Joon Won Yoon

Research Assistant Professor, Pediatrics

Emailj-yoon2@northwestern.edu

852 Citations

Research output per year

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Personal profile

Research Interests

I have been studying role for GLI family oncogenes and associated genes in cancers and multidrug resistance. Amplification and/or abnormal activation GLI1, the final effector of Sonic hedgehog signal, is observed in a wide variety of cancers (approximately 30% of solid tumors). However, the mechanism of GLI1 in the development of human cancers and multidrug resistance still remains unclear.

I have been studying the mechanism of action of GLI1 and its role for oncogenesis and multidrug resistance by identifying the direct binding partners and immediate downstream targets. Hedgehog-GLI signaling pathway is activated in some rhabdomyosarcomas (RMS) and Ewing sarcomas that are resistant to chemotherapy. I use Hedgehog-GLI signaling pathway inhibitors and conventional chemotherapy drugs together for the gene-specific and synergistic inhibition of drug-resistance in these tumors. These projects will be important in developing novel strategies to prevent or treat the cancers in a target specific manner.

Education/Academic qualification

PhD, University of Texas

… → 1993

Research interests

Cancer Biology
Gene Regulation
Molecular Biology
Pediatric Sarcomas
Signal Transduction

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Grants

1 Finished

Roles for Hedgehog Signaling in Rhabdomyosarcoma Biology and Drug Resistance: A Targetable Pathway with Treatment Implications

Walterhouse, D. O. & Yoon, J. W.

Hyundai Hope On Wheels

9/1/12 → 12/31/14

Project: Research project