Joon Won Yoon

Personal profile

Research Interests

I have been studying role for GLI family oncogenes and associated genes in cancers and multidrug resistance. Amplification and/or abnormal activation GLI1, the final effector of Sonic hedgehog signal, is observed in a wide variety of cancers (approximately 30% of solid tumors). However, the mechanism of GLI1 in the development of human cancers and multidrug resistance still remains unclear.

I have been studying the mechanism of action of GLI1 and its role for oncogenesis and multidrug resistance by identifying the direct binding partners and immediate downstream targets. Hedgehog-GLI signaling pathway is activated in some rhabdomyosarcomas (RMS) and Ewing sarcomas that are resistant to chemotherapy. I use Hedgehog-GLI signaling pathway inhibitors and conventional chemotherapy drugs together for the gene-specific and synergistic inhibition of drug-resistance in these tumors. These projects will be important in developing novel strategies to prevent or treat the cancers in a target specific manner.

Education/Academic qualification

PhD, University of Texas

… → 1993

Research interests

Cancer Biology
Gene Regulation
Molecular Biology
Pediatric Sarcomas
Signal Transduction

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Grants

1 Finished

Roles for Hedgehog Signaling in Rhabdomyosarcoma Biology and Drug Resistance: A Targetable Pathway with Treatment Implications

Walterhouse, D. O. & Yoon, J. W.

Hyundai Hope On Wheels

9/1/12 → 12/31/14

Project: Research project

Research Output

834 Citations
19 Article
1 Chapter
1 Short survey
1 Review article

Regulation of GLI1 by cis DNA elements and epigenetic marks

Taylor, R., Long, J., Yoon, J. W., Childs, R., Sylvestersen, K. B., Nielsen, M. L., Leong, K. F., Iannaccone, S., Walterhouse, D. O., Robbins, D. J. & Iannaccone, P., Jul 2019, In : DNA Repair. 79, p. 10-21 12 p.