Joon Won Yoon

  • 852 Citations
1993 …2020

Research output per year

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Personal profile

Research Interests

I have been studying role for GLI family oncogenes and associated genes in cancers and multidrug resistance. Amplification and/or abnormal activation GLI1, the final effector of Sonic hedgehog signal, is observed in a wide variety of cancers (approximately 30% of solid tumors). However, the mechanism of GLI1 in the development of human cancers and multidrug resistance still remains unclear.

I have been studying the mechanism of action of GLI1 and its role for oncogenesis and multidrug resistance by identifying the direct binding partners and immediate downstream targets. Hedgehog-GLI signaling pathway is activated in some rhabdomyosarcomas (RMS) and Ewing sarcomas that are resistant to chemotherapy. I use Hedgehog-GLI signaling pathway inhibitors and conventional chemotherapy drugs together for the gene-specific and synergistic inhibition of drug-resistance in these tumors. These projects will be important in developing novel strategies to prevent or treat the cancers in a target specific manner.

Education/Academic qualification

PhD, University of Texas

… → 1993

Research interests

  • Cancer Biology
  • Gene Regulation
  • Molecular Biology
  • Pediatric Sarcomas
  • Signal Transduction

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Grants

Research Output

  • 852 Citations
  • 20 Article
  • 1 Chapter
  • 1 Short survey
  • 1 Review article

Up-regulation of GLI1 in vincristine-resistant rhabdomyosarcoma and Ewing sarcoma

Yoon, J. W., Lamm, M., Chandler, C., Iannaccone, P. M. & Walterhouse, D. O., Jun 3 2020, In : BMC cancer. 20, 1, 511.

Research output: Contribution to journalArticle

Open Access
  • Regulation of GLI1 by cis DNA elements and epigenetic marks

    Taylor, R., Long, J., Yoon, J. W., Childs, R., Sylvestersen, K. B., Nielsen, M. L., Leong, K. F., Iannaccone, S., Walterhouse, D. O., Robbins, D. J. & Iannaccone, P., Jul 2019, In : DNA Repair. 79, p. 10-21 12 p.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Scopus citations

    Sonic hedgehog regulation of Foxf2 promotes cranial neural crest mesenchyme proliferation and is disrupted in cleft lip morphogenesis

    Everson, J. L., Fink, D. M., Yoon, J. W., Leslie, E. J., Kietzman, H. W., Ansen-Wilson, L. J., Chung, H. M., Walterhouse, D. O., Marazita, M. L. & Lipinski, R. J., Jan 1 2017, In : Development (Cambridge). 144, 11, p. 2082-2091 10 p.

    Research output: Contribution to journalArticle

  • 18 Scopus citations

    P53 modulates the activity of the GLI1 oncogene through interactions with the shared coactivator TAF9

    Yoon, J. W., Lamm, M. L. G., Iannaccone, S., Higashiyama, N., Leong, K. F., Iannaccone, P. M. & Walterhouse, D. O., Oct 1 2015, In : DNA Repair. 34, p. 9-17 9 p.

    Research output: Contribution to journalArticle

  • 11 Scopus citations

    Noncanonical regulation of the hedgehog mediator GLI1 by c-MYC in Burkitt lymphoma

    Yoon, J. W., Gallant, M., Lamm, M. L. G., Iannaccone, S., Vieux, K. F., Proytcheva, M., Hyjek, E., Iannaccone, P. M. & Walterhouse, D. O., Jun 1 2013, In : Molecular Cancer Research. 11, 6, p. 604-615 12 p.

    Research output: Contribution to journalArticle

  • 26 Scopus citations