Grants per year
Personal profile
Research Interests
retrovirus replication, reverse transcription, integration, virus assembly mechanisms, molecular genetics
Training Experience
| 1973 | Postdoctoral Fellowship, Albert Einstein College |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Biochemistry, Cornell University
… → 1970
Research interests keywords
- Biochemistry: Nucleic Acid
- Biochemistry: Proteins
- Genetic Engineering
- HIV Infection
- Molecular Biology
- Recombinant DNA
- Viral Oncology
- Virology
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Dive into the research topics where Jonathan Peter Leis is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Grants
- 8 Finished
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Controlling HIV release from cells with first-in-class drugs targeting virus budding
Leis, J. P. (PD/PI)
7/1/16 → 12/30/18
Project: Research project
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High Throughput Screening for Drugs that Disrupt Enveloped Virus Budding
Leis, J. P. (PD/PI)
Northwestern Memorial Foundation
1/1/12 → 12/31/13
Project: Research project
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HTS-001: High Throughput Screening for Small Molecule Inhibitors
Leis, J. P. (Subproject PI)
Searle Funds at The Chicago Community Trust
1/1/11 → 12/31/17
Project: Research project
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Structure/Function Analysis of the Retrovirus Integrase
Leis, J. P. (PD/PI)
National Institute of Allergy and Infectious Diseases
1/12/09 → 12/31/11
Project: Research project
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Understanding the Mechanism of Retrovirus Budding
Leis, J. P. (PD/PI)
National Institute of Allergy and Infectious Diseases
9/10/08 → 8/31/11
Project: Research project
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Ilaprazole and other novel prazole-based compounds that bind Tsg101 inhibit viral budding of herpes simplex virus 1 and 2 and human immunodeficiency virus from cells
Leis, J., Luan, C. H., Audia, J. E., Dunne, S. F. & Heathe, C. M., Jun 2021, In: Journal of virology. 95, 11, e00190.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Tsg101 chaperone function revealed by HIV-1 assembly inhibitors
Strickland, M., Ehrlich, L. S., Watanabe, S., Khan, M., Strub, M. P., Luan, C. H., Powell, M. D., Leis, J., Tjandra, N. & Carter, C. A., Dec 1 2017, In: Nature Communications. 8, 1, 1391.Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
Rous sarcoma virus retropepsin and avian myeloblastosis virus retropepsin
Ridky, T. W. & Leis, J., 2013, Handbook of Proteolytic Enzymes. Elsevier Ltd, Vol. 1. p. 210-213 4 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Budding of enveloped viruses: Interferon-induced ISG15 - Antivirus mechanisms targeting the release process
Seo, E. J. & Leis, J., 2012, In: Advances in Virology. 2012, 532723.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15
Kuang, Z., Seo, E. J. & Leis, J., Jul 2011, In: Journal of virology. 85, 14, p. 7153-7161 9 p.Research output: Contribution to journal › Article › peer-review
Open Access52 Scopus citations
Datasets
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Solution-state NMR structural ensemble of human Tsg101 UEV in complex with tenatoprazole
Strickland, M. (Contributor), Ehrlich, L. S. (Contributor), Watanabe, S. (Contributor), Khan, M. (Contributor), Strub, M.-P. (Contributor), Luan, C.-H. (Contributor), Powell, M. D. (Contributor), Leis, J. (Contributor), Tjandra, N. (Contributor) & Carter, C. A. (Contributor), Biological Magnetic Resonance Data Bank (BMRB), Nov 10 2017
DOI: 10.13018/BMR30285, https://bmrb.io/data_library/summary/index.php?bmrbId=30285
Dataset
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Solution-state NMR structural ensemble of human Tsg101 UEV in complex with tenatoprazole
Strickland, M. (Contributor), Ehrlich, L. S. (Contributor), Watanabe, S. (Contributor), Khan, M. (Contributor), Strub, M.-P. (Contributor), Luan, C.-H. (Contributor), Powell, M. D. (Contributor), Leis, J. (Contributor), Tjandra, N. (Contributor) & Carter, C. A. (Contributor), Protein Data Bank (PDB), Nov 15 2017
DOI: 10.2210/pdb5VKG, https://www.wwpdb.org/pdb?id=pdb_00005vkg
Dataset
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5VKG : Solution-state NMR structural ensemble of human Tsg101 UEV in complex with tenatoprazole
Strickland, M. (Contributor), Ehrlich, L. S. (Contributor), Watanabe, S. (Contributor), Khan, M. (Contributor), Strub, M.-P. (Contributor), Luan, C.-H. (Contributor), Powell, M. D. (Contributor), Leis, J. (Contributor), Tjandra, N. (Contributor) & Carter, C. A. (Contributor), RCSB-PDB, 2017
DOI: 10.2210/pdb5vkg/pdb, https://www.rcsb.org/structure/5VKG
Dataset