Grants per year
Personal profile
Research Interests
Our laboratory investigates stem cell biology and approaches to regeneration of the damaged or diseased nervous system. I direct the Northwestern University Stem Cell Institute and I established a hESC and iPS cell core laboratory for the University. I also am an active clinician. Our research has focused extensively on the regulation of gene expression by neural stem/progenitor cells and their differentiated progeny. We have defined signaling pathways that direct glial and neuronal lineage commitment and characterized patterns of gene expression that coordinate these processes in both the developing and adult nervous system. We have a series of studies that focus on the pathophysiology of spinal cord and traumatic brain injury, depression, and aging-related changes in cognition. I am currently the principle investigator in several multicenter gene therapy studies. I am also running clinical gene therapy trials in neuropathy.
Certifications and Licenses
| Internal Medicine | |
| Neurology |
Training Experience
| 1973 | Internship, Mount Sinai Hospital, Illinois |
| 1978 | Residency, New York Hospital/Cornell Medical Center |
Education/Academic qualification
MD, Cornell University Medical College
… → 1971
Keywords
- Alzheimer's Disease
- Brain Cancer / Nervous System Cancer
- Developmental Neurobiology
- Neurology
- Neuroscience
- Spinal Cord Injury
- Stem Cells
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2000 2024
BMP Signaling and Neurogenesis in Major Depressive Order
Disterhoft, J. F., Kessler, J., Peng, C. & Radulovic, J.
National Institute of Mental Health
4/1/19 → 1/31/24
Project: Research project
Bone Morphogenetic Proteins
Neurogenesis
Hippocampus
Depression
Antidepressive Agents
Neurogenesis
Dentate Gyrus
Brain
Bone Morphogenetic Protein 4
Intraventricular Infusions
Northwestern University Interdepartmental Neuroscience Postbaccalaureate Research Education Program
Acosta, A., Allada, R., Apkarian, A., Awatramani, R., Beeman, M., Bevan, M. D., Bozza, T. C., Cang, J., Chetkovich, D. M., Cobia, D. J., Contractor, A., Corcos, D. M., DeVries, S. H., Dewald, J. P. A., Dhar, S., Disterhoft, J. F., Dombeck, D. A., Elliott, J. M., Feng, Y., Ferreira, A. B., Gallio, M., Garcia-Anoveros, J., George Jr, A. L., Geula, C., Gordon, K. E., Gottfried, J. A., Grafman, J. H., Hartmann, M. J. Z., Heckman, C., Hespos, S. J., Jayaraman, A., Kahnt, T., Kearney, J. A., Kessler, J., Kiskinis, E., Kohtz, J., Kording, K. P., Kozorovitskiy, Y., Krainc, D., Larson, C., Lee, S. S. M., Li, L., Losh, M. C., Maccaferri, G., MacIver, M. A., Martina, M., Mazzulli, J., McLean, D., Mesulam, M., Miller, L. E., Miller, R. J., Mussa-Ivaldi, F., Nusslock, R., Opal, P., Ozdinler, P. H., Paller, K., Parrish, T. B., Prakriya, M., Radulovic, J., Raman, I. M., Reber, P. J., Redei, E., Rogalski, E., Sanchez, J. T., Sanz-Clemente, A., Savas, J. N., Schmidt, T. M., Schwartz, G. W., Segraves, M., Shepherd, G. M. G., Siddique, T., Solla, S. A., Surmeier Jr, D. J., Swanson, G. T., Topczewski, J., Tresch, M. C., Tysseling, V. M., Vassar, R. J., Voss, J. L., Wainwright, D. A., Wang, L., Weintraub, S., Woolley, C. S. & Wright, B. A.
National Institute of General Medical Sciences
5/1/17 → 4/30/22
Project: Research project
neurosciences
graduate
university
education
Cellular and Molecular Systems Biology of Preterm Birth
Bulun, S. E., Kessler, J., Peaceman, A. M. & Peng, C.
University of Chicago, March of Dimes Foundation
7/1/15 → 4/30/20
Project: Research project
Systems Biology
Premature Birth
Molecular Biology
Pregnancy
Pregnancy Maintenance
Research Education Program for Trainees in Neurology
Gertler, T. S., Kessler, J. & Simuni, T.
National Institute of Neurological Disorders and Stroke
7/1/15 → 6/30/20
Project: Research project
Neurology
Education
Mentors
Research
Internship and Residency
Research Output 1975 2019
BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification
Kan, C., Ding, N., Yang, J., Tan, Z., McGuire, T. L., Lu, H., Zhang, K., Berger, D. M. P., Kessler, J. & Kan, L., Jan 11 2019, In : Stem Cell Research and Therapy. 10, 1, 14.Research output: Contribution to journal › Article
Stem Cell Niche
Heterotopic Ossification
Stem cells
Wounds and Injuries
Diphtheria Toxin
Bmp signaling in molar cusp formation
Meguro, F., Porntaveetus, T., Kawasaki, M., Kawasaki, K., Yamada, A., Kakihara, Y., Saeki, M., Tabeta, K., Kessler, J., Maeda, T. & Ohazama, A., Jun 1 2019, In : Gene Expression Patterns. 32, p. 67-71 5 p.Research output: Contribution to journal › Article
Bone Morphogenetic Proteins
Tooth
Transgenic Mice
In Situ Hybridization
Corrigendum to ‘Conserved signaling pathways underlying heterotopic ossification’ (Bone (2018) 109 (43–48), (S8756328217301564) (10.1016/j.bone.2017.04.014))
Kan, C., Chen, L., Hu, Y., Ding, N., Lu, H., Li, Y., Kessler, J. & Kan, L., May 1 2019, In : Bone. 122, 1 p.Research output: Contribution to journal › Comment/debate
Heterotopic Ossification
Organized Financing
Bone and Bones
Emotions
corrigendum
1
Citation
(Scopus)
Full Factorial Microfluidic Designs and Devices for Parallelizing Human Pluripotent Stem Cell Differentiation
Chadly, D. M., Oleksijew, A. M., Coots, K. S., Fernandez, J. J., Kobayashi, S., Kessler, J. & Matsuoka, A. J., Feb 1 2019, In : SLAS Technology. 24, 1, p. 41-54 14 p.Research output: Contribution to journal › Article
Lab-On-A-Chip Devices
Pluripotent Stem Cells
Stem cells
Microfluidics
Cell Differentiation
Neuronal apolipoprotein E4 increases cell death and phosphorylated tau release in alzheimer disease
Wadhwani, A. R., Affaneh, A., Van Gulden, S. & Kessler, J., May 1 2019, In : Annals of neurology. 85, 5, p. 726-739 14 p.Research output: Contribution to journal › Article
Apolipoprotein E4
Alzheimer Disease
Cell Death
Neurons
Apolipoproteins E