• 16304 Citations
1975 …2018
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Research Output 1975 2018

2018
1 Citations

BMP-responsive protease HtrA1 is differentially expressed in astrocytes and regulates astrocytic development and injury response

Chen, J., Van Gulden, S., McGuire, T. L., Fleming, A. C., Oka, C., Kessler, J. A. & Peng, C. Y., Apr 11 2018, In : Journal of Neuroscience. 38, 15, p. 3840-3857 18 p.

Research output: Contribution to journalArticle

Astrocytes
Peptide Hydrolases
Temperature
Wounds and Injuries
Prosencephalon
2 Citations

Developmental profiling of microRNAs in the human embryonic inner ear

Chadly, D. M., Best, J., Ran, C., Bruska, M., Woźniak, W., Kempisty, B., Schwartz, M., LaFleur, B., Kerns, B. J., Kessler, J. A. & Matsuoka, A. J., Jan 1 2018, In : PLoS One. 13, 1, e0191452

Research output: Contribution to journalArticle

Inner Ear
MicroRNAs
microRNA
Ganglia
ears

Fibronectin EDA forms the chronic fibrotic scar after contusive spinal cord injury

Cooper, J. G., Jeong, S. J., McGuire, T. L., Sharma, S., Wang, W., Bhattacharyya, S., Varga, J. & Kessler, J. A., Aug 1 2018, In : Neurobiology of Disease. 116, p. 60-68 9 p.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Fibronectins
Cicatrix
Fibrosis
Gliosis

Full Factorial Microfluidic Designs and Devices for Parallelizing Human Pluripotent Stem Cell Differentiation

Chadly, D. M., Oleksijew, A. M., Coots, K. S., Fernandez, J. J., Kobayashi, S., Kessler, J. A. & Matsuoka, A. J., Jul 1 2018, (Accepted/In press) In : SLAS Technology.

Research output: Contribution to journalArticle

Lab-On-A-Chip Devices
Pluripotent Stem Cells
Stem cells
Microfluidics
Cell Differentiation

Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma

Pangeni, R. P., Zhang, Z., Alvarez, A. A., Wan, X., Sastry, N., Lu, S., Shi, T., Huang, T., Lei, C. X., James, C. D., Kessler, J. A., Brennan, C. W., Nakano, I., Lu, X., Hu, B., Zhang, W. & Cheng, S. Y., Apr 3 2018, In : Epigenetics. 13, 4, p. 432-448 17 p.

Research output: Contribution to journalArticle

Glioblastoma
Epigenomics
Glioma
Stem Cells
Genome

Lrp4/Wise regulates palatal rugae development through turing-type reaction-diffusion mechanisms

Kawasaki, M., Kawasaki, K., Meguro, F., Yamada, A., Ishikawa, R., Porntaveetus, T., Blackburn, J., Otsuka-Tanaka, Y., Saito, N., Ota, M. S., Sharpe, P. T., Kessler, J. A., Herz, J., Cobourne, M. T., Maeda, T. & Ohazama, A., Sep 1 2018, In : PloS one. 13, 9, e0204126

Research output: Contribution to journalArticle

Organogenesis
organogenesis
Hard Palate
mutants
transmembrane proteins
1 Citations
Bone Morphogenetic Proteins
Oligodendroglia
Ischemia
Bone Morphogenetic Protein Receptors
Bone and Bones
2017
1 Citations

Conserved signaling pathways underlying heterotopic ossification

Kan, C., Chen, L., Hu, Y., Ding, N., Lu, H., Li, Y., Kessler, J. A. & Kan, L., Mar 2 2017, (Accepted/In press) In : Bone.

Research output: Contribution to journalArticle

Heterotopic Ossification
Bone Morphogenetic Proteins
Inborn Genetic Diseases
Translational Medical Research
Fibroblast Growth Factors
1 Citations

Creating a stem cell niche in the inner ear using self-assembling peptide amphiphiles

Matsuoka, A. J., Sayed, Z. A., Stephanopoulos, N., Berns, E. J., Wadhwani, A. R., Morrissey, Z. D., Chadly, D. M., Kobayashi, S., Edelbrock, A. N., Mashimo, T., Miller, C. A., McGuire, T. L., Stupp, S. I. & Kessler, J. A., Dec 1 2017, In : PLoS One. 12, 12, e0190150

Research output: Contribution to journalArticle

isoleucyl-lysyl-valyl-alanyl-valine
Unsaturated polymers
Stem Cell Niche
cell transplantation
Cell Transplantation
1 Citations

Design, Assembly, Production, and Transfection of Synthetic Modified mRNA

Oh, S. & Kessler, J. A., Jan 1 2017, (Accepted/In press) In : Methods.

