Joseph Robert Podojil

  • 1352 Citations
20032022
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Personal profile

Research Interests

Dr. Podojil’s work has focused on the role of costimulatory molecule expression and function on both CD4+ T cells and APC populations during autoimmune diseases, such as multiple sclerosis, and he has a particular interest in neuroimmunology. His primary research focus is to determine the cellular and molecular mechanisms underlying the differential effect of structurally modified forms of anti-CD80 monoclonal antibody (mAb) in the CD4+ Th1 cell mediated disease model of PLP139-151-induced EAE. His current findings suggest that stimulation of CD80 on a CD4+ T cell activated in Th1-promoting conditions induces an increase in the amount of IFN-¿ produced per cell and increases Th1 cell survival within the CNS. These findings suggesting a mechanism by which anti-CD80 mAb treatment of PLP139-151-primed mice exacerbates disease, while treatment with anti-CD80 Fab fragments decrease disease severity. In line with his research studying the role of CD80 expression and reverse signaling to the cell expressing CD80, he has also been studying the role of B7-H4 in CD4+ T cell function. B7-H4 is a recently discovered B7-family member molecule hypothesized to inhibit effector CD4+ T cell responses. Since current approaches for regulation of human autoimmune diseases are largely broad-based immunosuppressive strategies necessitating the physical deletion/inhibition of entire subsets of T cells or non-specific inhibition of antigen presentation or pro-inflammatory cytokine production which could compromise the host’s ability to combat opportunistic pathogens and/or increase risk of neoplasia, therefore we are currently investing the ability of short-term therapy with B7-H4 Ig may prove to be clinically viable.

Training Experience

2010Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine

Education/Academic qualification

PhD, Loyola University-Stritch School of Medicine

… → 2004

Research interests

  • Autoimmune Diseases
  • Diabetes
  • Endocrinology
  • Immunology
  • Multiple Sclerosis
  • Neuroscience

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  • 12 Similar Profiles
T-Lymphocytes Medicine & Life Sciences
Autoimmune Experimental Encephalomyelitis Medicine & Life Sciences
Oligodendroglia Medicine & Life Sciences
Regulatory T-Lymphocytes Medicine & Life Sciences
Autoimmune Diseases Medicine & Life Sciences
Multiple Sclerosis Medicine & Life Sciences
Myelin Sheath Medicine & Life Sciences
Antigens Medicine & Life Sciences

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Grants 2006 2022

Type 1 Diabetes Mellitus
T-Lymphocytes
Inbred NOD Mouse
Therapeutics
Proteins
Demyelinating Diseases
T-Lymphocytes
Myelin Sheath
Multiple Sclerosis
Oligodendroglia
Urinary Bladder Neoplasms
Muscle Neoplasms
Drug Therapy
Neoplasms
Precision Medicine

Research Output 2003 2019

  • 1352 Citations
  • 27 Article
  • 5 Review article
  • 1 Chapter
2 Citations (Scopus)

Overcoming challenges in treating autoimmuntity: Development of tolerogenic immune-modifying nanoparticles

Pearson, R. M., Podojil, J. R., Shea, L. D., King, N. J. C., Miller, S. D. & Getts, D. R., Jun 1 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 18, p. 282-291 10 p.

Research output: Contribution to journalReview article

Nanoparticles
Celiac Disease
T-Lymphocytes
Autoimmune Diseases
Clinical Trials
2 Citations (Scopus)

Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis

Chen, Y., Podojil, J. R., Kunjamma, R. B., Jones, J., Weiner, M., Lin, W., Miller, S. D. & Popko, B., Feb 1 2019, In : Brain. 142, 2, p. 344-361 18 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Oligodendroglia
Therapeutics
Autoimmune Experimental Encephalomyelitis
CNS Demyelinating Autoimmune Diseases
17 Citations (Scopus)

APOBEC-mediated mutagenesis in urothelial carcinoma is associated with improved survival, mutations in DNA damage response genes, and immune response

Glaser, A. P., Fantini, D., Wang, Y., Yu, Y., Rimar, K. J., Podojil, J. R., Miller, S. D. & Meeks, J. J., Jan 1 2018, In : Oncotarget. 9, 4, p. 4537-4548 12 p.

Research output: Contribution to journalArticle

Mutagenesis
DNA Damage
Carcinoma
Mutation
Survival
6 Citations (Scopus)

B7-H4 modulates regulatory CD4+T cell induction and function via ligation of a semaphorin 3a/Plexin A4/Neuropilin-1 Complex

Podojil, J. R., Chiang, M. Y., Ifergan, I., Copeland, R., Liu, L. N., Maloveste, S., Langermann, S., Liebenson, D., Balabanov, R. D., Chi, H., Chen, L., Vignali, D. A. A. & Miller, S. D., Aug 1 2018, In : Journal of Immunology. 201, 3, p. 897-907 11 p.

Research output: Contribution to journalArticle

Semaphorin-3A
Neuropilin-1
Regulatory T-Lymphocytes
Ligation
Semaphorins
3 Citations (Scopus)

ILDR2-Fc is a novel regulator of immune homeostasis and inducer of antigen-specific immune tolerance

Podojil, J. R., Hecht, I., Chiang, M. Y., Vaknin, I., Barbiro, I., Novik, A., Neria, E., Rotman, G. & Miller, S. D., Mar 15 2018, In : Journal of Immunology. 200, 6, p. 2013-2024 12 p.

Research output: Contribution to journalArticle

Immune Tolerance
Homeostasis
Antigens
Immunomodulation
Autoimmune Experimental Encephalomyelitis