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Jonathan Peter Leis

  • 5678 Citations
1970 …2021
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Personal profile

Research Interests

retrovirus replication, reverse transcription, integration, virus assembly mechanisms, molecular genetics

Training Experience

1973Postdoctoral Fellowship, Albert Einstein College

Education/Academic qualification

PhD, Cornell University

… → 1970

Research interests

  • Biochemistry: Nucleic Acid
  • Biochemistry: Proteins
  • Genetic Engineering
  • HIV Infection
  • Molecular Biology
  • Recombinant DNA
  • Viral Oncology
  • Virology

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  • 1 Similar Profiles
Rous sarcoma virus Medicine & Life Sciences
Avian Sarcoma Viruses Medicine & Life Sciences
Viruses Chemical Compounds
Retroviridae Medicine & Life Sciences
HIV-1 Medicine & Life Sciences
Avian Myeloblastosis Virus Medicine & Life Sciences
RNA-Directed DNA Polymerase Medicine & Life Sciences
DNA Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2001 2021

DF-007: Synthesis of a Matrix/Library of Prazole Analogs as Viral Budding Inhibitors

Leis, J. P. & Luan, C.

Searle Funds at The Chicago Community Trust

1/1/17 → 12/31/21

Project: Research project

Controlling HIV release from cells with first-in-class drugs targeting virus budding

Leis, J. P.

Campbell Foundation

7/1/16 → 12/30/18

Project: Research project

Virus Release
Drug Delivery Systems
HIV
HIV Infections
Immune System

High Throughput Screening for Drugs that Disrupt Enveloped Virus Budding

Leis, J. P.

Northwestern Memorial Foundation

1/1/12 → 12/31/13

Project: Research project

HTS-001: High Throughput Screening for Small Molecule Inhibitors

Leis, J. P.

Searle Funds at The Chicago Community Trust

1/1/11 → 12/31/17

Project: Research project

Structure/Function Analysis of the Retrovirus Integrase

Leis, J. P.

National Institute of Allergy and Infectious Diseases

1/12/09 → 12/31/11

Project: Research project

Research Output 1970 2017

5 Citations (Scopus)

Tsg101 chaperone function revealed by HIV-1 assembly inhibitors

Strickland, M., Ehrlich, L. S., Watanabe, S., Khan, M., Strub, M. P., Luan, C. H., Powell, M. D., Leis, J., Tjandra, N. & Carter, C. A., Dec 1 2017, In : Nature Communications. 8, 1, 1391.

Research output: Contribution to journal › Article

human immunodeficiency virus
Ubiquitin
inhibitors
HIV-1
assembly

Rous sarcoma virus retropepsin and avian myeloblastosis virus retropepsin

Ridky, T. W. & Leis, J., Aug 29 2013, Handbook of Proteolytic Enzymes. Elsevier Ltd., Vol. 1. p. 210-213 4 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Avian Myeloblastosis Virus
Rous sarcoma virus
5 Citations (Scopus)

Budding of enveloped viruses: Interferon-induced ISG15 - Antivirus mechanisms targeting the release process

Seo, E. J. & Leis, J., Dec 1 2012, In : Advances in Virology. 2012, 532723.

Research output: Contribution to journal › Article

Virus Release
Interferons
Viruses
Innate Immunity
Cell Membrane
31 Citations (Scopus)

Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15

Kuang, Z., Seo, E. J. & Leis, J., Jul 1 2011, In : Journal of virology. 85, 14, p. 7153-7161 9 p.

Research output: Contribution to journal › Article

Retroviridae
interferons
Interferons
endosomes
protein transport
78 Citations (Scopus)

The interferon-induced gene ISG15 blocks retrovirus release from cells late in the budding process

Pincetic, A., Kuang, Z., Seo, E. J. & Leis, J. P., May 1 2010, In : Journal of virology. 84, 9, p. 4725-4736 12 p.

Research output: Contribution to journal › Article

Retroviridae
interferons
Interferons
Endosomal Sorting Complexes Required for Transport
Virus Release