• 18140 Citations
1975 …2020

Research output per year

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Personal profile

Research Interests

Our laboratory investigates stem cell biology and approaches to regeneration of the damaged or diseased nervous system. I direct the Northwestern University Stem Cell Institute and I established a hESC and iPS cell core laboratory for the University. I also am an active clinician. Our research has focused extensively on the regulation of gene expression by neural stem/progenitor cells and their differentiated progeny. We have defined signaling pathways that direct glial and neuronal lineage commitment and characterized patterns of gene expression that coordinate these processes in both the developing and adult nervous system. We have a series of studies that focus on the pathophysiology of spinal cord and traumatic brain injury, depression, and aging-related changes in cognition. I am currently the principle investigator in several multicenter gene therapy studies. I am also running clinical gene therapy trials in neuropathy.

Certifications and Licenses

Internal Medicine

Training Experience

1973Internship, Mount Sinai Hospital, Illinois
1978Residency, New York Hospital/Cornell Medical Center

Education/Academic qualification

MD, Cornell University Medical College

… → 1971

Research interests

  • Alzheimer's Disease
  • Brain Cancer / Nervous System Cancer
  • Developmental Neurobiology
  • Neurology
  • Neuroscience
  • Spinal Cord Injury
  • Stem Cells

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  • Research Output

    Bone morphogenetic protein 4 targeting glioma stem-like cells for malignant glioma treatment: Latest advances and implications for clinical application

    Nayak, S., Mahenthiran, A., Yang, Y., McClendon, M., Mania-Farnell, B., James, C. D., Kessler, J. A., Tomita, T., Cheng, S. Y., Stupp, S. I. & Xi, G., Feb 2020, In : Cancers. 12, 2, 516.

    Research output: Contribution to journalReview article

    Open Access
  • Intravenous Immunomodulatory Nanoparticle Treatment for Traumatic Brain Injury

    Sharma, S., Ifergan, I., Kurz, J. E., Linsenmeier, R. A., Xu, D., Cooper, J. G., Miller, S. D. & Kessler, J. A., Mar 1 2020, In : Annals of neurology. 87, 3, p. 442-455 14 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Spinal Cord Injury Results in Chronic Mechanical Stiffening

    Cooper, J. G., Sicard, D., Sharma, S., Van Gulden, S., McGuire, T. L., Cajiao, M. P., Tschumperlin, D. J. & Kessler, J. A., Feb 1 2020, In : Journal of neurotrauma. 37, 3, p. 494-506 13 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Temporal Sampling of Enzymes from Live Cells by Localized Electroporation and Quantification of Activity by SAMDI Mass Spectrometry

    Mukherjee, P., Berns, E. J., Patino, C. A., Hakim Moully, E., Chang, L., Nathamgari, S. S. P., Kessler, J. A., Mrksich, M. & Espinosa, H. D., Jul 1 2020, In : Small. 16, 26, 2000584.

    Research output: Contribution to journalArticle

  • Activating newborn neurons suppresses depression and anxiety-like behaviors

    Tunc-Ozcan, E., Peng, C. Y., Zhu, Y., Dunlop, S. R., Contractor, A. & Kessler, J. A., Dec 1 2019, In : Nature communications. 10, 1, 3768.

    Research output: Contribution to journalArticle

    Open Access
  • 10 Scopus citations