Research output: Contribution to journalArticle

Transfection
Synthetic Genes
Messenger RNA
RNA Stability
Safety
8 Citations

Directed differentiation of human embryonic stem cells toward placode-derived spiral ganglion-like sensory neurons

Matsuoka, A. J., Morrissey, Z. D., Zhang, C., Homma, K., Belmadani, A., Miller, C. A., Chadly, D. M., Kobayashi, S., Edelbrock, A. N., Tanaka-Matakatsu, M., Whitlon, D. S., Lyass, L., McGuire, T. L., Stupp, S. I. & Kessler, J. A., Mar 1 2017, In : Stem Cells Translational Medicine. 6, 3, p. 923-936 14 p.

Research output: Contribution to journalArticle

Spiral Ganglion
Sensory Receptor Cells
Neurons
Ear
Ectoderm
Pyramidal Tracts
Spinal Cord Injuries
Cell Movement
2 Citations

Gli1-labeled adult mesenchymal stem/progenitor cells and hedgehog signaling contribute to endochondral heterotopic ossification

Kan, C., Chen, L., Hu, Y., Ding, N., Li, Y., McGuire, T. L., Lu, H., Kessler, J. A. & Kan, L., Mar 2 2017, (Accepted/In press) In : Bone.

Research output: Contribution to journalArticle

Heterotopic Ossification
Adult Stem Cells
Hedgehogs
Mesenchymal Stromal Cells
Osteogenesis
7 Citations

Hippocampal bone morphogenetic protein signaling mediates behavioral effects of antidepressant treatment

Brooker, S. M., Gobeske, K. T., Chen, J., Peng, C. Y. & Kessler, J. A., Jun 1 2017, In : Molecular Psychiatry. 22, 6, p. 910-919 10 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Antidepressive Agents
Neurogenesis
Hippocampus
Fluoxetine
5 Citations

Intravenous immune-modifying nanoparticles as a therapy for spinal cord injury in mice

Jeong, S. J., Cooper, J. G., Ifergan, I., McGuire, T. L., Xu, D., Hunter, Z., Sharma, S., McCarthy, D., Miller, S. D. & Kessler, J. A., Dec 1 2017, In : Neurobiology of Disease. 108, p. 73-82 10 p.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Nanoparticles
Monocytes
Microglia
Cicatrix

Microenvironmental factors that regulate mesenchymal stem cells: Lessons learned from the study of heterotopic ossification

Kan, C., Chen, L., Hu, Y., Lu, H., Li, Y., Kessler, J. A. & Kan, L., Jan 1 2017, In : Histology and Histopathology. 32, 10, p. 977-985 9 p.

Research output: Contribution to journalReview article

Heterotopic Ossification
Mesenchymal Stromal Cells
Pathologic Processes
Stromal Cells
Osteogenesis
7 Citations

MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma

Huang, T. , Kim, C. K. , Alvarez, A. A. , Pangeni, R. P. , Wan, X. , Song, X. , Shi, T. , Yang, Y. , Sastry, N. , Horbinski, C. M. , Lu, S. , Stupp, R. , Kessler, J. A. , Nishikawa, R. , Nakano, I. , Sulman, E. P. , Lu, X. , James, C. D. , Yin, X. M. , Hu, B. & 1 others Cheng, S. Y., Dec 11 2017, In : Cancer Cell. 32, 6, p. 840-855.e8

Research output: Contribution to journalArticle

Autophagy
Glioblastoma
Phosphorylation
Radiotherapy
Serine
4 Citations
Amyotrophic Lateral Sclerosis
Safety
Intramuscular Injections
Injections
Retreatment
2 Citations

TGF-β family signaling in neural and neuronal differentiation, development, and function

Meyers, E. A. & Kessler, J. A., Jan 1 2017, In : Cold Spring Harbor perspectives in biology. 9, 8, a022244

Research output: Contribution to journalArticle

Neurology
Transforming Growth Factor beta
Nervous System
Modulators
Embryonic Development
2016
12 Citations

A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways

Huang, T., Alvarez, A. A., Pangeni, R. P., Horbinski, C. M., Lu, S., Kim, S. H., James, C. D., Raizer, J. J., Kessler, J. A., Brenann, C. W., Sulman, E. P., Finocchiaro, G., Tan, M., Nishikawa, R., Lu, X., Nakano, I., Hu, B. & Cheng, S. Y., Oct 4 2016, In : Nature communications. 7, 12885

Research output: Contribution to journalArticle

phenotype
Glioblastoma
regulators
Phenotype
Networks (circuits)
17 Citations

A tenascin-C mimetic peptide amphiphile nanofiber gel promotes neurite outgrowth and cell migration of neurosphere-derived cells

Berns, E. J., Álvarez, Z., Goldberger, J. E., Boekhoven, J., Kessler, J. A., Kuhn, H. G. & Stupp, S. I., Jun 1 2016, In : Acta Biomaterialia. 37, p. 50-58 9 p.

