Grants per year
Personal profile
Research Interests
Our lab uses biophysical methods, with particular emphasis on micromanipulation of single DNA molecules and single chromosomes, to study the internal structure of chromosomes in vivo, and to study chromosome-organizing proteins and DNA topoisomerases in vitro. We also develop mathematical models relevant to these types of experiments. Projects in progress involve combining fluorescence microscopy and force microscopy in experiments on DNA-protein complexes and whole chromosomes, and in-vivo studies of coupling of chromosome dynamics to gene expression.
Education/Academic qualification
Physics, PhD, Massachusetts Institute of Technology
… → 1989
Physics, BSc, University of Alberta
… → 1984
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Grants
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Center for 3D Structure and Physics of the Genome
University of Massachusetts Medical School, National Institute of Diabetes and Digestive and Kidney Diseases
8/1/17 → 7/31/20
Project: Research project
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Project 3
Backman, V., Crispino, J. D., Goldman, R., Marko, J. F., Motter, A. E. & Szleifer, I. G.
5/19/15 → 4/30/21
Project: Research project
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Analyzing the role of chromatin compaction in nuclear mechanics, structure, and function
National Institute of General Medical Sciences
4/1/18 → 3/31/20
Project: Research project
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Center for 3D Structure and Physics of the Genome
University of Massachusetts Medical School, National Institute of Diabetes and Digestive and Kidney Diseases
8/1/16 → 7/31/17
Project: Research project
Research Output
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Chromosome organization by one-sided and two-sided loop extrusion
Banigan, E. J., van den Berg, A. A., Brandão, H. B., Marko, J. F. & Mirny, L. A., Apr 2020, In: eLife. 9, e53558.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Coarse-grained modelling of DNA plectoneme pinning in the presence of base-pair mismatches
Desai, P. R., Brahmachari, S., Marko, J. F., Das, S. & Neuman, K. C., Nov 4 2020, In: Nucleic acids research. 48, 19, p. 10713-10725 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Micromanipulation of prophase I chromosomes from mouse spermatocytes reveals high stiffness and gel-like chromatin organization
Biggs, R. J., Liu, N., Peng, Y., Marko, J. F. & Qiao, H., Dec 1 2020, In: Communications Biology. 3, 1, 542.Research output: Contribution to journal › Article › peer-review
Open Access -
Physics and Biology (of Chromosomes)
Marko, J. F., Jan 17 2020, In: Journal of Molecular Biology. 432, 2, p. 621-631 11 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
The Smc5/6 Core Complex Is a Structure-Specific DNA Binding and Compacting Machine
Serrano, D., Cordero, G., Kawamura, R., Sverzhinsky, A., Sarker, M., Roy, S., Malo, C., Pascal, J. M., Marko, J. F. & D'Amours, D., Dec 17 2020, In: Molecular cell. 80, 6, p. 1025-1038.e5Research output: Contribution to journal › Article › peer-review
1 Scopus citations