John F Marko

Professor, Molecular Biosciences
Professor, Physics and Astronomy
Astronomy PhD Program
Interdisciplinary Biological Sciences PhD Program

Phone847 467 1276
Emailjohn-marko@northwestern.edu

Source: Scopus

Research output per year

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Personal profile

Research Interests

Our lab uses biophysical methods, with particular emphasis on micromanipulation of single DNA molecules and single chromosomes, to study the internal structure of chromosomes in vivo, and to study chromosome-organizing proteins and DNA topoisomerases in vitro. We also develop mathematical models relevant to these types of experiments. Projects in progress involve combining fluorescence microscopy and force microscopy in experiments on DNA-protein complexes and whole chromosomes, and in-vivo studies of coupling of chromosome dynamics to gene expression.

Education/Academic qualification

Physics, PhD, Massachusetts Institute of Technology

… → 1989

Physics, BSc, University of Alberta

… → 1984

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3 Active
22 Finished

Micromechanical basis of meiotic chromosome condensation and architecture
Marko, J. F.
University of Illinois at Urbana-Champaign, National Institute of General Medical Sciences
8/1/20 → 7/31/25
Project: Research project
Center for 3D Structure and Physics of the Genome
Marko, J. F.
University of Massachusetts Medical School, National Institute of Diabetes and Digestive and Kidney Diseases
8/1/17 → 7/31/20
Project: Research project
Project 3
Backman, V., Crispino, J. D., Goldman, R., Marko, J. F., Motter, A. E. & Szleifer, I. G.
National Cancer Institute
5/19/15 → 4/30/21
Project: Research project
Analyzing the role of chromatin compaction in nuclear mechanics, structure, and function
Marko, J. F.
National Institute of General Medical Sciences
4/1/18 → 3/31/20
Project: Research project
Center for 3D Structure and Physics of the Genome
Marko, J. F.
University of Massachusetts Medical School, National Institute of Diabetes and Digestive and Kidney Diseases
8/1/16 → 7/31/17
Project: Research project

13267 Citations
174 Article
9 Comment/debate
8 Chapter
7 Review article
More

Chromosome organization by one-sided and two-sided loop extrusion
Banigan, E. J., van den Berg, A. A., Brandão, H. B., Marko, J. F. & Mirny, L. A., Apr 2020, In: eLife. 9, e53558.
Research output: Contribution to journal › Article › peer-review

Open Access
6 Scopus citations
Coarse-grained modelling of DNA plectoneme pinning in the presence of base-pair mismatches
Desai, P. R., Brahmachari, S., Marko, J. F., Das, S. & Neuman, K. C., Nov 4 2020, In: Nucleic acids research. 48, 19, p. 10713-10725 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Micromanipulation of prophase I chromosomes from mouse spermatocytes reveals high stiffness and gel-like chromatin organization
Biggs, R. J., Liu, N., Peng, Y., Marko, J. F. & Qiao, H., Dec 1 2020, In: Communications Biology. 3, 1, 542.
Research output: Contribution to journal › Article › peer-review

Open Access
Physics and Biology (of Chromosomes)
Marko, J. F., Jan 17 2020, In: Journal of Molecular Biology. 432, 2, p. 621-631 11 p.
Research output: Contribution to journal › Article › peer-review
1 Scopus citations
The Smc5/6 Core Complex Is a Structure-Specific DNA Binding and Compacting Machine
Serrano, D., Cordero, G., Kawamura, R., Sverzhinsky, A., Sarker, M., Roy, S., Malo, C., Pascal, J. M., Marko, J. F. & D'Amours, D., Dec 17 2020, In: Molecular cell. 80, 6, p. 1025-1038.e5
Research output: Contribution to journal › Article › peer-review
1 Scopus citations