• 7413 Citations
1991 …2020

Research output per year

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Personal profile

Research Interests

Research in the Crispino laboratory is focused on investigating the regulatory mechanisms governing normal and malignant blood cell development, with an emphasis on understanding the growth of erythroid cells (red blood cells) and megakaryocytes (platelet-producing cells). In addition, the group has a major interest in learning how changes in normal essential regulatory molecules lead to human blood diseases, including acute leukemias and myeloproliferative neoplasms (MPNs). The lab seeks to make seminal basic science discoveries while simultaneously translating these discoveries in ways that will benefit patients with hematologic malignancies.

Education/Academic qualification

PhD, Massachusetts Institute of Technology

… → 1996

Research interests

  • Blood Cancer (leukemia and lymphomas)
  • Gene Regulation
  • Molecular Biology
  • Blood and Bleeding Disorders (anemia, clotting, etc.)

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  • Research Output

    Acute megakaryocytic leukemia

    McNulty, M. & Crispino, J. D., Feb 2020, In : Cold Spring Harbor Perspectives in Medicine. 10, 2, a034884.

    Research output: Contribution to journalArticle

  • GATA1 mutations in red cell disorders

    Ling, T. & Crispino, J. D., Jan 1 2020, In : IUBMB Life. 72, 1, p. 106-118 13 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Preface to IUBMB life special issue on GATA transcription factors in development, differentiation, and disease

    Strouboulis, J. & Crispino, J. D., Jan 1 2020, In : IUBMB Life. 72, 1, p. 8-9 2 p.

    Research output: Contribution to journalEditorial

    Activation of JAK/STAT signaling in megakaryocytes sustains myeloproliferation in vivo

    Woods, B., Chen, W., Chiu, S., Marinaccio, C., Fu, C., Gu, L., Bulic, M., Yang, Q., Zouak, A., Jia, S., Suraneni, P. K., Xu, K., Levine, R. L., Crispino, J. D. & Wen, Q. J., Oct 1 2019, In : Clinical Cancer Research. 25, 19, p. 5901-5912 12 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    AKT activation is a feature of CALR mutant myeloproliferative neoplasms

    Fu, C., Wen, Q. J., Marinaccio, C., Ling, T., Chen, W., Bulic, M., Lasho, T., Tefferi, A., Crispino, J. D. & Xu, K., Jan 1 2019, In : Leukemia. 33, 1, p. 271-274 4 p.

    Research output: Contribution to journalArticle