Grants per year
Personal profile
Research Interests
Our lab uses biophysical methods, with particular emphasis on micromanipulation of single DNA molecules and single chromosomes, to study the internal structure of chromosomes in vivo, and to study chromosome-organizing proteins and DNA topoisomerases in vitro. We also develop mathematical models relevant to these types of experiments. Projects in progress involve combining fluorescence microscopy and force microscopy in experiments on DNA-protein complexes and whole chromosomes, and in-vivo studies of coupling of chromosome dynamics to gene expression.
Education/Academic qualification
Physics, PhD, Massachusetts Institute of Technology
… → 1989
Physics, BSc, University of Alberta
… → 1984
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Center for 3D Structure and Physics of the Genome
University of Massachusetts Medical School, National Human Genome Research Institute
9/18/20 → 6/30/25
Project: Research project
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Project 3
Marko, J. F., Backman, V., Goldman, R., Motter, A. E. & Szleifer, I. G.
5/19/15 → 4/30/22
Project: Research project
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Analyzing the role of chromatin compaction in nuclear mechanics, structure, and function
National Institute of General Medical Sciences
4/1/18 → 3/31/20
Project: Research project
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Center for 3D Structure and Physics of the Genome
University of Massachusetts Medical School, National Institute of Diabetes and Digestive and Kidney Diseases
8/1/17 → 7/31/20
Project: Research project
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Hp1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics
Strom, A. R., Biggs, R. J., Banigan, E. J., Wang, X., Chiu, K., Herman, C., Collado, J., Yue, F., Politz, J. C. R., Tait, L. J., Scalzo, D., Telling, A., Groudine, M., Brangwynne, C. P., Marko, J. F. & Stephens, A. D., Jun 2021, In: eLife. 10, e63972.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Liquid chromatin Hi-C characterizes compartment-dependent chromatin interaction dynamics
Belaghzal, H., Borrman, T., Stephens, A. D., Lafontaine, D. L., Venev, S. V., Weng, Z., Marko, J. F. & Dekker, J., Mar 2021, In: Nature Genetics. 53, 3, p. 367-378 12 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Single-molecule micromanipulation studies of methylated DNA
Zaichuk, T. & Marko, J. F., Jun 1 2021, In: Biophysical Journal. 120, 11, p. 2148-2155 8 p.Research output: Contribution to journal › Article › peer-review
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Chromosome organization by one-sided and two-sided loop extrusion
Banigan, E. J., van den Berg, A. A., Brandão, H. B., Marko, J. F. & Mirny, L. A., Apr 2020, In: eLife. 9, e53558.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Coarse-grained modelling of DNA plectoneme pinning in the presence of base-pair mismatches
Desai, P. R., Brahmachari, S., Marko, J. F., Das, S. & Neuman, K. C., Nov 4 2020, In: Nucleic acids research. 48, 19, p. 10713-10725 13 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations