John F Disterhoft

  • 13090 Citations
1968 …2024
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Research Output 1968 2019

2009
10 Citations (Scopus)

Autophosphorylation of αCaMKII downregulates excitability of CA1 pyramidal neurons following synaptic stimulation

Sametsky, E. A., Disterhoft, J. F. & Ohno, M., Jul 1 2009, In : Neurobiology of Learning and Memory. 92, 1, p. 120-123 4 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Pyramidal Cells
Down-Regulation
Learning
Neurons
240 Citations (Scopus)

Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry

Bond, A. M., Vangompel, M. J. W., Sametsky, E. A., Clark, M. F., Savage, J. C., Disterhoft, J. F. & Kohtz, J., Aug 1 2009, In : Nature Neuroscience. 12, 8, p. 1020-1027 8 p.

Research output: Contribution to journalArticle

Untranslated RNA
Interneurons
Prosencephalon
gamma-Aminobutyric Acid
Hippocampus
30 Citations (Scopus)

Blocking the BK channel impedes acquisition of trace eyeblink conditioning

Matthews, E. A. & Disterhoft, J. F., Feb 1 2009, In : Learning and Memory. 16, 2, p. 106-109 4 p.

Research output: Contribution to journalArticle

Large-Conductance Calcium-Activated Potassium Channels
Learning
Action Potentials
Hippocampus
Conditioning (Psychology)
63 Citations (Scopus)

BMP signaling mediates effects of exercise on hippocampal neurogenesis and cognition in mice

Gobeske, K. T., Das, S., Bonaguidi, M. A., Weiss, C., Radulovic, J., Disterhoft, J. F. & Kessler, J., Oct 20 2009, In : PloS one. 4, 10, e7506.

Research output: Contribution to journalArticle

bone morphogenetic proteins
Bone Morphogenetic Proteins
neurogenesis
Neurogenesis
cognition
24 Citations (Scopus)

Caudate nucleus is critically involved in trace eyeblink conditioning

Flores, L. C. & Disterhoft, J. F., Nov 18 2009, In : Journal of Neuroscience. 29, 46, p. 14511-14520 10 p.

Research output: Contribution to journalArticle

Caudate Nucleus
Learning
Rabbits
Basal Ganglia
Neurons
47 Citations (Scopus)

Intrinsic neuronal excitability is reversibly altered by a single experience in fear conditioning

McKay, B. M., Matthews, E. A., Oliveira, F. A. & Disterhoft, J. F., Nov 1 2009, In : Journal of neurophysiology. 102, 5, p. 2763-2770 8 p.

Research output: Contribution to journalArticle

Fear
Learning
Patch-Clamp Techniques
Cues
Conditioning (Psychology)
107 Citations (Scopus)

Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes

Cahill, M. E., Xie, Z., Day, M., Barbolina, M. V., Miller, C. A., Weiss, C., Radulovic, J., Sweatt, J. D., Disterhoft, J. F., Surmeier Jr, D. J. & Penzes, P., Aug 4 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 31, p. 13058-13063 6 p.

Research output: Contribution to journalArticle

Morphogenesis
Spine
Phenotype
Guanine Nucleotide Exchange Factors
Dendritic Spines
49 Citations (Scopus)
Pyramidal Cells
Cyclic AMP-Dependent Protein Kinases
Learning
Protein Kinase C
Baths
68 Citations (Scopus)

Memory deficits are associated with impaired ability to modulate neuronal excitability in middle-aged mice

Kaczorowski, C. C. & Disterhoft, J. F., Jun 1 2009, In : Learning and Memory. 16, 6, p. 362-366 5 p.

Research output: Contribution to journalArticle

Aptitude
Memory Disorders
Fear
Learning
Neuronal Plasticity
62 Citations (Scopus)

The fast and slow after hyperpolarizations are differentially modulated in hippocampal neurons by aging and learning

Matthews, E. A., Linardakis, J. M. & Disterhoft, J. F., Apr 15 2009, In : Journal of Neuroscience. 29, 15, p. 4750-4755 6 p.