Research output: Contribution to journalArticle

Nanofibers
Tenascin
Amphiphiles
Peptides
Cell Movement
11 Citations

Increased bone morphogenetic protein signaling contributes to age-related declines in neurogenesis and cognition

Meyers, E. A., Gobeske, K. T., Bond, A. M., Jarrett, J. C., Peng, C. Y. & Kessler, J. A., Jan 1 2016, In : Neurobiology of Aging. 38, p. 164-175 12 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Neurogenesis
Cognition
Bone Morphogenetic Protein 4
Dentate Gyrus
23 Citations

Role of adult hippocampal neurogenesis in persistent pain

Apkarian, A. V., Mutso, A. A., Centeno, M. V., Kan, L., Wu, M., Levinstein, M., Banisadr, G., Gobeske, K. T., Miller, R. J., Radulovic, J., Hen, R. & Kessler, J. A., Feb 1 2016, In : Pain. 157, 2, p. 418-428 11 p.

Research output: Contribution to journalArticle

Neurogenesis
Pain
Learning
Intraventricular Infusions
Antimitotic Agents
6 Citations

β1-integrin restricts astrocytic differentiation of adult hippocampal neural stem cells

Brooker, S. M., Bond, A. M., Peng, C. Y. & Kessler, J. A., Jul 1 2016, In : GLIA. 64, 7, p. 1235-1251 17 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Integrins
Dentate Gyrus
Astrocytes
Stem Cell Niche
2015
3 Citations
Blood-Brain Barrier
Integrins
Cerebral Cortex
Endothelial Cells
Astrocytes
35 Citations

Bioactive DNA-peptide nanotubes enhance the differentiation of neural stem cells into neurons

Stephanopoulos, N., Freeman, R., North, H. A., Sur, S., Jeong, S. J., Tantakitti, F., Kessler, J. A. & Stupp, S. I., Jan 14 2015, In : Nano letters. 15, 1, p. 603-609 7 p.

Research output: Contribution to journalArticle

Peptide Nanotubes
stem cells
activity (biology)
Stem cells
neurons
6 Citations
Pluripotent Stem Cells
Neuroglia
Astrocytes
Neurons
Cerebral Cortex
13 Citations

Isolating single cells in a neurosphere assay using inertial microfluidics

Nathamgari, S. S. P., Dong, B., Zhou, F., Kang, W., Giraldo-Vela, J. P., McGuire, T., McNaughton, R. L., Sun, C., Kessler, J. A. & Espinosa, H. D., Oct 14 2015, In : Lab on a Chip. 15, 24, p. 4591-4597 7 p.

Research output: Contribution to journalArticle

Microfluidics
Stem cells
Assays
Flow rate
Sorting
76 Citations

MiR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma

Kouri, F. M., Hurley, L. A., Daniel, W. L., Day, E. S., Hua, Y., Hao, L., Peng, C. Y., Merkel, T. J., Queisser, M. A., Ritner, C., Zhang, H., David James, C., Sznajder, J. I., Chin, L., Giljohann, D. A., Kessler, J. A., Peter, M. E., Mirkin, C. A. & Stegh, A. H., Jan 1 2015, In : Genes and Development. 29, 7, p. 732-745 14 p.

Research output: Contribution to journalArticle

Glioblastoma
Apoptosis
Glioma
Growth
Neoplasms
3 Citations

Neurology - The next 10 years

Baron, R., Ferriero, D. M., Frisoni, G. B., Bettegowda, C., Gokaslan, Z. L., Kessler, J. A., Vezzani, A., Waxman, S. G., Jarius, S., Wildemann, B. & Weller, M., Nov 1 2015, In : Nature Reviews Neurology. 11, 11, p. 658-664 7 p.

