• 12848 Citations
1984 …2020

Research output per year

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Personal profile

Research Interests

Our lab uses biophysical methods, with particular emphasis on micromanipulation of single DNA molecules and single chromosomes, to study the internal structure of chromosomes in vivo, and to study chromosome-organizing proteins and DNA topoisomerases in vitro. We also develop mathematical models relevant to these types of experiments. Projects in progress involve combining fluorescence microscopy and force microscopy in experiments on DNA-protein complexes and whole chromosomes, and in-vivo studies of coupling of chromosome dynamics to gene expression.

Education/Academic qualification

Physics, PhD, Massachusetts Institute of Technology

… → 1989

Physics, BSc, University of Alberta

… → 1984

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Grants

Research Output

Chromosome organization by one-sided and two-sided loop extrusion

Banigan, E. J., van den Berg, A. A., Brandão, H. B., Marko, J. F. & Mirny, L. A., Apr 2020, In : eLife. 9, e53558.

Research output: Contribution to journalArticle

Open Access
  • 1 Scopus citations

    Physics and Biology (of Chromosomes)

    Marko, J. F., Jan 17 2020, In : Journal of Molecular Biology. 432, 2, p. 621-631 11 p.

    Research output: Contribution to journalArticle

  • Chromatin's physical properties shape the nucleus and its functions

    Stephens, A. D., Banigan, E. J. & Marko, J. F., Jun 2019, In : Current Opinion in Cell Biology. 58, p. 76-84 9 p.

    Research output: Contribution to journalReview article

  • 12 Scopus citations
  • 1 Scopus citations

    DNA-segment-capture model for loop extrusion by structural maintenance of chromosome (SMC) protein complexes

    Marko, J. F., De Los Rios, P., Barducci, A. & Gruber, S., Jul 26 2019, In : Nucleic acids research. 47, 13, p. 6956-6972 17 p.

    Research output: Contribution to journalArticle

    Open Access
  • 10 Scopus citations