Grants per year
Personal profile
Research Interests
Autopsy pathology, Cardiac pathology
Lipids are important regulators of the activity of many proteins including those involved in cardiac, vascular, pulmonary, and neural regulation, yet little is known about the molecular mechanisms mediating these effects. My laboratory staff members are engaged in a program of basic research to elucidate the molecular mechanisms by which lipids act as specific ligands to regulate cellular responses, and to investigate in select areas of cardiovascular disease how aberrations of signaling pathways may play a vital role in the pathogenesis of human disease.
We have used the family of phosphoinositide-specific phospholipase C isoforms as a model to study protein-lipid interactions. Upon stimulation by various hormones these membrane associated enzymes hydrolyze polyphosphoinositides to yield second messengers such diacylglycerol and inositol 1,4,5-trisphosphate. The determinants of enzyme function are complex and can be broken down into several primary components: substrate binding and catalysis, enzyme translocation, and regulation. During the past several years we have identified the structural motifs in the PLC delta 1 isoform that mediate each of the three primary functions. All three motifs require the binding of a specific lipid for function. The structural motif mediating translocation also modulates the rate catalysis, and is encoded by a unique domain termed the pleckstrin homology or PH domain. This newly discovered protein module of 100 amino acids exists in many molecules (including PLC d1) that participate in signal transduction. Our research is among the first to demonstrate a clear function in signal transduction for the PH domain, and serves a paradigm for the activation and regulation of many signaling molecules.
Certifications and Licenses
Anatomic Pathology |
Training Experience
1991 | Fellowship, Duke University Medical Center |
1992 | Residency, Duke University Medical Center |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
MD, Medicine, Dartmouth Medical School
… → 1987
Research interests keywords
- Biochemistry: Lipids
- Cardiovascular Diseases
- Molecular Pharmacology
- Signal Transduction
- Vascular Biology
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Integrated epidemiology of systemic and plaque-specific immunologic features of human atherosclerosis
Feinstein, M. J. (PD/PI), Thorp, E. B. (PD/PI), Alexandria, S. J. (Co-Investigator), Lloyd-Jones, D. M. (Co-Investigator), Lomasney, J. W. (Co-Investigator), Rasmussen-Torvik, L. J. (Co-Investigator) & Glinton, K. E. (Other)
National Heart, Lung, and Blood Institute
8/1/24 → 5/31/28
Project: Research project
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Targeting abnormal alveolar immune activation and failed epithelial repair in COVID-19
Budinger, G. S. (PD/PI), Budinger, G. S. (PD/PI), Misharin, A. (PD/PI), Misharin, A. (PD/PI), Abdala-Valencia, H. (Co-Investigator), Abdala-Valencia, H. (Co-Investigator), Agrawal, A. (Co-Investigator), Braun, R. I. (Co-Investigator), Braun, R. I. (Co-Investigator), Casalino Matsuda, M. S. (Co-Investigator), Casalino Matsuda, M. S. (Co-Investigator), Horvath, C. M. (Co-Investigator), Horvath, C. M. (Co-Investigator), Lomasney, J. W. (Co-Investigator), Lomasney, J. W. (Co-Investigator), Prakriya, M. (Co-Investigator), Prakriya, M. (Co-Investigator), Wunderink, R. G. (Co-Investigator), Wunderink, R. G. (Co-Investigator), Yamashita, M. (Co-Investigator), Yamashita, M. (Co-Investigator), Casalino Matsuda, M. S. (Other) & Casalino Matsuda, M. S. (Other)
National Heart, Lung, and Blood Institute
4/1/22 → 3/31/26
Project: Research project
