Grants per year
Personal profile
Research Interests
I have been studying role for GLI family oncogenes and associated genes in cancers and multidrug resistance. Amplification and/or abnormal activation GLI1, the final effector of Sonic hedgehog signal, is observed in a wide variety of cancers (approximately 30% of solid tumors). However, the mechanism of GLI1 in the development of human cancers and multidrug resistance still remains unclear.
I have been studying the mechanism of action of GLI1 and its role for oncogenesis and multidrug resistance by identifying the direct binding partners and immediate downstream targets. Hedgehog-GLI signaling pathway is activated in some rhabdomyosarcomas (RMS) and Ewing sarcomas that are resistant to chemotherapy. I use Hedgehog-GLI signaling pathway inhibitors and conventional chemotherapy drugs together for the gene-specific and synergistic inhibition of drug-resistance in these tumors. These projects will be important in developing novel strategies to prevent or treat the cancers in a target specific manner.
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, University of Texas
… → 1993
Research interests
- Cancer Biology
- Gene Regulation
- Molecular Biology
- Pediatric Sarcomas
- Signal Transduction
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Grants
- 1 Finished
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Roles for Hedgehog Signaling in Rhabdomyosarcoma Biology and Drug Resistance: A Targetable Pathway with Treatment Implications
Walterhouse, D. O. & Yoon, J. W.
9/1/12 → 12/31/14
Project: Research project
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CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment
Galat, Y., Gu, H., Perepitchka, M., Taylor, R., Yoon, J. W., Glukhova, X. A., Li, X. N., Beletsky, I. P., Walterhouse, D. O., Galat, V. & Iannaccone, P. M., May 2021, In: Stem Cells. 39, 5, p. 564-580 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Up-regulation of GLI1 in vincristine-resistant rhabdomyosarcoma and Ewing sarcoma
Yoon, J. W., Lamm, M., Chandler, C., Iannaccone, P. & Walterhouse, D., Jun 3 2020, In: BMC cancer. 20, 1, 511.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Regulation of GLI1 by cis DNA elements and epigenetic marks
Taylor, R., Long, J., Yoon, J. W., Childs, R., Sylvestersen, K. B., Nielsen, M. L., Leong, K. F., Iannaccone, S., Walterhouse, D. O., Robbins, D. J. & Iannaccone, P., Jul 2019, In: DNA Repair. 79, p. 10-21 12 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Sonic hedgehog regulation of Foxf2 promotes cranial neural crest mesenchyme proliferation and is disrupted in cleft lip morphogenesis
Everson, J. L., Fink, D. M., Yoon, J. W., Leslie, E. J., Kietzman, H. W., Ansen-Wilson, L. J., Chung, H. M., Walterhouse, D. O., Marazita, M. L. & Lipinski, R. J., 2017, In: Development (Cambridge). 144, 11, p. 2082-2091 10 p.Research output: Contribution to journal › Article › peer-review
33 Scopus citations -
P53 modulates the activity of the GLI1 oncogene through interactions with the shared coactivator TAF9
Yoon, J. W., Lamm, M. L. G., Iannaccone, S., Higashiyama, N., Leong, K. F., Iannaccone, P. M. & Walterhouse, D. O., Oct 1 2015, In: DNA Repair. 34, p. 9-17 9 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations