Grants per year
Personal profile
Research Interests
Our laboratory investigates stem cell biology and approaches to regeneration of the damaged or diseased nervous system. I direct the Northwestern University Stem Cell Institute and I established a hESC and iPS cell core laboratory for the University. I also am an active clinician. Our research has focused extensively on the regulation of gene expression by neural stem/progenitor cells and their differentiated progeny. We have defined signaling pathways that direct glial and neuronal lineage commitment and characterized patterns of gene expression that coordinate these processes in both the developing and adult nervous system. We have a series of studies that focus on the pathophysiology of spinal cord and traumatic brain injury, depression, and aging-related changes in cognition. I am currently the principle investigator in several multicenter gene therapy studies. I am also running clinical gene therapy trials in neuropathy.
Certifications and Licenses
| Internal Medicine | |
| Neurology |
Training Experience
| 1973 | Internship, Mount Sinai Hospital, Illinois |
| 1978 | Residency, New York Hospital/Cornell Medical Center |
Education/Academic qualification
MD, Cornell University Medical College
… → 1971
Research interests
- Alzheimer's Disease
- Brain Cancer / Nervous System Cancer
- Developmental Neurobiology
- Neurology
- Neuroscience
- Spinal Cord Injury
- Stem Cells
Fingerprint Dive into the research topics where John Kessler is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 8 Similar Profiles
Neurons
Medicine & Life Sciences
Stem Cells
Medicine & Life Sciences
Bone Morphogenetic Proteins
Medicine & Life Sciences
Substance P
Medicine & Life Sciences
Nerve Growth Factor
Medicine & Life Sciences
Heterotopic Ossification
Medicine & Life Sciences
Astrocytes
Medicine & Life Sciences
Neural Stem Cells
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2000 2024
BMP Signaling and Neurogenesis in Major Depressive Order
Disterhoft, J. F., Kessler, J., Peng, C. & Radulovic, J.
National Institute of Mental Health
4/1/19 → 1/31/24
Project: Research project
Bone Morphogenetic Proteins
Neurogenesis
Hippocampus
Depression
Antidepressive Agents
Neurogenesis
Dentate Gyrus
Brain
Bone Morphogenetic Protein 4
Intraventricular Infusions
Northwestern University Interdepartmental Neuroscience Postbaccalaureate Research Education Program
Acosta, A., Allada, R., Apkarian, A., Awatramani, R., Beeman, M., Bevan, M. D., Bozza, T. C., Cang, J., Chetkovich, D. M., Cobia, D. J., Contractor, A., Corcos, D. M., DeVries, S. H., Dewald, J. P. A., Dhar, S., Disterhoft, J. F., Dombeck, D. A., Elliott, J. M., Feng, Y., Ferreira, A. B., Gallio, M., Garcia-Anoveros, J., George Jr, A. L., Geula, C., Gordon, K. E., Gottfried, J. A., Grafman, J. H., Hartmann, M. J. Z., Heckman, C., Hespos, S. J., Jayaraman, A., Kahnt, T., Kearney, J. A., Kessler, J., Kiskinis, E., Kohtz, J., Kording, K. P., Kozorovitskiy, Y., Krainc, D., Larson, C., Lee, S. S. M., Li, L., Losh, M. C., Maccaferri, G., MacIver, M. A., Martina, M., Mazzulli, J., McLean, D., Mesulam, M., Miller, L. E., Miller, R. J., Mussa-Ivaldi, F., Nusslock, R., Opal, P., Ozdinler, P. H., Paller, K., Parrish, T. B., Prakriya, M., Radulovic, J., Raman, I. M., Reber, P. J., Redei, E., Rogalski, E., Sanchez, J. T., Sanz-Clemente, A., Savas, J. N., Schmidt, T. M., Schwartz, G. W., Segraves, M., Shepherd, G. M. G., Siddique, T., Solla, S. A., Surmeier Jr, D. J., Swanson, G. T., Topczewski, J., Tresch, M. C., Tysseling, V. M., Vassar, R. J., Voss, J. L., Wainwright, D. A., Wang, L., Weintraub, S., Woolley, C. S. & Wright, B. A.
National Institute of General Medical Sciences
5/1/17 → 4/30/22
Project: Research project
neurosciences
graduate
university
education
Cellular and Molecular Systems Biology of Preterm Birth
Bulun, S. E., Kessler, J., Peaceman, A. M. & Peng, C.
University of Chicago, March of Dimes Foundation
7/1/15 → 4/30/20
Project: Research project
Systems Biology
Premature Birth
Molecular Biology
Pregnancy
Pregnancy Maintenance
Research Education Program for Trainees in Neurology
Gertler, T. S., Kessler, J. & Simuni, T.
National Institute of Neurological Disorders and Stroke
7/1/15 → 6/30/20
Project: Research project
Neurology
Education
Mentors
Research
Internship and Residency
Research Output 1975 2019
3
Citations
(Scopus)
Activating newborn neurons suppresses depression and anxiety-like behaviors
Tunc-Ozcan, E., Peng, C. Y., Zhu, Y., Dunlop, S. R., Contractor, A. & Kessler, J. A., Dec 1 2019, In : Nature communications. 10, 1, 3768.Research output: Contribution to journal › Article
Open Access
anxiety
Neurogenesis
neurons
Neurons
Anxiety
3
Citations
(Scopus)
BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification
Kan, C., Ding, N., Yang, J., Tan, Z., McGuire, T. L., Lu, H., Zhang, K., Berger, D. M. P., Kessler, J. A. & Kan, L., Jan 11 2019, In : Stem Cell Research and Therapy. 10, 1, 14.Research output: Contribution to journal › Article
Stem Cell Niche
Heterotopic Ossification
Stem cells
Wounds and Injuries
Diphtheria Toxin
Bmp signaling in molar cusp formation
Meguro, F., Porntaveetus, T., Kawasaki, M., Kawasaki, K., Yamada, A., Kakihara, Y., Saeki, M., Tabeta, K., Kessler, J. A., Maeda, T. & Ohazama, A., Jun 2019, In : Gene Expression Patterns. 32, p. 67-71 5 p.Research output: Contribution to journal › Article
Bone Morphogenetic Proteins
Tooth
Transgenic Mice
In Situ Hybridization
BMP signaling mediates glioma stem cell quiescence and confers treatment resistance in glioblastoma
Sachdeva, R., Wu, M., Johnson, K., Kim, H., Celebre, A., Shahzad, U., Graham, M. S., Kessler, J., Chuang, J. H., Karamchandani, J., Bredel, M., Verhaak, R. & Das, S., Dec 1 2019, In : Scientific reports. 9, 1, 14569.Research output: Contribution to journal › Article
Open Access
Glioblastoma
Glioma
Stem Cells
Neoplastic Stem Cells
temozolomide
Corrigendum to ‘Conserved signaling pathways underlying heterotopic ossification’ (Bone (2018) 109 (43–48), (S8756328217301564) (10.1016/j.bone.2017.04.014))
Kan, C., Chen, L., Hu, Y., Ding, N., Lu, H., Li, Y., Kessler, J. & Kan, L., May 1 2019, In : Bone. 122, 1 p.Research output: Contribution to journal › Comment/debate
Heterotopic Ossification
Organized Financing
Bone and Bones
Emotions
corrigendum