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Microglia mediate cognitive dysfunction in elderly survivors of pneumonia
Budinger, G. S. (PD/PI), Budinger, G. S. (PD/PI), Misharin, A. (PD/PI), Misharin, A. (PD/PI), Lomasney, J. W. (Co-Investigator) & Lomasney, J. W. (Co-Investigator)
2/1/22 → 1/31/25
Project: Research project
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Comprehensive Cardiac Structure-Function Analysis in Heart Transplantation
Carr, J. (PD/PI), Carr, J. (PD/PI), Markl, M. (PD/PI), Markl, M. (PD/PI), Elbaz, M. (Co-Investigator), Elbaz, M. (Co-Investigator), Ghafourian, K. (Co-Investigator), Ghafourian, K. (Co-Investigator), Lee, D. C. (Co-Investigator), Lee, D. C. (Co-Investigator), Lin, K. (Co-Investigator), Lomasney, J. W. (Co-Investigator), Lomasney, J. W. (Co-Investigator), Ragin, A. (Co-Investigator), Ragin, A. (Co-Investigator), Rigolin, V. H. (Co-Investigator), Rigolin, V. H. (Co-Investigator), Thomas, J. D. (Co-Investigator), Thomas, J. D. (Co-Investigator), Vorovich, E. E. (Co-Investigator), Vorovich, E. E. (Co-Investigator), Yancy, C. W. (Co-Investigator), Yancy, C. W. (Co-Investigator), Pahl, E. (Other) & Pahl, E. (Other)
National Heart, Lung, and Blood Institute
7/1/21 → 4/30/26
Project: Research project
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Immunologic, Inflammatory, and Clinical contributors to HIV-Related Heart Failure with Preserved Ejection Fraction (HFpEF)
Feinstein, M. J. (PD/PI), Feinstein, M. J. (PD/PI), Alexandria, S. J. (Co-Investigator), Lloyd-Jones, D. M. (Co-Investigator), Lloyd-Jones, D. M. (Co-Investigator), Lomasney, J. W. (Co-Investigator), Lomasney, J. W. (Co-Investigator), Petito, L. C. (Co-Investigator), Petito, L. C. (Co-Investigator), Shah, S. J. (Co-Investigator), Shah, S. J. (Co-Investigator), Thorp, E. B. (Co-Investigator) & Thorp, E. B. (Co-Investigator)
National Heart, Lung, and Blood Institute
2/25/21 → 1/31/25
Project: Research project
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Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia
The NU SCRIPT Study Investigators, 2024, (Accepted/In press) In: Nature Immunology. 25, 9, p. 1607-1622 16 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
In Vivo Mapping of Myocardial Injury Outside the Infarct Zone: Tissue at an Intermediate Pathological State
Ren, K., Hou, S., Johnson, S. E., Lomasney, J., Haney, C. R., Lee, J., Ge, Z.-D., Lee, D. C., Goldberger, J. J., Arora, R. K. & Zhao, M., May 7 2024, In: Journal of the American Heart Association. 13, 9, e032577.Research output: Contribution to journal › Article › peer-review
Open Access -
Prolonged exposure to lung-derived cytokines is associated with activation of microglia in patients with COVID-19
The Northwestern University Successful Clinical Response In Pneumonia Therapy (NU SCRIPT) Investigators7, 2024, In: JCI Insight. 9, 8, e178859.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Consensus statement on the processing, interpretation and reporting of temporal artery biopsy for arteritis
Nair, V., Fishbein, G. A., Padera, R., Seidman, M. A., Castonguay, M., Leduc, C., Tan, C. D., Rodriguez, E. R., Maleszewski, J. J., Miller, D., Romero, M., Lomasney, J., d'Amati, G., De Gaspari, M., Rizzo, S., Angelini, A., Basso, C., Litovsky, S., Buja, L. M. & Stone, J. R. & 1 others, , Nov 1 2023, In: Cardiovascular Pathology. 67, 107574.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Don't judge a book by its cover: a case report of apolipoprotein A-IV cardiac amyloidosis
Basel Allaw, M., Sinha, A., Ghafourian, K., Avery, R., Weinberg, R. L., Lomasney, J. W., Shah, S. J. & Patel, R. B., Aug 1 2023, In: European Heart Journal - Case Reports. 7, 8, ytad341.Research output: Contribution to journal › Article › peer-review
Open Access