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Personal profile

Research Interests

Our laboratory investigates stem cell biology and approaches to regeneration of the damaged or diseased nervous system. I direct the Northwestern University Stem Cell Institute and I established a hESC and iPS cell core laboratory for the University. I also am an active clinician. Our research has focused extensively on the regulation of gene expression by neural stem/progenitor cells and their differentiated progeny. We have defined signaling pathways that direct glial and neuronal lineage commitment and characterized patterns of gene expression that coordinate these processes in both the developing and adult nervous system. We have a series of studies that focus on the pathophysiology of spinal cord and traumatic brain injury, depression, and aging-related changes in cognition. I am currently the principle investigator in several multicenter gene therapy studies. I am also running clinical gene therapy trials in neuropathy.

Certifications and Licenses

Internal Medicine

Training Experience

1973Internship, Mount Sinai Hospital, Illinois
1978Residency, New York Hospital/Cornell Medical Center

Education/Academic qualification

MD, Cornell University Medical College

… → 1971

Research interests

  • Alzheimer's Disease
  • Brain Cancer / Nervous System Cancer
  • Developmental Neurobiology
  • Neurology
  • Neuroscience
  • Spinal Cord Injury
  • Stem Cells

Fingerprint Dive into the research topics where John Kessler is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 8 Similar Profiles
Neurons Medicine & Life Sciences
Stem Cells Medicine & Life Sciences
Bone Morphogenetic Proteins Medicine & Life Sciences
Substance P Medicine & Life Sciences
Nerve Growth Factor Medicine & Life Sciences
Heterotopic Ossification Medicine & Life Sciences
Astrocytes Medicine & Life Sciences
Neural Stem Cells Medicine & Life Sciences

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Grants 2000 2024

Bone Morphogenetic Proteins
Antidepressive Agents
Dentate Gyrus
Bone Morphogenetic Protein 4
Intraventricular Infusions
Systems Biology
Premature Birth
Molecular Biology
Pregnancy Maintenance
Internship and Residency

Research Output 1975 2019

3 Citations (Scopus)

Activating newborn neurons suppresses depression and anxiety-like behaviors

Tunc-Ozcan, E., Peng, C. Y., Zhu, Y., Dunlop, S. R., Contractor, A. & Kessler, J. A., Dec 1 2019, In : Nature communications. 10, 1, 3768.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification

Kan, C., Ding, N., Yang, J., Tan, Z., McGuire, T. L., Lu, H., Zhang, K., Berger, D. M. P., Kessler, J. A. & Kan, L., Jan 11 2019, In : Stem Cell Research and Therapy. 10, 1, 14.

Research output: Contribution to journalArticle

Stem Cell Niche
Heterotopic Ossification
Stem cells
Wounds and Injuries
Diphtheria Toxin

Bmp signaling in molar cusp formation

Meguro, F., Porntaveetus, T., Kawasaki, M., Kawasaki, K., Yamada, A., Kakihara, Y., Saeki, M., Tabeta, K., Kessler, J. A., Maeda, T. & Ohazama, A., Jun 2019, In : Gene Expression Patterns. 32, p. 67-71 5 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Transgenic Mice
In Situ Hybridization

BMP signaling mediates glioma stem cell quiescence and confers treatment resistance in glioblastoma

Sachdeva, R., Wu, M., Johnson, K., Kim, H., Celebre, A., Shahzad, U., Graham, M. S., Kessler, J., Chuang, J. H., Karamchandani, J., Bredel, M., Verhaak, R. & Das, S., Dec 1 2019, In : Scientific reports. 9, 1, 14569.

Research output: Contribution to journalArticle

Open Access
Stem Cells
Neoplastic Stem Cells

Corrigendum to ‘Conserved signaling pathways underlying heterotopic ossification’ (Bone (2018) 109 (43–48), (S8756328217301564) (10.1016/j.bone.2017.04.014))

Kan, C., Chen, L., Hu, Y., Ding, N., Lu, H., Li, Y., Kessler, J. & Kan, L., May 1 2019, In : Bone. 122, 1 p.

Research output: Contribution to journalComment/debate

Heterotopic Ossification
Organized Financing
Bone and Bones