Grants per year
Personal profile
Research Interests
Our laboratory investigates stem cell biology and approaches to regeneration of the damaged or diseased nervous system. I direct the Northwestern University Stem Cell Institute and I established a hESC and iPS cell core laboratory for the University. I also am an active clinician. Our research has focused extensively on the regulation of gene expression by neural stem/progenitor cells and their differentiated progeny. We have defined signaling pathways that direct glial and neuronal lineage commitment and characterized patterns of gene expression that coordinate these processes in both the developing and adult nervous system. We have a series of studies that focus on the pathophysiology of spinal cord and traumatic brain injury, depression, and aging-related changes in cognition. I am currently the principle investigator in several multicenter gene therapy studies. I am also running clinical gene therapy trials in neuropathy.
Certifications and Licenses
| Internal Medicine | |
| Neurology |
Training Experience
| 1973 | Internship, Mount Sinai Hospital, Illinois |
| 1978 | Residency, New York Hospital/Cornell Medical Center |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
MD, Medicine, Cornell University Medical College
… → 1971
Research interests keywords
- Alzheimer's Disease
- Brain Cancer / Nervous System Cancer
- Developmental Neurobiology
- Neurology
- Neuroscience
- Spinal Cord Injury
- Stem Cells
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Live Cell Analysis Device (LCAD) with Multiplexed Cytokine Sensing for Investigation of Neuroinflammatory Phenotypes - Kessler Group
Kessler, J. (Co-PD/PI) & Peng, C.-Y. (Co-PD/PI)
6/1/24 → 5/31/27
Project: Research project
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Regulation of Hippocampal Neurogenesis and Behavior by Noggin
Kessler, J. (PD/PI), Kessler, J. (PD/PI), Peng, C.-Y. (Co-Investigator) & Peng, C.-Y. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
3/15/23 → 2/29/28
Project: Research project
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Predoctoral and Postdoctoral Training Program in Aging and Dementia
Vassar, R. J. (PD/PI), Vassar, R. J. (PD/PI), Weintraub, S. (PD/PI), Weintraub, S. (PD/PI), Allada, R. (Other), Allada, R. (Other), Bevan, M. D. (Other), Bevan, M. D. (Other), Caraveo Piso, G. (Other), Caraveo Piso, G. (Other), Carvill, G. L. (Other), Carvill, G. L. (Other), Chan, S. (Other), Chan, S. (Other), Contractor, A. (Other), Contractor, A. (Other), Disterhoft, J. F. (Other), Disterhoft, J. F. (Other), Dombeck, D. A. (Other), Dombeck, D. A. (Other), Dong, H. (Other), Dong, H. (Other), Ferreira, A. B. (Other), Ferreira, A. B. (Other), Flanagan, M. E. (Other), Flanagan, M. E. (Other), Gefen, T. D. (Other), Gefen, T. D. (Other), Geula, C. (Other), Geula, C. (Other), Gratton, C. (Other), Gratton, C. (Other), He, C. (Other), He, C. (Other), Kahnt, T. (Other), Kahnt, T. (Other), Kalb, R. G. (Other), Kalb, R. G. (Other), Kennedy, A. (Other), Kennedy, A. (Other), Kessler, J. (Other), Kessler, J. (Other), Kiskinis, E. (Other), Kiskinis, E. (Other), Klein, W. L. (Other), Klein, W. L. (Other), Kozorovitskiy, Y. (Other), Kozorovitskiy, Y. (Other), Krainc, D. (Other), Krainc, D. (Other), Li, L. (Other), Li, L. (Other), Mazzulli, J. (Other), Mazzulli, J. (Other), Mesulam, M.-M. (Other), Mesulam, M.-M. (Other), Miller, R. J. (Other), Miller, R. J. (Other), Morimoto, R. I. (Other), Morimoto, R. I. (Other), Opal, P. (Other), Opal, P. (Other), Ozdinler, H. (Other), Ozdinler, H. (Other), Paller, K. (Other), Paller, K. (Other), Parisiadou, L. (Other), Parisiadou, L. (Other), Penzes, P. (Other), Penzes, P. (Other), Pinto, L. (Other), Pinto, L. (Other), Prakriya, M. (Other), Prakriya, M. (Other), Reber, P. J. (Other), Reber, P. J. (Other), Roberts, A. L. (Other), Roberts, A. L. (Other), Rogalski, E. (Other), Rogalski, E. (Other), Savas, J. N. (Other), Savas, J. N. (Other), Surmeier Jr, D. J. (Other), Surmeier Jr, D. J. (Other), Swanson, G. T. (Other), Swanson, G. T. (Other), Voss, J. L. (Other), Voss, J. L. (Other), Zee, P. C. (Other), Zee, P. C. (Other), Zelano, C. (Other) & Zelano, C. (Other)
5/1/22 → 4/30/27
Project: Research project
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Research Education Program for Trainees in Neurology
Kessler, J. (PD/PI), Kessler, J. (PD/PI), Simuni, T. (PD/PI), Simuni, T. (PD/PI), Sobota, R. S. (Other) & Sobota, R. S. (Other)
National Institute of Neurological Disorders and Stroke
7/1/20 → 6/30/25
Project: Research project
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The impact of cardio exercise on hippocampal neuronal circuits that improve cognitive function and affective behavior
Kessler, J. (PD/PI)
1/1/22 → 12/31/23
Project: Research project
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Inhibition of Bone Morphogenetic Protein Signaling Prevents Tau Pathology in iPSC Derived Neurons and PS19 Mice