Research output: Contribution to journalReview article

Neurology
Research
Precision Medicine
Therapeutics
21 Citations

β1-integrin alters ependymal stem cell BMP receptor localization and attenuates astrogliosis after spinal cord injury

North, H. A., Pan, L., McGuire, T. L., Brooker, S. & Kessler, J. A., Jan 1 2015, In : Journal of Neuroscience. 35, 9, p. 3725-3733 9 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein Receptors
Spinal Cord Injuries
Integrins
Stem Cells
Astrocytes
2014
82 Citations

Aligned neurite outgrowth and directed cell migration in self-assembled monodomain gels

Berns, E. J., Sur, S., Pan, L., Goldberger, J. E., Suresh, S., Zhang, S., Kessler, J. A. & Stupp, S. I., Jan 1 2014, In : Biomaterials. 35, 1, p. 185-195 11 p.

Research output: Contribution to journalArticle

Nanofibers
Scaffolds
Cell Movement
Neurites
Gels
10 Citations

BMP signaling induces astrocytic differentiation of clinically derived oligodendroglioma propagating cells

Srikanth, M., Kim, J., Das, S. & Kessler, J. A., Feb 1 2014, In : Molecular Cancer Research. 12, 2, p. 283-294 12 p.

Research output: Contribution to journalArticle

Oligodendroglioma
Bone Morphogenetic Proteins
Stem Cells
Glioma
Smad Proteins
22 Citations

BMP signaling regulates the tempo of adult hippocampal progenitor maturation at multiple stages of the lineage

Bond, A. M., Peng, C. Y., Meyers, E. A., McGuire, T., Ewaleifoh, O. & Kessler, J. A., Jan 1 2014, In : Stem Cells. 32, 8, p. 2201-2214 14 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Stem Cells
Neurons
Neural Stem Cells
Neurogenesis
29 Citations

EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis

Feng, H. , Lopez, G. Y. , Kim, C. K. , Alvarez, A. , Duncan, C. G. , Nishikawa, R. , Nagane, M. , Su, A. J. A. , Auron, P. E. , Hedberg, M. L. , Wang, L. , Raizer, J. J. , Kessler, J. A. , Parsa, A. T. , Gao, W. Q. , Kim, S. H. , Minata, M. , Nakano, I. , Grandis, J. R. , McLendon, R. E. & 7 others Bigner, D. D., Lin, H. K., Furnari, F. B., Cavenee, W. K., Hu, B., Yan, H. & Cheng, S. Y., Jan 1 2014, In : Journal of Clinical Investigation. 124, 9, p. 3741-3756 16 p.

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 6
Carcinogenesis
Phosphorylation
Head and Neck Neoplasms
Neuropilins
25 Citations

Evaluation of the cellular origins of Heterotopic ossification

Kan, L. & Kessler, J. A., Jan 1 2014, In : Orthopedics. 37, 5, p. 329-340 12 p.

Research output: Contribution to journalReview article

Heterotopic Ossification
Population
Osteogenesis
Myositis Ossificans
Biological Phenomena
20 Citations

Microfluidic device for stem cell differentiation and localized electroporation of postmitotic neurons

Kang, W., Giraldo-Vela, J. P., Nathamgari, S. S. P., McGuire, T., McNaughton, R. L., Kessler, J. A. & Espinosa, H. D., Dec 7 2014, In : Lab on a Chip. 14, 23, p. 4486-4495 10 p.

Research output: Contribution to journalArticle

Lab-On-A-Chip Devices
Electroporation
Stem cells
Microfluidics
Neurons
10 Citations

MicroRNAs participate in the murine oligodendroglial response to perinatal hypoxia-ischemia

Birch, D., Britt, B. C., Dukes, S. C., Kessler, J. A. & Dizon, M. L. V., Oct 1 2014, In : Pediatric Research. 76, 4, p. 334-340 7 p.

Research output: Contribution to journalArticle

MicroRNAs
Ischemia
Stem Cells
Wounds and Injuries
Cell Differentiation
7 Citations

Opioid signaling in mast cells regulates injury responses associated with heterotopic ossification

Kan, L., Mutso, A. A., McGuire, T. L., Apkarian, A. V. & Kessler, J. A., Mar 1 2014, In : Inflammation Research. 63, 3, p. 207-215 9 p.

Research output: Contribution to journalArticle

Heterotopic Ossification
Mast Cells
Opioid Analgesics
Wounds and Injuries
Methionine Enkephalin
2 Citations

Optimization of a microfluidic device for localized electroporation of cells

Kang, W., Nathamgari, S. S. P., Giraldo-Vela, J. P., McNaughton, R. L., Kessler, J. & Espinosa, H. D., Jan 1 2014, 14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014. Institute of Electrical and Electronics Engineers Inc., p. 1-3 3 p. 6968068

Research output: Chapter in Book/Report/Conference proceedingConference contribution

microfluidic devices
Microfluidics
optimization
Optimization
Cell
57 Citations
Cholinergic Neurons
Alzheimer Disease
Cell Death
Stem Cells
Induced Pluripotent Stem Cells
46 Citations

Store-operated CRAC channels regulate gene expression and proliferation in neural progenitor cells

Somasundaram, A., Shum, A. K., McBride, H. J., Kessler, J. A., Feske, S., Miller, R. J. & Prakriya, M., Jan 1 2014, In : Journal of Neuroscience. 34, 27, p. 9107-9123 17 p.

