Jon W Lomasney

  • 5480 Citations
1985 …2019

Research output per year

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Personal profile

Research Interests

Autopsy pathology, Cardiac pathology

Lipids are important regulators of the activity of many proteins including those involved in cardiac, vascular, pulmonary, and neural regulation, yet little is known about the molecular mechanisms mediating these effects. My laboratory staff members are engaged in a program of basic research to elucidate the molecular mechanisms by which lipids act as specific ligands to regulate cellular responses, and to investigate in select areas of cardiovascular disease how aberrations of signaling pathways may play a vital role in the pathogenesis of human disease. We have used the family of phosphoinositide-specific phospholipase C isoforms as a model to study protein-lipid interactions. Upon stimulation by various hormones these membrane associated enzymes hydrolyze polyphosphoinositides to yield second messengers such diacylglycerol and inositol 1,4,5-trisphosphate. The determinants of enzyme function are complex and can be broken down into several primary components: substrate binding and catalysis, enzyme translocation, and regulation. During the past several years we have identified the structural motifs in the PLC delta 1 isoform that mediate each of the three primary functions. All three motifs require the binding of a specific lipid for function. The structural motif mediating translocation also modulates the rate catalysis, and is encoded by a unique domain termed the pleckstrin homology or PH domain. This newly discovered protein module of 100 amino acids exists in many molecules (including PLC d1) that participate in signal transduction. Our research is among the first to demonstrate a clear function in signal transduction for the PH domain, and serves a paradigm for the activation and regulation of many signaling molecules.

Certifications and Licenses

Anatomic Pathology

Training Experience

1991Fellowship, Duke University Medical Center
1992Residency, Duke University Medical Center

Education/Academic qualification

MD, Dartmouth Medical School

… → 1987

Research interests

  • Biochemistry: Lipids
  • Cardiovascular Diseases
  • Molecular Pharmacology
  • Signal Transduction
  • Vascular Biology

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Grants

  • Research Output

    Open Access

    Constitutive expression of a dominant-negative TGF-β type II receptor in the posterior left atrium leads to beneficial remodeling of atrial fibrillation substrate

    Kunamalla, A., Ng, J., Parini, V., Yoo, S., Mcgee, K. A., Tomson, T. T., Gordon, D., Thorp, E. B., Lomasney, J., Zhang, Q., Shah, S., Browne, S., Knight, B. P., Passman, R., Goldberger, J. J., Aistrup, G. L. & Arora, R., Jun 24 2016, In : Circulation research. 119, 1, p. 69-82 14 p.

    Research output: Contribution to journalArticle

  • 15 Scopus citations

    Fulminant capillary leak syndrome in a patient with systemic sclerosis treated with imatinib mesylate

    Hinchcliff, M. E., Lomasney, J., Johnson, J. A. & Varga, J., Oct 1 2016, In : Rheumatology (United Kingdom). 55, 10, p. 1916-1918 3 p.

    Research output: Contribution to journalLetter

    3 Scopus citations
  • 10 Scopus citations

    Cardiomyocytes induce macrophage receptor shedding to suppress phagocytosis

    Zhang, S., Yeap, X. Y., Grigoryeva, L., Dehn, S., DeBerge, M., Tye, M., Rostlund, E., Schrijvers, D., Zhang, Z. J., Sumagin, R., Tourtellotte, W. G., Lee, D., Lomasney, J., Morrow, J. & Thorp, E. B., Oct 1 2015, In : Journal of Molecular and Cellular Cardiology. 87, p. 171-179 9 p.

    Research output: Contribution to journalArticle

  • 11 Scopus citations