Affaneh, A., Linden, A. K., Tunc-Ozcan, E., Tsai, Y. H., Peng, C. Y. & Kessler, J. A., Apr 2025, In: Annals of neurology. 97, 4, p. 657-672 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Intravenous Immunomodulatory Nanoparticles Prevent Secondary Damage after Traumatic Brain Injury
Bertossi, R., Kurz, J. E., McGuire, T., Peng, C. Y. & Kessler, J. A., Jan 1 2025, In: Journal of neurotrauma. 42, 1-2, p. 94-106 13 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Correction: Current Strategies of Modeling Human Trophoblast Using Human Pluripotent Stem Cells in vitro, (Current Protocols, (2023), 3, (e875), 10.1002/cpz1.875)
Cheung, V. C., Bui, T., Soncin, F., Bai, T., Kessler, J. A., Parast, M. M. & Horii, M., Apr 2024, In: Current Protocols. 4, 4, e1049.Research output: Contribution to journal › Comment/debate › peer-review
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Corrigendum: miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma
Kouri, F. M., Hurley, L. A., Daniel, W. L., Day, E. S., Hua, Y., Hao, L., Peng, C. Y., Merkel, T. J., Queisser, M. A., Ritner, C., Zhang, H., James, C. D., Sznajder, J. I., Chin, L., Giljohann, D. A., Kessler, J. A., Peter, M. E., Mirkin, C. A. & Stegh, A. H., Apr 1 2024, In: Genes & development. 38, 7-8, p. 355 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Death Induced by Survival gene Elimination (DISE) correlates with neurotoxicity in Alzheimer’s disease and aging
Paudel, B., Jeong, S. Y., Martinez, C. P., Rickman, A., Haluck-Kangas, A., Bartom, E. T., Fredriksen, K., Affaneh, A., Kessler, J. A., Mazzulli, J. R., Murmann, A. E., Rogalski, E., Geula, C., Ferreira, A., Heckmann, B. L., Green, D. R., Sadleir, K. R., Vassar, R. & Peter, M. E., Dec 2024, In: Nature communications. 15, 1, 264.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations
Datasets
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Additional file 12: of BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification
Kan, C. (Creator), Ding, N. (Creator), Yang, J. (Contributor), Tan, Z. (Creator), McGuire, T. L. (Creator), Lu, H. (Contributor), Zhang, K. (Contributor), Berger, D. M. P. (Creator), Kessler, J. A. (Creator) & Kan, L. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.7581161, https://springernature.figshare.com/articles/Additional_file_12_of_BMP-dependent_injury-induced_stem_cell_niche_as_a_mechanism_of_heterotopic_ossification/7581161
Dataset
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Additional file 7: of BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification
Kan, C. (Creator), Ding, N. (Creator), Yang, J. (Contributor), Tan, Z. (Creator), McGuire, T. L. (Creator), Lu, H. (Contributor), Zhang, K. (Contributor), Berger, D. M. P. (Creator), Kessler, J. A. (Creator) & Kan, L. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.7581209, https://springernature.figshare.com/articles/Additional_file_7_of_BMP-dependent_injury-induced_stem_cell_niche_as_a_mechanism_of_heterotopic_ossification/7581209
Dataset
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Additional file 6: of BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification
Kan, C. (Creator), Ding, N. (Creator), Yang, J. (Contributor), Tan, Z. (Creator), McGuire, T. L. (Creator), Lu, H. (Contributor), Zhang, K. (Contributor), Berger, D. M. P. (Creator), Kessler, J. A. (Creator) & Kan, L. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.7581200, https://springernature.figshare.com/articles/Additional_file_6_of_BMP-dependent_injury-induced_stem_cell_niche_as_a_mechanism_of_heterotopic_ossification/7581200
Dataset
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Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma
Pangeni, R. P. (Creator), Zhang, Z. (Creator), Alvarez, A. A. (Creator), Wan, X. (Creator), Sastry, N. (Creator), Lu, S. (Creator), Shi, T. (Creator), Huang, T. (Creator), Lei, C. X. (Creator), James, C. D. (Contributor), Kessler, J. A. (Creator), Brennan, C. W. (Contributor), Nakano, I. (Creator), Lu, X. (Creator), Hu, B. (Creator), Zhang, W. (Creator) & Cheng, S.-Y. (Creator), Taylor & Francis, 2018
DOI: 10.6084/m9.figshare.6638873.v1, https://tandf.figshare.com/articles/dataset/Genome-wide_methylomic_and_transcriptomic_analyses_identify_subtype-specific_epigenetic_signatures_commonly_dysregulated_in_glioma_stem_cells_and_glioblastoma/6638873/1
Dataset
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Additional file 4: of BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification
Kan, C. (Creator), Ding, N. (Creator), Yang, J. (Contributor), Tan, Z. (Creator), McGuire, T. L. (Creator), Lu, H. (Contributor), Zhang, K. (Contributor), Berger, D. M. P. (Creator), Kessler, J. A. (Creator) & Kan, L. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.7581188, https://springernature.figshare.com/articles/Additional_file_4_of_BMP-dependent_injury-induced_stem_cell_niche_as_a_mechanism_of_heterotopic_ossification/7581188
Dataset