Grants per year
Personal profile
Research Interests
Our laboratory investigates stem cell biology and approaches to regeneration of the damaged or diseased nervous system. I direct the Northwestern University Stem Cell Institute and I established a hESC and iPS cell core laboratory for the University. I also am an active clinician. Our research has focused extensively on the regulation of gene expression by neural stem/progenitor cells and their differentiated progeny. We have defined signaling pathways that direct glial and neuronal lineage commitment and characterized patterns of gene expression that coordinate these processes in both the developing and adult nervous system. We have a series of studies that focus on the pathophysiology of spinal cord and traumatic brain injury, depression, and aging-related changes in cognition. I am currently the principle investigator in several multicenter gene therapy studies. I am also running clinical gene therapy trials in neuropathy.
Certifications and Licenses
Internal Medicine | |
Neurology |
Training Experience
1973 | Internship, Mount Sinai Hospital, Illinois |
1978 | Residency, New York Hospital/Cornell Medical Center |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
MD, Medicine, Cornell University Medical College
… → 1971
Research interests keywords
- Alzheimer's Disease
- Brain Cancer / Nervous System Cancer
- Developmental Neurobiology
- Neurology
- Neuroscience
- Spinal Cord Injury
- Stem Cells
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- 1 Similar Profiles
Network
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Regulation of Hippocampal Neurogenesis and Behavior by Noggin
National Institute of Neurological Disorders and Stroke
3/15/23 → 2/29/28
Project: Research project
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Predoctoral and Postdoctoral Training Program in Aging and Dementia
Vassar, R. J., Weintraub, S., Allada, R., Bevan, M. D., Caraveo Piso, G., Carvill, G. L., Chan, S., Contractor, A., Disterhoft, J. F., Dombeck, D. A., Dong, H., Ferreira, A. B., Flanagan, M. E., Gefen, T. D., Geula, C., Gratton, C., He, C., Kahnt, T., Kalb, R. G., Kennedy, A., Kessler, J., Kiskinis, E., Klein, W. L., Kozorovitskiy, Y., Krainc, D., Li, L., Mazzulli, J., Mesulam, M., Miller, R. J., Morimoto, R. I., Opal, P., Ozdinler, H., Paller, K., Parisiadou, L., Penzes, P., Pinto, L., Prakriya, M., Reber, P. J., Roberts, A. L., Rogalski, E., Savas, J. N., Surmeier Jr, D. J., Swanson, G. T., Voss, J. L., Zee, P. C. & Zelano, C.
5/1/22 → 4/30/27
Project: Research project
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The impact of cardio exercise on hippocampal neuronal circuits that improve cognitive function and affective behavior
1/1/22 → 12/31/23
Project: Research project
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Neural activity and circuitry-mediated hippocampal stress responses
National Institute of Mental Health
7/22/21 → 6/30/23
Project: Research project
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Immune-modifying nanoparticles for the treatment of traumatic brain injury
National Institute of Neurological Disorders and Stroke
8/1/20 → 4/30/25
Project: Research project
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Why Some Mice Are Smarter Than Others: The Impact of Bone Morphogenetic Protein Signaling on Cognition
Bonds, J. A., Tunc-Ozcan, E., Dunlop, S. R., Rawat, R., Peng, C. Y. & Kessler, J. A., Jan 2023, In: eNeuro. 10, 1, ENEURO.0213-22.2022.Research output: Contribution to journal › Article › peer-review
Open Access -
Hippocampal BMP signaling as a common pathway for antidepressant action
Tunc-Ozcan, E., Brooker, S. M., Bonds, J. A., Tsai, Y. H., Rawat, R., McGuire, T. L., Peng, C. Y. & Kessler, J. A., Jan 2022, In: Cellular and Molecular Life Sciences. 79, 1, 31.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Ketamine activates adult-born immature granule neurons to rapidly alleviate depression-like behaviors in mice
