Joseph Robert Podojil

  • 1471 Citations
20032022

Research output per year

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Personal profile

Research Interests

Dr. Podojil’s work has focused on the role of costimulatory molecule expression and function on both CD4+ T cells and APC populations during autoimmune diseases, such as multiple sclerosis, and he has a particular interest in neuroimmunology. His primary research focus is to determine the cellular and molecular mechanisms underlying the differential effect of structurally modified forms of anti-CD80 monoclonal antibody (mAb) in the CD4+ Th1 cell mediated disease model of PLP139-151-induced EAE. His current findings suggest that stimulation of CD80 on a CD4+ T cell activated in Th1-promoting conditions induces an increase in the amount of IFN-¿ produced per cell and increases Th1 cell survival within the CNS. These findings suggesting a mechanism by which anti-CD80 mAb treatment of PLP139-151-primed mice exacerbates disease, while treatment with anti-CD80 Fab fragments decrease disease severity. In line with his research studying the role of CD80 expression and reverse signaling to the cell expressing CD80, he has also been studying the role of B7-H4 in CD4+ T cell function. B7-H4 is a recently discovered B7-family member molecule hypothesized to inhibit effector CD4+ T cell responses. Since current approaches for regulation of human autoimmune diseases are largely broad-based immunosuppressive strategies necessitating the physical deletion/inhibition of entire subsets of T cells or non-specific inhibition of antigen presentation or pro-inflammatory cytokine production which could compromise the host’s ability to combat opportunistic pathogens and/or increase risk of neoplasia, therefore we are currently investing the ability of short-term therapy with B7-H4 Ig may prove to be clinically viable.

Training Experience

2010Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine

Education/Academic qualification

PhD, Loyola University/Stritch School of Medicine

… → 2004

Research interests

  • Autoimmune Diseases
  • Diabetes
  • Endocrinology
  • Immunology
  • Multiple Sclerosis
  • Neuroscience

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Grants

  • Research Output

    • 1471 Citations
    • 27 Article
    • 5 Review article
    • 1 Chapter

    Overcoming challenges in treating autoimmuntity: Development of tolerogenic immune-modifying nanoparticles

    Pearson, R. M., Podojil, J. R., Shea, L. D., King, N. J. C., Miller, S. D. & Getts, D. R., Jun 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 18, p. 282-291 10 p.

    Research output: Contribution to journalReview article

  • 7 Scopus citations

    Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis

    Chen, Y., Podojil, J. R., Kunjamma, R. B., Jones, J., Weiner, M., Lin, W., Miller, S. D. & Popko, B., Feb 1 2019, In : Brain. 142, 2, p. 344-361 18 p.

    Research output: Contribution to journalArticle

  • 10 Scopus citations

    APOBEC-mediated mutagenesis in urothelial carcinoma is associated with improved survival, mutations in DNA damage response genes, and immune response

    Glaser, A. P., Fantini, D., Wang, Y., Yu, Y., Rimar, K. J., Podojil, J. R., Miller, S. D. & Meeks, J. J., Jan 1 2018, In : Oncotarget. 9, 4, p. 4537-4548 12 p.

    Research output: Contribution to journalArticle

  • 22 Scopus citations

    B7-H4 modulates regulatory CD4+T cell induction and function via ligation of a semaphorin 3a/Plexin A4/Neuropilin-1 Complex

    Podojil, J. R., Chiang, M. Y., Ifergan, I., Copeland, R., Liu, L. N., Maloveste, S., Langermann, S., Liebenson, D., Balabanov, R. D., Chi, H., Chen, L., Vignali, D. A. A. & Miller, S. D., Aug 1 2018, In : Journal of Immunology. 201, 3, p. 897-907 11 p.

    Research output: Contribution to journalArticle

  • 11 Scopus citations

    ILDR2-Fc is a novel regulator of immune homeostasis and inducer of antigen-specific immune tolerance

    Podojil, J. R., Hecht, I., Chiang, M. Y., Vaknin, I., Barbiro, I., Novik, A., Neria, E., Rotman, G. & Miller, S. D., Mar 15 2018, In : Journal of Immunology. 200, 6, p. 2013-2024 12 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations