Research Output 1975 2018

2018

Developmental profiling of microRNAs in the human embryonic inner ear

Chadly, D. M., Best, J., Ran, C., Bruska, M., Woźniak, W., Kempisty, B., Schwartz, M., LaFleur, B., Kerns, B. J., Kessler, J. A. & Matsuoka, A. J. Jan 1 2018 In : PLoS ONE. 13, 1, e0191452

Research output: Contribution to journalArticle

Inner Ear
MicroRNAs
microRNA
Ganglia
ears
Bone Morphogenetic Proteins
Oligodendroglia
Ischemia
Bone Morphogenetic Protein Receptors
Bone and Bones
2017

Conserved signaling pathways underlying heterotopic ossification

Kan, C., Chen, L., Hu, Y., Ding, N., Lu, H., Li, Y., Kessler, J. A. & Kan, L. Mar 2 2017 (Accepted/In press) In : Bone.

Research output: Contribution to journalArticle

Heterotopic Ossification
Bone Morphogenetic Proteins
Inborn Genetic Diseases
Translational Medical Research
Fibroblast Growth Factors

Creating a stem cell niche in the inner ear using self-assembling peptide amphiphiles

Matsuoka, A. J., Sayed, Z. A., Stephanopoulos, N., Berns, E. J., Wadhwani, A. R., Morrissey, Z. D., Chadly, D. M., Kobayashi, S., Edelbrock, A. N., Mashimo, T., Miller, C. A., McGuire, T. L., Stupp, S. I. & Kessler, J. A. Dec 1 2017 In : PLoS ONE. 12, 12, e0190150

Research output: Contribution to journalArticle

isoleucyl-lysyl-valyl-alanyl-valine
Unsaturated polymers
Stem Cell Niche
cell transplantation
Cell Transplantation

Design, Assembly, Production, and Transfection of Synthetic Modified mRNA

Oh, S. & Kessler, J. A. Jan 1 2017 (Accepted/In press) In : Methods.

Research output: Contribution to journalArticle

Transfection
Synthetic Genes
Messenger RNA
RNA Stability
Safety
6 Citations

Directed differentiation of human embryonic stem cells toward placode-derived spiral ganglion-like sensory neurons

Matsuoka, A. J., Morrissey, Z. D., Zhang, C., Homma, K., Belmadani, A., Miller, C. A., Chadly, D. M., Kobayashi, S., Edelbrock, A. N., Tanaka-Matakatsu, M., Whitlon, D. S., Lyass, L., McGuire, T. L., Stupp, S. I. & Kessler, J. A. Mar 1 2017 In : Stem Cells Translational Medicine. 6, 3, p. 923-936 14 p.

Research output: Contribution to journalArticle

Spiral Ganglion
Sensory Receptor Cells
Neurons
Ear
Ectoderm
Pyramidal Tracts
Spinal Cord Injuries
Cell Movement
1 Citations

Gli1-labeled adult mesenchymal stem/progenitor cells and hedgehog signaling contribute to endochondral heterotopic ossification

Kan, C., Chen, L., Hu, Y., Ding, N., Li, Y., McGuire, T. L., Lu, H., Kessler, J. A. & Kan, L. Mar 2 2017 (Accepted/In press) In : Bone.

Research output: Contribution to journalArticle

Heterotopic Ossification
Adult Stem Cells
Hedgehogs
Mesenchymal Stromal Cells
Osteogenesis
2 Citations

Hippocampal bone morphogenetic protein signaling mediates behavioral effects of antidepressant treatment

Brooker, S. M., Gobeske, K. T., Chen, J., Peng, C. Y. & Kessler, J. A. Jun 1 2017 In : Molecular Psychiatry. 22, 6, p. 910-919 10 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Antidepressive Agents
Neurogenesis
Hippocampus
Fluoxetine

Intravenous immune-modifying nanoparticles as a therapy for spinal cord injury in mice

Jeong, S. J., Cooper, J. G., Ifergan, I., McGuire, T. L., Xu, D., Hunter, Z., Sharma, S., McCarthy, D., Miller, S. D. & Kessler, J. A. Dec 1 2017 In : Neurobiology of Disease. 108, p. 73-82 10 p.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Nanoparticles
Monocytes
Microglia
Cicatrix

Microenvironmental factors that regulate mesenchymal stem cells: Lessons learned from the study of heterotopic ossification

Kan, C., Chen, L., Hu, Y., Lu, H., Li, Y., Kessler, J. A. & Kan, L. Jan 1 2017 In : Histology and Histopathology. 32, 10, p. 977-985 9 p.

