Research Output 1975 2017

2017

Conserved signaling pathways underlying heterotopic ossification

Kan, C., Chen, L., Hu, Y., Ding, N., Lu, H., Li, Y., Kessler, J. A. & Kan, L. Mar 2 2017 (Accepted/In press) In : Bone.

Research output: Research - peer-reviewArticle

Heterotopic Ossification
Bone Morphogenetic Proteins
Inborn Genetic Diseases
Translational Medical Research
Fibroblast Growth Factors

Directed differentiation of human embryonic stem cells toward placode-derived spiral ganglion-like sensory neurons

Matsuoka, A. J., Morrissey, Z. D., Zhang, C., Homma, K., Belmadani, A., Miller, C. A., Chadly, D. M., Kobayashi, S., Edelbrock, A. N., Tanaka-Matakatsu, M., Whitlon, D. S., Lyass, L., McGuire, T. L., Stupp, S. I. & Kessler, J. A. Mar 1 2017 In : Stem Cells Translational Medicine. 6, 3, p. 923-936 14 p.

Research output: Research - peer-reviewArticle

Spiral Ganglion
Sensory Receptor Cells
Neurons
Human Embryonic Stem Cells
Ear
Pyramidal Tracts
Spinal Cord Injuries
Cell Movement

Gli1-labeled adult mesenchymal stem/progenitor cells and hedgehog signaling contribute to endochondral heterotopic ossification

Kan, C., Chen, L., Hu, Y., Ding, N., Li, Y., McGuire, T. L., Lu, H., Kessler, J. A. & Kan, L. Mar 2 2017 (Accepted/In press) In : Bone.

Research output: Research - peer-reviewArticle

Heterotopic Ossification
Adult Stem Cells
Hedgehogs
Mesenchymal Stromal Cells
Osteogenesis

Intravenous immune-modifying nanoparticles as a therapy for spinal cord injury in mice

Jeong, S. J., Cooper, J. G., Ifergan, I., McGuire, T. L., Xu, D., Hunter, Z., Sharma, S., McCarthy, D., Miller, S. D. & Kessler, J. A. Dec 1 2017 In : Neurobiology of Disease. 108, p. 73-82 10 p.

Research output: Research - peer-reviewArticle

Spinal Cord Injuries
Nanoparticles
Therapeutics
Monocytes
Microglia

Microenvironmental factors that regulate mesenchymal stem cells: Lessons learned from the study of heterotopic ossification

Kan, C., Chen, L., Hu, Y., Lu, H., Li, Y., Kessler, J. A. & Kan, L. 2017 In : Histology and Histopathology. 32, 10, p. 977-985 9 p.

Research output: Research - peer-reviewReview article

Heterotopic Ossification
Mesenchymal Stromal Cells
Pathologic Processes
Stromal Cells
Osteogenesis
1 Citations
Amyotrophic Lateral Sclerosis
Safety
Intramuscular Injections
Injections
Retreatment
Transforming Growth Factor beta
Neurology
Nervous System
Embryonic Development
Central Nervous System
2016
1 Citations

A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways

Huang, T., Alvarez, A. A., Pangeni, R. P., Horbinski, C. M., Lu, S., Kim, S. H., James, C. D., Raizer, J. J., Kessler, J. A., Brenann, C. W., Sulman, E. P., Finocchiaro, G., Tan, M., Nishikawa, R., Lu, X., Nakano, I., Hu, B. & Cheng, S. Y. Oct 4 2016 In : Nature Communications. 7, 12885

Research output: Research - peer-reviewArticle

Glioblastoma
Phenotype
phenotype
Networks (circuits)
regulators
7 Citations

A tenascin-C mimetic peptide amphiphile nanofiber gel promotes neurite outgrowth and cell migration of neurosphere-derived cells

Berns, E. J., Álvarez, Z., Goldberger, J. E., Boekhoven, J., Kessler, J. A., Kuhn, H. G. & Stupp, S. I. Jun 1 2016 In : Acta Biomaterialia. 37, p. 50-58 9 p.

Research output: Research - peer-reviewArticle

Nanofibers
Tenascin
Cell Movement
Gels
Peptides
1 Citations

Hippocampal bone morphogenetic protein signaling mediates behavioral effects of antidepressant treatment

Brooker, S. M., Gobeske, K. T., Chen, J., Peng, C. Y. & Kessler, J. A. Oct 4 2016 (Accepted/In press) In : Molecular Psychiatry.

