• 12120 Citations
1984 …2020
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Personal profile

Research Interests

Our lab uses biophysical methods, with particular emphasis on micromanipulation of single DNA molecules and single chromosomes, to study the internal structure of chromosomes in vivo, and to study chromosome-organizing proteins and DNA topoisomerases in vitro. We also develop mathematical models relevant to these types of experiments. Projects in progress involve combining fluorescence microscopy and force microscopy in experiments on DNA-protein complexes and whole chromosomes, and in-vivo studies of coupling of chromosome dynamics to gene expression.

Education/Academic qualification

Physics, PhD, Massachusetts Institute of Technology

… → 1989

Physics, BSc, University of Alberta

… → 1984

Fingerprint Dive into the research topics where John F Marko is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
deoxyribonucleic acid Physics & Astronomy
DNA Medicine & Life Sciences
Chromosomes Medicine & Life Sciences
Chromatin Medicine & Life Sciences
helices Physics & Astronomy
Helix Mathematics
Micromanipulation Medicine & Life Sciences
Molecules Mathematics

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Grants 2005 2020

Research Output 1984 2019

Chromatin's physical properties shape the nucleus and its functions

Stephens, A. D., Banigan, E. J. & Marko, J. F., Jun 1 2019, In : Current Opinion in Cell Biology. 58, p. 76-84 9 p.

Research output: Contribution to journalReview article

Cell Nucleus
1 Citation (Scopus)

Effects of altering histone posttranslational modifications on mitotic chromosome structure and mechanics

Biggs, R., Liu, P. Z., Stephens, A. D. & Marko, J. F., Jan 1 2019, In : Molecular biology of the cell. 30, 7, p. 820-827 8 p.

Research output: Contribution to journalArticle

Histone Code
Chromosome Structures
Post Translational Protein Processing

Multimodal interference-based imaging of nanoscale structure and macromolecular motion uncovers UV induced cellular paroxysm

Gladstein, S., Almassalha, L. M., Cherkezyan, L., Chandler, J. E., Eshein, A., Eid, A., Zhang, D., Wu, W., Bauer, G. M., Stephens, A. D., Morochnik, S., Subramanian, H., Marko, J. F., Ameer, G. A., Szleifer, I. G. & Backman, V., Dec 1 2019, In : Nature communications. 10, 1, 1652.

Research output: Contribution to journalArticle

Open Access
Imaging techniques
Light interference
Cell death

Receptor-Ligand Rebinding Kinetics in Confinement

Erbaş, A., Olvera de la Cruz, M. & Marko, J. F., May 7 2019, In : Biophysical Journal. 116, 9, p. 1609-1624 16 p.

Research output: Contribution to journalArticle

Binding Sites
Drug Design
Biosensing Techniques
1 Citation (Scopus)

Twist-bend coupling and the statistical mechanics of the twistable wormlike-chain model of DNA: Perturbation theory and beyond

Nomidis, S. K., Skoruppa, E., Carlon, E. & Marko, J. F., Mar 18 2019, In : Physical Review E. 99, 3, 032414.

Research output: Contribution to journalArticle

statistical mechanics
Statistical Mechanics
Perturbation Theory
deoxyribonucleic acid