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Jonathan Peter Leis

  • 5749 Citations
1970 …2021

Research output per year

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Personal profile

Research Interests

retrovirus replication, reverse transcription, integration, virus assembly mechanisms, molecular genetics

Training Experience

1973Postdoctoral Fellowship, Albert Einstein College

Education/Academic qualification

PhD, Cornell University

… → 1970

Research interests

  • Biochemistry: Nucleic Acid
  • Biochemistry: Proteins
  • Genetic Engineering
  • HIV Infection
  • Molecular Biology
  • Recombinant DNA
  • Viral Oncology
  • Virology

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Grants

DF-007: Synthesis of a Matrix/Library of Prazole Analogs as Viral Budding Inhibitors

Leis, J. P. & Luan, C.

Searle Funds at The Chicago Community Trust

1/1/17 → 12/31/21

Project: Research project

Controlling HIV release from cells with first-in-class drugs targeting virus budding

Leis, J. P.

Campbell Foundation

7/1/16 → 12/30/18

Project: Research project

    • High Throughput Screening for Drugs that Disrupt Enveloped Virus Budding

    Leis, J. P.

    Northwestern Memorial Foundation

    1/1/12 → 12/31/13

    Project: Research project

    HTS-001: High Throughput Screening for Small Molecule Inhibitors

    Leis, J. P.

    Searle Funds at The Chicago Community Trust

    1/1/11 → 12/31/17

    Project: Research project

    Structure/Function Analysis of the Retrovirus Integrase

    Leis, J. P.

    National Institute of Allergy and Infectious Diseases

    1/12/09 → 12/31/11

    Project: Research project

    Research Output

    Tsg101 chaperone function revealed by HIV-1 assembly inhibitors

    Strickland, M., Ehrlich, L. S., Watanabe, S., Khan, M., Strub, M. P., Luan, C. H., Powell, M. D., Leis, J., Tjandra, N. & Carter, C. A., Dec 1 2017, In : Nature Communications. 8, 1, 1391.

    Research output: Contribution to journal › Article

    • 10 Scopus citations

    Rous sarcoma virus retropepsin and avian myeloblastosis virus retropepsin

    Ridky, T. W. & Leis, J., Aug 29 2013, Handbook of Proteolytic Enzymes. Elsevier Ltd., Vol. 1. p. 210-213 4 p.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

    Budding of enveloped viruses: Interferon-induced ISG15 - Antivirus mechanisms targeting the release process

    Seo, E. J. & Leis, J., Dec 1 2012, In : Advances in Virology. 2012, 532723.

    Research output: Contribution to journal › Article

    • 6 Scopus citations

    Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15

    Kuang, Z., Seo, E. J. & Leis, J., Jul 1 2011, In : Journal of virology. 85, 14, p. 7153-7161 9 p.

    Research output: Contribution to journal › Article

    • 33 Scopus citations

    The interferon-induced gene ISG15 blocks retrovirus release from cells late in the budding process

    Pincetic, A., Kuang, Z., Seo, E. J. & Leis, J., May 1 2010, In : Journal of virology. 84, 9, p. 4725-4736 12 p.

    Research output: Contribution to journal › Article

    • 81 Scopus citations