Research output: Research - peer-reviewArticle

Bone Morphogenetic Proteins
Antidepressive Agents
Neurogenesis
Hippocampus
Fluoxetine
7 Citations

Increased bone morphogenetic protein signaling contributes to age-related declines in neurogenesis and cognition

Meyers, E. A., Gobeske, K. T., Bond, A. M., Jarrett, J. C., Peng, C. Y. & Kessler, J. A. 2016 In : Neurobiology of Aging. 38, p. 164-175 12 p.

Research output: Research - peer-reviewArticle

Bone Morphogenetic Proteins
Neurogenesis
Cognition
Bone Morphogenetic Protein 4
Dentate Gyrus
18 Citations

Role of adult hippocampal neurogenesis in persistent pain

Apkarian, A. V., Mutso, A. A., Centeno, M. V., Kan, L., Wu, M., Levinstein, M., Banisadr, G., Gobeske, K. T., Miller, R. J., Radulovic, J., Hen, R. & Kessler, J. A. Feb 1 2016 In : Pain. 157, 2, p. 418-428 11 p.

Research output: Research - peer-reviewArticle

Neurogenesis
Pain
Learning
Intraventricular Infusions
Antimitotic Agents

β1-integrin restricts astrocytic differentiation of adult hippocampal neural stem cells

Brooker, S. M., Bond, A. M., Peng, C. Y. & Kessler, J. A. Jul 1 2016 In : GLIA. 64, 7, p. 1235-1251 17 p.

Research output: Research - peer-reviewArticle

Neural Stem Cells
Integrins
Dentate Gyrus
Astrocytes
Population
2015
3 Citations
Blood-Brain Barrier
Integrins
Cerebral Cortex
Endothelial Cells
Astrocytes
25 Citations

Bioactive DNA-peptide nanotubes enhance the differentiation of neural stem cells into neurons

Stephanopoulos, N., Freeman, R., North, H. A., Sur, S., Jeong, S. J., Tantakitti, F., Kessler, J. A. & Stupp, S. I. Jan 14 2015 In : Nano Letters. 15, 1, p. 603-609 7 p.

Research output: Research - peer-reviewArticle

Peptide Nanotubes
Stem cells
Nanotubes
Neurons
DNA
5 Citations
Pluripotent Stem Cells
Neuroglia
Astrocytes
Neurons
Cerebral Cortex
8 Citations

Isolating single cells in a neurosphere assay using inertial microfluidics

Nathamgari, S. S. P., Dong, B., Zhou, F., Kang, W., Giraldo-Vela, J. P., McGuire, T., McNaughton, R. L., Sun, C., Kessler, J. A. & Espinosa, H. D. Oct 14 2015 In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 15, 24, p. 4591-4597 7 p.

Research output: Research - peer-reviewArticle

Stem cells
Microfluidics
Assays
Flow rate
Population
49 Citations

MiR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma

Kouri, F. M., Hurley, L. A., Daniel, W. L., Day, E. S., Hua, Y., Hao, L., Peng, C. Y., Merkel, T. J., Queisser, M. A., Ritner, C., Zhang, H., David James, C., Sznajder, J. I., Chin, L., Giljohann, D. A., Kessler, J. A., Peter, M. E., Mirkin, C. A. & Stegh, A. H. 2015 In : Genes and Development. 29, 7, p. 732-745 14 p.

Research output: Research - peer-reviewArticle

Glioblastoma
Apoptosis
Growth
Neoplasms
Therapeutics
3 Citations

Neurology - The next 10 years

Baron, R., Ferriero, D. M., Frisoni, G. B., Bettegowda, C., Gokaslan, Z. L., Kessler, J. A., Vezzani, A., Waxman, S. G., Jarius, S., Wildemann, B. & Weller, M. Nov 1 2015 In : Nature Reviews Neurology. 11, 11, p. 658-664 7 p.

Research output: Research - peer-reviewReview article

Neurology
Research
Precision Medicine
Therapeutics
12 Citations

β1-integrin alters ependymal stem cell BMP receptor localization and attenuates astrogliosis after spinal cord injury

North, H. A., Pan, L., McGuire, T. L., Brooker, S. & Kessler, J. A. 2015 In : Journal of Neuroscience. 35, 9, p. 3725-3733 9 p.

