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John F Marko

  • 12607 Citations
1984 …2020

Research output per year

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Personal profile

Research Interests

Our lab uses biophysical methods, with particular emphasis on micromanipulation of single DNA molecules and single chromosomes, to study the internal structure of chromosomes in vivo, and to study chromosome-organizing proteins and DNA topoisomerases in vitro. We also develop mathematical models relevant to these types of experiments. Projects in progress involve combining fluorescence microscopy and force microscopy in experiments on DNA-protein complexes and whole chromosomes, and in-vivo studies of coupling of chromosome dynamics to gene expression.

Education/Academic qualification

Physics, PhD, Massachusetts Institute of Technology

… → 1989

Physics, BSc, University of Alberta

… → 1984

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Grants

Analyzing the role of chromatin compaction in nuclear mechanics, structure, and function

Marko, J. F.

National Institute of General Medical Sciences

4/1/18 → 3/31/20

Project: Research project

    • Center for 3D Structure and Physics of the Genome

    Marko, J. F.

    University of Massachusetts Medical School, National Institute of Diabetes, Digestive and Kidney Diseases

    8/1/17 → 7/31/20

    Project: Research project

    Project 3

    Backman, V., Crispino, J. D., Goldman, R., Marko, J. F. & Motter, A. E.

    National Cancer Institute

    5/19/15 → 4/30/20

    Project: Research project

    • Center for 3D Structure and Physics of the Genome

    Marko, J. F.

    University of Massachusetts Medical School, National Institute of Diabetes, Digestive and Kidney Diseases

    8/1/16 → 7/31/17

    Project: Research project

    Activities of Nucleoprotein Complexes Visualized in Single-Molecule Experiments

    Marko, J. F.

    National Institute of General Medical Sciences

    6/1/16 → 5/31/19

    Project: Research project

    Research Output

    Physics and Biology (of Chromosomes)

    Marko, J. F., Jan 17 2020, In : Journal of Molecular Biology. 432, 2, p. 621-631 11 p.

    Research output: Contribution to journal › Article

    • Chromatin's physical properties shape the nucleus and its functions

    Stephens, A. D., Banigan, E. J. & Marko, J. F., Jun 2019, In : Current Opinion in Cell Biology. 58, p. 76-84 9 p.

    Research output: Contribution to journal › Review article

    • 6 Scopus citations

    Chromosome disentanglement driven via optimal compaction of loop-extruded brush structures

    Brahmachari, S. & Marko, J. F., Dec 10 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 50, p. 24956-24965 10 p.

    Research output: Contribution to journal › Article

    • 1 Scopus citations

    DNA-segment-capture model for loop extrusion by structural maintenance of chromosome (SMC) protein complexes

    Marko, J. F., De Los Rios, P., Barducci, A. & Gruber, S., Jul 26 2019, In : Nucleic acids research. 47, 13, p. 6956-6972 17 p.

    Research output: Contribution to journal › Article

    Open Access
    • 5 Scopus citations

    Effects of altering histone posttranslational modifications on mitotic chromosome structure and mechanics

    Biggs, R., Liu, P. Z., Stephens, A. D. & Marko, J. F., Jan 1 2019, In : Molecular biology of the cell. 30, 7, p. 820-827 8 p.

    Research output: Contribution to journal › Article

    • 3 Scopus citations