Research output: Contribution to journalArticle

Learning
Neurons
Action Potentials
Synapses
Potassium
2008
34 Citations (Scopus)
Cyclic AMP-Dependent Protein Kinases
Neurons
Pyramidal Cells
Learning
Membranes
37 Citations (Scopus)

Delay Discrimination and Reversal Eyeblink Classical Conditioning in Abstinent Chronic Alcoholics

Fortier, C. B., Steffen, E. M., LaFleche, G., Venne, J. R., Disterhoft, J. F. & McGlinchey, R. E., Mar 1 2008, In : Neuropsychology. 22, 2, p. 196-208 13 p.

Research output: Contribution to journalArticle

Classical Conditioning
Alcoholics
Aptitude
Prosencephalon
Discrimination Learning
11 Citations (Scopus)

Enhanced neuronal excitability in rat CA1 pyramidal neurons following trace eyeblink conditioning acquisition is not due to alterations in IM

Kuo, A. G., Lee, G., McKay, B. M. & Disterhoft, J. F., Feb 1 2008, In : Neurobiology of Learning and Memory. 89, 2, p. 125-133 9 p.

Research output: Contribution to journalArticle

Pyramidal Cells
Inbred BN Rats
Learning
Rabbits
Isoproterenol
9 Citations (Scopus)
Optical Devices
Shock
Blinking
Artifacts
Cornea
17 Citations (Scopus)

Functional magnetic resonance imaging of delay and trace eyeblink conditioning in the primary visual cortex of the rabbit

Miller, M. J., Weiss, C., Song, X., Iordanescu, G., Disterhoft, J. F. & Wyrwicz, A. M., May 7 2008, In : Journal of Neuroscience. 28, 19, p. 4974-4981 8 p.

Research output: Contribution to journalArticle

Visual Cortex
Magnetic Resonance Imaging
Learning
Rabbits
Somatosensory Cortex
114 Citations (Scopus)

Neural substrates underlying human delay and trace eyeblink conditioning

Cheng, D. T., Disterhoft, J. F., Power, J. M., Ellis, D. A. & Desmond, J. E., Jun 10 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 23, p. 8108-8113 6 p.

Research output: Contribution to journalArticle

Hippocampus
Classical Conditioning
Cerebellum
Conditioning (Psychology)
Laboratory Animals
5 Citations (Scopus)

Procedural Memory System Supports Single Cue Trace Eyeblink Conditioning in Medial Temporal Lobe Amnesia

McGlinchey, R. E., Capozzi, S. M., Fortier, C. B. & Disterhoft, J. F., Mar 1 2008, In : Neuropsychology. 22, 2, p. 278-282 5 p.

Research output: Contribution to journalArticle

Amnesia
Temporal Lobe
Cues
Learning
Control Groups
60 Citations (Scopus)

The BK-mediated fAHP is modulated by learning a hippocampus-dependent task

Matthews, E. A., Weible, A. P., Shah, S. & Disterhoft, J. F., Sep 30 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 39, p. 15154-15159 6 p.

Research output: Contribution to journalArticle

Action Potentials
Hippocampus
Learning
Large-Conductance Calcium-Activated Potassium Channels
Neurons
133 Citations (Scopus)

Where is the trace in trace conditioning?

Woodruff-Pak, D. S. & Disterhoft, J. F., Feb 1 2008, In : Trends in Neurosciences. 31, 2, p. 105-112 8 p.

Research output: Contribution to journalReview article

Cerebellar Cortex
Prosencephalon
Brain
Conditioning (Psychology)
Learning
2007
88 Citations (Scopus)

Alterations in intrinsic neuronal excitability during normal aging

Disterhoft, J. F. & Oh, M. M., Jun 1 2007, In : Aging Cell. 6, 3, p. 327-336 10 p.