Research output: Research - peer-reviewArticle

Bone Morphogenetic Protein Receptors
Spinal Cord Injuries
Integrins
Stem Cells
Astrocytes
2014
60 Citations

Aligned neurite outgrowth and directed cell migration in self-assembled monodomain gels

Berns, E. J., Sur, S., Pan, L., Goldberger, J. E., Suresh, S., Zhang, S., Kessler, J. A. & Stupp, S. I. 2014 In : Biomaterials. 35, 1, p. 185-195 11 p.

Research output: Research - peer-reviewArticle

Cell Movement
Gels
Growth
Neuronal Outgrowth
Scaffolds
7 Citations

BMP signaling induces astrocytic differentiation of clinically derived oligodendroglioma propagating cells

Srikanth, M., Kim, J., Das, S. & Kessler, J. A. Feb 2014 In : Molecular Cancer Research. 12, 2, p. 283-294 12 p.

Research output: Research - peer-reviewArticle

Oligodendroglioma
Bone Morphogenetic Proteins
Stem Cells
Glioma
Smad Proteins
13 Citations

BMP signaling regulates the tempo of adult hippocampal progenitor maturation at multiple stages of the lineage

Bond, A. M., Peng, C. Y., Meyers, E. A., McGuire, T., Ewaleifoh, O. & Kessler, J. A. 2014 In : Stem Cells. 32, 8, p. 2201-2214 14 p.

Research output: Research - peer-reviewArticle

Bone Morphogenetic Proteins
Stem Cells
Neurons
Neural Stem Cells
Neurogenesis
18 Citations

EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis

Feng, H. , Lopez, G. Y. , Kim, C. K. , Alvarez, A. , Duncan, C. G. , Nishikawa, R. , Nagane, M. , Su, A. J. A. , Auron, P. E. , Hedberg, M. L. , Wang, L. , Raizer, J. J. , Kessler, J. A. , Parsa, A. T. , Gao, W. Q. , Kim, S. H. , Minata, M. , Nakano, I. , Grandis, J. R. , McLendon, R. E. & 7 others Bigner, D. D., Lin, H. K., Furnari, F. B., Cavenee, W. K., Hu, B., Yan, H. & Cheng, S. Y. Sep 2 2014 In : Journal of Clinical Investigation. 124, 9, p. 3741-3756 16 p.

Research output: Research - peer-reviewArticle

TNF Receptor-Associated Factor 6
Carcinogenesis
Phosphorylation
Neoplasms
Head and Neck Neoplasms
18 Citations

Evaluation of the cellular origins of Heterotopic ossification

Kan, L. & Kessler, J. A. 2014 In : Orthopedics. 37, 5, p. 329-340 12 p.

Research output: Research - peer-reviewReview article

Heterotopic Ossification
Population
Osteogenesis
Myositis Ossificans
Biological Phenomena
15 Citations

Microfluidic device for stem cell differentiation and localized electroporation of postmitotic neurons

Kang, W., Giraldo-Vela, J. P., Nathamgari, S. S. P., McGuire, T., McNaughton, R. L., Kessler, J. A. & Espinosa, H. D. Dec 7 2014 In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 14, 23, p. 4486-4495 10 p.

Research output: Research - peer-reviewArticle

Stem cells
Microfluidics
Neurons
Plasmids
Lab-On-A-Chip Devices
8 Citations

MicroRNAs participate in the murine oligodendroglial response to perinatal hypoxia-ischemia

Birch, D., Britt, B. C., Dukes, S. C., Kessler, J. A. & Dizon, M. L. V. Oct 1 2014 In : Pediatric research. 76, 4, p. 334-340 7 p.

Research output: Research - peer-reviewArticle

MicroRNAs
Ischemia
Wounds and Injuries
Hypoxia
Stem Cells
4 Citations

Opioid signaling in mast cells regulates injury responses associated with heterotopic ossification

Kan, L., Mutso, A. A., McGuire, T. L., Apkarian, A. V. & Kessler, J. A. Mar 2014 In : Inflammation Research. 63, 3, p. 207-215 9 p.

