Joon Won Yoon

  • Source: Scopus
1993 …2021

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Personal profile

Research Interests

I have been studying role for GLI family oncogenes and associated genes in cancers and multidrug resistance. Amplification and/or abnormal activation GLI1, the final effector of Sonic hedgehog signal, is observed in a wide variety of cancers (approximately 30% of solid tumors). However, the mechanism of GLI1 in the development of human cancers and multidrug resistance still remains unclear.

I have been studying the mechanism of action of GLI1 and its role for oncogenesis and multidrug resistance by identifying the direct binding partners and immediate downstream targets. Hedgehog-GLI signaling pathway is activated in some rhabdomyosarcomas (RMS) and Ewing sarcomas that are resistant to chemotherapy. I use Hedgehog-GLI signaling pathway inhibitors and conventional chemotherapy drugs together for the gene-specific and synergistic inhibition of drug-resistance in these tumors. These projects will be important in developing novel strategies to prevent or treat the cancers in a target specific manner.

Expertise related to UN Sustainable Devlopment Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

PhD, University of Texas

… → 1993

Research interests

  • Cancer Biology
  • Gene Regulation
  • Molecular Biology
  • Pediatric Sarcomas
  • Signal Transduction


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