik, V., Hicks, W. L., Hawes, N. L., Byers, S., Smith, R. S., Hurd, R., Howell, D., Gregg, R. G., Chang, B., Naggert, J. K., Troy, J. B., Pinto, L. H., Nishina, P. M. & McCall, M. A., Sep 22 2008, In : Journal of Physiology. 586, 18, p. 4409-4424 16 p.

Research output: Contribution to journalArticle

44 Scopus citations

A time domain finite element model of extracellular neural stimulation predicts that non-rectangular stimulus waveforms may offer safety benefits

Cantrell, D. R. & Troy, J. B., Dec 1 2008, Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08. p. 2768-2771 4 p. 4649776. (Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology").

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations

Incorporation of the electrode-electrolyte interface into finite-element models of metal microelectrodes

Cantrell, D. R., Inayat, S., Taflove, A., Ruoff, R. S. & Troy, J. B., Mar 1 2008, In : Journal of Neural Engineering. 5, 1, p. 54-67 14 p.

Research output: Contribution to journalArticle

71 Scopus citations

Patch clamp technique: Review of the current state of the art and potential contributions from nanoengineering

Zhao, Y., Inayat, S., Dikin, D. A., Singer, J. H., Ruoff, R. S. & Troy, J. B., Jan 1 2008, In : Proceedings of the Institution of Mechanical Engineers, Part N: Journal of Nanoengineering and Nanosystems. 222, 1, p. 1-11 11 p.

Research output: Contribution to journalReview article

42 Scopus citations

Survey of the Research Opportunities Afforded by Genetic Variation in the Mouse Visual System

Pinto, L. H. & Troy, J. B., 2008, Eye, Retina, and Visual System of the Mouse. Chalupa, L. M. & Williams, R. W. (eds.). Cambridge, MA: MIT Press, p. 61-69

Research output: Chapter in Book/Report/Conference proceedingChapter

The smooth monostratified ganglion cell: Evidence for spatial diversity in the Y-cell pathway to the lateral geniculate nucleus and superior colliculus in the macaque monkey

Crook, J. D., Peterson, B. B., Packer, O. S., Robinson, F. R., Gamlin, P. D., Troy, J. B. & Dacey, D. M., Nov 26 2008, In : Journal of Neuroscience. 28, 48, p. 12654-12671 18 p.

Research output: Contribution to journalArticle

54 Scopus citations

Y-cell receptive field and collicular projection of parasol ganglion cells in macaque monkey retina

Crook, J. D., Peterson, B. B., Packer, O. S., Robinson, F. R., Troy, J. B. & Dacey, D. M., Oct 29 2008, In : Journal of Neuroscience. 28, 44, p. 11277-11291 15 p.

Research output: Contribution to journalArticle

86 Scopus citations
2007

Generation, identification and functional characterization of the nob4 mutation of Grm6 in the mouse

Pinto, L. H., Vitaterna, M. H., Shimomura, K., Siepka, S. M., Balannik, V., McDearmon, E. L., Omura, C., Lumayag, S., Invergo, B. M., Glawe, B., Cantrell, D. R., Inayat, S., Olvera, M. A., Vessey, K. A., McCall, M. A., Maddox, D., Morgans, C. W., Young, B., Pletcher, M. T., Mullins, R. F. & 2 others, Troy, J. B. & Takahashi, J. S., Jan 1 2007, In : Visual Neuroscience. 24, 1, p. 111-123 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

Interpretation of the mouse electroretinogram

Pinto, L. H., Invergo, B., Shimomura, K., Takahashi, J. S. & Troy, J. B., Nov 1 2007, In : Documenta Ophthalmologica. 115, 3, p. 127-136 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Promoting advanced writing skills in an upper-level engineering class

Yalvac, B., Smith, H. D., Troy, J. B. & Hirsch, P., Apr 2007, In : Journal of Engineering Education. 96, 2, p. 117-128 12 p.

Research output: Contribution to journalArticle

65 Scopus citations
2006

Modeling the electrode-electrolyte interface for recording and stimulating electrodes

Troy, J. B., Cantrell, D. R., Taflove, A. & Ruoff, R. S., Dec 1 2006, 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06. p. 879-881 3 p. 4028999. (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations