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John Kessler

  • 17845 Citations
1975 …2024

Research output per year

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Personal profile

Research Interests

Our laboratory investigates stem cell biology and approaches to regeneration of the damaged or diseased nervous system. I direct the Northwestern University Stem Cell Institute and I established a hESC and iPS cell core laboratory for the University. I also am an active clinician. Our research has focused extensively on the regulation of gene expression by neural stem/progenitor cells and their differentiated progeny. We have defined signaling pathways that direct glial and neuronal lineage commitment and characterized patterns of gene expression that coordinate these processes in both the developing and adult nervous system. We have a series of studies that focus on the pathophysiology of spinal cord and traumatic brain injury, depression, and aging-related changes in cognition. I am currently the principle investigator in several multicenter gene therapy studies. I am also running clinical gene therapy trials in neuropathy.

Certifications and Licenses

Internal Medicine
Neurology

Training Experience

1973Internship, Mount Sinai Hospital, Illinois
1978Residency, New York Hospital/Cornell Medical Center

Education/Academic qualification

MD, Cornell University Medical College

… → 1971

Research interests

  • Alzheimer's Disease
  • Brain Cancer / Nervous System Cancer
  • Developmental Neurobiology
  • Neurology
  • Neuroscience
  • Spinal Cord Injury
  • Stem Cells

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Grants

Mitochondrial Stress Response in FUS proteinopathy and related dementia

Fushimi, K., Kiskinis, E., Kessler, J. & Wu, J.

National Institute of Aging

9/30/19 → 9/30/20

Project: Research project

    • BMP Signaling and Neurogenesis in Major Depressive Order

    Disterhoft, J. F., Kessler, J., Peng, C. & Radulovic, J.

    National Institute of Mental Health

    4/1/19 → 1/31/24

    Project: Research project

    • Role of BMP Signaling in the Aging Brain

    Kessler, J. & Peng, C.

    National Institute of Aging

    9/15/17 → 5/31/22

    Project: Research project

    • Northwestern University Interdepartmental Neuroscience Postbaccalaureate Research Education Program

    Acosta, A., Allada, R., Apkarian, A., Awatramani, R., Beeman, M., Bevan, M. D., Bozza, T. C., Cang, J., Chetkovich, D. M., Cobia, D. J., Contractor, A., Corcos, D. M., DeVries, S. H., Dewald, J. P. A., Dhar, S., Disterhoft, J. F., Dombeck, D. A., Elliott, J. M., Feng, Y., Ferreira, A. B., Gallio, M., Garcia-Anoveros, J., George Jr, A. L., Geula, C., Gordon, K. E., Gottfried, J. A., Grafman, J. H., Hartmann, M. J. Z., Heckman, C., Hespos, S. J., Jayaraman, A., Kahnt, T., Kearney, J. A., Kessler, J., Kiskinis, E., Kohtz, J., Kording, K. P., Kozorovitskiy, Y., Krainc, D., Larson, C., Lee, S. S. M., Li, L., Losh, M. C., Maccaferri, G., MacIver, M. A., Martina, M., Mazzulli, J., McLean, D., Mesulam, M., Miller, L. E., Miller, R. J., Mussa-Ivaldi, F., Nusslock, R., Opal, P., Ozdinler, P. H., Paller, K., Parrish, T. B., Prakriya, M., Radulovic, J., Raman, I. M., Reber, P. J., Redei, E., Rogalski, E., Sanchez, J. T., Sanz-Clemente, A., Savas, J. N., Schmidt, T. M., Schwartz, G. W., Segraves, M., Shepherd, G. M. G., Siddique, T., Solla, S. A., Surmeier Jr, D. J., Swanson, G. T., Topczewski, J., Tresch, M. C., Tysseling, V. M., Vassar, R. J., Voss, J. L., Wainwright, D. A., Wang, L., Weintraub, S., Woolley, C. S. & Wright, B. A.

    National Institute of General Medical Sciences

    5/1/17 → 4/30/22

    Project: Research project

    • Research Education Program for Trainees in Neurology

    Gertler, T. S., Kessler, J. & Simuni, T.

    National Institute of Neurological Disorders and Stroke

    7/1/15 → 6/30/20

    Project: Research project

    • Research Output

    Bone morphogenetic protein 4 targeting glioma stem-like cells for malignant glioma treatment: Latest advances and implications for clinical application

    Nayak, S., Mahenthiran, A., Yang, Y., McClendon, M., Mania-Farnell, B., James, C. D., Kessler, J. A., Tomita, T., Cheng, S. Y., Stupp, S. I. & Xi, G., Feb 2020, In : Cancers. 12, 2, 516.

    Research output: Contribution to journal › Review article

    Open Access

    • Intravenous Immunomodulatory Nanoparticle Treatment for Traumatic Brain Injury

    Sharma, S., Ifergan, I., Kurz, J. E., Linsenmeier, R. A., Xu, D., Cooper, J. G., Miller, S. D. & Kessler, J. A., Mar 1 2020, In : Annals of neurology. 87, 3, p. 442-455 14 p.

    Research output: Contribution to journal › Article

    • 1 Scopus citations

    Spinal Cord Injury Results in Chronic Mechanical Stiffening

    Cooper, J. G., Sicard, D., Sharma, S., Van Gulden, S., McGuire, T. L., Cajiao, M. P., Tschumperlin, D. J. & Kessler, J. A., Feb 1 2020, In : Journal of neurotrauma. 37, 3, p. 494-506 13 p.

    Research output: Contribution to journal › Article

    • Activating newborn neurons suppresses depression and anxiety-like behaviors

    Tunc-Ozcan, E., Peng, C. Y., Zhu, Y., Dunlop, S. R., Contractor, A. & Kessler, J. A., Dec 1 2019, In : Nature communications. 10, 1, 3768.

    Research output: Contribution to journal › Article

    Open Access
    • 7 Scopus citations

    BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification

    Kan, C., Ding, N., Yang, J., Tan, Z., McGuire, T. L., Lu, H., Zhang, K., Berger, D. M. P., Kessler, J. A. & Kan, L., Jan 11 2019, In : Stem Cell Research and Therapy. 10, 1, 14.

    Research output: Contribution to journal › Article

    • 4 Scopus citations