Rawat, R., Tunc-Ozcan, E., McGuire, T. L., Peng, C. Y. & Kessler, J. A., Dec 2022, In: Nature communications. 13, 1, 2650.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Establishment of human induced trophoblast stem-like cells from term villous cytotrophoblasts
Bai, T., Peng, C. Y., Aneas, I., Sakabe, N., Requena, D. F., Billstrand, C., Nobrega, M., Ober, C., Parast, M. & Kessler, J. A., Oct 2021, In: Stem Cell Research. 56, 102507.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Gene therapy for diabetic peripheral neuropathy: A randomized, placebo-controlled phase III study of VM202, a plasmid DNA encoding human hepatocyte growth factor
the VM202 study group, May 2021, In: Clinical and Translational Science. 14, 3, p. 1176-1184 9 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations
Datasets
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Additional file 10: of BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification
Kan, C. (Creator), Ding, N. (Creator), Yang, J. (Contributor), Tan, Z. (Creator), McGuire, T. L. (Creator), Lu, H. (Contributor), Zhang, K. (Contributor), Berger, D. M. (Creator), Kessler, J. (Creator) & Kan, L. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.7581143.v1, https://springernature.figshare.com/articles/Additional_file_10_of_BMP-dependent_injury-induced_stem_cell_niche_as_a_mechanism_of_heterotopic_ossification/7581143/1
Dataset
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Additional file 6: of BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification
Kan, C. (Creator), Ding, N. (Creator), Yang, J. (Contributor), Tan, Z. (Creator), McGuire, T. L. (Creator), Lu, H. (Contributor), Zhang, K. (Contributor), Berger, D. M. (Creator), Kessler, J. (Creator) & Kan, L. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.7581200.v1, https://springernature.figshare.com/articles/Additional_file_6_of_BMP-dependent_injury-induced_stem_cell_niche_as_a_mechanism_of_heterotopic_ossification/7581200/1
Dataset
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Additional file 5: of BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification
Kan, C. (Creator), Ding, N. (Creator), Yang, J. (Contributor), Tan, Z. (Creator), McGuire, T. L. (Creator), Lu, H. (Contributor), Zhang, K. (Contributor), Berger, D. M. (Creator), Kessler, J. (Creator) & Kan, L. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.7581191, https://springernature.figshare.com/articles/Additional_file_5_of_BMP-dependent_injury-induced_stem_cell_niche_as_a_mechanism_of_heterotopic_ossification/7581191
Dataset
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Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma
Pangeni, R. P. (Creator), Zhang, Z. (Creator), Alvarez, A. A. (Creator), Wan, X. (Contributor), Sastry, N. (Contributor), Lu, S. (Contributor), Shi, T. (Contributor), Huang, T. (Contributor), Lei, C. X. (Creator), James, C. D. (Contributor), Kessler, J. (Creator), Brennan, C. W. (Creator), Nakano, I. (Creator), Lu, X. (Contributor), Hu, B. (Creator), Zhang, W. (Creator) & Cheng, S. (Creator), Taylor & Francis, 2018
DOI: 10.6084/m9.figshare.6638873.v1, https://tandf.figshare.com/articles/Genome-wide_methylomic_and_transcriptomic_analyses_identify_subtype-specific_epigenetic_signatures_commonly_dysregulated_in_glioma_stem_cells_and_glioblastoma/6638873/1
Dataset
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Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma
Pangeni, R. P. (Creator), Zhang, Z. (Creator), Alvarez, A. A. (Creator), Wan, X. (Contributor), Sastry, N. (Contributor), Lu, S. (Contributor), Shi, T. (Contributor), Huang, T. (Contributor), Lei, C. X. (Creator), James, C. D. (Contributor), Kessler, J. (Creator), Brennan, C. W. (Creator), Nakano, I. (Creator), Lu, X. (Contributor), Hu, B. (Creator), Zhang, W. (Creator) & Cheng, S. (Creator), figshare, 2018
DOI: 10.6084/m9.figshare.6638873, https://tandf.figshare.com/articles/Genome-wide_methylomic_and_transcriptomic_analyses_identify_subtype-specific_epigenetic_signatures_commonly_dysregulated_in_glioma_stem_cells_and_glioblastoma/6638873
Dataset