Research output: Contribution to journalArticle

Stem Cells
Gene Expression
Neurogenesis
NFATC Transcription Factors
Neural Stem Cells
26 Citations

β1-integrin and integrin linked kinase regulate astrocytic differentiation of neural stem cells

Pan, L., North, H. A., Sahni, V., Jeong, S. J., Mcguire, T. L., Berns, E. J., Stupp, S. I. & Kessler, J. A., Aug 6 2014, In : PLoS One. 9, 8, e104335

Research output: Contribution to journalArticle

isoleucyl-lysyl-valyl-alanyl-valine
Neural Stem Cells
integrins
Stem cells
Integrins
2013
11 Citations

Cadherin-11 Regulates Motility in Normal Cortical Neural Precursors and Glioblastoma

Schulte, J. D., Srikanth, M., Das, S., Zhang, J., Lathia, J. D., Yin, L., Rich, J. N., Olson, E. C., Kessler, J. A. & Chenn, A., Aug 7 2013, In : PLoS One. 8, 8, e70962

Research output: Contribution to journalArticle

cadherins
Glioblastoma
Tumors
Cell Movement
cell movement
12 Citations

Estradiol promotes neural stem cell differentiation into endothelial lineage and angiogenesis in injured peripheral nerve

Sekiguchi, H., Ii, M., Jujo, K., Thorne, T., Ito, A., Klyachko, E., Hamada, H., Kessler, J. A., Tabata, Y., Kawana, M., Asahi, M., Hagiwara, N. & Losordo, D. W., Jan 1 2013, In : Angiogenesis. 16, 1, p. 45-58 14 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Stem cells
Peripheral Nerves
Cell Differentiation
Estradiol
21 Citations

Glast-expressing progenitor cells contribute to heterotopic ossification

Kan, L., Peng, C. Y., McGuire, T. L. & Kessler, J. A., Mar 1 2013, In : Bone. 53, 1, p. 194-203 10 p.

Research output: Contribution to journalArticle

Heterotopic Ossification
Stem Cells
Osteogenesis
Skeleton
Population
16 Citations

Mutations in extracellular matrix genes NID1 and LAMC1 cause autosomal dominant dandy-walker malformation and occipital cephaloceles

Darbro, B. W. , Mahajan, V. B. , Gakhar, L. , Skeie, J. M. , Campbell, E. , Wu, S. , Bing, X. , Millen, K. J. , Dobyns, W. B. , Kessler, J. A. , Jalali, A. , Cremer, J. , Segre, A. , Manak, J. R. , Aldinger, K. A. , Suzuki, S. , Natsume, N. , Ono, M. , Hai, H. D. , Viet, L. T. & 6 others Loddo, S., Valente, E. M., Bernardini, L., Ghonge, N., Ferguson, P. J. & Bassuk, A. G., Aug 1 2013, In : Human mutation. 34, 8, p. 1075-1079 5 p.

Research output: Contribution to journalArticle

Dandy-Walker Syndrome
Encephalocele
Extracellular Matrix
Mutation
Genes
18 Citations

Nanofiber-mediated inhibition of focal adhesion kinase sensitizes glioma stemlike cells to epidermal growth factor receptor inhibition

Srikanth, M., Das, S., Berns, E. J., Kim, J., Stupp, S. I. & Kessler, J. A., Mar 1 2013, In : Neuro-Oncology. 15, 3, p. 319-329 11 p.

Research output: Contribution to journalArticle

Nanofibers
Focal Adhesion Protein-Tyrosine Kinases
Epidermal Growth Factor Receptor
Glioma
Integrins
21 Citations
Hepatocyte Growth Factor
Diabetic Neuropathies
Peripheral Nervous System Diseases
Visual Analog Scale
Protein Isoforms
1 Citations

Stem cell therapies for the treatment of spinal cord injuries: Current progress in basic science and clinical research

North, H. & Kessler, J., Dec 1 2013, Emerging Trends in Cell and Gene Therapy. Humana Press Inc, p. 319-346 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cell- and Tissue-Based Therapy
Stem cells
Spinal Cord Injuries
Stem Cells
Research