Research output: Contribution to journalReview article

Heterotopic Ossification
Mesenchymal Stromal Cells
Pathologic Processes
Stromal Cells
Osteogenesis
1 Citations

MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma

Huang, T. , Kim, C. K. , Alvarez, A. A. , Pangeni, R. P. , Wan, X. , Song, X. , Shi, T. , Yang, Y. , Sastry, N. , Horbinski, C. M. , Lu, S. , Stupp, R. , Kessler, J. A. , Nishikawa, R. , Nakano, I. , Sulman, E. P. , Lu, X. , James, C. D. , Yin, X. M. , Hu, B. & 1 others Cheng, S. Y. Dec 11 2017 In : Cancer Cell. 32, 6, p. 840-855.e8

Research output: Contribution to journalArticle

Autophagy
Glioblastoma
Phosphorylation
Radiotherapy
Serine
3 Citations
Amyotrophic Lateral Sclerosis
Safety
Intramuscular Injections
Injections
Retreatment
1 Citations

TGF-β family signaling in neural and neuronal differentiation, development, and function

Meyers, E. A. & Kessler, J. A. Jan 1 2017 In : Cold Spring Harbor Perspectives in Biology. 9, 8, a022244

Research output: Contribution to journalArticle

Neurology
Transforming Growth Factor beta
Nervous System
Modulators
Embryonic Development
2016
6 Citations

A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways

Huang, T., Alvarez, A. A., Pangeni, R. P., Horbinski, C. M., Lu, S., Kim, S. H., James, C. D., Raizer, J. J., Kessler, J. A., Brenann, C. W., Sulman, E. P., Finocchiaro, G., Tan, M., Nishikawa, R., Lu, X., Nakano, I., Hu, B. & Cheng, S. Y. Oct 4 2016 In : Nature Communications. 7, 12885

Research output: Contribution to journalArticle

phenotype
Glioblastoma
regulators
Phenotype
Networks (circuits)
12 Citations

A tenascin-C mimetic peptide amphiphile nanofiber gel promotes neurite outgrowth and cell migration of neurosphere-derived cells

Berns, E. J., Álvarez, Z., Goldberger, J. E., Boekhoven, J., Kessler, J. A., Kuhn, H. G. & Stupp, S. I. Jun 1 2016 In : Acta Biomaterialia. 37, p. 50-58 9 p.

Research output: Contribution to journalArticle

Nanofibers
Tenascin
Amphiphiles
Peptides
Cell Movement
8 Citations

Increased bone morphogenetic protein signaling contributes to age-related declines in neurogenesis and cognition

Meyers, E. A., Gobeske, K. T., Bond, A. M., Jarrett, J. C., Peng, C. Y. & Kessler, J. A. Jan 1 2016 In : Neurobiology of Aging. 38, p. 164-175 12 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Neurogenesis
Cognition
Bone Morphogenetic Protein 4
Dentate Gyrus
20 Citations

Role of adult hippocampal neurogenesis in persistent pain

Apkarian, A. V., Mutso, A. A., Centeno, M. V., Kan, L., Wu, M., Levinstein, M., Banisadr, G., Gobeske, K. T., Miller, R. J., Radulovic, J., Hen, R. & Kessler, J. A. Feb 1 2016 In : Pain. 157, 2, p. 418-428 11 p.

Research output: Contribution to journalArticle

Neurogenesis
Pain
Learning
Intraventricular Infusions
Antimitotic Agents
5 Citations

β1-integrin restricts astrocytic differentiation of adult hippocampal neural stem cells

Brooker, S. M., Bond, A. M., Peng, C. Y. & Kessler, J. A. Jul 1 2016 In : GLIA. 64, 7, p. 1235-1251 17 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Integrins
Dentate Gyrus
Astrocytes
Stem Cell Niche
2015
3 Citations
Blood-Brain Barrier
Integrins
Cerebral Cortex
Endothelial Cells
Astrocytes
32 Citations

Bioactive DNA-peptide nanotubes enhance the differentiation of neural stem cells into neurons

Stephanopoulos, N., Freeman, R., North, H. A., Sur, S., Jeong, S. J., Tantakitti, F., Kessler, J. A. & Stupp, S. I. Jan 14 2015 In : Nano letters. 15, 1, p. 603-609 7 p.

