Grants per year
Personal profile
Research Interests
Our lab uses biophysical methods, with particular emphasis on micromanipulation of single DNA molecules and single chromosomes, to study the internal structure of chromosomes in vivo, and to study chromosome-organizing proteins and DNA topoisomerases in vitro. We also develop mathematical models relevant to these types of experiments. Projects in progress involve combining fluorescence microscopy and force microscopy in experiments on DNA-protein complexes and whole chromosomes, and in-vivo studies of coupling of chromosome dynamics to gene expression.
Education/Academic qualification
Physics, PhD, Massachusetts Institute of Technology
… → 1989
Physics, BSc, University of Alberta
… → 1984
Fingerprint Dive into the research topics where John F Marko is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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deoxyribonucleic acid
Physics & Astronomy
DNA
Medicine & Life Sciences
Chromosomes
Medicine & Life Sciences
Chromatin
Medicine & Life Sciences
helices
Physics & Astronomy
Helix
Mathematics
Micromanipulation
Medicine & Life Sciences
Proteins
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2005 2020
Analyzing the role of chromatin compaction in nuclear mechanics, structure, and function
National Institute of General Medical Sciences
4/1/18 → 3/31/20
Project: Research project
Mechanics
Chromatin
Blister
Lamins
Cell Differentiation
Center for 3D Structure and Physics of the Genome
University of Massachusetts Medical School, National Institute of Diabetes, Digestive and Kidney Diseases
8/1/17 → 7/31/20
Project: Research project
Project 3
Backman, V., Crispino, J. D., Goldman, R., Marko, J. F. & Motter, A. E.
5/19/15 → 4/30/20
Project: Research project
Oncology
Center for 3D Structure and Physics of the Genome
University of Massachusetts Medical School, National Institute of Diabetes, Digestive and Kidney Diseases
8/1/16 → 7/31/17
Project: Research project
Activities of Nucleoprotein Complexes Visualized in Single-Molecule Experiments
National Institute of General Medical Sciences
6/1/16 → 5/31/19
Project: Research project
Research Output 1984 2020
Physics and Biology (of Chromosomes)
Marko, J. F., Jan 17 2020, In : Journal of Molecular Biology. 432, 2, p. 621-631 11 p.Research output: Contribution to journal › Article
Physics
Chromosomes
Computational Biology
Molecular Biology
5
Citations
(Scopus)
Chromatin's physical properties shape the nucleus and its functions
Stephens, A. D., Banigan, E. J. & Marko, J. F., Jun 2019, In : Current Opinion in Cell Biology. 58, p. 76-84 9 p.Research output: Contribution to journal › Review article
Chromatin
Lamins
Mechanics
Cytoskeleton
Cell Nucleus
1
Citation
(Scopus)
Chromosome disentanglement driven via optimal compaction of loop-extruded brush structures
Brahmachari, S. & Marko, J. F., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 50, p. 24956-24965 10 p.Research output: Contribution to journal › Article
Chromosomes
Type II DNA Topoisomerase
Genome
Metaphase
Chromatin
5
Citations
(Scopus)
DNA-segment-capture model for loop extrusion by structural maintenance of chromosome (SMC) protein complexes
Marko, J. F., De Los Rios, P., Barducci, A. & Gruber, S., Jul 26 2019, In : Nucleic acids research. 47, 13, p. 6956-6972 17 p.Research output: Contribution to journal › Article
Open Access
Chromosomes
Maintenance
DNA
Proteins
Catalytic DNA
1
Citation
(Scopus)
Effects of altering histone posttranslational modifications on mitotic chromosome structure and mechanics
Biggs, R., Liu, P. Z., Stephens, A. D. & Marko, J. F., Jan 1 2019, In : Molecular biology of the cell. 30, 7, p. 820-827 8 p.Research output: Contribution to journal › Article
Histone Code
Chromosome Structures
Post Translational Protein Processing
Mechanics
Chromosomes