Research output: Contribution to journalReview article

Learning
Pyramidal Cells
Hippocampus
Rabbits
195 Citations (Scopus)

BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice

Ohno, M., Cole, S. L., Yasvoina, M., Zhao, J., Citron, M., Berry, R., Disterhoft, J. F. & Vassar, R., Apr 1 2007, In : Neurobiology of Disease. 26, 1, p. 134-145 12 p.

Research output: Contribution to journalArticle

Memory Disorders
Gene Deletion
Transgenic Mice
Alzheimer Disease
Neurons
38 Citations (Scopus)
Gyrus Cinguli
Rabbits
Neuronal Tract-Tracers
Prosencephalon
Learning
54 Citations (Scopus)

Cortical barrel lesions impair whisker-CS trace eyeblink conditioning

Galvez, R., Weible, A. P. & Disterhoft, J. F., Jan 1 2007, In : Learning and Memory. 14, 1, p. 94-100 7 p.

Research output: Contribution to journalArticle

Vibrissae
Learning
Conditioning (Psychology)
51 Citations (Scopus)

Stability and plasticity of intrinsic membrane properties in hippocampal CA1 pyramidal neurons: Effects of internal anions

Kaczorowski, C. C., Disterhoft, J. F. & Spruston, N., Feb 1 2007, In : Journal of Physiology. 578, 3, p. 799-818 20 p.

Research output: Contribution to journalArticle

Pyramidal Cells
Apamin
Anions
Patch-Clamp Techniques
Action Potentials
2006
40 Citations (Scopus)

Comparisons of dorsal and ventral hippocampus cornu ammonis region 1 pyramidal neuron activity during trace eye-blink conditioning in the rabbit

Weible, A. P., O'Reilly, J. A., Weiss, C. & Disterhoft, J. F., Aug 4 2006, In : Neuroscience. 141, 3, p. 1123-1137 15 p.

Research output: Contribution to journalArticle

Pyramidal Cells
Hippocampus
Rabbits
Neurons
Conditioning (Psychology)
23 Citations (Scopus)

Differential effects of αCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitability

Ohno, M., Sametsky, E. A., Silva, A. J. & Disterhoft, J. F., Apr 1 2006, In : European Journal of Neuroscience. 23, 8, p. 2235-2240 6 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinases
Learning
Mutation
Water
Neurons
22 Citations (Scopus)

Galantamine increases excitability of CA1 hippocampal pyramidal neurons

Oh, M. M., Wu, W. W., Power, J. M. & Disterhoft, J. F., Jan 9 2006, In : Neuroscience. 137, 1, p. 113-123 11 p.

Research output: Contribution to journalArticle

Galantamine
Pyramidal Cells
Excitatory Postsynaptic Potentials
Bungarotoxins
Nicotinic Receptors
1107 Citations (Scopus)

Intraneuronal β-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: Potential factors in amyloid plaque formation

Oakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L., Berry, R. & Vassar, R., Oct 4 2006, In : Journal of Neuroscience. 26, 40, p. 10129-10140 12 p.

Research output: Contribution to journalArticle

Amyloid Plaques
Amyloid
Transgenic Mice
Alzheimer Disease
Neurons
137 Citations (Scopus)

Learning, aging and intrinsic neuronal plasticity

Disterhoft, J. F. & Oh, M. M., Oct 1 2006, In : Trends in Neurosciences. 29, 10, p. 587-599 13 p.

Research output: Contribution to journalReview article

Neuronal Plasticity
Learning
Pyramidal Cells
Neurons
Brain
50 Citations (Scopus)

Pharmacological and molecular enhancement of learning in aging and Alzheimer's disease

Disterhoft, J. F. & Oh, M. M., Mar 1 2006, In : Journal of Physiology Paris. 99, 2-3, p. 180-192 13 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Hippocampus
Learning
Pharmacology
Amyloid beta-Protein Precursor
17 Citations (Scopus)

Simultaneous training on two hippocampus-dependent tasks facilitates acquisition of trace eyeblink conditioning

Kuo, A. G., Lee, G. & Disterhoft, J. F., Mar 1 2006, In : Learning and Memory. 13, 2, p. 201-207 7 p.