Research output: Contribution to journalArticle

Peptide Nanotubes
stem cells
activity (biology)
Stem cells
neurons
5 Citations
Pluripotent Stem Cells
Neuroglia
Astrocytes
Neurons
Cerebral Cortex
12 Citations

Isolating single cells in a neurosphere assay using inertial microfluidics

Nathamgari, S. S. P., Dong, B., Zhou, F., Kang, W., Giraldo-Vela, J. P., McGuire, T., McNaughton, R. L., Sun, C., Kessler, J. A. & Espinosa, H. D. Oct 14 2015 In : Lab on a Chip. 15, 24, p. 4591-4597 7 p.

Research output: Contribution to journalArticle

Microfluidics
Stem cells
Assays
Flow rate
Sorting
63 Citations

MiR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma

Kouri, F. M., Hurley, L. A., Daniel, W. L., Day, E. S., Hua, Y., Hao, L., Peng, C. Y., Merkel, T. J., Queisser, M. A., Ritner, C., Zhang, H., David James, C., Sznajder, J. I., Chin, L., Giljohann, D. A., Kessler, J. A., Peter, M. E., Mirkin, C. A. & Stegh, A. H. Jan 1 2015 In : Genes and Development. 29, 7, p. 732-745 14 p.

Research output: Contribution to journalArticle

Glioblastoma
Apoptosis
Glioma
Growth
Neoplasms
3 Citations

Neurology - The next 10 years

Baron, R., Ferriero, D. M., Frisoni, G. B., Bettegowda, C., Gokaslan, Z. L., Kessler, J. A., Vezzani, A., Waxman, S. G., Jarius, S., Wildemann, B. & Weller, M. Nov 1 2015 In : Nature Reviews Neurology. 11, 11, p. 658-664 7 p.

Research output: Contribution to journalReview article

Neurology
Research
Precision Medicine
Therapeutics
16 Citations

β1-integrin alters ependymal stem cell BMP receptor localization and attenuates astrogliosis after spinal cord injury

North, H. A., Pan, L., McGuire, T. L., Brooker, S. & Kessler, J. A. Jan 1 2015 In : Journal of Neuroscience. 35, 9, p. 3725-3733 9 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein Receptors
Spinal Cord Injuries
Integrins
Stem Cells
Astrocytes
2014
70 Citations

Aligned neurite outgrowth and directed cell migration in self-assembled monodomain gels

Berns, E. J., Sur, S., Pan, L., Goldberger, J. E., Suresh, S., Zhang, S., Kessler, J. A. & Stupp, S. I. Jan 1 2014 In : Biomaterials. 35, 1, p. 185-195 11 p.

Research output: Contribution to journalArticle

Nanofibers
Scaffolds
Cell Movement
Neurites
Gels
9 Citations

BMP signaling induces astrocytic differentiation of clinically derived oligodendroglioma propagating cells

Srikanth, M., Kim, J., Das, S. & Kessler, J. A. Feb 1 2014 In : Molecular Cancer Research. 12, 2, p. 283-294 12 p.

Research output: Contribution to journalArticle

Oligodendroglioma
Bone Morphogenetic Proteins
Stem Cells
Glioma
Smad Proteins
17 Citations

BMP signaling regulates the tempo of adult hippocampal progenitor maturation at multiple stages of the lineage

Bond, A. M., Peng, C. Y., Meyers, E. A., McGuire, T., Ewaleifoh, O. & Kessler, J. A. Jan 1 2014 In : Stem Cells. 32, 8, p. 2201-2214 14 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Stem Cells
Neurons
Neural Stem Cells
Neurogenesis
27 Citations

EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis

Feng, H. , Lopez, G. Y. , Kim, C. K. , Alvarez, A. , Duncan, C. G. , Nishikawa, R. , Nagane, M. , Su, A. J. A. , Auron, P. E. , Hedberg, M. L. , Wang, L. , Raizer, J. J. , Kessler, J. A. , Parsa, A. T. , Gao, W. Q. , Kim, S. H. , Minata, M. , Nakano, I. , Grandis, J. R. , McLendon, R. E. & 7 others Bigner, D. D., Lin, H. K., Furnari, F. B., Cavenee, W. K., Hu, B., Yan, H. & Cheng, S. Y. Jan 1 2014 In : Journal of Clinical Investigation. 124, 9, p. 3741-3756 16 p.

