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Joseph S Brunzelle

  • 3577 Citations
19962019
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  • 2 Similar Profiles
Crystal structure Chemical Compounds
Catalytic Domain Medicine & Life Sciences
Histones Medicine & Life Sciences
Methylation Medicine & Life Sciences
Methyltransferases Medicine & Life Sciences
Proteins Medicine & Life Sciences
Ligands Medicine & Life Sciences
Enzymes Medicine & Life Sciences

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Grants 2011 2016

Structural Insights Into the Function of A Frataxin

Brunzelle, J. S.

Wayne State University, National Institute of Diabetes, Digestive and Kidney Diseases

9/16/11 → 7/31/16

Project: Research project

Research Output 1996 2019

  • 3577 Citations
  • 89 Article
  • 2 Comment/debate
2 Citations (Scopus)

Structural and Antiviral Studies of the Human Norovirus GII.4 Protease

Muzzarelli, K. M., Kuiper, B., Spellmon, N., Brunzelle, J., Hackett, J., Amblard, F., Zhou, S., Liu, P., Kovari, I. A., Yang, Z., Schinazi, R. F. & Kovari, L. C., Jan 1 2019, (Accepted/In press) In : Biochemistry.

Research output: Contribution to journal › Article

Norovirus
Antiviral Agents
Peptide Hydrolases
Pharmaceutical Preparations
Disease Outbreaks
2 Citations (Scopus)

Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states

Yan, Y., Edward Zhou, X., Novick, S. J., Shaw, S. J., Li, Y., Brunzelle, J. S., Hitoshi, Y., Griffin, P. R., Eric Xu, H. & Melcher, K., Jan 1 2019, In : Journal of Biological Chemistry. 294, 3, p. 953-967 15 p.

Research output: Contribution to journal › Article

AMP-Activated Protein Kinases
Nucleotides
Pharmacology
Chemical activation
Phosphotransferases
4 Citations (Scopus)

A functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity

Cornett, E. M., Dickson, B. M., Krajewski, K., Spellmon, N., Umstead, A., Vaughan, R. M., Shaw, K. M., Versluis, P. P., Cowles, M. W., Brunzelle, J. S., Yang, Z., Vega, I. E., Sun, Z. W. & Rothbart, S. B., Nov 28 2018, In : Science Advances. 4, 11, eaav2623.

Research output: Contribution to journal › Article

Methyltransferases
Proteomics
Lysine
Methylation
Proteome
1 Citation (Scopus)

Crystal structure of Campylobacter jejuni peroxide regulator

Sarvan, S., Charih, F., Butcher, J., Brunzelle, J. S., Stintzi, A. & Couture, J. F., Jul 1 2018, In : FEBS Letters. 592, 13, p. 2351-2360 10 p.

Research output: Contribution to journal › Article

Campylobacter jejuni
Peroxides
Crystal structure
DNA
Proteins
4 Citations (Scopus)

Functional insights into the interplay between DNA interaction and metal coordination in ferric uptake regulators

Sarvan, S., Charih, F., Askoura, M., Butcher, J., Brunzelle, J. S., Stintzi, A. & Couture, J. F., Dec 1 2018, In : Scientific reports. 8, 1, 7140.

Research output: Contribution to journal › Article

Campylobacter jejuni
Metals
DNA
Regulator Genes
Gene Expression