Grants per year
Personal profile
Research Interests
Our laboratory investigates stem cell biology and approaches to regeneration of the damaged or diseased nervous system. I direct the Northwestern University Stem Cell Institute and I established a hESC and iPS cell core laboratory for the University. I also am an active clinician. Our research has focused extensively on the regulation of gene expression by neural stem/progenitor cells and their differentiated progeny. We have defined signaling pathways that direct glial and neuronal lineage commitment and characterized patterns of gene expression that coordinate these processes in both the developing and adult nervous system. We have a series of studies that focus on the pathophysiology of spinal cord and traumatic brain injury, depression, and aging-related changes in cognition. I am currently the principle investigator in several multicenter gene therapy studies. I am also running clinical gene therapy trials in neuropathy.
Certifications and Licenses
| Internal Medicine | |
| Neurology |
Training Experience
| 1973 | Internship, Mount Sinai Hospital, Illinois |
| 1978 | Residency, New York Hospital/Cornell Medical Center |
Education/Academic qualification
MD, Cornell University Medical College
… → 1971
Research interests
- Alzheimer's Disease
- Brain Cancer / Nervous System Cancer
- Developmental Neurobiology
- Neurology
- Neuroscience
- Spinal Cord Injury
- Stem Cells
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Grants
Immune-modifying nanoparticles for the treatment of traumatic brain injury
National Institute of Neurological Disorders and Stroke
8/1/20 → 4/30/25
Project: Research project
Research Education Program for Trainees in Neurology
National Institute of Neurological Disorders and Stroke
7/1/20 → 6/30/25
Project: Research project
Mitochondrial Stress Response in FUS proteinopathy and related dementia
Fushimi, K., Kessler, J., Kiskinis, E. & Wu, J.
9/30/19 → 9/30/20
Project: Research project
BMP Signaling and Neurogenesis in Major Depressive Order
Disterhoft, J. F., Kessler, J., Peng, C. & Radulovic, J.
National Institute of Mental Health
4/1/19 → 1/31/24
Project: Research project
Research Output
Bone morphogenetic protein 4 targeting glioma stem-like cells for malignant glioma treatment: Latest advances and implications for clinical application
Nayak, S., Mahenthiran, A., Yang, Y., McClendon, M., Mania-Farnell, B., James, C. D., Kessler, J. A., Tomita, T., Cheng, S. Y., Stupp, S. I. & Xi, G., Feb 2020, In : Cancers. 12, 2, 516.Research output: Contribution to journal › Review article
Open Access
Intravenous Immunomodulatory Nanoparticle Treatment for Traumatic Brain Injury
Sharma, S., Ifergan, I., Kurz, J. E., Linsenmeier, R. A., Xu, D., Cooper, J. G., Miller, S. D. & Kessler, J. A., Mar 1 2020, In : Annals of neurology. 87, 3, p. 442-455 14 p.Research output: Contribution to journal › Article
2
Scopus
citations
Spinal Cord Injury Results in Chronic Mechanical Stiffening
Cooper, J. G., Sicard, D., Sharma, S., Van Gulden, S., McGuire, T. L., Cajiao, M. P., Tschumperlin, D. J. & Kessler, J. A., Feb 1 2020, In : Journal of neurotrauma. 37, 3, p. 494-506 13 p.Research output: Contribution to journal › Article
2
Scopus
citations
Temporal Sampling of Enzymes from Live Cells by Localized Electroporation and Quantification of Activity by SAMDI Mass Spectrometry
Mukherjee, P., Berns, E. J., Patino, C. A., Hakim Moully, E., Chang, L., Nathamgari, S. S. P., Kessler, J. A., Mrksich, M. & Espinosa, H. D., Jul 1 2020, In : Small. 16, 26, 2000584.Research output: Contribution to journal › Article
Activating newborn neurons suppresses depression and anxiety-like behaviors
Tunc-Ozcan, E., Peng, C. Y., Zhu, Y., Dunlop, S. R., Contractor, A. & Kessler, J. A., Dec 1 2019, In : Nature communications. 10, 1, 3768.Research output: Contribution to journal › Article
Open Access
10
Scopus
citations