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Personal profile

Research Interests

Research in the Crispino laboratory is focused on investigating the regulatory mechanisms governing normal and malignant blood cell development, with an emphasis on understanding the growth of erythroid cells (red blood cells) and megakaryocytes (platelet-producing cells). In addition, the group has a major interest in learning how changes in normal essential regulatory molecules lead to human blood diseases, including acute leukemias and myeloproliferative neoplasms (MPNs). The lab seeks to make seminal basic science discoveries while simultaneously translating these discoveries in ways that will benefit patients with hematologic malignancies.

Education/Academic qualification

PhD, MIT

… → 1996

Keywords

  • Blood Cancer (leukemia and lymphomas)
  • Gene Regulation
  • Molecular Biology
  • Blood and Bleeding Disorders (anemia, clotting, etc.)

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Megakaryocytes Medicine & Life Sciences
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Down Syndrome Medicine & Life Sciences
Mutation Medicine & Life Sciences
Leukemia Medicine & Life Sciences
Primary Myelofibrosis Medicine & Life Sciences
Hematopoiesis Medicine & Life Sciences
Neoplasms Medicine & Life Sciences

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Grants 2006 2024

Neoplasms
Essential Thrombocythemia
Polycythemia Vera
Primary Myelofibrosis
Clustered Regularly Interspaced Short Palindromic Repeats
Neoplasms
Medicine
Research
Population
B-Cell Leukemia
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Growth Inhibitors
Caspase 9
B-Lymphocytes
Primary Myelofibrosis
Megakaryocytes
Organized Financing
Research
Fibrosis

Research Output 1991 2019

AKT activation is a feature of CALR mutant myeloproliferative neoplasms

Fu, C., Wen, Q., Marinaccio, C., Ling, T., Chen, W., Bulic, M., Lasho, T., Tefferi, A., Crispino, J. D. & Xu, K., Jan 1 2019, In : Leukemia. 33, 1, p. 271-274 4 p.

Research output: Contribution to journalArticle

Neoplasms
2 Citations (Scopus)

An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia

Swaroop, A., Oyer, J. A., Will, C. M., Huang, X., Yu, W., Troche, C., Bulic, M., Durham, B. H., Wen, Q., Crispino, J. D., MacKerell, A. D., Bennett, R. L., Kelleher, N. L. & Licht, J. D., Jan 31 2019, In : Oncogene. 38, 5, p. 671-686 16 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Mutation
Histones
Methylation
Lysine

GATA-1: A potential novel biomarker for the differentiation of essential thrombocythemia and myelofibrosis

Lally, J., Boasman, K., Brown, L., Martinelli, V., Cappuccio, I., Sovani, V., Marinaccio, C., Crispino, J. D., Graham, C. & Rinaldi, C., Jan 1 2019, In : Journal of Thrombosis and Haemostasis.

Research output: Contribution to journalArticle

Essential Thrombocythemia
Primary Myelofibrosis
Biomarkers
Megakaryocytes
Messenger RNA

Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia

Zhao, Z., Wang, L., Volk, A. G., Birch, N. W., Stoltz, K. L., Bartom, E. T., Marshall, S. A., Rendleman, E. J., Nestler, C. M., Shilati, J., Schiltz, G. E., Crispino, J. D. & Shilatifard, A., Jan 1 2019, In : Genes and Development. 33, 1-2, p. 61-74 14 p.

Research output: Contribution to journalArticle

Aspartate Ammonia-Lyase
Threonine
Leukemia
Casein Kinase II
Therapeutics
2 Citations (Scopus)

USP7 cooperates with NOTch1 to drive the oncogenic transcriptional program in T-cell leukemia

Jin, Q., Martinez, C. A., Arcipowski, K. M., Zhu, Y., Gutierrez-Diaz, B. T., Wang, K. K., Johnson, M. R., Volk, A. G., Wang, F., Wu, J., Grove, C., Wang, H., Sokirniy, I., Thomas, P. M., Goo, Y. A., Abshiru, N. A., Hijiya, N., Peirs, S., Vandamme, N., Berx, G. & 27 othersGoosens, S., Marshall, S. A., Rendleman, E. J., Takahashi, Y., Wang, L., Rawat, R., Bartom, E. T., Collings, C. K., Van Vlierberghe, P., Strikoudis, A., Kelly, S., Ueberheide, B., Mantis, C., Kandela, I., Bourquin, J. P., Bornhauser, B., Serafin, V., Bresolin, S., Paganin, M., Accordi, B., Basso, G., Kelleher, N. L., Weinstock, J., Kumar, S., Crispino, J. D., Shilatifard, A. & Ntziachristos, P., Jan 1 2019, In : Clinical Cancer Research. 25, 1, p. 222-239 18 p.

Research output: Contribution to journalArticle

Open Access
Ubiquitin-Specific Proteases
T-Cell Leukemia
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Chromatin