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 6
Carcinogenesis
Phosphorylation
Head and Neck Neoplasms
Neuropilins
23 Citations

Evaluation of the cellular origins of Heterotopic ossification

Kan, L. & Kessler, J. A. Jan 1 2014 In : Orthopedics. 37, 5, p. 329-340 12 p.

Research output: Contribution to journalReview article

Heterotopic Ossification
Population
Osteogenesis
Myositis Ossificans
Biological Phenomena
19 Citations

Microfluidic device for stem cell differentiation and localized electroporation of postmitotic neurons

Kang, W., Giraldo-Vela, J. P., Nathamgari, S. S. P., McGuire, T., McNaughton, R. L., Kessler, J. A. & Espinosa, H. D. Dec 7 2014 In : Lab on a Chip. 14, 23, p. 4486-4495 10 p.

Research output: Contribution to journalArticle

Lab-On-A-Chip Devices
Electroporation
Stem cells
Microfluidics
Neurons
9 Citations

MicroRNAs participate in the murine oligodendroglial response to perinatal hypoxia-ischemia

Birch, D., Britt, B. C., Dukes, S. C., Kessler, J. A. & Dizon, M. L. V. Oct 1 2014 In : Pediatric research. 76, 4, p. 334-340 7 p.

Research output: Contribution to journalArticle

MicroRNAs
Ischemia
Stem Cells
Wounds and Injuries
Cell Differentiation
6 Citations

Opioid signaling in mast cells regulates injury responses associated with heterotopic ossification

Kan, L., Mutso, A. A., McGuire, T. L., Apkarian, A. V. & Kessler, J. A. Mar 1 2014 In : Inflammation Research. 63, 3, p. 207-215 9 p.

Research output: Contribution to journalArticle

Heterotopic Ossification
Mast Cells
Opioid Analgesics
Wounds and Injuries
Methionine Enkephalin
1 Citations

Optimization of a microfluidic device for localized electroporation of cells

Kang, W., Nathamgari, S. S. P., Giraldo-Vela, J. P., McNaughton, R. L., Kessler, J. & Espinosa, H. D. Jan 1 2014 14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014. Institute of Electrical and Electronics Engineers Inc., p. 1-3 3 p. 6968068

Research output: Chapter in Book/Report/Conference proceedingConference contribution

microfluidic devices
Microfluidics
optimization
Optimization
Cell
51 Citations
Cholinergic Neurons
Alzheimer Disease
Cell Death
Stem Cells
Induced Pluripotent Stem Cells
35 Citations

Store-operated CRAC channels regulate gene expression and proliferation in neural progenitor cells

Somasundaram, A., Shum, A. K., McBride, H. J., Kessler, J. A., Feske, S., Miller, R. J. & Prakriya, M. Jan 1 2014 In : Journal of Neuroscience. 34, 27, p. 9107-9123 17 p.

Research output: Contribution to journalArticle

Stem Cells
Gene Expression
Neurogenesis
NFATC Transcription Factors
Neural Stem Cells
24 Citations

β1-integrin and integrin linked kinase regulate astrocytic differentiation of neural stem cells

Pan, L., North, H. A., Sahni, V., Jeong, S. J., Mcguire, T. L., Berns, E. J., Stupp, S. I. & Kessler, J. A. Aug 6 2014 In : PLoS ONE. 9, 8, e104335

Research output: Contribution to journalArticle

isoleucyl-lysyl-valyl-alanyl-valine
Neural Stem Cells
integrins
Stem cells
Integrins
2013
11 Citations

Cadherin-11 Regulates Motility in Normal Cortical Neural Precursors and Glioblastoma

Schulte, J. D., Srikanth, M., Das, S., Zhang, J., Lathia, J. D., Yin, L., Rich, J. N., Olson, E. C., Kessler, J. A. & Chenn, A. Aug 7 2013 In : PLoS ONE. 8, 8, e70962

Research output: Contribution to journalArticle

cadherins
Glioblastoma
Tumors
Cell Movement
cell movement
10 Citations

Estradiol promotes neural stem cell differentiation into endothelial lineage and angiogenesis in injured peripheral nerve

Sekiguchi, H., Ii, M., Jujo, K., Thorne, T., Ito, A., Klyachko, E., Hamada, H., Kessler, J. A., Tabata, Y., Kawana, M., Asahi, M., Hagiwara, N. & Losordo, D. W. Jan 1 2013 In : Angiogenesis. 16, 1, p. 45-58 14 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Stem cells
Peripheral Nerves
Cell Differentiation
Estradiol
21 Citations

Glast-expressing progenitor cells contribute to heterotopic ossification

Kan, L., Peng, C. Y., McGuire, T. L. & Kessler, J. A. Mar 1 2013 In : Bone. 53, 1, p. 194-203 10 p.