Research output: Contribution to journalArticle

Hippocampus
Water
Aptitude
Conditioning (Psychology)
Learning
182 Citations (Scopus)

Temporal memory deficits in Alzheimer's mouse models: Rescue by genetic deletion of BACE1

Ohno, M., Chang, L., Tseng, W., Oakley, H., Citron, M., Klein, W. L., Vassar, R. & Disterhoft, J. F., Jan 1 2006, In : European Journal of Neuroscience. 23, 1, p. 251-260 10 p.

Research output: Contribution to journalArticle

Genetic Models
Memory Disorders
Amyloid beta-Protein Precursor
Transgenic Mice
Fear
51 Citations (Scopus)

Vibrissa-signaled eyeblink conditioning induces somatosensory cortical plasticity

Galvez, R., Weiss, C., Weible, A. P. & Disterhoft, J. F., Sep 8 2006, In : Journal of Neuroscience. 26, 22, p. 6062-6068 7 p.

Research output: Contribution to journalArticle

Vibrissae
Rabbits
Somatosensory Cortex
Electron Transport Complex IV
Prosencephalon
2005
32 Citations (Scopus)

Acute stress facilitates trace eyeblink conditioning in C57BL/6 male mice and increases the excitability of their CA1 pyramidal neurons

Weiss, C., Sametsky, E., Sasse, A., Spiess, J. & Disterhoft, J. F., Mar 1 2005, In : Learning and Memory. 12, 2, p. 138-143 6 p.

Research output: Contribution to journalArticle

Pyramidal Cells
Shock
Corticosterone
Conditioning (Psychology)
Tail
11 Citations (Scopus)

A fiber optic-based system for behavioral eyeblink measurement in a MRI environment

Miller, M. J., Li, L., Weiss, C., Disterhoft, J. F. & Wyrwicz, A. M., Jan 30 2005, In : Journal of Neuroscience Methods. 141, 1, p. 83-87 5 p.

Research output: Contribution to journalArticle

Myelinated Nerve Fibers
Echo-Planar Imaging
Aptitude
Artifacts
Magnetic Resonance Imaging
57 Citations (Scopus)
Thyroid Hormones
Alcohols
Mothers
Therapeutics
GAP-43 Protein
65 Citations (Scopus)

GLYX-13: A monoclonal antibody-derived peptide that acts as an N-methyl-D-aspartate receptor modulator

Moskal, J. R., Kuo, A. G., Weiss, C., Wood, P. L., O'Connor Hanson, A., Kelso, S., Harris, R. B. & Disterhoft, J. F., Dec 1 2005, In : Neuropharmacology. 49, 7, p. 1077-1087 11 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Monoclonal Antibodies
Peptides
Dizocilpine Maleate
Glycine
11 Citations (Scopus)

Trace eyeblink conditioning in abstinent alcoholic individuals: Effects of complex task demands and prior conditioning

McGlinchey, R. E., Capozzi, S. M., Fortier, C. B. & Disterhoft, J. F., Mar 1 2005, In : Neuropsychology. 19, 2, p. 159-170 12 p.

Research output: Contribution to journalArticle

Alcoholics
Cues
Classical Conditioning
Alcohols
Conditioning (Psychology)
21 Citations (Scopus)

Trace eyeblink conditioning requires the hippocampus but not autophosphorylation of αCaMKII in mice

Ohno, M., Tseng, W., Silva, A. J. & Disterhoft, J. F., May 1 2005, In : Learning and Memory. 12, 3, p. 211-215 5 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Hippocampus
Learning
Point Mutation
Fear
2004
125 Citations (Scopus)

Aging, spatial learning, and total synapse number in the rat CA1 stratum radiatum

Geinisman, Y., Ganeshina, O., Yoshida, R., Berry, R. W., Disterhoft, J. F. & Gallagher, M., Jan 1 2004, In : Neurobiology of Aging. 25, 3, p. 407-416 10 p.