Research output: Research - peer-reviewArticle

Heterotopic Ossification
Mast Cells
Opioid Analgesics
Wounds and Injuries
Pain
1 Citations

Optimization of a microfluidic device for localized electroporation of cells

Kang, W., Nathamgari, S. S. P., Giraldo-Vela, J. P., McNaughton, R. L., Kessler, J. & Espinosa, H. D. Nov 26 2014 14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014. Institute of Electrical and Electronics Engineers Inc., p. 1-3 3 p. 6968068

Research output: ResearchConference contribution

Microfluidics
Optimization
Cell
microfluidic devices
optimization
44 Citations
Cholinergic Neurons
Alzheimer Disease
Cell Death
Stem Cells
Basal Forebrain
29 Citations

Store-operated CRAC channels regulate gene expression and proliferation in neural progenitor cells

Somasundaram, A., Shum, A. K., McBride, H. J., Kessler, J. A., Feske, S., Miller, R. J. & Prakriya, M. 2014 In : Journal of Neuroscience. 34, 27, p. 9107-9123 17 p.

Research output: Research - peer-reviewArticle

Stem Cells
Gene Expression
Calcium Release Activated Calcium Channels
Neurogenesis
NFATC Transcription Factors
18 Citations

β1-integrin and integrin linked kinase regulate astrocytic differentiation of neural stem cells

Pan, L., North, H. A., Sahni, V., Jeong, S. J., Mcguire, T. L., Berns, E. J., Stupp, S. I. & Kessler, J. A. Aug 6 2014 In : PLoS ONE. 9, 8, e104335

Research output: Research - peer-reviewArticle

Neural Stem Cells
Integrins
integrin-linked kinase
Stem cells
integrins
2013
10 Citations

Cadherin-11 Regulates Motility in Normal Cortical Neural Precursors and Glioblastoma

Schulte, J. D., Srikanth, M., Das, S., Zhang, J., Lathia, J. D., Yin, L., Rich, J. N., Olson, E. C., Kessler, J. A. & Chenn, A. Aug 7 2013 In : PLoS ONE. 8, 8, e70962

Research output: Research - peer-reviewArticle

Glioblastoma
osteoblast cadherin
cadherins
Tumors
Neoplasms
9 Citations

Estradiol promotes neural stem cell differentiation into endothelial lineage and angiogenesis in injured peripheral nerve

Sekiguchi, H., Ii, M., Jujo, K., Thorne, T., Ito, A., Klyachko, E., Hamada, H., Kessler, J. A., Tabata, Y., Kawana, M., Asahi, M., Hagiwara, N. & Losordo, D. W. Jan 2013 In : Angiogenesis. 16, 1, p. 45-58 14 p.

Research output: Research - peer-reviewArticle

Neural Stem Cells
Peripheral Nerves
Cell Differentiation
Estradiol
Stem cells
17 Citations

Glast-expressing progenitor cells contribute to heterotopic ossification

Kan, L., Peng, C. Y., McGuire, T. L. & Kessler, J. A. Mar 2013 In : Bone. 53, 1, p. 194-203 10 p.

Research output: Research - peer-reviewArticle

Heterotopic Ossification
Stem Cells
Osteogenesis
Population
Skeleton
13 Citations

Mutations in extracellular matrix genes NID1 and LAMC1 cause autosomal dominant dandy-walker malformation and occipital cephaloceles

Darbro, B. W. , Mahajan, V. B. , Gakhar, L. , Skeie, J. M. , Campbell, E. , Wu, S. , Bing, X. , Millen, K. J. , Dobyns, W. B. , Kessler, J. A. , Jalali, A. , Cremer, J. , Segre, A. , Manak, J. R. , Aldinger, K. A. , Suzuki, S. , Natsume, N. , Ono, M. , Hai, H. D. , Viet, L. T. & 6 others Loddo, S., Valente, E. M., Bernardini, L., Ghonge, N., Ferguson, P. J. & Bassuk, A. G. Aug 2013 In : Human Mutation. 34, 8, p. 1075-1079 5 p.

Research output: Research - peer-reviewArticle

Dandy-Walker Syndrome
Encephalocele
Extracellular Matrix
Mutation
Genes
14 Citations

Nanofiber-mediated inhibition of focal adhesion kinase sensitizes glioma stemlike cells to epidermal growth factor receptor inhibition

Srikanth, M., Das, S., Berns, E. J., Kim, J., Stupp, S. I. & Kessler, J. A. Mar 2013 In : Neuro-Oncology. 15, 3, p. 319-329 11 p.

