Grants per year
Personal profile
Research Interests
We use imaging approaches to acquire large-scale recordings of neural activity during behavior, focusing on deep-brain areas implicated in neurological and psychiatric diseases, such as striatum. We use these tools to delineate the functional contribution of neuronal sub-populations in these brain areas to normal behavior in control subjects and pathological behavior in models for brain diseases. Our aim is to target these neural substrates to improve treatment outcomes for neuropsychiatric diseases.
Training Experience
| 2015 | Fellowship, Pfizer |
| 2018 | Postdoctoral Fellowship, Stanford University |
Education/Academic qualification
PhD, Biochemistry, University of Washington
… → 2011
Research interests keywords
- Brain and Nervous System
- Cell Imaging
- Drug Discovery
- Movement Disorders
- Nervous System Diseases
- Neurobiology
- Neuroscience
- Parkinson’s Disease
- Pharmacology
- Physiology
- Schizophrenia
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Investigation of Pallidal Neurons in Motor Inhibition
Chan, S. (PD/PI), Kennedy, A. (Co-Investigator), Parker, J. G. (Co-Investigator) & Xenias, H. S. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
2/20/24 → 1/31/28
Project: Research project
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Dissecting sugar-induced modulation of gut-brain circuits
Beutler, L. R. (PD/PI) & Parker, J. G. (Co-Investigator)
12/31/22 → 12/30/27
Project: Research project
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Dopamine, Synaptic Plasticity and Striatal Ensemble Dynamics Underlying Motor Learning
Parker, J. G. (PD/PI), Parker, J. G. (PD/PI), Contractor, A. (Co-Investigator), Contractor, A. (Co-Investigator) & Yun, S. (Other)
National Institute of Neurological Disorders and Stroke
9/1/21 → 5/31/26
Project: Research project
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Dopamine’s Role in the Striatal Ensemble Dynamics of Learned Actions
Parker, J. G. (PD/PI)
1/1/20 → 12/31/22
Project: Research project
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Sucrose overconsumption impairs AgRP neuron dynamics and promotes palatable food intake
Lorch, C. M., Hayes, N. W., Xia, J. L., Fleps, S. W., McMorrow, H. E., Province, H. S., Frydman, J. A., Parker, J. G. & Beutler, L. R., Feb 27 2024, In: Cell reports. 43, 2, 113675.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Top-down control of flight by a non-canonical cortico-amygdala pathway
Borkar, C. D., Stelly, C. E., Fu, X., Dorofeikova, M., Le, Q. S. E., Vutukuri, R., Vo, C., Walker, A., Basavanhalli, S., Duong, A., Bean, E., Resendez, A., Parker, J. G., Tasker, J. G. & Fadok, J. P., Jan 25 2024, In: Nature. 625, 7996, p. 743-749 7 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Antipsychotic drug efficacy correlates with the modulation of D1 rather than D2 receptor-expressing striatal projection neurons
Yun, S., Yang, B., Anair, J. D., Martin, M. M., Fleps, S. W., Pamukcu, A., Yeh, N. H., Contractor, A., Kennedy, A. & Parker, J. G., Aug 2023, In: Nature neuroscience. 26, 8, p. 1417-1428 12 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
The effect of selective nigrostriatal dopamine excess on behaviors linked to the cognitive and negative symptoms of schizophrenia
Moya, N. A., Yun, S., Fleps, S. W., Martin, M. M., Nadel, J. A., Beutler, L. R., Zweifel, L. S. & Parker, J. G., Mar 2023, In: Neuropsychopharmacology. 48, 4, p. 690-699 10 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Fiber photometry in striatum reflects primarily nonsomatic changes in calcium
Legaria, A. A., Matikainen-Ankney, B. A., Yang, B., Ahanonu, B., Licholai, J. A., Parker, J. G. & Kravitz, A. V., Sep 2022, In: Nature neuroscience. 25, 9, p. 1124-1128 5 p.Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations
Datasets
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Striatal fiber photometry reflects primarily non-somatic changes in calcium
Legaria, A. A. (Contributor), Matikainen-Ankney, B. A. (Contributor), Yang, B. (Contributor), Ahanonu, B. (Contributor), Licholai, J. A. (Contributor), Parker, J. G. (Contributor) & Kravitz, A. V. (Contributor), figshare, 2022
DOI: 10.6084/m9.figshare.20277702, https://springernature.figshare.com/articles/dataset/Striatal_fiber_photometry_reflects_primarily_non-somatic_changes_in_calcium/20277702
Dataset