Research output: Contribution to journalArticle

Hippocampal CA1 Region
Synapses
Learning
Young Adult
Spatial Learning
29 Citations (Scopus)

Aging-related alterations in the distribution of Ca2+-dependent PKC isoforms in rabbit hippocampus

Van de Zee, E. A., Palm, I. F., O'Connor, M., Maizels, E. T., Hunzicker-Dunn, M. & Disterhoft, J. F., Nov 29 2004, In : Hippocampus. 14, 7, p. 849-860 12 p.

Research output: Contribution to journalArticle

Hippocampus
Protein Isoforms
Rabbits
Interneurons
Proteins
417 Citations (Scopus)

BACE1 Deficiency Rescues Memory Deficits and Cholinergic Dysfunction in a Mouse Model of Alzheimer's Disease

Ohno, M., Sametsky, E. A., Younkin, L. H., Oakley, H., Younkin, S. G., Citron, M., Vassar, R. & Disterhoft, J. F., Jan 8 2004, In : Neuron. 41, 1, p. 27-33 7 p.

Research output: Contribution to journalArticle

Memory Disorders
Cholinergic Agents
Alzheimer Disease
Amyloid
Amyloid Precursor Protein Secretases
64 Citations (Scopus)

Biophysical alterations of hippocampal pyramidal neurons in learning, ageing and Alzheimer's disease

Disterhoft, J. F., Wu, W. W. & Ohno, M., Jan 1 2004, In : Ageing Research Reviews. 3, 4, p. 383-406 24 p.

Research output: Contribution to journalShort survey

Pyramidal Cells
Neurons
Alzheimer Disease
Aging of materials
Learning

Cognitive Neuroscience

Weiss, C. & Disterhoft, J. F., Jan 1 2004, Encyclopedia of Social Measurement. Elsevier Inc, p. 341-349 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cognitive Neuroscience
34 Citations (Scopus)

Galantamine Facilitates Acquisition of Hippocampus-Dependent Trace Eyeblink Conditioning in Aged Rabbits

Weible, A. P., Oh, M. M., Lee, G. & Disterhoft, J. F., Jan 1 2004, In : Learning and Memory. 11, 1, p. 108-115 8 p.

Research output: Contribution to journalArticle

Galantamine
Hippocampus
Rabbits
Cholinergic Agents
Learning
46 Citations (Scopus)
Pyramidal Cells
N-Methyl-D-Aspartate Receptors
Baths
Neurons
Nitrendipine
102 Citations (Scopus)

Trace eyeblink conditioning is hippocampally dependent in mice

Tseng, W., Guan, R., Disterhoft, J. F. & Weiss, C., Mar 26 2004, In : Hippocampus. 14, 1, p. 58-65 8 p.

Research output: Contribution to journalArticle

Ibotenic Acid
Inbred C57BL Mouse
Neurons
Electrophysiology
Dentate Gyrus
2003
67 Citations (Scopus)
Gyrus Cinguli
Rabbits
Neurons
Signal-To-Noise Ratio
Brain Stem
17 Citations (Scopus)

Conditional Discrimination Learning in Patients with Bilateral Medial Temporal Lobe Amnesia

Fortier, C. B., Disterhoft, J. F., Capozzi, S., Kilduff, P., Cronin-Golomb, A. & McGlinchey, R. E., Dec 1 2003, In : Behavioral Neuroscience. 117, 6, p. 1181-1195 15 p.

Research output: Contribution to journalArticle

Discrimination Learning
Amnesia
Temporal Lobe
Aptitude
Light