Research output: Research - peer-reviewArticle

Nanofibers
Focal Adhesion Protein-Tyrosine Kinases
Epidermal Growth Factor Receptor
Glioma
Integrins
14 Citations
Hepatocyte Growth Factor
Diabetic Neuropathies
Peripheral Nervous System Diseases
Visual Analog Scale
Protein Isoforms
1 Citations

Stem cell therapies for the treatment of spinal cord injuries: Current progress in basic science and clinical research

North, H. & Kessler, J. Dec 1 2013 Emerging Trends in Cell and Gene Therapy. Humana Press Inc., p. 319-346 28 p.

Research output: ResearchChapter

Cell- and Tissue-Based Therapy
Spinal Cord Injuries
Stem Cells
Research
Therapeutics
90 Citations

The emerging roles of microRNAs in CNS injuries

Bhalala, O. G., Srikanth, M. & Kessler, J. A. Jun 2013 In : Nature Reviews Neurology. 9, 6, p. 328-339 12 p.

Research output: Research - peer-reviewReview article

MicroRNAs
Wounds and Injuries
Spinal Cord Injuries
Stroke
Messenger RNA
2012
12 Citations

BMP receptor 1A regulates development of hypothalamic circuits critical for feeding behavior

Peng, C. Y., Mukhopadhyay, A., Jarrett, J. C., Yoshikawa, K. & Kessler, J. A. Nov 28 2012 In : Journal of Neuroscience. 32, 48, p. 17211-17224 14 p.

Research output: Research - peer-reviewArticle

Bone Morphogenetic Protein Receptors
Feeding Behavior
Leptin
Bone and Bones
Proteins
6 Citations

Bmp signalling in filiform tongue papillae development

Kawasaki, K., Porntaveetus, T., Oommen, S., Ghafoor, S., Kawasaki, M., Otsuka-Tanaka, Y., Blackburn, J., Kessler, J. A., Sharpe, P. T. & Ohazama, A. Jun 2012 In : Archives of Oral Biology. 57, 6, p. 805-813 9 p.

Research output: Research - peer-reviewArticle

Tongue
Mechanical Stress
Mastication
In Situ Hybridization
Genes
12 Citations

CNS demyelination in fibrodysplasia ossificans progressiva

Kan, L., Kitterman, J. A., Procissi, D., Chakkalakal, S., Peng, C. Y., McGuire, T. L., Goldsby, R. E., Pignolo, R. J., Shore, E. M., Kaplan, F. S. & Kessler, J. A. Dec 2012 In : Journal of Neurology. 259, 12, p. 2644-2655 12 p.

Research output: Research - peer-reviewArticle

Myositis Ossificans
Demyelinating Diseases
Bone Morphogenetic Proteins
Neurologic Manifestations
Heterotopic Ossification
88 Citations

microRNA-21 regulates astrocytic response following spinal cord injury

Bhalala, O. G., Pan, L., Sahni, V., McGuire, T. L., Gruner, K., Tourtellotte, W. G. & Kessler, J. A. Dec 12 2012 In : Journal of Neuroscience. 32, 50, p. 17935-17947 13 p.

Research output: Research - peer-reviewArticle

MicroRNAs
Spinal Cord Injuries
Astrocytes
Porifera
Cicatrix

Multipotent stem cells in the embryonic nervous system

Peng, C. Y., Jalali, A., Bonaguidi, M., Hamill, C. & Kessler, J. A. Jan 1 2012 Neural Development and Stem Cells: Third Edition. Springer New York, p. 81-122 42 p.

Research output: ResearchChapter

Multipotent Stem Cells
Neural Stem Cells
Nervous System
Stem Cells
Neuroglia
57 Citations

Nanotechnology - Novel therapeutics for CNS disorders

Srikanth, M. & Kessler, J. A. Jun 2012 In : Nature Reviews Neurology. 8, 6, p. 307-318 12 p.

Research output: Research - peer-reviewReview article

Nanotechnology
Therapeutics
Central Nervous System Diseases
Nervous System Diseases
Blood-Brain Barrier
21 Citations

Pleiotropic effects of the bone morphogenetic proteins on development of the enteric nervous system

Chalazonitis, A. & Kessler, J. A. Jun 2012 In : Developmental Neurobiology. 72, 6, p. 843-856 14 p.

Research output: Research - peer-reviewArticle

Enteric Nervous System
Bone Morphogenetic Proteins
Neurons
Neuroglia
Neural Crest