Research output: Contribution to journalArticle

Heterotopic Ossification
Stem Cells
Osteogenesis
Skeleton
Population
14 Citations

Mutations in extracellular matrix genes NID1 and LAMC1 cause autosomal dominant dandy-walker malformation and occipital cephaloceles

Darbro, B. W. , Mahajan, V. B. , Gakhar, L. , Skeie, J. M. , Campbell, E. , Wu, S. , Bing, X. , Millen, K. J. , Dobyns, W. B. , Kessler, J. A. , Jalali, A. , Cremer, J. , Segre, A. , Manak, J. R. , Aldinger, K. A. , Suzuki, S. , Natsume, N. , Ono, M. , Hai, H. D. , Viet, L. T. & 6 others Loddo, S., Valente, E. M., Bernardini, L., Ghonge, N., Ferguson, P. J. & Bassuk, A. G. Aug 1 2013 In : Human mutation. 34, 8, p. 1075-1079 5 p.

Research output: Contribution to journalArticle

Dandy-Walker Syndrome
Encephalocele
Extracellular Matrix
Mutation
Genes
16 Citations

Nanofiber-mediated inhibition of focal adhesion kinase sensitizes glioma stemlike cells to epidermal growth factor receptor inhibition

Srikanth, M., Das, S., Berns, E. J., Kim, J., Stupp, S. I. & Kessler, J. A. Mar 1 2013 In : Neuro-Oncology. 15, 3, p. 319-329 11 p.

Research output: Contribution to journalArticle

Nanofibers
Focal Adhesion Protein-Tyrosine Kinases
Epidermal Growth Factor Receptor
Glioma
Integrins
17 Citations
Hepatocyte Growth Factor
Diabetic Neuropathies
Peripheral Nervous System Diseases
Visual Analog Scale
Protein Isoforms
1 Citations

Stem cell therapies for the treatment of spinal cord injuries: Current progress in basic science and clinical research

North, H. & Kessler, J. Dec 1 2013 Emerging Trends in Cell and Gene Therapy. Humana Press Inc, p. 319-346 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cell- and Tissue-Based Therapy
Stem cells
Spinal Cord Injuries
Stem Cells
Research
103 Citations

The emerging roles of microRNAs in CNS injuries

Bhalala, O. G., Srikanth, M. & Kessler, J. A. Jun 1 2013 In : Nature Reviews Neurology. 9, 6, p. 328-339 12 p.

Research output: Contribution to journalReview article

MicroRNAs
Wounds and Injuries
Spinal Cord Injuries
Gene Knock-In Techniques
Stroke
2012
15 Citations

BMP receptor 1A regulates development of hypothalamic circuits critical for feeding behavior

Peng, C. Y., Mukhopadhyay, A., Jarrett, J. C., Yoshikawa, K. & Kessler, J. A. Nov 28 2012 In : Journal of Neuroscience. 32, 48, p. 17211-17224 14 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein Receptors
Feeding Behavior
Leptin
Agouti-Related Protein
Bone and Bones
7 Citations

Bmp signalling in filiform tongue papillae development

Kawasaki, K., Porntaveetus, T., Oommen, S., Ghafoor, S., Kawasaki, M., Otsuka-Tanaka, Y., Blackburn, J., Kessler, J. A., Sharpe, P. T. & Ohazama, A. Jun 1 2012 In : Archives of Oral Biology. 57, 6, p. 805-813 9 p.

Research output: Contribution to journalArticle

Tongue
Mechanical Stress
Mastication
In Situ Hybridization
Genes
15 Citations

CNS demyelination in fibrodysplasia ossificans progressiva

Kan, L., Kitterman, J. A., Procissi, D., Chakkalakal, S., Peng, C. Y., McGuire, T. L., Goldsby, R. E., Pignolo, R. J., Shore, E. M., Kaplan, F. S. & Kessler, J. A. Dec 1 2012 In : Journal of Neurology. 259, 12, p. 2644-2655 12 p.

Research output: Contribution to journalArticle

Myositis Ossificans
Demyelinating Diseases
Bone Morphogenetic Proteins
Neurologic Manifestations
Heterotopic Ossification